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Medical Internal Medicine

Location:
Ann Arbor, MI
Posted:
January 24, 2013

Contact this candidate

Resume:

David Michael Markovitz, M.D.

Professor, Internal Medicine/Infectious Diseases

**** *. ******* ****** *****, 5220 MSRB III

Ann Arbor, MI 48109-5640

734-***-****

abqbgt@r.postjobfree.com

Education and Training

June 1972 St. Louis Park High School, St. Louis Park, Minnesota

August 1976 University of Minnesota, Minneapolis, Minnesota, B.A.

June 1981 University of Minnesota, Minneapolis, Minnesota, M.D.

June 1981-June 1984 Residency, University of Rochester Associated Hospitals Program in Internal Medicine, Rochester, New York

June 1984-June 1986 Fellowship, Infectious Diseases Unit, Department of Internal Medicine, University of Rochester School of Medicine, Rochester, New York

July 1986-June 1988 Research Fellowship, Lineberger Cancer Center, Laboratory of Dr. Joseph S. Pagano, Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina

Certification and Licensure

1988-present Michigan

1986-1988 North Carolina

1982-1988 New York

1986-present American Board of Internal Medicine/Infectious Diseases Subspecialty

1984-present American Board of Internal Medicine

Academic, Administrative, and Clinical Appointments

June 1988-August 1994 Assistant Professor, Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan

September 1994-Aug. 2002 Associate Professor (with tenure), Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan

September 2002-present Professor (with tenure), Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan

Research Interests

Human Immunodeficiency Viruses Types 1 and 2Role of the DEK oncoprotein in cancer and inflammationRole of vimentin in microbial pathogenesis

Grants

Present and Active

Sponsor: Office of the Director, NIH/NCI (Transformative R01 Program)

Title: Replication of Endogenous Retroviruses in Modern Humans

PI: David M. Markovitz

Dates: 9/28/09-8/31/14

Funding Amount (total direct costs): $4,473,469

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Title: DEK and TNF Inhibitors in Juvenile Arthritis

PI: David M. Markovitz

Dates: 9/1/09-8/31/13

Funding Amount (total direct costs): $1,000,000

Sponsor: Michigan Institute for Clinical and Health Research

Title: The DEK Oncoprotein as a Therapeutic Target in Melanoma

PI: David M. Markovitz

Dates: 9/1/09-8/31/10

Funding Amount (total direct costs): $50,000

Sponsor: Novartis Diagnostics

Title: The Endogenous Retrovirus HERV-K as a Cancer Biomarker

PI: David M. Markovitz

Dates: 6/1/09-6/30/11

Funding Amount (total direct costs): $55,000

Sponsor: Arthritis Foundation

Title: Posttranslational modifications of DEK and their role in autoimmunity

PI: Ferdinand Kappes

Dates: 7/1/06-6/30/10

Role: Mentor

Funding Amount (total direct costs): $150,000

Sponsor: National Institutes of Health

Title: Curcumin: A Multimechanism HIV Microbicide

PI: Raju C. Reddy

Dates: 9/25/08-8/31/10

Role: Co-investigator

Funding Amount (Markovitz): $25,000 in total direct costs to the Markovitz laboratory

Sponsor: National Institutes of Health

Title: Targeting HIV-1 Regulatory RNA Elements

PI: Hashim Al-Hashimi

Dates: 04/01/10-03/31/15

Role: Co-Investigator

Funding Amount: $79,710 in total direct costs to the Markovitz Laboratory

Sponsor: Michigan Institute for Clinical and Health Research

Title: The Role of DEK in the Development of Arthritis

PI: Nirit Mor-Vaknin, Ph.D.

Dates: 7/1/08-6/30/10

Role: Mentor

Funding Amount (total direct costs): $100,000

Sponsor: University of Michigan GI Peptide Research Center

Title: The Function of Vimentin in the Development of Chronic Gut Inflammation

PI: Nirit Mor-Vaknin

Dates: 9/1/09-8/31/10

Role: Mentor

Funding Amount (total direct costs): $25,000

Sponsor: National Institutes of Health (K01 award)

Title: The Role of DEK in the Development of Arthritis

PI: Nirit Mor-Vaknin

Dates: 7/1/09-5/31/14

Role: Co-Mentor

Funding Amount (total direct costs): $490,000

Previous (since 2001)

Sponsor: National Heart, Lung, and Blood Institute

Title: Chemokines and HIV replication in alveolar macrophages

PI: Michael Coffey

Dates: 10/1/96-7/30/01

Role: Co-PI

Funding Amount: $460,000

Sponsor: National Cancer Institute

Title: Great Lakes Regional Center for AIDS Research

PI: Steven Wolinsky

Dates: 9/1/98-8/31/01

Role: Co-investigator

Funding Amount: $183,000

Sponsor: American Cancer Society

Title: Mechanism of action and biological effect of the DEK oncoprotein

PI: David M. Markovitz

Dates: 7/1/98-6/30/01

Funding Amount: $255,000

Sponsor: National Heart, Lung, and Blood Institute

Title: C-X-C Chemokines and Kaposi’s Sarcoma

PI: David M. Markovitz

Dates: 7/1/01-5/31/07

Funding Amount: $1,000,000

Sponsor: Arthritis Foundation

Title: Expression of DEK in macrophages: implications for JRA

PI: Nirit Mor-Vaknin

Dates: 7/1/00-6/30/02

Role: Mentor to Dr. Nirit Mor-Vaknin, Postdoctoral Fellow

Funding Amount: $70,000

Sponsor: National Institute of Allergy and Infectious Diseases

Title: Regulation of HIV-2 transcription and replication

PI: David M. Markovitz

Dates: 7/15/98-6/30/2003

Funding Amount: $986,679

Sponsor: Arthritis Foundation

Title: Role of DEK in JRA

PI: David M. Markovitz

Dates: 1/1/01-12/31/03

Funding Amount: $250,000

Sponsor: National Institute of Allergy and Infectious Diseases

Title: C-X-C Chemokines and HIV Pathogenesis

PI: David M. Markovitz

Dates: 9/30/04-4/14/05

Funding Amount: $135,000

Sponsor: University of Michigan Comprehensive Cancer Center Prostate Spore Pilot Project

