University Assistant

Nov ****

Zachary T. Ball

Department of Chemistry, MS 60, Rice University

**** **** **., *******, ** 77005

ph: 713-***-****

http://ztb.rice.edu/

abqc4o@r.postjobfree.com

E DUCATION

****-**** **.*. ** Chemistry, Stanford University, 2004. Thesis adviser: Prof. Barry M. Trost.

1995 1999 A.B. with highest honors in Chemistry, Harvard University, 1999. Adviser: Prof. Gregory

L. Verdine.

A PPOINTMENTS

2008 Institute of Biosciences and Bioengineering, Rice University Houston, TX

2008 Center for Biological and Environmental Nanotechnology, Rice Houston, TX

University

2008 Smalley Institute for Nanoscale Science and Technology, Rice Houston, TX

University

2006 Assistant Professor of Chemistry, Rice University Houston, TX

2006 2008 Norman Hackerman Welch Young Investigator, Rice University Houston, TX

2004 2006 Miller Research Fellow, Miller Institute for Basic Research in Berkeley, CA

Science, UC Berkeley. Adviser: Prof. Jean M. J. Fr chet

Mar Apr 2004 Visiting Researcher, Mahidol University Bangkok, Thailand

1999 2004 Graduate Research and Teaching Assistant, Stanford University Stanford, CA

1997 1999 Undergraduate Research, Harvard University Cambridge, MA

Summer 1998 Research Intern, Schering-Plough Research Institute Kenilworth, NJ

H ONORS AND AWARDS

2011 2016 NSF CAREER award

2006 2009 Norman Hackerman Welch Young Investigator Award

2004 2006 Miller Research Fellow, Miller Institute for Basic Research in Science, University of

California, Berkeley.

2001 2004 Althouse Family Fellow, Stanford Graduate Fellowship

1996 1999 Undergraduate Research Fellowship, Harvard College Research Program

1996 1999 John Harvard Honorary Scholarship, Harvard University

1995 National Merit Scholar

P UBLICATIONS

(40) Studies of asymmetric styrene cyclopropanation with a rhodium(II) metallopeptide catalyst

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Zachary T. Ball

developed with a high-throughput screen.

Sambasivan, R.; Ball, Z. T. Chirality, 2013, in press.

(39) A rhodium-catalyzed method for serum-stable cysteine modification.

Kundu, R.; Ball, Z. T. Chem. Commun. 2013, ASAP. doi:10.1039/C2CC37323H.

(38) Designing enzyme-like catalysis with rhodium (II) metallopeptides.

Ball, Z. T. Accts. Chem. Res., 2012, ASAP. doi:10.1021/ar300261h.

(37) Determination of orientational isomerism in rhodium(II) metallopeptides by pyrene fluorescence.

Sambasivan, R.; Ball, Z. T. Org. Biomol. Chem. 2012, 10, 8203 8206. doi:10.1039/C2OB26667A.

(36) Screening rhodium metallopeptide libraries on bead : Asymmetric cyclopropanation and a

solution to the enantiomer problem.

Sambasivan, R.; Ball, Z. T. Angew. Chem. Int. Ed. 2012, 51, 8568-8572.

doi:10.1002/anie.201202512.

(35) Sequence-specific inhibition of a designed metallopeptide catalyst.

Popp, B. V.; Chen, Z.; Ball, Z. T. Chem. Commun. 2012, 48, 7492-7494. doi:10.1039/C2CC33808D.

(34) Hybrid Organic Inorganic Inhibitors of a PDZ Interaction that Regulates the Endocytic Fate of

CFTR.

Kundu, R.; Cushing, P. R.; Popp, B. V.; Zhao, Y.; Madden, D. R.; Ball, Z. T. Angew. Chem. Int. Ed.

2012, 51, 7217 7220. doi:10.1002/anie.201202291.

(33) Catalytic Protein Modification with Dirhodium Metallopeptides: Specificity in Designed and

Natural Systems.

Chen, Z.; Vohidov, F.; Coughlin, J. M.; Stagg, L. J.; Arold, S. T.; Ladbury, J. E.; Ball, Z. T. J. Am. Chem.

Soc. 2012, 134, 101**-*****. doi:10.1021/ja302284p.

