JOHN C. REED, M.D., Ph.D.

Curriculum Vitae

February, 2012

Sanford-Burnham Medical Research Institute

Office Address

***** ***** ****** ***** ****

La Jolla, CA 92037

858-***-**** (O); 858-***-**** (Fax)

E-mail: abqshd@r.postjobfree.com

Education

1976-1980 B.A. University of Virginia, Charlottesville, VA

1980-1986 M.D., Ph.D. University of Pennsylvania, School of Medicine,

Philadelphia, PA

Postdoctoral Training

1986-1989 Resident in Clinical Pathology

Hospital of the University of Pennsylvania

Department of Pathology & Laboratory Medicine

1986-1988 Postdoctoral Fellow in Molecular Biology

Wistar Institute of Anatomy and Biology

Philadelphia, PA (C. Croce, Advisor)

Professional and Faculty Appointments

2010-present Chief Executive Officer

Sanford-Burnham Medical Research Institute

2010-present Donald Bren Chief Executive Chair

Sanford-Burnham Medical Research Institute

2002-2010 President & Chief Executive Officer

Sanford-Burnham Medical Research Institute

(formerly, Burnham Institute for Medical Research)

2007-2010 Donald Bren Presidential Chair

Burnham Institute for Medical Research

2007-present Adjunct Professor, Department of Biochemistry

University of Florida - Gainsville, Florida

2007-present Adjunct Professor, School of Medicine

University of Central Florida Orlando, Florida

2002-present Associate Member

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Whitaker Institute of Biomedical Engineering, University of

California, San Diego

1997-2011 Adjunct Professor, Department of Molecular Pathology

University of California at San Diego, School of Medicine

(UCSD)

1996-present Adjunct Professor, Department of Biology

San Diego State University

2002-2003 Director, Cancer Center

The Burnham Institute

1995-2001 Scientific Director

The Burnham Institute

1995-2000 Founder and Director, Program on Apoptosis and Cell Death

Research

The Burnham Institute

1994-2002 Deputy Director, Cancer Center

The Burnham Institute

1993-present Associate Member, Cancer Center

University of California at San Diego (UCSD)

1992-1995 Director, Oncogene and Tumor Suppressor Gene Program

The Burnham Institute

1989-1992 Assistant Director

Laboratory of Molecular Diagnosis

Hospital of the University of Pennsylvania

1989-1992 Assistant Professor

University of Pennsylvania School of Medicine

Department of Pathology & Laboratory Medicine

1988-1989 Research Associate

University of Pennsylvania School of Medicine

Department of Pathology & Laboratory Medicine

Awards and Honors (Selected)

2011 American Association for the Advancement of Science

2011 Fellow

2009 American Association of Neurological Surgeons

2009 Awardee, Theodore Kurze Lecture

2008 BIOCOM Life Sciences Heritage Award

Outstanding Contributions to Life Sciences

2007 Danny Thomas Lecture Series, 2007 Visiting Professor

St. Jude Children s Research Hospital

2007 Donald Ware Waddell Award

Outstanding Contributions to Cancer Research

2007 Achievement Rewards for College Scientists

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Scientist of the Year Award, San Diego Chapter

2006 Thomson Scientific Doctors of the decade, 1995-2006

Dr. Reed is 8th most highly-cited researcher in life-sciences

and medicine for the decade; 1st in field of Cell Biology; 1st in

field of General Biomedicine.

2006 PENN Medicine Distinguished Graduate Award

2003 Bristol-Myers Squibb Distinguished Cancer Researcher Award

2002 Institute for Scientific Informtion

Decade s most highly cited apoptosis researcher 1991-2001

(http://www.esi-topics.com/apoptosis/index.html)

2002 Harry B. Van Dyke Award

20th Harry B. Van Dyke Lecturer, Columbia University.

2000 Institute for Scientific Information

Ranked #1 Hottest Research in Life Sciences Worldwide

2000 Warner-Lambert/Parke Davis Award

American Society for Investigative Pathology (ASIP)

2000 American Academy of Neurology

Decade of the Brain Award

1999 Institute for Scientific Information

Ranked #1 Hottest Research in Life Sciences Worldwide

1999 35th Annual Harold G. Pritzker Memorial Lecture Presenter

Mount Sinai Hospital, University of Toronto

1999 1st Inaugural D. Wayne Calloway Memorial Lecture

Memorial Sloan-Kettering Cancer Center

1998 Local Hero in the Fight Against Breast Cancer Award

Susan G. Komen Foundation

1994 Stohlman Memorial Scholar Award

Leukemic Society of America

1991 American Association University Pathologists

1986 Upjohn Achievement Award

1985 Sheard Sanford Award

American Society of Clinical Pathologists

1985 Presidential Award

Reticuloendothelial Society

Membership in Honorary Societies

1986 Sigma Xi

1983 Alpha Omega Alpha

1980 Phi Beta Kappa

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Membership in Professional Societies (selected)

2002 2004 Young Presidents Organization (YPO)

1997 - 2003 American Association of Immunologists (AAI)

1996 - present Federation of American Socities for Experimental Biology (FASEB)

1995 - present American Socity for Investigative Pathology (ASIP)

1994 - present CALGB

1992 - present American Hematology Society (ASH)

1991 - present Eastern Cooperative Oncology Group (ECOG)

1991 - 1993 Academy Clinical Laboratory Physicians & Scientists (ACLPS)

1990 - present American Association for Cancer Research (AACR)

1986 - present American Society for Microbiology (ASM)

1981 - present American Association for the Advancement of Science (AAAS)

Medical Licensure

Pennsylvania #MD-041037-E (inactive)

California #G-081123 (active)

Committees and Study Sections:

2011 Member, Clinical & Translational Research Institute, UCSD

2011 Chair, AACR Basic Cancer Research Fellowships Scientific Review

Committee

2010 Co-chair, American Association for Cancer Research (AACR),

Special Conference on Cell Death Mechanisms and Cancer Therapy

2009-present Charter Member, Clinical and Translational Research Institute

(CTRI), University of California, San Diego

2008-2010 Chair of the NIH, MLPCN Steering Committee

2008 BIO-2008, Organizing Committee for Annual Meeting, San Diego,

CA

2008 National Institutes for Health, Rapid Access to Investigatory Drugs

(RAID), Chair, Review Committee

2007-2010 Francis Parker School, Science Review Committee

2007-2010 Governance Committee of the Independent Citizens Oversight

Committee (ICOC), California Institute for Regenerative Medicine

2007-present San Diego Consortium for Regenerative Medicine, Board of

Directors

2007-present San Diego Consortium for Systems Biology, Steering Committee

2007-present Sanford-Burnham Medical Research Institute, Board of Trustees,

Facilities Committee

2007-present International Bipolar Disease Foundation, Co-chair, Scientific

Advisory Board

2006 National Cancer Institute, Cellular & Tissue biology Special

Emphasis panel

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2006 National Cancer Institute, Molecular Biology Special Emphasis

Panel

2006-present SASS Foundation, Advisory Board

2006-2009 Scientific Advisory Board, University of New Mexico, SCOR grant,

Leukemia & Lymphomas Society of America

2006 Steering Committee, Molecular Medicine program/Nature Press

2005-present CONNECT, Executive Committee of Board of Directors

2005-2009 Board of Advisors for San Diego Center for Ethics in Science and

Technology

2005-2010 Legislative Subcommittee of the Independent Citizens Oversight

Committee (ICOC) for the California Institute of Regenerative

Medicine (CIRM)

