Dost ng r MD PhD

CURRICULUM VITAE

DATE PREPARED: 1/5/2011

Name: Dost ng r

Office Address: AB 320

McLean Hospital

*** **** ******

Belmont, MA 02478

Work Phone: 617-***-****

E-mail: abqc2y@r.postjobfree.com FAX: 617-***-****

Place of Birth: Istanbul, Turkey

Education:

1992 BA Oberlin College

1994 MS in Neuroscience Yale University

2000 MD/PhD in Neurobiology Washington University in St. Louis

Post-Doctoral Training:

Internship and Residencies:

2000-2001 Medicine Internship Massachusetts General Hospital/

Mt. Auburn Hospital

2001-2004 Resident in Psychiatry Massachusetts General Hospital/ McLean

Hospital

Faculty Academic Appointments:

2004-2006 Instructor in Psychiatry Harvard Medical School

2006- Assistant Prof. of Psychiatry Harvard Medical School

Administrative Appointments at Hospitals/Affiliated Institutions:

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Dost ng r MD PhD

2005-2006 Assistant Director Schizophrenia and Bipolar Disorder

Program, McLean Hospital

2006-2009 Director Schizophrenia and Bipolar Disorder

Program, McLean Hospital

2009- Clinical Director Psychotic Disorders Division, McLean

Hospital

Major Committee Appointments

Local

McLean Executive Committee Patient Care Assessment Committee

2006-

2007- MGH/McLean Adult Psychiatry Residency Steering Committee

2008- McLean Information Systems Steering Committee

2009- McLean Academic Steering Committee

2009- Data Safety Monitoring Board - "Lamotrigine Therapy in the Treatment of

Geriatric Bipolar Depression: An Evaluation of the Markers of Cerebral

Energy Metabolism Brent Forester (PI)

The President s Cabinet McLean Hospital

2010-

National/International

2009 Invited external reviewer for Catalan Agency for Health Technology Assessment

and Research (CAHTA) annual research award, Barcelona, Spain

2009 Invited expert to for The International Antipsychotic Clinically Equivalent and

Recommended Dose (ACER Dose) Study international survey of clinician

leader opinions in psychotic disorders; Nova Scotia, Canada

2010 National Network of Depression Centers Bipolar Disorder Task Group

Professional Societies:

1992- Society for Neuroscience

1992- Phi Beta Kappa Academic Society

2002- American Psychiatric Association

2003- American Medical Association

2006- International Society for Bipolar Disorder

2008- Associate Member, American College of Neuropsychopharmacology

Editorial Activities:

2002- Ad hoc reviewer Selected Journals from among many:

New England Journal of Medicine, Archives of General Psychiatry,

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Dost ng r MD PhD

American Journal of Psychiatry, Molecular Psychiatry, Biological

Psychiatry, Neuropsychopharmacology, Schizophrenia Research, Bipolar

Disorders, Psychiatry Research, Journal of Comparative Neurology,

Journal of Clinical Psychiatry, Journal of Clinical Psychopharmacology,

Journal of Psychiatry and Neuroscience, Neuropsychobiology

2002- 2005 Assistant Editor Harvard Review of Psychiatry

2004- Advisory Board-Permanent Reviewer European Psychiatry

2005- Associate Editor Harvard Review of Psychiatry

Honors and Prizes:

