CURRICULUM VITAE

Name: Lori A. White

Address: Department of Biochemistry and Microbiology

** ****** **.

Rutgers, The State University of NJ

New Brunswick, NJ 09801

tel. 732-***-**** X128

fax. 732-***-****

email. abqjmc@r.postjobfree.com

EDUCATION:

1988, B.A. Biology, University of Maine, Orono, ME

1990, M.S. Zoology, University of Maine, Orono, ME

1996, Ph.D. Biochemistry, Dartmouth Medical School, Hanover, NH

ACADEMIC APPOINTMENTS:

1996-2000 Postdoctoral Fellow, Department of Pathology, University of WI

4/00-9/00 Assistant Scientist, Department of Pharmacology, University of

WI

9/00-present Assistant Professor, Department of Biochemistry and

Microbiology, Rutgers, The State University of NJ

RESEARCH INTERESTS:

Molecular Biological Effects of Environmental Chemicals

- investigate the effect of the environmental chemical 2,3,7,8-tetrachlorodibenzo-p-

dioxin on skin carcinogenesis.

- Using zebrafish (Danio rerio) as a model system to investigate the effects of

environmental compounds on molecular pathways during development.

MAJOR COMMITTEE ASSIGNMENTS:

11/00-8/02 NJAES (NJ Agriculture Experiment Station) Distinguished

Lecture Series: From Molecules to Genomes and Back: 175 years

of Inquiry .

11/04-present Harbor Consortium

3/03 Review Committee, Exploratory Research Grants for NIEHS

Center, Environmental and Occupational Health Sciences Institute

(EOHSI)

3/04 Review Committee, Exploratory Research Grants for NIEHS

Center, EOHSI

4/05 Review Committee, Exploratory Research Grants for NIEHS

Center, EOHSI

5//05-present George H. Cook Honors Committee

2/05-5/05 Undergraduate Education Task Force Response Committee, Cook

College

5/05 Research Advisory Committee, Busch Biomedical Research

Grants.

PROFESSIONAL ACTIVITIES:

Member, Society of Toxicology

Member, The American Society for Biochemistry and Molecular Biology

Gordon Conference attendee, Mechanisms of Toxicology (2000)

Member, Harbor consortium (2003-present)

Gordon Conference attendee, Matrix Metalloproteinases (2005)

Invited Speaker to the international meeting on the Ah-Receptor (Sept. 2005)

Gordon Conference attendee, Mechanisms of Toxicology (2006)

GRANTS RECEIVED IN THE LAST 15 YEARS:

Previously Held Grants

1993 Predoctoral Fellow of the American Heart Association, NH Chapter.

12/94-11/95 Trainee on the NIAID Institutional Training Grant, Immunology of

Myeloid and Lymphoid Cells, Dartmouth Medical School (T32

AIO7363).

1996 Postdoctoral Fellow on the NRSA Training Grant, Environmental

Toxicology, University of WI.

1997-1999 National Research Service Award (NRSA) 1 F32 ES 05799-01 ZRG

1/01-12/01 Martin Schneider Memorial Melanoma Research Award, Effect of

Environmental Factors on Melanoma Invasion and Metastasis, Melanoma

Research Foundation, $20,000 (P.I.)

5/99-4/03 National Institute of Environmental Health Sciences (NIEHS)1 K22 ES

00334-01 ZES1, Role of The AhR/Arnt Signaling Pathway in Matrix

Remodeling, $300,000 (P.I.)

6/01 5/01 Exploratory Research Grant, Center for Environmental Health

Sciences, Environmental and Occupational Health Sciences Institute,

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on EMMPIRN

Expression in Skin, $15,000 (P.I.)

7/01-6/02 Busch Biomedical Research Grant, Effect of TCDD on EMMPRIN

Expression and Function in Stratified Squamous Epithelia $20,000

(P.I.)

6/04-5/05 Exploratory Research Grant, Center for Environmental Health Sciences,

Environmental and Occupational Health Sciences Institute, Matrix

Metalloproteinases as Biomarkers for Environmental Exposure in Japanese

Medaka $20,000 (P.I.)

