Medical Chemical

TIMOTHY B. PATRICK Distinguished Research Professor Phone: 618-***-****

Department of Chemistry Fax: 618-***-****

Southern Illinois University email: *******@****.***

Edwardsville, IL 62026-1652

EDUCATION AND EXPERIENCE:

Post-Ph.D. 1967-1969 Ohio State University

Ph.D. 1963-1967 West Virginia University

B.S. 1959-1963 Marshall University

2006-1985 Promoted to Distinguished Research Professor of Chemistry

Southern Illinois University at Edwardsville

1984-1985 Sabbatical leave spent at Washington University Medical School,

Department of Nuclear Medicine, St. Louis, Missouri

1976-2006 Professor, Department of Chemistry, Southern Illinois

University at Edwardsville (SIUE)

1977-1978 NIH Trainee in Reproductive Biology, Washington University

Medical School, St. Louis, Missouri

1976-1977 Sabbatical Leave spent at Washington University Medical School,

St. Louis, Missouri, Department of Obstetrics and Gynecologog

1972-1976 Associate Professor, Department of Chemistry, SIUE

1969-1972 Assistant Professor, Department of Chemistry, SIUE

1967-1969 NSF Post-Ph.D. Fellow, Ohio State University (with Dr. M.S.

Newman)

SPECIAL INTERESTS:

Research in organofluorine chemistry. New and improved methodology for

selectively introducing fluorine into organic molecules, designing fluorinated

synthons, and developing substrates for F-18 radiolabeling. Member of the

Fluorine Division of the American Chemical Society.

Research in organic synthetic methods with the involvement of reactive

intermediates, including carbenes, diazonium, and diazo species, aryl tri-

azenes, and free radicals.

Application on NMR spectroscopy in structure spectral relationships.

Studies in F-19 and N-15 NMR spectra of research samples. Coordination of

magnetic resonance facility at SIUE.

Teaching of experimental methods in organic chemistry. Developed the

undergraduate organic microscale laboratory curriculum for all undergraduate

students at SIUE.

Bio-Organic Chemistry. Development of fluorinated systems for the study

of biological mechanisms of activity.

PAPERS PRESENTED:

1. P.H. Patrick, T.B. Patrick, and W.J. Probst, "Eu(dpm)3-Induced Proton

Shifts of of Some Benzocycloalkenols," ISAS Newsletter 4, 8 (1972)

2. M.E. Hoel, T.B. Patrick, and W.J. Probst, "The Photocyclization of Meta-

Substituted Stilbenes," ISAS Newsletter 4, 8 (1972)

3. P.H. Patrick and T.B. Patrick, "The Effect of Eu(dpm)3 on the PMR Spectra

of Benzocyclopenten-2-ol and Benzocyclobuten-1-ol," Midwest ACS

Meeting, November (1972)

4. J.A. Schield, T.B. Patrick, and W.J. Probst, "Synthesis of Fluoroaromatic

Amines," ISAS Newsletter 5, 6 (1973)

5. T.B. Patrick and G.H. Kovitch, "Photolysis of Diethyl Mercurybisdiazoacetate

and Ethyl Diazoacetate in Chloroalkanes," 10th Midwest ACS Meeting, Iowa

City, Iowa, November (1974)

6. T.B. Patrick, M.A. Dorton, and J.G. Dolan, "Thioxanthenylidene: A Nucleo-

philic Carbene," 13th Midwest ACS Meeting, Rolla, MO, November (1977)

7. F. Sweet, T. Patrick, and R. Judd, "Synthesis and Testing of a New Estro-

genic Molecular Probe," Society for Gynecological Investigation (1979)

8. T.B. Patrick, G.L. Cantrell, and S.M. Inga, "Reactions of Diarylethylenes

and Diarylimines with CF3OF," 15th Midwest ACS Meeting, St. Louis, MO,

November (1979)