1997 Travel award; Affective Neuroscience Symposium; Madison, WI

2003 Solomon Research Award, Dept. Psychiatry, HMS; Boston, MA

2003 APA Travel Award to the Research Colloquium for Junior Investigators;

San Francisco, CA

2003 APA/Astra Zeneca Young Minds in Psychiatry Award

2004 Laughlin Fellow, American College of Psychiatrists; Miami Beach, FL

2004 Dupont-Warren Research Fellowship Award, Dept. Psychiatry, HMS;

Boston, MA

2004 NARSAD Young Investigator Award

2004 Thomas P. Hackett Award, Dept. Psychiatry Massachusetts General

Hospital

2004 Laughlin Award at Graduation, McLean Hospital

2005 Clinical Investigator Training Program Fellowship Award, MIT/HMS;

Boston, MA

2006 ACNP Young Investigator Memorial Travel Award

2007 Phillip L. Isenberg Teaching Award, MGH-McLean Psychiatry Residency

Program

2008 Leadership Development for Physicians and Scientists, Harvard Medical

School

2008 Alfred Pope Award for research, McLean Hospital

2008 Best Research Paper Award, East Meets West Psychiatry meeting,

Antalya, Turkey

Harvard Medical School Young Mentoring award nominated by

2010

mentees, selected by HMS

2010 Selected for Best Doctors in America 2011-2012 database

Report of Funded and Unfunded Projects

Funding Information

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Dost ng r MD PhD

Past Research Support

2004-2005 PI APA-Astra Zeneca Young Minds in Psychiatry Award $45,000

Type: Fellowship Award

Title: The role of the anterior cingulate cortex in cognitive interference tasks in schizophrenics

Goals: Use functional MRI to study cognitive interference tasks in schizophrenia

2004-2006 PI Harvard Medical School $45,000

Type: Dupont-Warren Fellowship Award

Title: Neural correlates of cognitive dysfunction in schizophrenia and bipolar disorder

Goals: Use functional MRI to study transitive inference in bipolar disorder and schizophrenia

2005-2007 PI Clinical Investigator Training Program, Harvard/MIT $110,000

Type: Fellowship Award

Title: Magnetic resonance spectroscopy studies on cellular function and neurotransmission in

bipolar disorder

Goals: Development of 13C magnetic resonance spectroscopy approaches to study bipolar

disorder

2004-2007 PI NARSAD $60,000

Type: Young Investigator Fellowship Award.

Title: The role of the medial temporal lobe and prefrontal cortex in paired object recognition in

subjects with schizophrenia and bipolar disorder

Goals: Use functional MRI to study the medial temporal lobe in paired object recognition in

schizophrenia

Current Research Support

2007-2012 PI NIMH $829,995

Type: K23 Career Development Award.

Title: MRS Studies of glutamate and GABA in bipolar disorder

Goals: Use magnetic resonance spectroscopy to examine glutamate and GABA levels in

manic, euthymic, and depressed phases of bipolar disorder

2007-2011 PI Jim and Pat Poitras Foundation $430,000

Type: Research Award

Title: Riluzole and Ampicillin in the Treatment of Bipolar Depression: A Study of the

Association Between Clinical Response and Change in Brain Glutamate Levels as Measured

by Proton Magnetic Resonance Spectroscopy

Goals: Study the effect of two innovative glutamatergic treatments for bipolar depression in

conjunction with in vivo measures of brain glutamate using magnetic resonance spectroscopy

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Dost ng r MD PhD

2006-2011 PI Louise Crane Foundation $48,000

Type: Research Award

Title: Carbon-13 Magnetic resonance spectroscopy in bipolar disorder and schizophrenia

Goals: Development of 13C magnetic resonance spectroscopy approaches to study schizophrenia

and bipolar disorder

2009-2012 PI Taplin Foundation $260,000

Type: Research Award

Title: Neuroimaging-genetics combination analysis in psychotic disorders

Goals: Examine the influence of genetic variation on brain phenotypes in psychotic disorders

through the collection of structural and functional MRI and genetics data from 300 subjects with

schizophrenia or bipolar disorder

Report of Local Teaching and Training

Undergraduate courses

Guest lecturer on Schizophrenia in Experience-Dependent Brain Development

2009

(MCB146) taught by Prof. Takao Hensch at Harvard University

Medical school courses

2003-2004 Harvard Medical School core clerkship in psychiatry, monthly lectures to rotating

3rd year medical students on Schizophrenia; Bipolar Disorder

2008- HMS/HST core psychiatry lecture on Schizophrenia

HMS core 2nd year psychiatry (PS 700M.J) lecture on Schizophrenia

2009-

Graduate medical courses

2003 MGH/McLean orientation didactic series for junior psychiatry residents on

antipsychotics and mood stabilizers

2003-present Didactic series on Schizophrenia and Bipolar Disorder for junior psychiatry

residents; Quarterly lectures on Mood Stabilizers; Evaluating Medication Effects;

Genetics; Epidemiology; Brain Abnormalities in Psychosis; Brain Abnormalities

in Mood Disorders

2004- 2007 Neuroscience Curriculum coordinator for the MGH/McLean Adult Psychiatry

residency; organize, teach and/or attend a series of 29 introductory lectures for

residents in their second year of training and a series of 15 advanced lectures for

residents in their fourth year of training.