2005-present Molecular Library Screening Center Network (MLSCN), Steering

Committee, National Institutes of Health

2005-2007 National Lifescience and Biotechnoloogy Research & Development

Advisory Bord, King Abdullah II, Jordan

2005-2006 NCI/Cancer Genome Project advisory committee

2004 Chair, Selection committee for Landon Prize from American

Association for Cancer Research

2004-2010 Independent Citizen s Oversight Committee (ICOC), governing

board of the California Institute for Regenerativae Medicine

( CIRM )

2004-2010 Legislative Subcommittee of the Independent Citizens Oversight

Committee (ICOC), Site-Selection Subcommittee

2004-2007 Singapore Biomedical Research Council, Scientific Advisory Board

2004-2007 Stratagene, Inc., Audit Committee

2003 AACR-NFCR Professorship in Basic Cancer Research Committee

2003-2006 American Society Hematology, Neoplasia Committee

2003 BIOCOM / San Diego Annual Dinner Honorary Host Committee

2003 BIOCOM / San Diego Science Ethics & Public Policy, Steering

Committee

2003-present BIOCOM / San Diego Science & Technology Committee

2003-2005 Board of Advisors for San Diego Center for Ethics in Science and

Technology

2003-2005 Child & Adolescent Bipolar Foundation, Scientific Advisory Board

2003 CONNECT; Most Innovative Products Awards, Judges Committee

2003 CONNECT; Life-Sciences Computing Initiative, Advisory

Committee

2003-2004 CONNECT; Life-science/Information Technology Global

Technology, Global Initiative Planning Committee

2003 Francis Parker High School, Science Chair Selection Committee

2003-present ISIS Pharmaceuticals, Compensation Committee

2003-present ISIS Pharmaceuticals, Nominating, Governance & Review

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Committee

2003 Organizing Committee, San Diego Ethics Forum in Science and

Technology

2003-present Pathology Co-chair, ECOG 1899

2003-2007 Selection Committee, Bristol Myers Squibb Prize for Cancer

Research

2003 Selection Committee, Distinguished Basic Science Cancer Professor,

American Association for Cancer Research

2003-2006 Steering Committee, Center for Ethics in Science and Technology

2003-2007 Stratagene, Inc., Compensation Committee

2003 UCSD, Pathology Chair Selection Committee

2002 AACR Nominating Committee

2002-2004 American Association for Cancer Research, Nominating Committee

2002-present breastcancer.org Advisory Board Member

2002-present Sanford-Burnham Medical Research Institute, Board of Trustees,

Finance Committee

2002-present Sanford-Burnham Medical Research Institute, Board of Trustees,

Nominating and Governance Committee

2002-present Sanford-Burnham Medical Research Institute, Board of Trustees,

Technology Transfer Committee

2002-present Sanford-Burnham Medical Research Institute, Board of Trustees,

Development Committee

2002-2009 CALGB Lymphoma Committee

2002 External Advisory Board, Institute of Medicine UCSD-Salk

Training Program

2002-2004 IDUN Pharmaceuticals, Recruitment Committee (Chair)

2001 AACR Special Conferences, Abstract Review Committee

2001-2010 Advisory Committee, UCSD Specialized Center of Research

(SCOR) on Leukemia & Lymphoma

2001 American Society of Hematology, Abstract Review Committee

2001 Organizing Committee, 9th International Congress on Tumor

Necrosis Factor and Related Cytokines

2001-2009 Scientific Subcommittee for Neoplasia, American Society

Hematology

2000-2003 National Cancer Institute/Advisory Committee on New Directions

in Prostate Cancer Therapy

1999-2004 Chair, CaP-CURE Translational Apoptosis Research Committee for

Prostate Cancer

1998-2004 International Forum for Corporate Directors (IFCD)

1998-2004 UCSD Cancer Center, San Diego, Scientific Advisory Board

1997-2000 American Association for Cancer Research, Program Committee

1997-2003 American Association for Cancer Research, Special Conference

Committee

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1997-1998 National Cancer Institute, Breast Cancer Progress Review Group

1997-2002 Scientific Advisory Board, MD Anderson Cancer Center, Cancer

Gene Therapy Program

1997-2004 Scientific Advisory Committee, Stanford Research Institute,

Program Project Grant

1997-2003 Scientific Advisory Committee, Thomas Jefferson University,

Program Project Grant

1996 Abstract Review Committee, American Society for Clinical

Oncology

1996 Abstract Review Committee, American Society of Hematology

1995-1998 Scientific Advisory Board, American Society for Clinical Oncology

(ASCO)

1995-2001 Scientific Advisory Board, Lymphoma Research Foundation of

America, Inc.

1995-2003 Study-Chair, ECOG Protocol 6491

1994 Breast Cancer SPORE grants. National Cancer Institute

1993 Pathology B Study Section, ad hoc. National Cancer Institute

1992 Gene Therapy Study-Section C, ad hoc. National Cancer Institute

1991-1993 American Cancer Society. Cell Biology Study Section

1991-2001 Laboratory Scientific Advisory Committee. Eastern Cooperative

Oncology Group (ECOG)

1989-1991 American Cancer Society. Cell and Developmental Biology Study

Section

Editorial Boards (selected):

1997 -2001 BLOOD

1995 -2004 Cancer Research

1994 -2004 Clinical Cancer Research

1996 -2001 Journal of Biological Chemistry

1996 -2001 Journal of Clinical Investigation

1996 -1998 Journal of Immunology

2002 -2007 Molecular & Cellular Biology

2000 -present Nature Reviews

2002 -present Cancer Biology & Therapy

2002 -present Cell Cycle

1994 -2005 Cell Death & Differentiation

2002 -2005 Oligonucleotides

2001 -present Expert Opinion on Therapeutic Targets

2000 -present Current Opinion in Investigational Drugs (COID)

1999 -2007 Mitochondrion

1999 -2007 Tumor Targeting

1998 -2000 Current Opinion in Oncologic, Endocrine and Metabolic Drugs

1998 -present International Journal of Oncology

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1998 -present Neoplasia

1996 -2004 Antisense and Nucleic Acid Drug Development

1996 -2006 Frontiers in Bioscience

1996 -1997 Journal of Inflammation

1996 -1998 Molecular and Cellular Differentiation

1996 -1998 Receptors & Signal Transduction

1995 -2002 Advances in Leukemia and Lymphoma

1994 -present Cancer Gene Therapy

1994 -present Molecular Carcinogenesis

1993 -1996 Antisense Research and Development

1993 -1999 Oncology Reports

2009-present Genes & Cancer

2009-present Oncogene

2010-present Oncotarget

2011-present Sequencing

Non-Academic Scientific Advisory Boards/Consulting: (past and present)

Abbott Laboratories, Inc. Chicago, IL [SAB/oncology division]

Apoptech Pharmaceuticals, Inc. San Diego, CA [Scientific Founder]

Apoptos, Inc. San Diego, CA [Scientific Founder (Chair, SAB)]

ARCS Foundation, Washington, DC [Science and Engineering Advisory Council]

BioCarta, Inc., San Diego, CA [SAB]

BioDuro LLC, San Diego, CA [SAB]

Biological Dynamics, San Diego, CA [SAB]

California Bipolar Foundation, San Diego, CA [SAB] (Co-chair)

California Healthcare Institute [Board of Directors]

Child & Adolescent Bipolar Foundation, Wilmette, IL [Professional Advisory

Council]

Entropia, Inc., San Diego, CA [Lifesciences SAB]

Genome BioSciences, Temecula, CA [SAB]

Genta, Inc., San Diego, CA [Scientific Advisory Board (SAB)]