Current Grants:

4/04-3/08 National Institute of Environmental Health Sciences (NIEHS) Role of AhR/Arnt

Signaling Pathway in Carcinogenesis $905, 863 (P.I.) (30%)

6/05-5/07 Development of Zebrafish (Danio rerio) as a model system to screen for botanical

compounds that alter glucose metabolism. The NIH Botanical Research Center,

9/1/05-8/30/10, $100,000 direct costs. (P.I.) (10%)

8/06-7/08 Design and Evaluation of Advanced Electrostatic Sampler for Total Bioaerosols,

National Institute of Occupational Safety and Health (NIOSH), $376,111 direct

costs,. Co-PI with G. Mainelis (P.I.), and P. Lioy. (10%)

Pending:

National Institutes of Health (NIH), The Role of the Inhibitor of DNA binding

(Id) proteins in zebrafish embryogenesis,$950,000 direct costs. (P.I.) (20%)

National Institutes of Health (NIH) Impact of microbial metabolism on the

toxicity of brominated flame retardants, $950,000 direct costs, Dr. Max

Haggbloom (Co-PI). (20%)

National Institute of Environmental Health Sciences (NIEHS) Role of AhR/Arnt

Signaling Pathway in Carcinogenesis $905, 863 (P.I.) (30%) (renewal)

TEACHING EXPERIENCE:

1. Environmental Toxicology, 1996, 1997, University of Wisconsin, Department of

Pharmacology. Lecturer for 3 classes.

2. Seminar in Biochemistry: Course lecturer, 2001-2005, Rutgers University,

Department of Biochemistry and Microbiology.

3. Perspectives in Agriculture and the Environment, 2001-2003, 2005 Rutgers

University, Cook College

4. Biochemical Mechanisms of Toxicology, 2001, 2005 Rutgers University,

Department of Biochemistry and Microbiology, Lecturer for 2 classes.

5. General Toxicology (Graduate Level Toxicology Course), 2001-2005. Lecturer

for 1 class.

6. Molecular Toxicology Laboratory, 2002-2005, Rutgers University, Department of

Biochemistry and Microbiology. Developed course and course materials.

7. Molecular Techniques in Toxicology, 2002-2005, Rutgers University and

Graduate Level Toxicology Course. Participated in course development.

8. Biochemistry of Cancer, 2005, Rutgers, University, Department of Biochemistry

and Microbiology. Developed course.

Student Training:

Member of the Graduate Faculty in Molecular Biosciences, Rutgers University 2001-

present.

Member of the Graduate Faculty in the Joint Graduate Program in Toxicology, Rutgers

University, 2000- present.

Graduate Students:

Ph.D.

Jedd Hillegass, JGPT (2002-8/07)*

Caren Villano, JGPT (2003-8/07)*

Kyle Murphy, Molecular Biosciences (2002-10/07)*

Jessica McCormick, Molecular Biosciences (2006-present)*

Ashely Petit, JGPT (2007-present)*

M.S.

Ana Cardoso, Environmental Sciences, (2001-2003) (M.S.)

Member of Thesis Committee:

Ana Cardoso, Environmental Sciences (M.S. 2003)*

Usha Sivaprasad, Nutritional Sciences (Ph.D. 2003)

Shaoming Huang, Entomology (Ph.D. 2006)

Caren Villano, JGPT (Ph.D. 2007)*

Member of Qualifying Examination Committees:

Ana Cardoso, Environmental Sciences (2001)*

Kelly Hogan, JGPT (2001)

Shaoming Huang, Entomology (2001)

Lisa Domico, JGPT (2003)

Kyle Murphy (2004)*

Marianne Baricevic, Molecular Biosciences (2004)

Marisol Gutierrez, JGPT (2004)

Jedd Hillegass, JGPT (2004)*

Caren Villano, JGPT (2005)*

Joel Cooper, JGPT (2005)

HeyRheon An, Environmental Sciences (2005)

Undergraduate Research Training:

G.H. Cook Scholars Program, Rutgers, Project Advisor for Elizabeth Myers 2003-

2004.

G.H. Cook Scholars Program, Rutgers, Project Advisor for Sharon Seelman,

2004-2005.

G.H. Cook Scholars Program, Rutgers, Project Advisor for Victoria Prince, 2004-

2005.