9. T.B. Patrick, G.L. Cantrell, J.J. Scheibel, and D. Flory, "Fluorination of

Diazo Compounds," 17th Midwest ACS Meeting, Columbia, MO, November (1981)

10. T.B. Patrick, K.H. Johri, and D.H. White, "Fluoro-decarboxylation with

Xenon Difluoride," National ACS Meeting, St. Louis, MO, May (1984)

11. T.B. Patrick, M.R. Kilbourn, M.J. Welch, "A New Route to F-18

Radiopharmaceuticals," 32nd Annual Meeting for the Society of

Nuclear Medicine, Houston, TX, June (1985)

12. T.B. Patrick, W.B. Bertrand, R. Mokhtar, K. Johri, D.H. White, "Replacement

of the Carboxylic Acid Function with Fluorine," Seventh Winter Fluorine

Conference, American Chemical Society, Orlando, FL, February (1985)

13. T.B. Patrick, D. DeGonia, R.P. Willaredt, "Aryltriazenes in Organic

Synthesis," 19th American Chemical Society Midwest Meeting, Springfield,

MO, November (1985)

14. M.R. Kilbourn, J.W. Brodack, D.Y. Chi, P.A. Jerabek, J.A. Katzenellenbogen,

T.B. Patrick, M.J. Welch, "F-18-Fluoride Ion: Versatile Reagent for

Radiopharmaceutical Synthesis." 33rd Annual Meeting for the

Society of Nuclear Medicine, Washington, DC, June (1986)

15. T.B. Patrick, K. Johri, B. Bertrand, "Mechanisms in Fluorodecarboxylation,"

20th American Chemical Society Midwest Meeting, Carbondale, IL, November

(1986)

16. T.B. Patrick, S. Nadji, D. Rief, "Mechanism, Structure and Stereochemistry

in Fluorodecarboxylation," Eighth Winter Fluorine Conference, American

Chemical Society, St. Petersburg, FL, February (1987)

17. T.B. Patrick and S. Nadji, "Carbanion Fluorination with Xenon Difluoride

Sulfur II," National American Chemical Society Meeting, New Orleans, LA,

August, 1987

18. T.B. Patrick, S. Bains, S. Hosseini,"Alpha-Fluoroaldehydes from a

Fluoromethyloxazoline", American Chemical Society National Meeting,

Boston, MA, April, 1990.

19. T.B. Patrick, S. Nadji, S. Khazaeli, K. Hering-Smith, "Mechanistic Studies

of Fluorodecarboxylation, " Eleventh Winter Fluorine Conference,

American Chemical Society, St. Petersburg, FL. February (1993)

20. T.B. Patrick, B. Neal, Y. Zhu, M. Lanahan, "Synthesis and Reactions of Two

New Fluoroalkenes," Twelth Winter Fluorine Conference, American Chemical

Society, St. Petersburg, FL. January (1995).

21. T.B. Patrick, L. Zhang, Q. Li, "Rearrangements in Deiodinative Fluorination",

Thirteenth Winter Fluorine Conference, American Chemical Society.

St. Petersburg, Florida, (1997).

22. T.B. Patrick, L. Zhang, Q. Li, S.Qian,"Gem-Difluoro Compounds

from the Rearrangement of Alkyl Iodides with Xenon Difluoride",

Fifteenth Winter Fluorine Conference, American Chemical

Society, St.Petersburg, Florida, (1999).

23. T. B Patrick, C. Fianu, E. Pak, B. Neal, K. Zaksas, "Some New

Fluorinated Dienophiles",

21st Winter Fluorine Conference,

American Chemical Society. St. Petersburg, Florida (2005).

24. T. B. Patrick, K. Gorrell, J. Rogers, H. Yu, D. Taylor

"Fluorinated Dienes in the Diels-Alder Reaction",

21st Winter Fluorine Conference,

American Chemical Society. St. Petersburg, Florida (2005).

Contact this candidate