GMP Companies, Inc., Fort Lauderdale, FL [SAB]

Hybritech, Inc., San Diego, CA

IDUN Pharmaceuticals, Inc., San Diego, CA [Scientific Co-Founder/SAB]

InSync Research, Inc. Alisa Veijo, CA [Chair; SAB]

ISIS Pharmaceuticals, Inc., Carlsbad, CA [SAB]

LabEx Immuno-Oncology, France [Institutional Board]

Life Sciences Information Technology, San Diego, CA [Member SAB]

McKinsey & Company, New York, NY [Member, SAB]

OSI Pharmaceuticals, Farmingdale, NY [SAB]

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Predictive Sciences, Inc., Boston, MA [SAB]

Quorex Pharmaceuticals, Inc., Carlsbad, CA [SAB]

Robertson, Stephens, and Company, San Francisco, CA

San Diego Life Sciences Accelerator, Rancho Santa Fe, CA [SAB]

San Diego Venture Group, San Diego, CA [SAB]

Shipton Group, Ltd., Shipton China Healthcare Fund [SAB]

Stratagene, Inc., La Jolla, CA [SAB]

Structural Bioinformatics, San Diego, CA [SAB]

Board of Directors/Board of Trustees (past and present)

Biocom, Board of Directors, San Diego, CA

Sanford-Burnham Medical Research Institute, Board of Trustees, La Jolla, CA

California Institute for Regenerative Medicine, Board of Directors, San Francisco,

CA

Clovis Oncology, Inc., Boulder, CO

Connect, Board of Directors, San Diego, CA

IDUN Pharmaceuticals, Inc., Board of Directors, San Diego, CA

ISIS Pharmaceuticals, Inc., Board of Directors, Carlsbad, CA

Pharmion, Inc., Board of Directors, Boulder, CO

Repros, Inc., Houston, TX

Sanford Consortium for Regenerative Medicine, La Jolla, CA

ScienceReagents, Inc., Board of Directors, San Diego, CA

Stratagene, Inc., Board of Directors, La Jolla, CA

San Diego Consortium for Regenerative Medicine, Board of Directors, San Diego,

CA

Grants (past and present)

1980 American Heart Association

Student Clerkship in Stroke Research

1980-2004 NIH (P30 CA30199)

Cancer Center Support Grant

198l-1986 National Institutes of Health

Medical Scientist Training Program Grant

1986-1988 National Institutes of Health

Postdoctoral Training Fellowship Grant

1988-1991 Leukemia Society of America, Special Fellow

Molecular Physiology of bcl-2

1988-1993 National Institutes of Health (R0l-CA47956)

Investigation of bcl-2 function through gene transfer

1989-1991 W.W. Smith Charitable Trust

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Kinase encoding proto-oncogenes in IL2 signal transduction

1989-1996 American Cancer Society

Clinical Investigation Grant (DHP 71185)

Mechanisms of bcl-2 oncogene activation

1991-1996 Leukemia Society of America, Scholar

Kinase encoding proto-oncogenes in IL2-signaling

1991-1994 National Institutes of Health (R01-CA54957)

Kinase encoding proto-oncogenes in IL2-signalling

1991-1994 Council for Tobacco Research (TRC 3ll3)

Molecular Cloning and Characterization of Novel Genes

that Regulate Programmed Cell Death

1992-1996 National Institutes of Health (R0l CA60181)

Mechanisms of Oncogene Activation and Function

1992-1995 National Institutes of Health (R0l-CA60381)

Antisense oligonucleotide approaches to BCL-2

1993-1997 National Institutes of Health (U01-CA-60421)

Clinicopath correlates with Bcl-2 in non-Hodgkin Lymphoma

1993-1996 American Cancer Society (IM 68470)

Regulation and Function of p56-Lck kinase by interleukin-2

1994 CaP-CURE Award

Bcl-2 and prostate cancer

1995-2006 National Institutes of Health (R01-CA67329)

BAG-1: A novel Bcl-2-binding protein

1995-1998 California Breast Cancer Research Program (1RB-0093)

Bax gene expression in breast cancer

1995 Susan G. Komen Breast Cancer Foundation (9527)

Significance of Bcl-2 and Bax expression in breast cancer

1995 American Cancer Society (DHP-32E)

Mechanisms of Bcl-2 oncogene activation

1996 US Army Medical and Material Command (RP951168)

Yeast genetics for delineating Bax/Bcl-2 pathway of cell death

regulation

1996 CaP CURE Award

Regulation of chemoresistance by Bcl-2/Bax heterodimers in

advanced prostate cancer

1996-2010 NIH (P01-CA069381)

Signal transduction and cell death regulation

1996-1999 National Institutes of Health (R01-CA-72994)

FAS-mediated T-cell apoptosis in HIV infection

1996-2006 NIH/NCI (P01-CA55164)

The therapy of AML

1996-1998 California Breast Cancer Research Program (2RB-0215)

Immune response to breast cancers: Function of TRAF proteins

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1996-2004 ECOG (U10-CA21115)

Prognostic significance of apoptosis regulators in advanced breast

cancer

1997-1999 CaP CURE Award

Phosphorylaton of Bcl-2 as an approach to the treatment of hormone

independent prostate cancer

1997-2001 US Army Medical Research Program (DAMD17-97-1-7294)

The role of IAP family genes in breast cancer

1998-2006 NIH (R01 AG15402)

Inhibition of proteases by IAPs

1998-2010 NIH (R01 AG15393)

BI-1, a regulator of ER-stress pathways linked to apoptosis

1998-2003 NIH (P01 CA 78040)

Drug Screening Assays for Apoptosis Targets

1998-1999 CaP CURE Award

ApoGenomics, Discovery of Novel Genes in Prostate Cancer

1998-2003 US Army Prostate Research Program (DAMD17-98-1-8584)

Regulation of hormone responses in prostate cancer BAG1L

1998-2001 US Army Medical Research Program (DAMD17-98-1-8563)

Functions of Beta- and Gamma-Catenins in Prostate Cancer

1999-2000 CaP CURE Award

ApoGenomics, Discovery of Novel Genes in Prostate Cancer

1999-2000 California Breast Cancer Research Program (BCRP 4JB-0061)

Role of Gamma-Catenin in a Breast Cancer Mouse Model

1999-2003 NIH (P01 CA88647)

Molecular studies of drug-resistance in CLL (Consortium Sub-

Contract)

2000-2010 NIH (RO1-GM060554)

Mitochondria and Apoptosis

2000-2001 CaP CURE Award

Apoptosis-sensitizing compounds for prostate cancer.

2000-2005 NIH (P01-CA81534)

Biochemistry of B-Cell Chronic Lymphocytic Leukemia

2000-2004 NIH (R01-GM61694)

CED-4 Family Proteins

2000-2003 GMP Companies Inc.

Diagnostic and prognostic marker research for cancer

2001-2006 NIH (P01 CA55164)

The Therapy of AML Project 3: Apoptosis and Chemotherapy in AML

2002-2004 California Breast Cancer Research Program (BCRP 8WB-0079)

PPAR modulators as apopotosis sensitizers for breast cancer

2002-2004 California Breast Cancer Research Program (BCRP 8WB-0110)

Structure and function of the Bax apoptosis regulator

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2002-2008 NIH (R01 AI056324)

PAAD-family proteins and innate immunity.