G.H. Cook Scholars Program, Rutgers, Co-Advisor for Nishit Shah, 2004-2005.

G.H. Cook Scholars Program, Rutgers, Co-Advisor for Brandy Houser, 2004-

2005.

Mabel Smith Douglass Honors Program, Rutgers, Advisor, Adenrele Akintobi,

2003-2005.

G.H. Cook Scholars Program, Rutgers, Project Advisor for Daniel Kagan, 2005-

2006.

G.H. Cook Scholars Program, Rutgers, Project Advisor for Brett Elo, 2005-2006.

G.H. Cook Scholars Program, Rutgers, Co-Advisor for Melissa Weidner, 2005-

2006.

Mabel Smith Douglass Honors Program, Rutgers, Advisor, Victoria LaPrete

2005-2006.

Over 15 undergraduates supported 2000- present.

Faculty sponsor for Rutgers University Cooperative Education students.

Advisor for the Comic Book Club (2003-2004)

Co-Advisor for the Biochemistry Club (2004-present)

INVITED SEMINARS AND SYMPOSIA

Invited Speaker, Department of Biochemistry, Seton Hall University, November, 7 2006.

Invited Speaker, Biochemistry and function of the Aryl hydrocarbon receptor and related

PAS-bHLH proteins, September 29-30, 2005 Dusseldorf, Germany.

Invited Speaker, BioRad Cell Biology Exhibitor Showcase, American Society for Cell

and Molecular Biology Meeting, December 7, 2004, Washington, DC.

Invited Speaker, BioRad Real-Time PCR Symposium, October 11, 2004, New York, NY.

Invited Platform Speaker, Society of Toxicology Annual Meeting, March 24, 2004,

Baltimore, MD.

Invited Platform Speaker, Society of Toxicology Annual Meeting, March 12, 2003, Salt

Lake City, UT.

Invited Speaker, Melanoma Research Foundation Workshop, November 16, 2002,

Williamsburg, VA.

Invited Speaker, Department of Nutritional Sciences, Rutgers, The State University of

NJ, October 11, 2002, New Brunswick, NJ.

Invited Speaker, Environmental and Occupational Health Sciences Center, Core I,

Piscataway, NJ.

Invited Speaker, Department of Biochemistry, University of New Hampshire, (November

2001) Durham, NH.

PUBLICATIONS:

Reviewed Papers

Prince, V., Hillegass, J., Villano, C.M., and White, L.A. Matrix Metalloproteinase

expression and activity is activated in Japanese Medaka (Oryzias latipes) following

exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. (Submitted-Aquatic Toxicology)

Hillegass, J., Villano, C.M. and White, L.A. The role of matrix metalloproteinase

expression in zebrafish (Danio rerio) craniofacial development. (Submitted-Matrix

Biology)

Villano, C.M., Hillegass, J., and White, L.A. Expression of the Helix-loop-Helix Inhibitor of

DNA Binding-1 (Id-1) Gene is Induced by all-trans Retinoic Acid in Zebrafish Embryos

(Submitted- Toxicological Sciences)

Murphy, K. A. and White, L.A. Interaction between the aryl hydrocarbon receptor (AhR)

and the Ras/Raf signaling pathways is required for AhR- induced expression of matrix

metalloproteinase-1 (MMP-1) in A2058 melanoma cells. (Submitted-Toxicology and

Applied Pharmacology).

Villano, C.M., Hillegass, J., and White, L.A. Expression of the Helix-loop-Helix Inhibitor of

DNA Binding-1 (Id-1) is Necessary for Zebrafish Embryogenesis (Submitted- Developmental

Dynamics).

Hillegass, J., Villano, C.M. and White, L.A. Matrix metalloproteinases are activated in

developing zebrafish (Danio rerio) embryos following exposure to dexamethasone or

hydrocortisone via a glucocorticoid receptor-dependent mechanism. (Accepted-

Toxicological Sciences)

Hillegass, J., Villano, C.M. and White, L.A. (2007) Matrix metalloproteinase-13 (MMP-

13) is required for zebrafish (Danio rerio) development and is a target for glucocorticoids

(Toxicological Sciences (EPUB)).