Quarterly lecture on Schizophrenia for junior psychiatry residents at the Erich

2006-2007

Lindemann Mental Health Center

MIT graduate course in Neurobiology of Disease visiting speaker

2009

Supervisory and training responsibilities

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Dost ng r MD PhD

2004- Harvard Medical School core clerkship in psychiatry, preceptor for rotating

medical students

2004- Supervision of second year residents in the Schizophrenia and Bipolar Disorder

Unit at McLean Hospital (3 weeks/year)

2004- Data acquisition/processing/analysis training on 3T and 4T MRI human scanners

at the Brain Imaging Center at McLean Hospital

2005- Supervision of structured clinical interviews by PhDs/MDs/research assistants

2006- 2008 McLean Hospital Psychopharmacology Consultation Service, attending

psychiatrist (1 month/year)

2009- Psychopharmacology supervision of third year residents (1 hour/week)

2010- Thesis Director for Mariya Gaber, M.Biotech. candidate at Harvard Extension

School. Thesis title Efficient management and recruitment of study sites to a

large prospective study on imaging modalities-could we have predicted successful

and unsuccessful sites

Formally supervised trainees

2006-2007 Allison Lin, B.S. Clinical study coordinator

2006 Caitlin Stork, B.A. Medical student

2006-2007 Bryan Pridgen, M.D. Psychiatry Chief Resident

2007-2008 Julie Wilbur, M.D. Psychiatry Chief Resident

2007- Kathryn Eve Lewandowski, Ph.D. Post-doctoral fellow (received the NIH loan

repayment award under my mentorship)

2007- Anita Bechtholt, Ph.D. Post-doctoral fellow (received the McLean

Rapaport Research Fellowship under my joint mentorship; now holds R03 from

NIH)

2008- Justin Baker, M.D., Ph.D. Psychiatry resident (received APIRE-

Janssen Psychiatry Resident Scholars Fellowship under my mentorship)

2008- Ann Shinn, M.D. Chief resident & post-doctoral fellow

(received APIRE-Lilly Fellowship, HMS Dupont-Warren Fellowship, Harvard-

MIT CITP Fellowship, and Psychiatry Research Minority Training Program award

under my mentorship)

Formal teaching of peers

Annual lecturer on Antipsychotics at McLean Psychiatry Update Course,

2006-

Boston, MA

Annual lecturer on Functional Neuroanatomy at MGH Board Review Course,

2006-2008

Boston, MA

Annual lecturer on Neurobiology of Schizophrenia at MGH

2006-

Psychopharmacology Course, Boston, MA

Local invited presentations

Grand Rounds, McLean Hospital: Findings from CATIE and STEP-BD

2008

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Dost ng r MD PhD

2009 Clinical Investigator Training Program visiting faculty speaker

Invited speaker Metabolic Syndrome and Antipsychotic Medications Partners

2010

Physicians Day

Grand Rounds, McLean Hospital: Basic research advances and clinical

2010

implications in schizophrenia and bipolar disorder

2010 Panel participant at Psychiatry Medical Student Education Day, Harvard Medical

School

Report of Regional, National and International Invited Teaching and Contributions

Regional

2003 The structure and function of prefrontal cortex

Invited lecturer for tape-recorded Practical Reviews in Psychiatry series edited

by Drs. Robert Abernethy, Andrew Brotman, Donald Goff

Social Work Grand Rounds at Salem Hospital, Salem, MA: Bipolar Disorder ;