(32) Organometallics Roundtable 2011.

Gladysz, J. A.; Ball, Z. T.; Bertrand, G.; Blum, S. A.; Dong, V. M.; Dorta, R.; Hahn, F. E.; Humphrey,

M. G.; Jones, W. D.; Klosin, J.; Manners, I.; Marks, T. J.; Mayer, J. M.; Rieger, B.; Ritter, J. C.;

Sattelberger, A. P.; Schomaker, J. M.; Yam, V. W.-W. Organometallics 2012, 31, 1.

doi:10.1021/om201234x.

(31) A general synthesis of dirhodium metallopeptides as MDM2 ligands.

Zaykov, A. N.; Ball, Z. T. Chem. Commun. 2011, 47, 10927. doi:10.1039/c1cc13169a.

(30) Site-Specific Protein Modification with a Dirhodium Metallopeptide Catalyst.

Chen, Z.; Popp, B. V.; Bovet, C. L.; Ball, Z. T. ACS Chem. Biol. 2011, 6, 920. doi:10.1021/cb2001523.

(29) Kinetic and stereoselectivity effects of phosphite ligands in dirhodium catalysis

Zaykov, A. N.; Ball, Z.T., Tetrahedron, 2011, 67, 4397 4401. doi: 10.1016/j.tet.2011.01.059

(28) Proximity-Driven Metallopeptide Catalysis: Remarkable Side-Chain Scope Enables Modification of

the Fos bZip Domain.

Popp, B.V.; Ball, Z.T., Chem. Sci. 2011, 2, 690 695. doi:10.1039/C0SC00564A

(27) Metallopeptides for Asymmetric Dirhodium Catalysis.

Sambasivan, R.; Ball, Z.T., J. Am. Chem. Soc., 2010, 132, 9289 9291. doi:10.1021/ja103747h

Copper-Catalyzed Remote sp3 C H Chlorination of Alkyl-Hydroperoxides

(26)

Kundu, R.; Ball, Z. T., Org. Lett. 2010, 12, 2460 2463. doi: 10.1021/ol100472t

(25) Structure-Selective Modification of Aromatic Side Chains with Dirhodium Metallopepide Catalysts

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Zachary T. Ball

Popp, B. V.; Ball, Z. T., J. Am. Chem. Soc. 2010, 132, 6660 6662. doi: 10.1021/ja101456c

(24) Helix Induction by Dirhodium: Access to Biocompatible Metallopeptides with Defined Secondary

Structure.

Zaykov, A. N.; Popp, B. V.; Ball, Z. T., Chem. Eur. J. 2010, 132, 6651 6659.

doi:10.1002/chem.200903092

(23) Allylcopper Intermediates with N-Heterocyclic Carbene Ligands: Synthesis, Structure, and

Catalysis

Russo, V.; Herron, J. R.; Ball, Z. T., Org. Lett. 2009, 12, 220-223. doi: 10.1021/ol902458v

(22) Catalytic Organocopper Chemistry from Organosiloxane Reagents

Herron, J. R.; Russo, V.; Valente, E. J.; Ball, Z. T., Chem. Eur. J. 2009, 15, 8713-8716. doi:

10.1002/chem.200901438

(21) Asymmetric Total Synthesis of Soraphen A: A Flexible Alkyne Strategy

Trost, B. M.; Sieber, J. D.; Qian, W.; Dhawan, R.; Ball, Z. T., Angew. Chem. Int. Ed. 2009, 48, 5478-

5481. doi: 10.1002/anie.200901907

(20) Controlling Peptide Structure with Coordination Chemistry: Robust and Reversible Peptide-

Dirhodium Ligation

Zaykov, A. N.; MacKenzie, K. R.; Ball, Z. T., Chem. Eur. J. 2009, 15, 8961-8965. doi:

10.1002/chem.200901266

(19) Synthesis and isotopic labeling of a naturally occurring alkyl-thiadiamondoid

Russo, V.; Allen, J.; Ball, Z. T. Chem. Commun., 2009, 595 596. doi: 10.1039/B818399F

(18) Synthesis and Reactivity of Functionalized Arylcopper Compounds by Transmetalation of

Organosilanes

Herron, J. R.; Ball, Z. T. J. Am. Chem. Soc. 2008, 130, 164**-*****. doi: 10.1021/ja8070804

(17) C-E Bond Formation Through Hydrosilylation of Alkynes

Ball, Z. T., In Comprehensive Organometallic Chemistry, 3rd ed.; Mingos, M.; Crabtree, R., Eds.