Akintobi, A.M., Villano, C.M., and White, L.A. (2007) 2,3,7,8-tetrachlorodibenzo-p-

dioxin (TCDD) exposure of Normal Human Dermal Fibroblasts results in AhR-

dependent and independent changes in gene expression. Toxicology and Applied

Pharmacology 220:9-17.

An, H.R., Mainelis, G., and White, L.A. (2006) Development and Calibration of Real-

Time PCR for Quantification of Airborne Microorganisms in Air Samples, Atmospheric

Environment, 40: 7924-7939.

Villano, C.M. and White, L.A. (2006) Expression of the helix-loop-helix protein

inhibitor of DNA binding-1 (Id-1) is activated by all-trans retinoic acid in normal human

keratinocytes. Toxicology and Applied Pharmacology 214:219-229.

Villano, C. M., Murphy, K.A., Akintobi, A. M. and White, L.A. (2006) 2,3,7,8-

tetrachlorodibenzo-p-dioxin activates MMP expression and invasion in melanoma cells.

Toxicology and Applied Pharmacology 210:212-224.

Murphy, K. A., Villano, C. M., Dorn, R., and White, L.A. (2004) Interaction between the

Aryl Hydrocarbon Receptor and Retinoic Acid Pathways Increases Matrix

Metalloproteinase-1 Expression in Keratinocytes. J. Biol. Chem. 279: 25284-93.

White, L.A., Mitchell, T. I., and Brinckerhoff, C.E. (2000) Transforming Growth Factor

Inhibitory Element (TIE) in the Rabbit Collagenase-1 (MMP-1) Gene Functions as a

Repressor of Constitutive Transcription. Biochim. BioPhys. Acta 1490: 259 -268.

White, L.A., Maute, C., and Brinckerhoff, C.E. (1998) Ets sites in the promoters of

matrix metalloproteinases (MMPs) collagenase (MMP-1) and stromelysin (MMP-3)

have an essential role as an auxiliary element in regulating basal and phorbol-induced

transcription. Connective Tissue Research, 36:321-335.

Vincenti, M.P., Coon, C.I., White, L.A., Barchowsky, A., and Brinckerhoff C.E. (1996)

Transcriptional activation of the interstitial collagenase gene (MMP-1) in IL-1-stimulated

fibroblasts is regulated by src-related tyrosine kinases. Arthritis and Rheumatism, 39:

574-582.

Dowse, H.B., Ringo, J., Power, J., Johnson, E. Kinney, K., and White, L. (1995). A

congenital heart defect in Drosophila caused by an action potential mutation. J of

Neurogenetics 10:153-168.

White, L.A. and Brinckerhoff, C. E. (1995) Two AP-1 elements in the collagenase

promoter have differential effects on basal and phorbol-induced transcription and bind

JunD, c-Fos and Fra-2. Matrix Biology 14: 715-725.

James, T.W., Wagner, R., White, L.A., Zwolak, R.M., and Brinckerhoff, C.E. (1993)

Induction of collagenase and stromelysin gene expression by mechanical injury in a

vascular smooth muscle cell-derived cell line. J. of Cell Phys. 157: 42-437.

White, L.A., Ringo, J.M., and Dowse, H.B. (1992) A circadian clock of Drosophila:

effects of deuterium oxide and mutations at the period locus. Chronobiology

International 9: 250-283.

White, L.A., Ringer, J.M., and Dowse, H.B. (1992) Effects of deuterium oxide and

temperature on heart rate in Drosophila melanogaster. J of Comp. Phys. 162: 278-283.

Newby, L.M., White, L.A., DiBartolomeis, S.M., Walker, B.J., Dowse, H.B., Ringo,

J.M., Khuda, N., and Jackson, F.R. (1991) Mutational analysis of the Drosophila

miniature-dusky (m-dy) locus: effects on cell size and circadian rhythms. Genetics 28:

571-582.

Reviews

Murphy, K.A., Quadro, L., and White, L. A. (2007) The intersection between the aryl

hydrocarbon receptor (AhR) and retinoic acid signaling pathways. In: Vitamins and

Hormones, volume 75. Litwack, G. ed.

