Yong-Chun Zeng

**** ***** **** *** *****, NC

***10

336-***-****

abqzme@r.postjobfree.com

OBJECTIVE

To obtain a challenging and rewarding position that allows me to contribute

my advanced educational, research, and organizational skills to a reputable

organization committed to excellence and advancements in science

SUMMARY OF QUALIFICATIONS

Leadership Skills

. Capable problem solver and decision maker; skilled in coaching and

delegating

. Proficient at planning, organizing and implementing projects and

programs

. Can operate effectively as a leader or member of a team

. In depth knowledge of GLP for drug safety study

Technical Skills

. Grossing, processing, embedding, H & E autostaining, microtome

sectioning, review slides, microphotography, proficiency with

troubleshooting staining inconsistencies

. Immunohistochemical staining on interneurons, neurofibres, and

biomarkers for tumor

. Pathological evaluation under microscope for preclinical toxicity

. Capable of writing pathological report, protocol, SOPs and relative

forms

. Competent with computer applications and related laboratory

equipment

. Pharmacokinetics/Toxicokinetics (WinNonlin),

Bioequivalence/Bioavailability, statistic analysis

Research Skills

. colony inventory of genotyping (PCR) for knockout mice

. whole cell patch clamp

. animal surgical model

PROFESSIONAL EXPERIENCE

LabCorp, RTP, NC 2012

Lab Service Team Leader, Dept. of Histology

Medicilon Preclinical Research LLC, Shanghai, China 2010-2011

Associate Director, Department of Pathology

MPI Research, Mattawan, MI 2007-2008

Research Associate III, Histology Plastics Laboratory, Analytical Dept, Bio-

Statistics Group

North Carolina State University, College of Veterinary Medicine, Raleigh,

NC 2005-2007

Postdoctoral Research Associate, Department of Molecular Biomedical Science

University of Nebraska Medical Center, Omaha, NE 1998-2004

Postdoctoral Research Associate, Department of Physiology, Department of

Microbiology & Pathology

EDUCATION

School of Medicine, Shanghai Jiao Tong University, Shanghai, China

MD in Medicine & Surgery 1984

School of Medicine, Shanghai Jiao Tong University, Shanghai, China

MSc in Pharmacology 1989

University of Rome "Tor Vergata", Rome, Italy

PhD in Neuroscience 1999

PROFESSIONAL ORGANIZATIONS

. HTL(ASCP)CM (Histotechnologist Board Certification #2579) 2008-

2011, American Society for Clinical Pathology (member #04226410)

. The American Physiological Society, 2000-2005 (regular member

#33142, Neural Control & Autonomic Regulation)

. American Association for the Advancement of Science, 1993, 2005-

2006

PRESENTATED ABSTRACTS /PUBLISHED PAPERS

ABSTRACTS:

1) Zeng Y.C. Reddy D.S.

Progesterone-derived neurosteroid 3alpha-hydroxy 5alpha-pregnan-20-one

inhibits spontaneous recurrent seizures in a rat model of temporal lobe

epilepsy

The FASEB Journal, 21: 885.15, 2007

2) Reddy D.S. Zeng Y.C., Shetty A.K.

Diminished spontaneous recurrent seizure activity following GABAergic

neurosteroid therapy in the pilocarpine model of chronic epilepsy

2006 Neuroscience Meeting, Atlanta, Oct 14-18, 2006

3) Zeng Y.C., Schultz H.D.

Effects of oxidative stress on TTX-r Nav 1.8 and Nav 1.9 INa in cardiac

afferent vagal neurons in diabetic rats.

The FASEB Journal, 18(5):A1258, 2004

4) Zeng Y.C., Li Y., Schultz H.D.

Oxidative stress and cardiac afferents in diabetes

The FASEB Journal, 17(5):A886, 2003

5) Zeng Y.C., Sun S.Y., Rozanski G., Xia X.H., Reddy P., Schultz H.D.

Superoxide anion attenuated INa in cardiac vagal chemosensory neurons from

diabetic rats

The FASEB Journal,16(5):829, 2002

6) Zeng Y.C., Sun S.Y., Xia X.H., Reddy P., Li Y., Schultz H.D.