2004

Schizophrenia

Invited Psychopharmacology Rounds speaker Cambridge Health Alliance,

2007

Somerville, MA

Featured in The Carlat Report a psychopharmacology review for psychiatrists

2009

2009 Boston Neuropsychiatric Society interview and presentation on Schizophrenia

Brigham and Women s Hospital Behavioral Neurology Group seminar speaker

2010

National

Nationally syndicated Doug Stephan s Good Day USA radio program

2004

discussing Psychotic Disorders

ABC s World News Tonight discussing Bipolar Disorder

2005

Grand Rounds Vanderbilt University Department of Psychiatry, Nashville, TN

2007

Consultant for ABC News Online Mental Health Resource Bipolar Disorder

2008

section

Grand Rounds University of Utah Medical School Department of Psychiatry,

2009

Salt Lake City, UT

2009 Grand Rounds - William K. Warren Jr. Frontiers in Neuroscience Conferences at

Laureate Hospital, Tulsa, OK

Keynote address on Antipsychotic Medications at the Florida Psychiatric

2009

Society annual meeting, Orlando, FL

Invited presentation Price/Thach Symposium, Washington University Medical

2010

School, St.Louis, MO

Invited presentation Laboratory of Neuro-Psychiatric Imaging (Dr. Kelvin Lim)

2010

Univesity of Minnesota, Minneapolis, MN

Panel presentation In vivo evidence for glial cell dysfunction in mood disorders

2010

at the Annual Meeting of Society of Biological Psychiatry, New Orleans, LA

International

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Dost ng r MD PhD

Invited speaker at featured panel Tics, compulsions and the basal ganglia ;

2003

Annual Meeting of the Turkish Psychiatry Association, Antalya, Turkey:

Functional neuroanatomy of the basal ganglia (in Turkish)

Invited speaker on Bipolar Disorder, Schizoaffective Disorder, Schizophrenia in

2008

East Meets West Psychiatry Conference, Antalya, Turkey

Report of Clinical Activities and Innovations

Licensure and Certification:

2002- present Massachusetts Medical License Registration

2005- present Board Certified in Adult Psychiatry

Practice Activities:

Psychiatry; inpatient unit; McLean Hospital; one week/year

Psychiatry; outpatient consultations; McLean Hospital; one two-hour consultation/month

Report of Scholarship

Peer Reviewed Publications in print or other media

Research Investigations

1. Deutch AY, ng r D, Duman RS (1995) Antipsychotic drugs induce Fos protein in the

thalamic paraventricular nucleus: a novel locus of antipsychotic drug action. Neuroscience

66:337-346.

2. Black KJ, ng r D, Perlmutter JS (1998) Putamen volume in idiopathic focal dystonia.

Neurology 51:819-824.

3. An X, Bandler R, ng r D, Price JL (1998) Prefrontal cortical projections to longitudinal

columns in the midbrain periaqueductal gray in macaque monkeys. J. Comp. Neurol.

401:455-479.

4. ng r D, An X, Price JL (1998) Prefrontal cortical projections to the hypothalamus in

macaque monkeys. J. Comp. Neurol. 401:480-505.

5. Drevets WC, ng r D, Price JL (1998) Neuroimaging abnormalities in the subgenual

prefrontal cortex: implications for the pathophysiology of familial mood disorders. Mol.

Psychiatry 3:220-226.

6. ng r D, Drevets WC, Price JL (1998) Glial reduction in the subgenual prefrontal cortex in

mood disorders. Proc. Natl. Acad. Sci. USA 95:132**-*****.

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Dost ng r MD PhD

7. Simpson JR, ng r D, Akbudak E, Conturo TE, Ollinger JM, Snyder AZ, Gusnard DA,

Raichle ME (2000) The emotional modulation of cognitive processing: an fMRI study. J.

Cogn. Neurosci. 12 Suppl 2:157-170.

8. Ferry AT, ng r D, An X, Price JL (2000) Prefrontal cortical projections to the striatum in

macaque monkeys: evidence for an organization related to prefrontal networks. J. Comp.

Neurol. 425:447-470.

9. Bowley MP, Drevets WC, ng r D, Price JL (2002) Low glial numbers in the amygdala in

Major Depressive Disorder. Biol. Psychiatry 52:404-412.

10. ng r D, Ferry AT, Price JL (2003) Architectonic analysis of the human orbital and medial

prefrontal cortex. J. Comp. Neurol. 460: 425-449.

11. ng r D, Farabaugh A, Iosifescu DV, Perlis R, Fava M (2005) Tridimensional personality

questionnaire factors in major depressive disorder: relationship to anxiety disorder

comorbidity and age of onset. Psychother. Psychosom. 74: 173-9

12. ng r D, Goff DC (2005) Obsessive-compulsive symptoms in schizophrenia: associated

clinical features, cognitive function and medication status. Schizophr. Res. 75: 349-62

13. ng r D, Zalesak M, Weiss AP, Ditman T, Titone D, Heckers S (2005) Hippocampal

activation during processing of previously seen visual stimulus pairs. Psychiatry Res.