Hillegass, J.M., Murphy, K.A., Villano, C.M. and White, L.A. (2006) The impact of

aryl hydrocarbon receptor signaling on matrix metabolism: implications for development

and disease. Biological Chemistry 387:1159-73.

Villano, C.M. and White, L.A. (2006) The Aryl hydrocarbon receptor (AhR) signaling

pathway and tissue remodeling: insights from the zebrafish (Danio rerio) model system.

Toxicological Sciences 92(1): 1-4.

Vincenti, M.P., White, L.A., Schroen, D.J., Benbow, U., and Brinckerhoff, C.E. (1996)

Regulating expression of the gene for matrix metalloproteinase-1 (collagenase):

mechanisms that control enzyme activity, transcription, and mRNA stability. Critical

Reviews in Eukaryotic Gene Expression 6: 391-411.

Abstracts and Presentations

Hillegass, J.M., Villano, C.M., White, L.A., and Cooper, K.R. (2007) Matrix

Metalloproteinase-2 and -9 are Essential for Zebrafish Embryogenesis and Serve as

Targets for Glucocorticoid Exposure. Mid-Atlantic Chapter of the Society of

Toxicology.

Hillegass, J., Villano, C.M., White, L.A., and Cooper, K. (2007) Matrix

metalloproteinase-2 and -9 are essential for zebrafish embryogenesis and serve as

targets for glucocorticoid exposure. Society of Toxicology.

Villano, C.M., Hillegass, J. and White, L.A. (2007) Role of the Inhibitor of DNA

binding-6 (Id6) in normal and all-trans retinoic acid exposed zebrafish embryo

development. Society of Toxicology.

Murphy, K.A., and White, L.A. (2007) 2,3,7,8-tetrachlorodibenzo-p-dioxin Induced

Matrix Metalloproteinase Expression in A2058 Melanoma Cells Requires the AhR

and ERK Pathways. Society of Toxicology

Hillegass, J.M., Villano, C.M., White, L.A., and Cooper, K.R. (2006) Matrix

Metalloproteinase Expression and Function During Zebrafish Embryogenesis:

Analysis of MMP-2, MMP-9, and MMP-13 Following Exposure to Dexamethasone

or Hydrocortisone. 7th International Conference on Zebrafish Development &

Genetics (Abstract No. 321).

Villano, C.M., Hillegass, J.M., Kagan, D., and White, L.A. (2006) Expression of the

Helix-loop-Helix Inhibitor of DNA Binding-6 (Id-6) Gene is Induced by all-trans

Retinoic Acid in Zebrafish Embryos. 7th International Conference on Zebrafish

Development & Genetics (Abstract No. 495).

Hillegass, J., Villano, C.M., White, L.A., and Cooper, K. (2006) Matrix

Metalloproteinase Expression and Function During Zebrafish Embryogenesis:

Analysis of MMP-2, MMP-9, and MMP-13 Following Exposure to Dexamethasone

and Hydrocortisone. Society of Toxicology

Villano, C.M., Hillegass, J. and White, L.A. (2006) Expression of the Helix-Loop-Helix

Inhibitor of DNA Binding-6 (Id-6) Gene is Induced by all-trans Retinoic Acid in

Zebrafish Embryos. Society of Toxicology.

Murphy, K.A., and White, L.A. (2006) 2,3,7,8-tetrachlorodibenzo-p-dioxin Induced

Matrix Metalloproteinase Expression in A2058 Melanoma Cells. Society of

Toxicology.

Akintobi, A., Villano, C.M., and White, L.A. (2006) 2,3,7,8-tetrachlorodibenzo-p-dioxin

Inhibits Expression of the Inhibitor of DNA Binding (ID)-1 and -3 in Normal Human

Fibroblasts. Society of Toxicology.

Hillegass, J.M., Villano, C.M., White, L.A., and Cooper, K.R. (2005) Exposure to

Hydrocortisone or Dexamethasone Causes a Strain-Dependent Effect on Matrix

Metalloproteinase Expression During Zebrafish Embryogenesis. Annual Meeting of

the Hudson Delaware Chapter of the Society of Environmental Toxicology and

Chemistry (SETAC).