2002-2005 DAMD (17-02-1-0313)

Structural Basis of Bcl-2-Regulated Mitochondrion-Dependent

Apoptosis

2004-2007 TRDRP (13RT-0130)

IAP Antagonists for Lung Cancer Treatment

2004-2006 California Breast Cancer Research Program (10WB-0194)

Novel Agents for Breast Cancer Therapy

2004-2009 NIH (P01 AI055789)

Virulence Factors and Cell Death

2004 CapCURE Award

IAP Antagonists for Prostate Cancer

2004-2007 Aventis Award

Taxotere and Inhibitor of Apoptosis Protein (IAP) Antagonists

2004 ABC2 Award

IAP Antagonists for Glioblastoma

2004-2009 NIH (R01 CA112053)

Mechanisms of the Hepatitis-B-X-interacting protein (HBXIP)

2005-2008 NIH (1 U54 HG003916)

San Diego Center for Chemical Genomics

2005-2010 NIH (U01 CA113318)

Apoptosis-Based Cancer Drug Discovery

2005-2006 NIH (U01 CA114810)

Evaluation of Predictive Signatures of Prostate Cancer

2005-2006 Oncomax/CRSA 0505

Characterization of SM5-1 and its role in Tumorigenesis

2005-2009 Department of Defense (PR054580)

Anti-apoptotic Drugs for Radioprotection

2005-2010 Leukemia & Lymphoma Society of America, SCOR (LLS 7332-06)

Chemical Antagonist of Caspase Inhibitors for Treatment of CLL

2006 NIH (MH077632)

Chemical inhibitors of anti-apoptotic protein Bfl-1

2006-2011 NIH (P01 CA081534)

Chronic Lymphocytic Leukemia Research Consortium

2006-2012 NIH (P01 CA55164)

Mechanisms of Apoptosis Dysregulation in AML

2006-2011 NIH (R01 HL082574)

Anti-Apoptotic Compounds for Treatment of Brain Ischemia

2006-2008 Department of the Army (06138006)

Cytoprotective Chemicals for Amyotrophic Lateral Sclerosis

Treatment

2006-2007 NIH (X01 MH079863)

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High Throughput Screening Assay for Hsp70 Inhibitors

2007-2008 NIH (R03 MH081277)

Chemical Antagonists of IAP-family Antiapoptotic Proteins

2007-2008 NIH (R03 DA024887)

Chemical Inhibitors of ER Stress

2007-2008 Apoptose Pharmaceuticals, Inc.

XIAP Sponsored Research Agreement

2008-2010 Department of Defense (PC074016)

Chemical Agonists of the PML/Daxx Pathway for Prostate Cancer

Therapy

2008-2013 NIH (1 U01 AI078048)

Countermeasures for Bioterrorism Targeting Cellular Host Factors

2008-2014 NIH (1 U54 HG005033)

Burnham Center for Chemical Genomics

2008-2009 NIH (1 R03 MH084844)

High Throughput Screening Assays for NOD1 and NOD2 Inhibitors

2008-2009 NIH (1 R03 MH0856677)

HTS Assay for UBC13, a Mediator of Inflammatory Signaling

2009-2013 NIH (1 R01 AI082629)

Yeast-based HTS Assay Technologies for Proteases

2009-2014 NIH/NCI (BOA#29XS123)

NCI Chemical Biology Consortium

2010-2012 NIH/NIMH (1 R03 MH090871)

Chemical Inhibitors of Autophagins for Autophagy Modulation

2010-2015 NIH/NIAID (1 R01 AI091967)

Virulence Mechanisms of Viral Bcl-2 Homologs

2010-2015 NIH/NIAID (1 P01 AI090935) (Young; Salk)

Project 2: Innate Immunity and HIV Restriction

2011-2016 NIH/NCI (1 R01 CA163743)

IAP family Proteins and Cancer

2012-2017 UCSD/NIH (1 P50 GM085764)

Gene Networks Regulating Cellular Response to Endoplasmic

Reticulum Stress

Other Activities

Founder and Chair, San Diego Apoptosis Research Group

Founder and Chair, San Diego Prostate Cancer Research Group

Lectures

Dr. Reed has delivered hundreds of lectures around the world. He has also served as

the organizer or co-organizer of scientific meetings for the American Association for

Reed page 14

Cancer Research (AACR), American Society of Hematology (ASH), American Society for

Clinical Oncology (ASCO), Gordon Research Conferences, and many other research

organizations.

BIBLIOGRAPHY

Publications:

Journals

1. Winn, H.R., Morii, S., Weaver, D.B., Reed, J.C., Ngai, A.C., Berne, R.M.K. Changes

in blood adenosine concentrations during hypoglycemia and posthypoxic

hyperemia. J. Cerebral Blood Flow Metabol. 3:(suppl.l) S449, l983.

2. Winn, H.R., Morii, S., Reed, J.C., Berne, R.M. Changes in brain adenosine during

and after transient (l5-30 sec.) hypoxia: Correlation with cerebrovascular

resistance. Stroke. ll:l3, l984.

3. Reed, J.C., Robb, R.J., Greene, W.C., Nowell, P.C. Effect of wheat germ agglutinin

on the interleukin pathway of human T lymphocyte activation. J. Immunol.

l34:3l4-323, l985.

4. Reed, J.C., Tadmori, W., Kamoun, M., Koretzky, G.A., Nowell, P.C. Suppression

of interleukin 2 receptor acquisition by monoclonal antibodies recognizing the 50

kd protein associated with the sheep erythrocyte receptor on human T

lymphocytes. J. Immunol. l34:l63l-1639, l985.

5. Tadmori, W., Reed, J.C., Nowell, P.C., Kamoun, M. Functional properties of the

50 kd protein associated with the E-receptor on human T lymphocytes:

Suppression of IL2 production by anti-p50 monoclonal antibodies. J. Immunol.

l34:l709-1716, 1985.

6. Taylor, D.S., Reed, J.C., Nowell, P.C. Stimulation and inhibition of human T cell

subsets by wheat germ agglutinin. J. Immunol. l34:3756-3761, l985.

7. Reed, J.C., Nowell, P.C., Hoover, R.G. Regulation of c-myc mRNA levels in

normal human lymphocytes by modulators of cellular proliferation. Proc. Natl.

Acad. Sci. USA 82:422l-4224, l985.

8. Reed, J.C., Greene, W.C., Hoover, R.G., Nowell, P.C. Monoclonal antibody

OKTllA inhibits and recombinant interleukin-2 (IL2) augments expression of IL2

receptors at a pretranslational level. J. Immunol. l34:2478-2482, l985.

9. Reed, J.C., Sabath, D.E., Hoover, R.G., Prystowsky, M.B.: Recombinant

interleukin-2 regulates levels of c-myc mRNA in a cloned murine T lymphocyte.

Mol. Cell. Biol. 5:336l-3368, l985.

10. Reed, J.C., Jegasothy, B.V., Batra, B.K., Weidenfeld, J., Smith, D.R., Nowell, P.C.

The lymphokine "inhibitor of DNA synthesis" (IDS) suppresses human T

lymphocyte proliferation by an interleukin-2 independent mechanism.

Lymphokine Res. 5:ll-20, l986.

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11. Reed, J.C., Alpers, J.D., Nowell, P.C., Hoover, R.G. Sequential expression of proto-

oncogenes during lectin-stimulated mitogenesis of normal human T lymphocytes.

Proc. Natl. Acad. Sci. USA 83:3982-3986, l986.

12. Reed, J.C., Abidi, A.H., Alpers, J.D., Hoover, R.G., Robb, R.J, Nowell, P.C. Effects

of cyclosporin A and dexamethasone on interleukin 2 receptor gene expression. J.

Immunol. l37:l50-154, l986.