Elsevier Ltd.: London, 2007; Vol. 10, pp 789 814.

(16) Amphiphilic Diblock Copolymer Compatibilizers and Their Effect on the Morphology and

Performance of P3HT:PCBM Solar Cells

Sivula, K.; Ball, Z. T.; Watanabe, N.; Fr chet, J. M. J. Adv. Mater. 2006, 18, 206. doi:

10.1002/adma.200501787

(15) Well-Defined, Living Polymers with High Fullerene Content and Their Use in Block Copolymers for

Solution-Phase and Bulk Organization

Ball, Z. T.; Sivula, K.; Fr chet, J. M. J. Macromolecules 2006, 39, 70 72. doi: 10.1021/ma052325b

(14) Alkyne Hydrosilylation Catalyzed by a Cationic Ruthenium Complex: Efficient and General Trans

Addition

Trost, B. M.; Ball, Z. T. J. Am. Chem. Soc. 2005, 127, 176**-*****. doi: 10.1021/ja0528580

(13) Selective synthesis of functionalized, tertiary silanes by diastereoselective rearrangement-

addition

Trost, B., M.; Ball, Z., T.; Kang, E.-J. Org. Lett. 2005, 7, 4911 4913. doi: 10.1021/ol0518636

(12) An Alkyne Hydrosilylation-Oxidation Strategy for the Selective Installation of Oxygen Functionality

Trost, B. M.; Ball, Z. T.; Laemmerhold, K. M. J. Am. Chem. Soc. 2005, 127, 100**-*****. doi:

10.1021/ja051578h

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Zachary T. Ball

(11) Addition of Metalloid Hydrides to Alkynes: Hydrometallation with Boron, Silicon, and Tin

Trost, B. M.; Ball, Z. T. Synthesis 2005, 853 887. doi: 10.1055/s-200*-******

(10) Synthetic Stitching with Silicon: Geminal Alkylation-Hydroxylation of Alkynyl Carbonyl Compounds

Trost, B. M.; Ball, Z. T. J. Am. Chem. Soc. 2004, 126, 139**-*****. doi: 10.1021/ja045971j

(9) A Theoretical Study on the Mechanism, Regiochemistry, and Stereochemistry of Hydrosilylation

Catalyzed by Cationic Ruthenium Complexes.

Chung, L. W.; Wu, Y.-D.; Trost, B. M.; Ball, Z. T. J. Am. Chem. Soc. 2003, 125, 115**-*****. doi:

10.1021/ja034833b

(8) Regioselective Hydrosilylation of Propargylic Alcohols: An Aldol Surrogate.

Trost, B. M.; Ball, Z. T.; J ge, T. Angew. Chem., Int. Ed. Engl. 2003, 42, 3415 3418. doi:

10.1002/anie.200351587

(7) Ruthenium-catalyzed vinylsilane synthesis and cross-coupling as a selective approach to alkenes:

Benzyldimethylsilyl as a robust vinylmetal functionality.

Trost, B. M.; Machacek, M. R.; Ball, Z. T. Org. Lett. 2003, 5, 1895 1898. doi: 10.1021/ol034463w

(6) Intramolecular endo-dig hydrosilylation catalyzed by ruthenium: Evidence for a new mechanistic

pathway.

Trost, B. M.; Ball, Z. T. J. Am. Chem. Soc. 2003, 125, 30 31. doi: 10.1021/ja028766h

(5) A Stereospecific Ruthenium-Catalyzed Allylic Alkylation.