Hillegass, J., Villano, C.M., White, L.A., and Cooper, K. (2005) Exposure to

H ydrocortisone or Dexamethasone Causes a Strain-Dependent Effect on Ma trix

M e tallopro teinase Expression During Zebrafish Embryogenesis. Annual Meeting of

the Hudson Delaware Chapter of the Society of Environmental Toxicology and

Chemistry (SETAC).

Hillegass, J., White, L.A., and Cooper, K. (2005) Matrix Metalloproteinase Inhibition

During Zebrafish Embryogenesis Following Exposure to Hydrocortisone and

Dexamethasone. Society of Toxicology

Murphy, K.A., Villano, C.M. and White, L.A. (2005) 2,3,7,8-Tetrachlorodibenzo-p-

dioxin Alters Expression of Retinoic Acid Receptors in Normal Human

Keratinocytes. Society of Toxicology.

Prince, V., LaPrete, V., Villano, C.M. and White, L.A. (2005) Matrix Metalloproteinases as

Biomarkers for Dioxin Exposure in Developing Japanese Medaka (Oryzias latipes). Society

of Toxicology.

Villano, C.M. and White, L.A. (2005) Expression of the Helix-loop-Helix Inhibitor of

DNA Binding-1 (Id-1) gene is Regulated by Retinoic Acid in Normal Human

Keratinocytes. Society of Toxicology

An, H-R, Mainelis, G, and White, L.A. (2005) Development of Real-Time PCR Protocols

for the Detection and Quantification of Airborne Microorganisms. American Society

of Microbiology.

Murphy K.A., Akintobi, A., Villano, C.M., and White, L.A. (2004) 2,3,7,8-

Tetracholodibenzo-p-dioxin (TCDD) Induces MMP Expression and Invasion in

A2058 Melanoma Cells. Society of Toxicology.

Villano, C.M., Myers, E., and White, L.A. (2004) Retinoic Acid Induced Expression of

the Helix-loop-Helix Inhibitory Protein Id-1 in Normal Human Keratinocytes. Society

of Toxicology.

Villano, C.V., Akintobi, A., Cardoso, A. and White, L.A. (2003) Effect of 2,3,7,8-

tetrachlorodibenzo-p-dioxin (TCDD) Exposure on Normal Human Melanocytes and

Melanoma Cell Lines. Society of Toxicology.

Murphy, K., Villano, C.V, Dorn,R. and White, L.A. Effect of TCDD and Retinoic Acid

on Matrix Metalloproteinase Expression in Normal Human Keratinocytes (2002)

Penn State, University Park, PA, 21st Summer Symposium in Molecular Biology:

Xenobiotic Receptors in Toxicology and Carcinogenesis.

Cardoso, A., Villano, C.V., Akintobi, A., and White, L.A. (2002) Effect of 2,3,7,8-

tetrachlorodibenzo-p-dioxin (TCDD) Exposure on Normal Human Melanocytes and

Melanoma Cell Lines. Penn State, University Park, PA, 21st Summer Symposium in

Molecular Biology: Xenobiotic Receptors in Toxicology and Carcinogenesis.

White, L.A., Capperino, C.D., and Allen-Hoffmann, B.L. (2000) 2,3,7,8-

Tetrachlorodibenzo-p-dioxin (TCDD) induces expression of the matrix remodeling

proteases. Gordon Research Conference, Mechanisms of Toxicity.

White, L.A. Capperino, C.D. and Allen-Hoffmann, B.L. (2000) TCDD induces

expression of matrix remodeling proteases. Society of Toxicology.

Weitzel, M.A., White, L.A., Jefcoate, C., and Allen-Hoffmann, B.L. (2000) TCDD and

suspension activate CYP1B1 expression in human keratinocytes and dermal

fibroblasts. Society of Toxicology.

White, L.A., and Allen-Hoffmann, B.L. (1997) Functions of AhR and Arnt genes in

skin. Gordon Research Conference, Epithelial Differentiation and Keratinization.

White, L.A. and Brinkerhoff, C.E. (1994) Basal vs phorbol induced transcription of the

collagenase gene depends on multiple cis-acting elements. Molecular Biology of the

Cell. 5.

White, L.A. and Brinckerhoff, C.E. (1993) AP-1 independent transcription of the

collagenase gene. Molecular Biology of the Cell 4: 302a.

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