Neuroimaging 139: 191-8

14. Farabaugh A, ng r D, Fava M, Hamill SK, Burns AM, Alpert J (2005) Personality

disorders and the tridimensional personality questionnaire factors in major depressive

disorder. J. Nerv. Ment. Dis. 193: 747-50

15. ng r D, Cullen TJ, Wolf DH, Rohan M, Barreira P, Zalesak M, Heckers S (2006) The

neural basis of relational memory deficits in schizophrenia. Arch. Gen. Psychiatry 63: 356-

65

16. Glick ID, Salzman C, Cohen BM, Klein DF, Moutier C, Nasrallah HA, ng r D, Wang P,

Zisook S (2007) Improving the pedagogy associated with the teaching of

psychopharmacology to improve practice. Acad. Psychiatry 31: 211-7

17. Naydenov AV, MacDonald ML, ng r D, Konradi C (2007) Differences in lymphocyte

electron transport gene expression levels between bipolar subjects and normal controls in

response to glucose deprivation stress. Arch Gen Psychiatry 64: 555-64

18. ng r D, Pohlman J, Dow AM, Eisch AJ, Edwin F, Heckers S, Cohen BM, Patel TB,

Carlezon WA (2007) Electroconvulsive seizures stimulate glial proliferation and reduce

expression of Sprouty2 within the prefrontal cortex of rats. Biol. Psychiatry 62: 505-12

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Dost ng r MD PhD

19. Chen Y, Norton D, ng r D, Heckers S (2007) Inefficient face detection in schizophrenia.

Schizophrenia Bull 34: 367-74

20. Yildiz-Yesiloglu A, Guleryuz S, ng r D, Renshaw P (2008) Protein kinase C inhibition in

the treatment of mania: A double-blind, placebo-controlled trial of tamoxifen. Arch Gen

Psychiatry 65: 255-63

21. Abler B, Greenhouse I, ng r D, Walter H, Heckers S (2008) Abnormal reward system

activation in mania. Neuropsychpharmacology 33: 2217-27

22. Chen Y, Norton D, ng r D (2008) Abnormal interactions of center and surround motion in

schizophrenia. Biol Psychiatry 64: 74-7

23. Karmacharya R, England ML, ng r D (2008) Delirious mania: clinical features and

treatment response. J Affect Disord 109: 312-6

24. Norton D, ng r D, Stromeyer C 3rd, Chen Y (2008) Altered 'three-flash' illusion in

response to two light pulses in schizophrenia. Schizophr Res 103: 275-82

25. ng r D, Jensen JE, Prescot AP, Lundy M, Stork CE, Cohen BM, Renshaw PF (2008)

Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania.

Biol Psychiatry 64: 718-26

26. ng r D, Lin L, Cohen BM (2009) Clinical characteristics influencing age at onset in

psychotic disorders. Compr Psychiatry 50: 13-9

27. Chen Y, Norton D, McBain R, ng r D, Heckers S (2009) Visual and cognitive processing

of face information in schizophrenia: Detection, discrimination and working memory.

Schizophr Res 107: 92-8

28. ng r D, Prescot AP, Jensen JE, Cohen BM, Renshaw PF (2009) Creatine abnormalities in

schizophrenia and bipolar disorder. Psychiatry Res. Neuroimaging 172: 44-8

29. Norton D, McBain R, Holt DJ, ng r D, Chen Y (2009) Association of impaired facial

affect recognition with basic facial and visual processing deficits in schizophrenia. Biol

Psychiatry 65: 1094-8

30. ng r D, Prescot AP, Jensen JE, Rouse ED, Cohen BM, Renshaw PF, Olson DP (2009) T2

relaxation time abnormalities in bipolar disorder and schizophrenia. Magn Reson Med 63:

1-8

31. Kaufman MJ, Prescot AP, ng r D, Evins AE, Barros TL, Medeiros CL, Covell J, Wang L,

Fava M, Renshaw PF (2009) Oral glycine administration increases brain glycine/creatine

ratios in men: A proton magnetic resonance spectroscopy study. Psychiatry Res 173: 143-9