13. Kern, J.A., Reed, J.C., Daniele, R.P., Nowell, P.C. Role of accessory cells for

expression of T cell activation genes. J. Immunol. l37:764-769, l986.

14. Hoxie, J.A., Alpers, J.D., Strauss, J., Huebner, K., Cederbaum, A., Reed, J.C.

Human immunodeficiency virus: Effects on T4 protein and mRNA levels in

infected cells. Science. 234:ll23-1127, l986.

15. Reed, J.C., Alpers, J.D., Scherle, P.A., Hoover, R.G., Nowell, P.C., Prystowsky,

M.B. Proto-oncogene expression in cloned T lymphocytes: Concanavalin A and

interleukin 2 induce different patterns of expression. Oncogene. l:223-228, l987.

16. Reed, J.C., Tsujimoto, Y., Alpers, J.D., Croce, C.M., Nowell, P.C. Regulation of bcl -

2 proto-oncogene expression during normal human lymphocyte proliferation.

Science. 236:l295-1299, l987.

17. Reed, J.C., Alpers, J.D., Nowell, P.C. Expression of c-myc proto-oncogenes in

normal human lymphocytes: regulation at both the pre- and post-transcriptional

levels. J. Clin. Invest. 80:l0l-106, l987.

18. Broome, H.E., Reed, J., Godillot, E., Hoover, R.G. Differential promoter util ization

in the c-myc gene induced by mitogens and interleukin 2 in human T lymphcytes.

Mol. Cell. Biol. 7:2988-2993, l987.

19. Nowell, P.C., Reed, J.C., Croce, C.M. Oncogenes in normal and neoplastic

lymphocytes. Clin. Immunol. Newsletter. 8:l7l-174, l987.

20. Kern, J.A., Lamb, R., Reed, J.C., Daniele, R.P., Nowell, P.C. Dexamethasone

inhibition of interleukin-l- production by human monocytes. J. Clin. Invest. 8l:237-

241, l988.

21. Reed, J.C., Nowell, P.C. Soluble inhibitors of T lymphocyte proliferation: tools for

dissecting pathways of T cell activation. Immunol. Res. 7:93-112, l988.

22. Malter, J., Reed, J., Kamoun, M. Induction and regulation of CD2 mRNA in

human lymphocytes. J. Immunol. l40:3233-3236, l988.

23. Kern, J.A., Lamb, R.J., Reed, J.C., Elias, J.A., Daniele, R.P. Interleukin-l-beta gene

expression in human monocytes and alveolar macrophages from normal and

sarcoidosis patients. Amer. Rev. Resp. Dis. l37:1180-1184, l988.

24. Reed, J.C., Prystowsky, M.B., Nowell, P.C. Regulation of gene expression in

lectin-stimulated or lymphokine-stimulated T lymphocytes effects cyclosporin A.

Transplantation 46 (Suppl.):85S, l988.

25. Reed, J., Cuddy, M., Slabiak, T., Croce, C., Nowell, P. Oncogenic potential of

human bcl-2 demonstrated by gene transfer. Nature. 336:259-261, l988.

26. Reed, J., Tsujimoto, Y., Epstein, S., Cuddy, M., Slabiak, T., Nowell, P., Croce, C.

Regulation of bcl-2 gene expression in lymphoid cell lines containing t(l4;l8) or

normal #l8 chromosomes. Oncogene Res. 4:271-282, 1989.

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27. Reed, J., Haldar, S., Cuddy, M., Croce, C., Makover, D. Deregulated BCL2

expression enhances growth of a human B cell line. Oncogene. 4:ll23-1127, l989.

28. Reed, J., Haldar, S., Cuddy, M., Croce, C., Makover, D. BCL2-mediated

tumorigenicity of a human T-lymphoid cell line: Synergy with MYC and

inhibition by BCL2 antisense. Proc. Natl. Acad. Sci. USA 87:3660-3664, l990.

29. Reed, J.C., Stein, C., Subasinghe, C., Haldar, S., Croce, C.M., Yum, S., Cohen, J.

Antisense-mediated inhibition of bcl-2 protooncogene expression and leukemic

cell growth and survival: Comparisons of phosphodiester and phosphorothioate

oligodeoxynucleotides. Cancer Res. 50:6565-6570, l990.

30. Reed, J.C., Haldar, S., Croce, C., Cuddy, M.: Complementation by BCL2 and C-

HA-RAS oncogenes in malignant transformation of rat embryo fibroblasts. Mol.

Cell. Biol. l0:4370-4374, l990.

31. Haldar, S., Reed, J., Beatty, C., Croce, C. Role of BCL2 in growth factor triggered

signal transduction. Cancer Res. 50:7399-7401, l991.

32. Makni, H., Malter, J., Reed, J.C., Lang, G., Kioussis, D., Kamoun, M.

Reconstitution of an active surface CD2 by DNA transfer in CD2 CD3+ JURKAT

cells facilitates CD3-T-cell receptor- mediated IL2 production. J. Immunol.

146:2522-2529, l991.

33. Makover, D., Cuddy, M., Bradley, K., Alpers, J., Sukhatme, V., Reed, J.C.

Phorbolester-mediated inhibition of growth and regulation of proto -oncogene

expression in the human T cell leukemia line JURKAT. Oncogene. 6:455-460, l991.

34. Turner, B., Rapp, U., App, H., Greene, M., Dobashi, K., Reed, J.C. Interleukin-2

induces tyrosine phosphorylation and activation of p72-74 RAF-l kinase in a T cell

line. Proc. Natl. Acad. Sci. USA 88:1227-1231, l99l.

35. Reed, J.C., Yum, S., Cuddy, M., Turner, B., Rapp, U. Differential regulation of the

p72-74 Raf-l kinase by RAS and SRC oncoproteins. Cell Growth & Differ. 2:235-243,

l99l.

36. Tanaka, S., Kant, J., Reed, J.C. A G A polymorphism in second exon of BCL2.

Nucleic Acids Res. l9:l964, l991.

37. Reed, J.C., Talwar, H.S., Rapp, U.R., Cuddy, M., Fisher, G.T. Mitochondrial

protein p26 BCL2 reduces growth factor requirements of NIH3T3 fibroblasts. Exp.

Cell Res. l95:277-283, l991.

38. Reed, J.C., Rapp, R., Cuddy, M. Transformed 3T3 cells have reduced levels and

altered subcellular distribution of the major PKC substrate protein MARCKS.

Cell. Sig. 3:569-576, l99l.

39. Louie, D., Kant, J., Brooks, J., Reed, J.C. Absence of t(l4;l8) translocation and BCL2

oncogene expression in Reed-Sternberg cells of non-Hodgkin's disease. Am. J.

Pathol. l39:l23l-1237, l99l.

40. Reed, J.C, Meister, L., Tanaka, S., Cuddy, M., Yum, S., Geyer, C., Pleasure, D.

Differential expression of the bcl-2 protooncogene in neuroblastoma and other

human tumor cell lines of neural origin. Cancer Res. 51:6529-6538, l991.

41. Geyer, C., Zhu Xiaoyun Z, Nowell, P., Reed, J.C. A new polymorphic pr obe on

chromosome 6q:0327A (D6593). Nucleic Acids Res. l9:5799, l99l.

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42. Tanaka, S., Louie, D., Kant, J., Reed, J.C. Application of a PCR-mismatch

technique to the Bcl-2 gene: Detection of point mutations in Bcl-2 genes of

malignancies with A t(14,18). Leukemia. 6:15S, 1992.