Trost, B. M.; Fraisse, P. L.; Ball, Z. T. Angew. Chem., Int. Ed. Engl. 2002, 41, 1059 1061. doi:

10.1002/1521-3773(20020315)41:63.0.CO;2-5

(4) A Chemoselective Reduction of Alkynes to (E)-Alkenes

Trost, B. M.; Ball, Z. T.; Joege, T. J. Am. Chem. Soc. 2002, 124, 7922 7923. doi: 10.1021/ja026457l

(3) Markovnikov Alkyne Hydrosilylation Catalyzed by Ruthenium Complexes

Trost, B. M.; Ball, Z. T. J. Am. Chem. Soc. 2001, 123, 127**-*****. doi: 10.1021/ja0121033

(2) A synthetic library of cell-permeable molecules

Koide, K.; Finkelstein, J. M.; Ball, Z.; Verdine, G. L. J. Am. Chem. Soc. 2001, 123, 398 408. doi:

10.1021/ja0023377

(1) The Design and Synthesis of Novel NK1/NK2 Dual Antagonists

Reichard, G. A.; Ball, Z. T.; Aslanian, R.; Anthes, J. C.; Shih, N. Y.; Piwinski, J. J. Bioorg. Med. Chem.

Lett. 2000, 10, 2329 2332. doi: 10.1016/S0960-894X(00)00463-7

P ATENTS

(2) Ball, Z. T.; Madden, D. R.; Kundu, R.; Popp, B. V.; Cushing, P. R., Small Molecule Conjugates with

Dimetal Species for Protein Inhibition. U.S. Patent Provisional Patent Application Application No.

61/658,760, Jul 20, 2012.

(1) Ball, Z. T.; Popp, B. V.; Zaykov, A. N., Metallopeptide Catalysts. U.S. Patent Application Number:

12/953075, Nov 23, 2010.

I NVITED LEC TURES

Apr 2013 Trinity University, Department of Chemistry, San Antonio, TX

Feb 2013 Purdue University, Department of Medicinal Chemistry and Molecular Pharmacology,

West Lafayette, IN

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Zachary T. Ball

Nov 2012 Catalysis with rhodium metallopeptides, The Twelfth International Conference on

New Aspects of Organic Chemistry (IKCOC-12), Kyoto, Japan

Nov 2012 Designing enzyme-like catalysts: A rhodium(II) metallopeptide case study, 2nd

International Symposium on Molecular Activation (plenary lecture, ISMA-2), Nara,

Japan

Nov 2012 Designing enzyme-like catalysts: A rhodium(II) metallopeptide case study, Osaka

University, Department of Applied Chemistry, Osaka, Japan

Oct 2012 Designing enzyme-like catalysts: A rhodium(II) metallopeptide case study, Rice

University, Department of Chemistry, Houston, TX

Oct 2012 Designing enzyme-like catalysts: A rhodium(II) metallopeptide case study,

University of Delaware, Department of Chemistry, Newark, DE

Sep 2012 Designing enzyme-like catalysts: A rhodium(II) metallopeptide case study,

University of Texas San Antonio, Department of Chemistry, San Antonio, TX

Sep 2012 Designing enzyme-like catalysts: A rhodium(II) metallopeptide case study,

University of West Virginia, Department of Chemistry, Morgantown, WV

Jun 2012 Rhodium(II) metallopeptides for asymmetric catalysis, Chirality 2012 Conference,

Young Investigators Symposium, Fort Worth, TX

Apr 2012 Catalysis with rhodium metallopeptides, Texas A&M University, Department of

Chemistry, College Station, TX

Apr 2012 Catalysis with rhodium metallopeptides, Texas Christian University, Department of

Chemistry, Fort Worth, TX

Apr 2012 Catalysis with rhodium metallopeptides, University of Texas Austin, Department of

Chemistry, Austin, TX

Mar 2012 Catalysis with rhodium metallopeptides, University of Houston, Department of

Chemistry, Houston, TX

Mar 2012 Catalysis with rhodium metallopeptides, Brigham Young University, Department of

Chemistry, Provo, UT

Mar 2012 Catalysis with rhodium metallopeptides, University of Wisconsin Madison, School

of Pharmacy, Madison, WI

Feb 2012 Catalysis with rhodium metallopeptides, University of Wisconsin Madison, Dept. of

Chemistry, Madison, WI

Feb 2012 Catalysis with rhodium(II) metallopeptides, Gordon Research Conference,

Chemistry & Biology of Peptides, Ventura, CA

Nov 2011 Catalysis with rhodium(II) metallopeptides, ACS Southwest Regional Meeting,