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Dost ng r MD PhD

32. Brennan BP, Hudson JI, Jensen JE, McCarthy JM, Roberts JL, Prescot AP, Cohen BM, Pope

HG, Renshaw PF, ng r D (2010). Rapid enhancement of glutamatergic neurotransmission

in bipolar depression following treatment with riluzole. Neuropsychopharmacology 35:

834-46

33. ng r D, Lundy M, Greenhouse I, Shinn AK, Menon V, Cohen BM, Renshaw PF (2010)

Default mode network abnormalities in bipolar disorder and schizophrenia. Psychiatry Res

Neuroimaging (in press)

34. Bechtholt-Gompf AJ, Walther HV, Adams MA, Carlezon WA, ng r D, Cohen BM (2010)

Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia without dysphoria

and impaired spatial memory. Neuropsychopharmacology (in press)

35. ng r D, Prescot AP, McCarthy JM, Cohen BM, Renshaw PF (2010) Elevated gamma-

aminobutyric acid levels in chronic schizophrenia. Biol Psychiatry (in press)

36. England ML, ng r D, Konopaske GT, Karmacharya R (2010) Catatonia in Psychotic

Patients: Clinical Features and Treatment Response. J Neuropsych Clin Neursci (In press)

37. Lewandowski KE, Cohen BM, ng r D (2010) Evolution of neuropsychological

dysfunction during the course of schizophrenia and bipolar disorder. Psychol Med. (in press)

38. Demirtas-Tatlidede A, Freitas C, Cromer JR, Safar L, ng r D, Stone WS, Seidman LJ,

Schmahmann JD, Pascual-Leone A (2010) Safety and proof of principle study of cerebellar

vermal theta burst stimulation in refractory schizophrenia. Schizophrenia Res. (in press)

39. Chen Y, McBain R, Norton D, ng r D (2010) Schizophrenia patients show augmented

spatial frame illusion for visual and visuomotor tasks. Neuroscience (in press)

40. Bracken B, Jensen JE, Prescot AP, Cohen BM, Renshaw PF, ng r D (2011) Brain

metabolite concentrations across cortical regions in healthy adults. Brain Res. (In press)

41. Bechtholt-Gompf A, Smith K, John C, Kang H, Carlezon WA, Cohen BM, ng r D (2011)

CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests

of acute antidepressant efficacy. Psychopharmacology (In press)

Peer-reviewed review articles

1. ng r D, Price JL (2000) The organization of networks within the orbital and medial

prefrontal cortex of rats, monkeys and humans. Cereb. Cortex 10:206-219.

2. Papakostas GI, ng r D, Mischoulon D, Fava M (2004) Cholesterol in mood and anxiety

disorders: review of the literature and new hypotheses. European Neuropsychopharma-

cology. 14: 135-42.

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Dost ng r MD PhD

3. ng r D, Heckers S (2004) A role of glia in electroconvulsive therapy. Harvard Rev.

Psych. 12: 253-62.

4. Sim K, Cullen TJ, ng r D, Heckers S (2006) Testing models of thalamic dysfunction in

schizophrenia using neuroimaging. J. Neural Transm. 113: 907-28

5. Lewandowski KE, Cohen BM, ng r D (2010) Evolution of neuropsychological

dysfunction during the course of schizophrenia and bipolar disorder. Psychol Med. (in press)

6. Yuksel AC, ng r D (2010) Magnetic resonance spectroscopy studies of glutamate-related

abnormalities in mood disorders. Biol Psychiatry (in press)

Non-peer reviewed publications in print or other media

Reviews, Chapters, Editorials

1. ng r D (2006) An approach to the patient with schizophrenia and other psychotic

disorders: delusions, hallucinations, disorganized speech, or grossly disorganized behavior. In

The ten-minute guide to psychiatric diagnosis and treatment, Ed. T.A. Stern. Professional

Publishing Group, New York, NY

2. ng r D (2006) Commentary on Obsessive compulsive symptoms in schizophrenia:

frequency and clinical features by Byerly et al. Evidence Based Mental Health 9: 28

3. ng r D (2007) Introduction to the special issue on schizophrenia. Harvard Rev. Psych.

