Manager Project

YASH PRALHAD GAD

***** ****** **** ** • Katy, TX 77450 • 832-***-**** • ****.***@*******.***

EXPERIENCE

SimVivo April 2007-Present

Co-Founder & Chief Executive Officer Houston, TX

Founded consulting company that provides computational science and systems modeling services for academic

and industrial applications, and consulting on educational outreach initiatives. Specialties in machine learning,

data mining, systems modeling, and neural networks.

• MD Anderson Cancer Center

o Developed mathematical model to predict the potential effect of a combined treatment of temsirolimus,

topotecan, and bortezomib in patients with different types of cancers. Made specific recommendations of

dose ranges and time courses of treatment.

o Created pharmacokinetic models of drug behavior and cell cycle models. Resulted in model’s prediction

aligning with clinical data gathered on patients utilizing the predicted dose ranges.

• Department of Homeland Security

o Co-Principal Investigator and grant writer for Department of Homeland Security Scientific Leadership

Bridge Award (Award #2009-ST-062-000031).

o Led research collaboration between Houston Community College, University of Houston-Downtown,

Rice University, and Sandia National Laboratories focusing on undergraduate research related to

homeland security in the areas of cybersecurity, materials research, and engineering.

o Created and taught a workshop introducing undergraduate students to methods in computational science

using Matlab. Developed applications involving economics, life science, physical science, and

engineering.

o Collaborated with Sandia National Laboratories during summer 2012:

§ Received approval for 2 user proposals at the Center for Integrated Nanotechnologies to

guide a team of undergraduate students on materials characterization of novel polymers.

§ Created a machine learning algorithm based on backpropagation using Matlab for Solar

Tower array users to help mine large datasets for optimal configurations of reflective mirrors

in extreme weather conditions.

• Houston Community College

o Co-Principal Investigator and grant writer for Houston Community College Chancellor’s Innovation Fund

Award “A Bioscience Pathway for the Underserved.”

o Led partnership between Houston Community College, Rice University and Baylor College of Medicine

to form a matriculation pipeline for minority students into medical school.

o Created curriculum for a research and medicine survey course with summer research and clinical

shadowing components for 20 undergraduate students.

• National Institute of Health Small Business Innovation Research Submission

o Made submission for the December 2012 cycle for Phase I funding.

o Proposed development of a software suite to mine electronic health records and public databases of

patient information for novel diagnostic criteria for dementia.

o Created novel algorithms based in machine learning and artificial intelligence to establish quantitative

diagnostic parameters, and developed pipeline for implementing these findings in the software suite.

University of Illinois at Urbana-Champaign September 1999-May 2007

Doctoral Thesis Researcher, Biophysics and Computational Biology Urbana, IL

Completed Ph.D. in Biophysics and Computational Biology, with an emphasis in computational neuroscience and

machine learning algorithms. Utilized Matlab for creation and analysis of computational models.

Research Experience

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o Developed abstract neural network model of brain circuitry within the cerebellum, and used state

space analysis and control theory to explain how sparse innervation patterns can still exert large

influences over an interconnected network. Used genetic algorithm to search configurations space.

o Created a biophysically realistic simulation of neural electrical activity within the cerebellum to

decipher the signal processing used by the brain to control short eye movements.

o Developed and tested a novel machine learning algorithm derived from the delta rule that theorized

how the brain can learn to correct for errors in eye movements.

Teaching Experience

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o Created and graded exams and homework for Biophysics 401, Biophysics 410zz, Neuroscience 404,

and Physiology 417

o Lectured for Biophysics 401 and Neuroscience 404

Additional Experience

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o Completed workshop in methods in computational chemistry and molecular dynamics simulations.

o Completed independent study tutorial to utilize the SEED genome analysis environment to mine and

annotate public genomic databases for homologs of key tumor suppressing and DNA repair genes.

Assembled a functional pathway of these genes using sequence analysis techniques.