43. Tanaka, S., Louie, D., Kant, J., Reed, J. Frequent somatic mutations in translocated

BCL2 genes of non-Hodgkin's lymphoma patients. Blood. 79:229-237, l992.

44. Torigoe, T., O'Connor, R., Fagard, R., Fischer, S., Santoli, D., Reed, J. Regulation of

SRC-family protein tyrosine kinases by Interleukins, IL2 and IL3. Leukemia. 6:94S,

l992.

45. Torigoe, T., Saragovi, H.U., Reed, J.C. Interleukin 2 regulates the activity of the

LYN protein-tyrosine kinase in a B-cell line. Proc. Natl. Acad. Sci. USA 89:2674-

2678, l992.

46. Carr, J.J., Reed, J.C., Choplin, R.H., Pope, Jr, T.L., Case, L.D. Plain and computed

radiography for detecting experimentally induced pneumothorax in cadavers:

implications for detection in patients. Radiology, 183:193-199, 1992.

47. O Connor, R., Torigoe, T., Reed, J.C., Santoli, D. Phenotypic changes induced by

interleukin-2 (IL2) and IL-3 in an immature T-lymphocytic leukemia are

associated with regulated expression of IL-2 receptor beta chain and of protein

tyrosine kinases LCK and LYN. Blood. 80:1017-1025, 1992.

48. Katsumata, M., Siegel, R., Louie, D., Miyashita, T., Tanaka, S., Greene, M., Reed,

J.C. Differential effects of bcl-2 on B- and T- lymphocytes in transgenic mice. Proc.

Natl. Acad. Sci. USA 89: 113**-*****, 1992.

49. Torigoe, T., O'Conno,r R., Fagard, R., Fischer, S., Santoli, D., Reed, J,C.

Interleukin-4 inhibits IL-2-induced proliferation of a human T-leukemia cell line

without interfering with p56-Lck kinase activation. Cytokine 4: 369-376, 1992.

50. O'Connor, R., Torigoe, T., Reed, J.C., Santoli, D. Modulation of IL2 receptor

chain and protein tyrosine kinases lck and lyn in myeloid-lymphoid

differentiation of an immature T-lymphocyte leukemia. Blood. 80: 1017-1025, 1992.

51. Torigoe, T., O'Connor, R., Reed, J.C., Santoli, D. Interleukin-3 regulates the

activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell

lines. Blood. 80: 617-624, 1992.

52. Siegel, R., Katsumata, M., Miyashita, T., Louie, D., Greene, M., Reed, J.C.

Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2

transgenic mice. Proc. Natl. Acad. Sci. USA 89: 7003-7007, l992.

53. Reed, J.C., Cuddy, M., Cho, D. Regulation of p26-Bcl-2 protein levels in human

peripheral blood lymphocytes. Lab. Investig. 67:443-449, l992.

54. Reed, J.C., Tanaka, S., Cuddy, M., Cho, D., Smith, J., Kallen, R., Sargovi, U.,

Torigoe, T. A strategy for generating monoclonal antibodies against recombinant

Baculovirus-produced proteins: application to the Bcl-2 onco-protein. Analytical

Biochem. 205: 70-76, 1992.

55. Karnitz, L., Sutor, S., Torigoe, T., Reed, J.C., McKearn, D., Leibson, P., Abraham, R.

Effects of p56Ick deficiency on the growth and cytolytic effector function of an

interleukin-2-dependent cytotoxic T-cell line. Mol Cell Biol. 12: 4521-4530, 1992.

56. Reed, J.C., Tanaka, S., Cuddy, M. Cell cycle analysis of p26-Bcl-2 protein levels in

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proliferating lymphoma and leukemia cell lines. Cancer Res. 52: 2802, 1992.

57. Cazals-Hatem, D., Louie, D., Tanaka, S., Reed, J.C. Molecular cloning and DNA

sequence analysis of cDNA encoding chicken homolog of the Bcl-2 oncoprotein.

Biochim. Biophys Act., 1132:109-113, 1992.

58. Miyashita, T., Reed, J.C. Bcl-2 gene transfer increases relative resistance of S49.1

and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by

glucocorticoids and multiple chemotherapeutic drugs. Cancer Res. 52: 5407-5411,

1992.

59. Feinstein, E., Gale, R.P., Reed, J., Canaani, E. Expression of the normal p53 gene

induces differentiation of K562 cells. Oncogene. 7:1853-1857, 1992.

60. Quill, H., Riley, M.P., Cho, E.A., Casnellie, J.E., Reed, J.C., Torigoe, T. Anergic Th1

cells expressed altered levels of protein tyrosine kinases p56-LCK and p56-FYN. J.

Immunol. 149:2887-2893, 1992.

61. Taichman, R., Torigoe, T., Tanaka, S., Miyashita, T., Reed, J.C. Gene transfer

investigations of p56-LCK function in IL-2-dependent T-cell lines: Implications

for mechanisms of IL-2-signal transduction. Cytokine. 4: 441-453, 1992.

62. Vanhaesebroeck, B., Reed, J.C., DeValck, D., Miyashita, Y., Tanaka, S., Beyaert, R.,

Van Roy, F., Fiers, W. Effect of BCL-2 proto oncogene expression on tumor

necrosis factor-mediated cytotoxicity. Oncogene. 8:1075-1081, 1993.

63. Levine, B., Huang, Q., Isaacs, J.T., Reed, J.C., Griffin, D.E., Hardwick, J.M.

Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular

oncogene. Nature. 361: 739-742, 1993.

64. Baffy, G., Miyashita, T., Williamson, J.R., Reed, J.C. Apoptosis induced by

withdrawal of Interleukin-3 [IL-3] from an IL-3-dependent hematopoietic cell line

associated with repartitioning of intracellular calcium and is blocked by enforced

Bcl-2 oncoprotein production. J. Biol Chem. 268:6511-6519, 1993.

65. Jacobson, M.D., Burne, J.F., King, M.P., Miyashita, T., Reed, J.C., Raff, M.C.

Apoptosis and Bcl-2 protein in cells without mitochondrial DNA. Nature. 361:

365-368, 1993.

66. Miyashita, T., Reed, J.C. Bcl-2 oncoprotein blocks chemotherapy-induced

apoptosis in a human leukemia cell line. Blood 81: 151-157, 1993.

67. Reed, J.C., Tanaka, S.T. Somatic Point mutations in the translocated bcl-2 genes of

non-Hodgkin's lymphomas and lymphocytic leukemias: Implications for

mechanisms of tumor progression. Leukemia & Lymphoma. 10: 157-163, 1993.

68. Tanaka, S., Saito, K., Reed, J.C. Structure-function analysis of the apoptosis-

suppressing Bcl-2 oncoprotein: Substitution of a heterologous transmembrane

domain restores function to truncated Bcl-2 proteins. J. Biol. Chem. 268:10920-

10926, 1993.

69. Hanada, M., Krajewski, S., Tanaka, S., Cazals-Hatem, D., Spengler, B.A., Ross,

R.A., Biedler, J.L., Reed, J.C. Regulation of Bcl-2 oncoprotein levels with

differentiation of human neuroblastoma cells. Cancer Res. 53:4978-4986, 1993.

70. Taichman, R., Merida, I., Gaulton, G., Reed, J.C. Evidence that protein tyrosine

kinase p56-Lck regulates the activity of phosphatidylinositol-3'-kinase in

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Interleukin-2-dependent T-cells. J Biol Chem. 268:200**-*****, 1993.

71. Turner, B.C., Rapp, U.R., Tonks, N., Reed, J.C. Interleukin 2 regulates Raf-1 kinase

activity through a tyrosine phosphorylation-dependent mechanism in a T-cell line.

