Supervisor Manager
Resume:
Diana Xuan Yu, Ph.D
*** **** *** ** *****: 858-***-****
St. Petersburg, Fl 33703 Email: ************@*******.***
EDUCATION
University of California, San Diego
Ph.D. in Bioengineering, September 2008, GPA 3.86
University of California, Berkeley
Bachelor of Science in Bioengineering, December 2002, GPA 3.93
RESEARCH AND PROFESSIONAL EXPERIENCE
Salk Institute for Biological Sciences, Laboratory of Genetics, La Jolla CA
Postdoctoral Research Associate, Dec. 2008 present Supervisor: Dr. Fred Gage
Field: Neuroscience and Stem Cell Biology
Differentiation of human embryonic and induced pluriopotent stem cells to neurons
Transplantation of ES derived neurons to murine cortex and hippocampus in vivo
Organotypic brain slice culture system to assay neuronal integration
Tissue/cell culture, histology, microscopy, RT qPCR, Western blot techniques
Supervise/train laboratory technicians, devise project work flow
University of California, San Diego, Dept. of Bioengineering, La Jolla CA
Graduate Research Associate, Aug. 2004 –Nov. 2008 Supervisor: Dr. Gabriel A. Silva
Field: Retinal Neural Engineering
Assess functional properties of retinal neural networks using imaging techniques
Differentiate adult stem cells into functional photoreceptors for retinal degenerative diseases
Assess effects surface chemistry on the viability and functionality of stem cells
Matlab analysis of calcium signaling properties in astrocytic/neuronal networks
Sandia National Laboratory, Dept. of Biosystems Research, Livermore, CA
Research Internship, March 2001 Aug. 2003 Supervisor: Dr. Anup Singh
Field: Biosensors and lab on chip
Developed biosensors for Organophosphates using genetically engineered Moraxella Bacterium in sol gel
medium
Developed cell sorting techniques using dielectrophoretic trapping on microfluidic circuitry of insulating posts
Protein analysis of D. Vulgaris in response to heat, pH, and oxidative stress
LEADERSHIP EXPERIENCE
Laboratory Technician Supervisor, 2008 – present
Salk Institute for Biological Sciences, Laboratory of Genetics Gage
Train laboratory technicians in tissue culture, microscopy, molecular biology, and histology techniques
Manage and direct team of laboratory technicians and student research assistants to meet project milestones
Manage multiple research projections, including collaborations with academic labs and industry
Written research proposals for collaborations between academic and industry R&D department
Undergraduate Student Mentor, 2005 – 2008
University of California, San Diego, Dept. of Bioengineering
Trained undergraduate research assistants in tissue culture techniques and scientific writing
Mentored students received numerous awards including Undergraduate Student Research Grant, the
Chancellors Research Scholarship, Outstanding Undergraduate Research Award, STARS Research Program
INVITED TALKS
"Modeling Hippocampal Neurogenesis Using Human Pluoripotent Stem Cells." McDonnell Foundation
Research Symposium, Salk Institute. May 2012.
"Aberrant Neurogenesis in Hippocampal Neurons Derived from Induced Pluripotent Stem Cells of
Schizophrenia Patients." Sanofi Aventis Research Collaboration Symposium, Salk Institute. June 2011.
PUBLICATIONS
Yu D, DiGiorgio P, Mei A, Yao J, Lisuk D, Jappelli R, Silberman P, Gage FH. Modeling hippocampal neurogenesis
using human pluripotent stem cells. (manuscript in preparation)
Giorgetti A *, Marchetto MC*, Li M*, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardos JC, Monasterio
MB, Bardy C, Cassiani Ingoni R, Liu GH, Gage FH, Izpisua Belmonte JC. Cord Blood derived neuronal cells by
ectopic expression of Sox2 and c MYC. PNAS. Jul 31; 109(31): 12556 61 (2012). *contributed equally
Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri AR. A model for neural
developmental and treatment of Rett syndrome using human induced pluriopotent stem cells. Cell. Nov 12;
142(4):527 29 (2010).
Brennand KJ, Simone A, Jou J, Gelboin Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S,
Sebat J, Gage FH. Modeling schizophrenia using human induced pluripotent stem cells. Nature. May
12;473(7346):221 5 (2011)
Yu D, Chow SK, MacDonald CL, Buibas M, Silva GA. Amyloid beta peptide directly induces spontaneous calcium
transients, delayed intercellular caclium waves and gliosis in rat cortical astrocytes. ASN Neuro Jan 25: 2(1):6
(2010).
Yu D, Buibas M, Chow SK, Lee I, Silva GA. Characterization of calcium mediated intracellular and intercellular
signaling in the rMC 1 Müller glial cell line. Cell Mol Bioeng, Mar 1;2(1): 144 155 (2009).
Yu D*, Ho M*, Davidson MC, Silva GA. Comparison of standard surface chemistries for culturing mesenchymal
stem cells prior to neural differentiation. Biomaterials 27(24): 4333 9 (2006). *contributed equally
Yu D, Volponi J, Chhabra S, Brinker S, Mulchandani A, Singh A. Aqueous sol gel encapsulation of genetically
engineered Moraxella spp. cells for the detection of organophosphates. Biosensors & Bioelectronics 20: 1433 7
(2005).
REFERENCES
Dr. Fred F. Gage, Ph.D
Professor, Salk Institute of Biological Studies
****@****.***
858-***-**** x1012
Lynne Moore
Lab Manager of Laboratory of Genetics Gage, Salk Institute of Biological Studies
*****@****.***
858-***-**** x1007
Dr. Gabriel A. Silva M.Sc., Ph.D.
Associate Professor, UC San Diego
******@****.***
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