University of Houston-Downtown June 2005-August 2005

Research Mentor Houston, TX

Created summer research project in computational neuroscience for two teams of undergraduate students.

• Completed projects using the modeling software GENESIS to create realistic models of cerebellar Purkinje

cell microzones and cell firing patterns under normal and isolated conditions.

• Presented student teams’ findings at a research symposium at the University of Houston-Downtown.

Houston PREP June 1995-August 2000

Instructor and Site Manager Houston, TX

Involved in the development of course material and administration for the Houston PREP program, a summer

program for minority students interested in science and engineering.

• Created and taught courses in SAT preparation, Visual Basic, Java, computational science and biology for

middle and high school students.

• Site manager for first satellite site of Houston PREP located at the Houston Community College Northwest

campus. Led a group of four faculty and six undergraduate students to oversee 80 middle school and high

school students.

PUBLICATIONS

Gad YP and Anastasio TJ. Simulating the Shaping of the Fastigial Deep Nuclear Saccade Command by

Cerebellar Purkinje Cells. Neural Networks 2010

Anastasio TJ and Gad YP. Sparse cerebellar innervation can morph the dynamics of a model oculomotor neural

integrator. Journal of Computional Neuroscience 2006

Yoon J, Gad Y, Wu Z. “Mathematical Modeling of Protein Structure Using Distance Geometry”. Technical

Report TR00-24 for the Computational and Applied Mathematics Department of Rice University 2000

Manna SK, Gad YP, Mukhopadhyay A, Aggarwal BB. Suppression of tumor necrosis factor-activated nuclear

transcription factor-kappaB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone.

Biochemical Pharmacology, 57(7): 763-74 1999

CONFERENCE PUBLICATIONS AND PRESENTATIONS

Society for Neuroscience, presentation titled “Sparse cerebellar innervation can morph the dynamics of a model

oculomotor neural integrator” 2005

CMS Colloquium at University of Houston-Downtown, presentation titled “Learning Cerebellar Contributions to

Saccade Generation” 2004

Supercomputing, presentation titled “Neural Networks: Instructional Material” 2002

SIAM Symposium on Computational Models, poster presentation titled “Mathematical Modeling of Protein

Structure Using Distance Geometry” 2002

MU-SPIN Conference, poster presentation titled “Development of Interactive Pre-College Computational Science

Enrichment” 1999

COMPLETED RESEARCH SUPPORT

2012 User Proposal RA2012A0003 and RA2012A0004 for the Center for Integrated Nanotechnologies

(CINT) at Sandia National Laboratories, Albuquerque, NM.

2010-2012 Co-PI and Project Lead for Department of Homeland Security Scientific Leadership Bridge Award

(Award #2009-ST-062-000031).

2010-2011 Project Lead for Houston Community College Chancellor’s Innovation Award “A Bioscience

Pathway for the Under-served”

2002-2003 Systems and Integrative Biology Training Grant, University of Illinois at Urbana-Champaign.

2001-2002 Molecular and Integrative Biology Training Grant, University of Illinois at Urbana-Champaign.

2000-2001 Biophysics and Computational Biology Training Grant, University of Illinois at Urbana-

Champaign.

EDUCATION

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN Urbana, IL

Doctor of Philosophy September 1999-May 2007

Field of Study: Biophysics and Computational Biology

Thesis: Computational Models of Cerebellar Purkinje and Fastigial Neuron Behavior During Horizontal Saccades

GPA: 3.7

JOHNS HOPKINS UNIVERSITY Baltimore, MD

Bachelor of Arts September 1994-May 1996

Major: Biology; Minor: Psychology

GPA: 3.08

SKILLS

Programming Languages – Matlab (instructor), Visual Basic (instructor), Java (instructor), C++, Pascal,

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HTML, R, Python, and iOS development

Linguistics – Marathi (fluent, spoken), Spanish

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AWARDS & RECOGNITION

Best Speaker Presentation, UIUC Molecular and Integrative Physiology Department Retreat – 2003

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Hopkins Outstanding Multicultural Student – 1996

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