Proc. Natl. Acad. Sci. USA. 90:5544-5548, 1993.

72. Hanada, M., Delia, D., Aiello, A., Stadtmauer, E., Reed, J.C. bcl-2 gene

hypomethylation and high-level expression in B-cell chronic lymphocytic

leukemia. Blood. 82:1820-1828, 1993.

73. Kitada, S., Miyashita, T., Tanaka, S., Reed, J.C. Investigations of antisense

oligonucleotides targeted against bcl-2 RNAs. Antisense Res & Develop. 3:157-169,

1993.

74. Krajewski, S., Tanaka, S., Takayama, S., Schibler, M.J., Fenton, W., Reed, J.C.

Investigations of the subcellular distribution of the BCL-2 oncoprotein: residence

in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial

membranes. Cancer Res. 53:4701-4714, 1993.

75. Taichman, R., Torigoe, T., Reed, J.C. A strategy for constructing inducible

expression plasmids for T-lymphocytes. Biotechniques. 14:181-182, 1993.

76. Frank, T.S., Reed, J.C., Brooks, S.J. Absence of expression of c-sis and

transforming growth factor- mRNA in malignant fibrous histiocytoma. Int. J.

Surgical Path. 1:117-122, 1993.

77. Sancho, J., Peter, M.E., Franco, R., Dieleman, S., Kang, J.S., Fagard, R., Woods, J.,

Reed, J.C., Kamoun, M., Terhorst, C. Coupling of GTP-binding to the T cell

receptor zeta chain with TCR-mediated signal transduction. J. Immunology.

150:3230-3242, 1993.

78. Behl, C., Hovey III, L., Krajewski, S., Schubert, D., Reed, J.C. Bcl-2 prevents killing

of neuronal cell lines by L-glutamate but not by amyloid-beta peptide. BBRC.

197:949-956, 1993.

79. Torigoe, T., Millan, J.A., Chan, K.W., Taichman, R., Brian, A.A., Reed, J.C.,

Tachman, R. Protein tyrosine kinase p56-Lck regulates lymphocyte function-

associated 1 adhesion molecule expression, granule exocytosis, and cytolytic

effector function in a cloned T-cell. J. Exp. Med. 180:1115-1127, 1994.

80. Wang, H-G., Miyashita, T., Takayama, S., Sato, T., Torigoe, T., Krajewski, S.,

Tanaka, S., Hovey III, L., Troppmair, J., Rapp, U.R., Reed, J.C. Apoptosis

regulation by interaction of Bcl-2 protein and Raf-1 kinase. Oncogene. 9:2751-2756,

1994.

81. Takayama, S., Cazals-Hatem, D.L., Kitada, S., Tanaka, S., Miyashita, T., Hovey,

L.R., Huen, D., Rickinson, A., Veerapandian, P., Krajewski, S., Saito, K., Reed, J.C.

Evolutionary conservation of function among mammalian, avian, and viral

homologs of the Bcl-2 oncoprotein: structure-function implications. DNA & Cell

Biol. 13:679-692, 1994.

82. Clevenger, C.V., Torigoe, T., Reed, J.C. Prolactin induces the rapid

phosphorylation and activation of Prolactin Receptor-Associated Raf-1 kinase in a

T-cell line. J Biol. Chem. 260:5559-5565, 1994.

83. Kamesaki, H., Zwiebel, J.A., Reed, J.C., Cossman, J. Role of bcl-2 and IL-5 in the

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regulation of anti-IgM induced growth arrest and apoptosis in immature B-cell

lines - a cooperative regulation model for B-cell clonal deletion. J. Immunology.

152:3294-3305, 1994.

84. Reed, J.C., Kitada, S., Takayama, S., Miyashita, T. Regulation of chemoresistance

by the bcl-2 oncoprotein in non-Hodgkin's lymphoma and lymphocytic leukemia

cell lines. Annals. Oncology. 5 (Suppl. 1):S61-S65, 1994.

85. de Jong, D., Prins, F.A., Mason, D.Y., Reed, J.C., van Ommen, G.B., Kluin, P.M.

Subcellular localization of the bcl-2 protein in malignant and normal lymphoid

cells. Cancer Res. 54:256-260, 1994.

86. Kitada, S., Takayama, S., DeRiel, K., Tanaka, S., Reed, J.C. Reversal of

chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene

expression. Antisense Res. & Dev. 4:71-79, 1994.

87. Reed, J.C. Bcl-2 and the regulation of programmed cell death. J. Cell Biol. 124:1-6,

1994.

88. Lu, Q-L., Hanby, A.M., Hajibacheri, M.A.N., Gschmeissner, S.E., Lu, P-J., Tayler-

Papadimitriou, J., Krajewski, S., Reed, J.C,. Wright, N.A. Bcl-2 protein localizes to

the chromosomes of mitotic nucleic and is correlated with the cell cycle in

cultured epithelial cell lines. J. Cell Sci. 107:363-371, 1994.

89. Sato, T., Irie, S., Krajewski, S., Reed, J.C. Cloning and sequencing of cDNA

encoding rat Bcl-2 protein. Gene 140:291-292, 1994.

90. Selvakumaran, M., Lin, H.K., Reed. J.C., Tanaka, S., Liebermann, D.A., Hoffman,

B. The novel differentiation-associated gene MyD 118, proto-oncogenes myb,

myc, and bcl-2, and the differentiated state modulate TGF1-induced apoptosis of

myleloid leukemia cells. Mol. Cell Biol. 14:2352-2360, 1994.

91. Sakuragi, N., Ooukos, G., Furth, E.E., Bronner, M.P., VanArsdale, C.M., Krajewski,

S., Reed, J.C., Strauss III, J.F. Differentiation dependent expression of the bcl -2

gene in the trophoblast lineage. J. Soc. Gyn. Invest. 1:164-172, 1994.

92. Selvakumaran, M., Lin, H-K., Miyashita, T., Wang, H.G., Krajewski, S., Reed, J.C.,

Hoffman, B., Liebermann, D. Immediate early up-regulation of bax expression by

p53 but not TGF1: a paradigm for distinct apoptotic pathways. Oncogene. 9:1791-

1798, 1994.

93. Tang, C., Willingham, M.C., Reed, J.C., Miyashita, T., Tourkina, E., Ponnathpur,

V., Huang, Y., Ray, S., Mahoney, M.E., Bullock, G., Bhalla, K. High levels of p26-

Bcl-2 oncoprotein retard Taxol-induced apoptosis in human pre-B-leukemia cells.

Leukemia 8:1960-1969, 1994.

94. Griffiths, S.D., Goodhead, D.T., Marsden, S.J., Wright, E.G., Krajewski, S., Reed,

J.C., Korsmeyer, S.J., Greaves, M. Interleukin 7-dependent B lymphocyte

precursor cells are ultrasensitive to apoptosis. J. Exp. Med. 179:1789-1797, 1994.

95. Torigoe, T., Millan, J.A., Takayama, S., Taichman, R., Miyashita, T., Reed, J.C. Bcl-

2 inhibits T-cell-mediated cytolysis of leukemia cell line. Cancer Res. 54:4851-4854,

1994.

96. Prehn, J., Bindokas, V., Maruccilli, C.J., Krajewski, S., Reed, J.C., Miller, R.J.

Regulation of neuronal bcl-2 protein expression and calcium homeostasis by

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transforming growth factor type confers wide-ranging protection on rat

hippocampal neurons. Proc. Natl. Acad. Sci. USA 91:125**-*****, 1994.