15: 187-8

4. Holt D, ng r D, Wright CI, Dickerson BC, Rauch SL (2008) Neuroanatomical systems

relevant to neuropsychiatric disorders. In Comprehensive Clinical Psychiatry, Eds. T.A.

Stern, J.F. Rosenbaum, M. Fava, J. Biederman, S.L. Rauch. Mosby Inc., Philadelphia, PA

Narrative Report

I am a psychiatrist at McLean Hospital, with a background in neurobiology research and

clinical psychiatry. I continue to weave these interests together in my work with patients with

major psychotic disorders (schizophrenia and bipolar disorder). I hold an NIMH K23 career

development award on neuroimaging in bipolar disorder and currently spend 75% of my time on

research, and 25% on clinical administration and teaching.

I have an M.D./Ph.D. from the Washington University in St.Louis where I studied the

neuroanatomy of the monkey prefrontal cortex in relation to visceral control and mood disorders

in the laboratory of Dr. Joseph Price. As part of this work, I described networks within the

prefrontal cortex involved in processing multimodal sensory inputs for emotional salience and

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Dost ng r MD PhD

generating context-appropriate somatic and visceral reactions. I then proceeded to study the

same brain areas in humans and reported that there is a reduction in glial cell number in the

prefrontal cortex of patients with major depression and bipolar disorder. The finding of glial cell

changes in the brains of patients with mood disorders was novel at the time, and it helped spark a

literature which emphasizes cellular resilience and plasticity as crucial processes in mood

disorders. Following the end of my residency, I decided to focus on developing in vivo

approaches to studying glial cell function and neurotransmission in psychiatric disorders. In this

pursuit, I have utilized proton and carbon 13 magnetic resonance spectroscopy (MRS) to study

brain metabolism and glial cell function in vivo in schizophrenia and bipolar disorder, under the

mentorship of Dr. Perry Renshaw. I have also combined these approaches with structural and

functional brain imaging to obtain convergent evidence concerning abnormalities in psychiatric

conditions. Using proton MRS, I study the neurotransmitters glutamate and GABA in the anterior

cingulate cortex and parietal cortex. Since glial cells remove these neurotransmitters from the

synaptic cleft after they have been released, glial dysfunction should be reflected in glutamate

and GABA dynamics in the brain, and our findings are consistent with this hypothesis. Based on

this work, I obtained an NIMH K23 Career Development Award. I am principally responsible

for the design, execution and reporting of these projects.

In addition to my neuroimaging work, I am PI on a large genotype-phenotype study of

psychosis in collaboration with Drs. Bruce Cohen and McLean and Jordan Smoller at MGH. We

have published clinical phenotyping papers from this study, and genetics publications are

forthcoming. Finally, I also have active collaborations with an animal neuroscience group at

McLean Hospital, particularly Dr. Anita Bechtholt who started her work under my mentorship

and has become independent. This work focuses on probing the role played by glial cells in

glutamate metabolism in rodent models of mood disorders.

Following my residency training at the MGH/McLean Adult Psychiatry program (2000-

2004), I have remained active in teaching and clinical administration along with my research. I

continue to teach junior residents and medical students. In recognition of my contributions to the

residency as a teacher, I was asked to serve as the Neuroscience Curriculum coordinator for the

MGH/McLean Adult Psychiatry residency training program starting in July 2004. In 2007, I won

the Philip L. Isenberg teaching award, which is voted on by residents graduating from the

program every year. I continue to supervise and teach psychiatry residents and medical students

as well as mentor junior faculty in my research group. In 2010, I was nominated by my mentees

and won the HMS Young Mentorship Award. My clinical administrative responsibility

expanded first with my appointment as director of the Schizophrenia and Bipolar Disorder

Program in 2006 (involving a 28 bed inpatient unit) and next with my appointment as Clinical

Direcor of the Psychotic Disorders Division in 2009 (involving 2 inpatient units, a residential

house, and a specialty outpatient clinic staffed with 11 psychiatrists and multiple additional staff

members). I also contribute to hospital-wide activities by serving on the Residency Training

Committee, the Information Systems Steering Committee, and the Academic Steering

Committee.

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