Effect of exercise and heart failure on NOS isoforms in the carotid body of

rabbits

The FASEB Journal, 16(5):829, 2002

7) Xia X.H., Sun S.Y., Cornish K.G., Reddy P., Zeng Y.C., Schultz H.D.

Role of dopamine in the enhancement of peripheral chemoreflex function in

heart failure

The FASEB Journal, 16(5):828, 2002

8) Amenta F., Bongrani S., Bronzetti E., Cadel S., Ricci A., Valsecchi B.,

Zeng Y.C.

Effect of long term monoamine oxidase-B inhibitor treatment on the

structure of the hippocampus of the aged rat (Proceedings of Alzheimer's

Disease and Related Disorders held in Padova, Italy on 12-17 July 1993)

Advances in the Biosciences 87: 435-440, 1993

9) Zeng Y.C., Jin Z.J., Gu P.K.

Apply flash electroretinography in visual pharmacology and toxicology

Eur. J. Pharmacol. 183(6): 2436, 1990

ORIGINAL PAPERS:

1)Reddy D.S., Zeng Y.C.

Differential anesthetic activity of ketamine and the GABAergic neurosteroid

allopregnanolone in mice lacking progesterone receptor A and B subtypes

Methods and Findings in Experimental and Clinical Pharmacology 29(10):659-

64, 2007 Dec

2) Xiong H., Zeng Y.C., Zheng J., Thylin M.R., Gendelman H.E.,

Soluble HIV-1 infected macrophage secretory products mediate blockade of

long-term potentiation: a mechanism for cognitive dysfunction in HIV-1-

associated dementia

J.NeuroVirology 5: 519-528, 1999

3) Zheng J., Thylin M.R., Ghorpade A., Xiong H., Persidsky Y., Cotter R.,

Niemann D., Che MH., Zeng Y.C., Gelbard H.A., Shepard R.B., Swartz J.M.,

Gendelman H.E.,

Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic

mechanisms of HIV-1-associated dementia

J. Neuroimmunology 98: 185-200, 1999

4) Zeng Y.C., Bongrani S., Bronzetti E., Cadel S., Ricci A., Valsecchi B.,

Amenta F.,

Influence of long term treatment with L-deprenyl on the age-dependent

microanatomical changes in the rat hippocampus

Mech. Ageing Dev. 79:169-185, 1995

5) Zeng Y.C., Bongrani S., Bronzetti E., Cadel S., Ricci A., Valsecchi B.,

Amenta F.

Influence of long term treatment with L-deprenyl on the age-dependent

changes in rat brain microanatomy

Mechanisms of Ageing and Development 73:113-26, 1994

6) Zeng Y.C., Domenici M.R., Frank C., Sagratella S., Scotti de Carolis A.

Effects of adenosinergic drugs on hypoxia-induced electrophysiological

changes in rat hippocampal slices

Life Sci. 51(13): 1073-82, 1992

7) Zeng Y.C., Pezzola A., Scotti de Carolis A., Sagratella S.

Inhibitory influence of morphinans on ictal and interictal EEG changes

induced by cortical application of penicillin in rabbits: a comparative

study with NMDA antagonists and pentobarbitone

Pharmacol. Biochem. Behav. 43(2): 651-6, 1992

8) Zeng Y.C., Jin Z.J., Gu P.K.

Retinal toxicity in albino rabbits induced by intravitreal injection of

strophanthin-K

J. Ocul. Pharmacol. 6(1): 51-60, 1990

REVIEWS:

1) Xiong H., Zeng Y.C., Lewis T., Zheng J., Persidsky Y., Gendelman H.E.,

HIV-1 infected mononuclear phagocyte secretory products affect neuronal

physiology leading to cellular demise Relevance for HIV-1-associated

dementia

J.NeuroVirology 6 Suppl 1: S14-23, 2000

2) Polidori C., Zeng Y.C., Zaccheo D., Amenta F.

Age-related changes in the visual cortex: a review

Arch. Gerontol. Geriatr. 17: 145-164, 1993

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