97. Miyashita, T., Harigai, M., Hanada, M., Reed, J.C. Identification of a p53-

dependent negative response element in the bcl-2 gene. Cancer Res. 54:3131-3135,

1994.

98. Miyashita, T., Krajewski, S., Krajewska, M., Wang, H.G., Lin, H.K., Hoffman, B.,

Lieberman, D., Reed, .JC. Tumor suppressor p53 is a regulator of bcl-2 and bax in

gene expression in vitro and in vivo. Oncogene. 9:1799-1805, 1994.

99. Sato, T., Hanada, M., Bodrug, S., Irie, S, Iwama, N., Boise, L.H., Thompson, C.B.,

Golemis, E., Fong, L., Wang, H-G., Reed, J.C. Interactions among members of the

bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl. Acad.

Sci. USA 91:9238-9242, 1994.

100. Haldar, S., Jena, N., DuBois, G.C., Takayama, S., Reed, J.C., Fu, S.S., Croce, C.M.

Purification and characterization of the bcl-2 protein. Arch Biochem & Biophysics.

315:483-488, 1994.

101. Shabaik, A.S., Krajewski, S., Burgan, A., Krajewska, M., Reed, J.C. bcl-2 proto-

oncogene expression in normal, hyperplastic, and neoplastic prostate tissue. J.

Urol. Pathol. 3:17-27, 1995.

102. Krajewski, S., Bodrug, S., Gascoyne, R., Berean, K., Krajewska, M., Reed, J.C.

Immunohistochemical analysis of mcl-1 and bcl-2 proteins in normal and

neoplastic lymph nodes. Am. J. Path .145:515-525, 1994.

103. Epperly, M.W., Santucci, M.A., Reed, J.C., Shields, D., Halloran, A., Greenberger,

J.S. Expression of the human Bcl-2 transgene increases the radiation resistance of

a hematopoietic progenitor cell line. Rad. Oncology Invest. 2:77-83, 1994.

104. Krajewski, S., Krajewska, M., Shabaik, A., Miyashita, T., Wang, H.G., Reed, J.C.

Immunohistochemical determination of in vivo distribution of Bax, a dominant

inhibitor of Bcl-2. Am. J. Pathol. 145:1323-1336, 1994.

105. Ruoslahti, E., Reed, J.C. Anchorage dependence, integrins, and apoptosis. Cell.

77:477-478, 1994.

106. Newmeyer, D., Farschon, D.M., Reed, J.C. Cell-free apoptosis in Xenopus egg

extracts: inhibition by Bcl-2 and requirement for an ornganelle fraction enriched in

mitochondria. Cell. 79:353-364, 1994.

107. Reed, J.C. Cell death and the bcl-2 gene. Contemp Oncol. 4:29-42, 1994.

108. Siegel, R.M., Katsumata, M., Lang, M., Reed, J.C., Greene, M.I. Repertoire

selection and kinetics of T cell development in transgenic mice overexpressing Bcl-

2. Transgenics. 1:155-162, 1994.

109. Selvakumaran, M., Reed, J.C., Liebermann, D., Hoffman, B. Progression of the

myeloid differentiation program is dominant to TGF- 1-induced apoptosis in M1

myeloid leukemic cells. Blood. 84:1036-1042, 1994.

110. Krajewski, S., Krajewska, M., Shabaik, A., Wang, H-G., Irie, S., Fong, L., Reed, J.C.

Immunohistochemical analysis of in vivo patterns of Bcl-X expression. Cancer Res,

54:5501-5507, 1994.

111. Broome, H.E., Dargan, C.M., Bessent, E.F., Krajewski, S., Reed, J.C. Apoptosis and

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Bcl-2 expression in cultured murine splenic T cells. Immunology. 84:375-382, 1995.

112. Sato, T., Irie, S., Kitada, S., Reed, J.C. FAP-1: A protein tyrosine phosphatase that

associates with Fas. Science. 268:411-415, 1995.

113. Delia, D., Aiello, A., Formelli, F., Miyashita, T., Reed, J.C., Pierotti, M. Regulation

of apoptosis by N-(4-hydroxyphenyl) retinamide and role of Bcl-2. Blood. 85:359-

367, 1995.

114. Bronner, M., Culin, C., Reed, J.C., Furth, E.E. Bcl-2 proto-oncogene and the

gastrointestinal epithelial tumor progression model. Am J Pathol, 146:20-26, 1995.

115. Krajewski, S., Chatten, J., Hanada, M., Reed, J.C. Immunohistochemical analysis

of the Bcl-2 oncoprotein in human neuroblastomas. Lab Invest, 71:42-54, 1995.

116. Takayama, S., Sato, T., Krajewski, S., Kochel, K., Irie, S., Millan, J., Reed, J.C.

Cloning and functional analysis of BAG-1: a novel Bcl-2 binding protein with anti-

cell death activity. Cell. 80:279-284, 1995.

117. Miyashita, T., Reed, J.C. Tumor suppressor p53 is a direct transcriptional

activator of human bax gene. Cell. 80:293-299, 1995.

118. Kenny, J.J., Tucker, P.W., Katsumata, M., Greene, M., Reed, J.C., Longo, D.L.

Analysis of antigen-driven positive and negative selection of phosphocholine-

specific bone marrow B cells. Current Topics Micro & Immuno. 194:235-244, 1995.

119. Zhang, Z., Vuori, K., Reed, J.C., Ruoslahti, E. The alpha 5 beta 1 integrin supports

survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad

Sci USA 92:6161-6165, 1995.

120. Kajstura, J., Mansukhani, M., Cheng, W., Reiss, K., Krajewski, S., Reed, J.C.,

Sonnenblick, E.H., Anversa, P. Programmed cell death and expression of the

protooncogene bcl-2 in myocytes during postnatal maturation of the heart. Exp.

Cell Res. 219:110-121, 1995.

121. Wang, H-G., Millan, J.A., Cox, A.D., Der, C.J., Rapp, U.R., Beck, T., Reed, J.C. R-

Ras promotes apoptosis caused by growth factor deprivation via a bcl -2

suppressible mechanism. J Cell Biol 129:1103-1114, 1995.

122. Tabibzadeh, S., Kapur, S., Kong, Q.F., Liu, R.Y., Klein, T.W., Newton, C., Torigoe,

T., Reed, J.C. Leukocyte vesicles are distinct structural identities with biological

potential. Cell Vision. 2:398-406, 1995.

123. Sato, T., Irie, S., Reed, J.C. A novel member of the TRAF family of putative signal

transducing proteins binds to the cytosolic domain of CD40. FEBS Lett. 358:113-

118, 1995.

124. Weller, M., Malipiero, U., Aguzzi, A., Reed, J.C., Fontana, A. Protooncogene bcl-2

gene transfer abrogates Fas-APO-1 antibody-mediated apoptosis of human

malignant glioma cells and confers resistance to chemotherapeutic drugs and

therapeutic irradiation. J Clin Invest 95:2633-2643, 1995.

125. Hanada, M., Aim -Semp, C., Sato, T., Reed, J.C. Structure-function analysis of

bcl-2 protein: identification of conserved domains important for

homodimerization with bcl-2 and heterodimerization with bax. J Biol Chem

270:119**-*****, 1995.

126. Bodrug, S.E., Aim -Semp, C., Sato, T., Krajewski, S., Hanada, M., Reed, J.C.

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Biochemical and functional comparisons of Mcl-1 and Bcl-2 proteins: evidence for

a novel mechanism of regulating Bcl-2 family protein function. Cell Death & Differ.

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