Austin, TX

Nov 2011 Catalysis with rhodium(II) metallopeptides, University of Illinois at Urbana

Champagn, Champaign, IL

Oct 2011 Catalysis with rhodium(II) metallopeptides, University of Illinois at Chicago, Chicago,

IL

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Zachary T. Ball

Oct 2011 Catalysis with rhodium(II) metallopeptides, University of Pittsburgh, Pittsburgh, PA

Sep 2011 Catalysis with rhodium(II) metallopeptides, University of Arizona, Tucson, AZ

Sep 2011 Catalysis with rhodium(II) metallopeptides, Arizona State University, Tucson, AZ

Sep 2011 Structures and functions of dirhodium metallopeptides, Young Academic

Investigators Symposium, ACS National Meeting, Denver, CO

Aug 2011 Designing enzyme-like reactivity with dirhodium metallopeptides, International

Conference on Biological Inorganic Chemistry, Vancouver, CA

May 2011 Diverse structures and functions of dirhodium metallopeptides, Stone Symposium,

Baylor University, Waco, TX

May 2011 Diverse structures and functions of dirhodium metallopeptides, Univ. of Maryland,

College Park, MD

May 2011 Diverse structures and functions of dirhodium metallopeptides, Georgetown

University, Washington, DC

Apr 2011 Diverse structures and functions of dirhodium metallopeptides, SUNY Buffalo,

Buffalo, NY

Apr 2011 Diverse structures and functions of dirhodium metallopeptides, Syracuse

University, Syracuse, NY

Mar 2011 Diverse structures and functions of dirhodium metallopeptides, Ohio State

University, Columbus, OH

`Nov 2010 Proteins as substrates: Selective catalysis in complex environments, Keith Fagnou

Memorial Lectureship, Ottawa University, Ottawa, ON, CA

Oct 2010 Proteins as substrates: Selective catalysis in complex environments, Gonzaga

University, Spokane WA

Sep 2010 Proteins as substrates: Selective catalysis in complex environments, University of

South Florida, Tampa, FL

Jul 2010 Proteins as substrates: Selective catalysis in complex environments, NSF workshop

on Organic Synthesis and Natural Products Chemistry. Squam Lake, NH

Dec 2009 Dirhodium Metallopeptides, Mesa State College, Grand Junction, CO

Nov 2009 Dirhodium Metallopeptides: Synthesis, Structure, and Function, University of

Houston, Houston, TX

Apr 2008 Synthesis and Reactivity of Organocopper Complexes from Organosilane

Transmetalation, Southwest Catalysis Society Spring Meeting, Houston TX

July 2008 Copper Complexes for Carbon-Silicon Bond Activation, short talk, Gordon Research

Conference on Organometallic Chemistry, Newport, RI

A DVISING AND POSTGRA DUATE - SCHOLAR SPONSOR

Graduate Students: Postdoctoral Fellow:

Jessica Herron (PhD 2006 2012) Brian Popp (2008 2011)

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Zachary T. Ball

Alexander Zaykov (PhD 2006 2011) Jane Coughlin (2011 )

Vincenzo Russo (MS 2007 2010) Undergraduates:

Rituparna Kundu (2008 ) Eric Silberman (2007 2008)

Cara Bovet (2008 2009) Stephen Ahn (2007)

Ramya Sambasivan (2009 ) Jake Smith (2008)

Zhen Chen (MS 2009 2012) Dillon Miles (2009 2011)

Farrukh Vohidov (2010 ) Jeremy Larus-Stone (2010 2011)

Matthew Minus (2011 ) Rejnal Tushe (2010)

Robert Ferguson (2011 ) Enrique Vazquez (2011)

Michael Yu (2011 )

Fei Tang (2011 2012)

Matthew Stampfl (2012 )

Julian Cooper (2012 )

R ESEARCH SUPPORT (1 00% UNLESS OTHERWISE I NDICATED)

Aug 2006 Rice University Startup Funds.

Aug 2006 Jul 2009 Norman Hackerman Welch Young Investigator Award, $135,000 (declined final

year of funding).

Oct 2007 Mar 2008 Synthesis of Geochemistry Standards, $25,000, ExxonMobil Upstream

Research Company.

Aug 2008 July 2011 New Strategies for Catalytic Bond Formation, $150,000, The Welch

Foundation.

Oct 2008 Jul 2011 Stabilization, Transport, and Propulsion of Single-Walled Carbon Nanotubes

(SWNTs) in Model Oil Reservoir Environments, $450,000, Advanced Energy

Consortium (35%, with Matteo Pasquali).

Jun 2009 May 2011 Developing Immunotherapeutics for Methamphetamine Abuse, $20,000 to

ZTB (co-investigator with Frank Orson), NIH U01.

Sept 2009 Aug 2011 Synthesis and Application of Functionalized Organocopper Species by C-Si

Bond Activation of Organosilane Precursors, $100,000, ACS Petroleum

Research Fund.

Jan 2010 Jan 2013 Upgrade of High Performance Digital NMR Spectrometers, $416,135 (co-PI,

departmental instrumentation grant), NSF.

Oct 2010 Feb 2011 Metallopeptide catalysts for protein modification and elucidation of protein-

protein interactions, $100,000 (PI 51%,with co-PI John Ladbury), John S. Dunn

Gulf Coast Consortium for Chemical Genomics.

Apr 2011 Mar 2016 CAREER: Structure-selective Protein Modification with Dirhodium

Metallopeptide Catalysts, $550,000, NSF CAREER award.

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Zachary T. Ball

Aug 2011 July 2014 New Strategies for Catalytic Bond Formation, $160,000, The Welch

Foundation.

Feb 2012 Jan 2013 Potent organometallic inhibitors of Signal Transducer and Activator of

Transcription 3 (STAT3), $160,000 (PI 42%, with co-PIs David Tweardy and

Michele Redell), Simmons Family Foundation Collaborative Research Fund.

Jan 2013 Jan 2014 CAREER: Structure-selective Protein Modification with Dirhodium

Metallopeptide Catalysts, $47,680, NSF AGEP GRS supplement.

Sep 2012 Sep 2014 Potent organometallic inhibitors of Signal Transducer and Activator of

Transcription 3 (STAT3) $381,486 (PI 38%, with co-PIs David Tweardy and

Michele Redell), NIH/NCI 1R21CA170625-01.

D EPARTMENTAL AND UNI VERSITY ACTIVITIES

Chemistry Department: Undergraduate Advising Committee (2006 2007, 2008 )

Graduate Admissions Committee (2006 2009, 2011 )

Graduate Recruitment Committee (2006 2009, 2011 )

Undergraduate Curriculum Committee (2008 )

Student Awards Committee (2006 2008)

Seminar Committee (2007 )

Graduate Curriculum Committee (2008 )

University: Faculty Associate, Lovett College (2007 )

Shared Equipment Authority (SEA) (2007 )

R ELATED ACTIVITIES

Reviewing: During my time at Rice, I have served as a reviewer for ACS Catalysis, ACS

Chemical Biology, Applied Organometallics, Biopolymers, Catalysis Science &

Technology, Chemical Communications, Chemical Reviews, Chemical Science,

Chemistry: a European Journal, Chemistry of Materials, Inorganic Chemistry,

Journal of Organic Chemistry, Journal of Physical Chemistry, Journal of the

American Chemical Society, Langmuir, MedChemComm, Organic and

Biomolecular Chemistry, Organic Letters, Tetrahedron, and Tetrahedron Letters.

In addition, I have served as a reviewer for the ACS Petroleum Research Fund,

the John S. Dunn Gulf Coast Consortium for Chemical Genomics, the

Leverhulme Trust, the Netherlands Organisation for Scientific Research, the

NSF, and the Shota Rustaveli National Science Foundation (Georgia).

Collaborators: Prof. Michael Diehl, Rice University; Prof. John Ladbury, M.D. Anderson Cancer

Center; Prof. Dean Madden, Dartmouth University Medical School; Prof. Frank

Orson, Baylor College of Medicine; Prof. Matteo Pasquali, Rice University; Prof.

Michele Redell, Baylor College of Medicine; Prof. Joff Silberg, Rice University;

David Tweardy, Baylor College of Medicine.

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