Title: Role of secreted vimentin in the pathogenesis of prostate cancer

PI: David M. Markovitz

Dates: 6/1/04-5/31/05

Funding Amount: $50,000

Sponsor: MI Institute for Clinical and Health Research

Title: Use of HERV-K (HML-2) as a biomarker for lymphoma and breast cancer

PI: Scott D. Gitlin

Dates: 10/1/07-9/30/08

Role: Co-investigator

Funding Amount (Markovitz): $35,000

Sponsor: Burroughs Wellcome Fund

Title: Clinical Scientist Award in Translational Research

PI: David M. Markovitz

Dates: 1/1/04-12/31/08

Funding Amount: $750,000

Sponsor: UMHS Faculty Group Practice Board of Directors

Title: DEK as a Biomarker in JRA/JIA

PI: Barbara S. Adams

Dates: 9/1/08-8/31/09

Role: Co-investigator

Funding Amount (Markovitz): $11,500

Sponsor: National Institute of Allergy and Infectious Diseases

Title: C-X-C Chemokines and HIV Pathogenesis

PI: David M. Markovitz

Dates: 4/15/05-12/31/09

Funding Amount: $1,115,000

Honors and Awards

1976 University of Minnesota, B.A., Magna Cum Laude

1990 National Cancer Institute - Clinical Investigator Award

1991 Life and Health Insurance Medical Research Fund Scholar

1997 American Society for Clinical Investigation

2003 Burroughs Wellcome Fund Clinical Scientist Award in Translational Research

2004 Association of American Physicians

Memberships in Professional Societies

American Society for Microbiology

American Association for the Advancement of Science

Infectious Diseases Society of America

American Federation for Clinical Research

Central Society for Clinical Research

American Society for Clinical Investigation

Association of American Physicians

Editorial Positions, Boards, and Peer-Review Service

Editorial Board

Journal of Virology

2002-2007

Ad Hoc Reviewer (Journals)

AIDS Research and Human Retroviruses

1992-present

Blood

1993-present

Journal of Clinical Investigation

1994-present

Journal of Biological Chemistry

1995-present

Clinical Infectious Diseases

1994-present

Journal of Virology

1995-present

Journal of Infectious Diseases

1995-present

Proceedings of the National Academy of Sciences, USA

1999-present

Molecular Endocrinology

1999-present

Virology

2002-present

Nature Immunology

2004-present

Molecular and Cellular Biology

2006-present

Cancer Research

2008-present

Journal of Molecular Evolution

2008-present

PLoS Genetics

2009-present

Cancer Research

2009-present

Ad Hoc Reviewer (Grants)

Veterans' Administration Medical Centers

1991-present

National Science Foundation

1994-present

National Institutes of Health

1996-present

Food and Drug Administration

2003-present

Teaching

Clinical Teaching

Instruction of medical students and Infectious Diseases fellows in the outpatient clinic

Instruction of medical students, residents, and Infectious Diseases fellows on Infectious Diseases Consult Service (two months/year)

Undergraduate Students

Laboratory research mentor for Ms. Amruta Mundade, Ms. Anna Tavakkoli, Mr. Nilesh Shah, and Ms. Kim Guo (Dr. Shah is now an Internal Medicine faculty member at UCSD, Ms. Guo is attending the University of Michigan Medical School, Ms. Tavakkoli is attending the University of Florida Medical School, and the late Ms. Mundade was accepted into the University of Michigan Medical School). The current undergraduate students in the laboratory are Anjan Saha, Yue (Anna) Yu, Angie Contreras and Miguel Rivas.

Master’s Students

Ayesha Khan, Department of Epidemiology, School of Public Health, University of Michigan

Amalie Dick, University of Konstanz (Germany)

Medical Students in Laboratory

Pre-clinical advisor and laboratory mentor for Ms. Juliet Mavromatis (Dr. Mavromatis is now an Internal Medicine faculty member at Emory University).

Laboratory research instruction for Ms. Kristin Robinson, medical student, for which she won the AOA Award for Best Research by a Medical Student (Dr. Robinson is now a faculty member at the University of California at Davis).

Laboratory research instruction for Ms. Lisa Bodley (Dr. Sprague [Bodley] is now a pediatrician at IHA Pediatric Healthcare Associates, Canton, MI).

Laboratory research instruction for Mr. Sia Dahi (currently a fourth-year medical student at the University of Michigan)

Laboratory research instruction for Mr. Joseph Wollman (currently a second-year medical student at the University of Michigan)

Ph.D. Preliminary Examination Committees

Sin-Hang Chan, Department of Microbiology and Immunology

Eric Humke, Cellular and Molecular Biology Program

Yifei Wu, Cellular and Molecular Biology Program

Irfan Lodhi, Cellular and Molecular Biology Program

Kelly Seidl, Immunology Program

Vilasack Thammavongsa, Immunology Program

Eric Komuniecki, Immunology Program

Travis Maures, Cellular and Molecular Biology Program

Matthew Pratt-Hyatt, Cellular and Molecular Biology Program

Adam MacNeil, Harvard School of Public Health

Elizabeth Wonderlich, Cellular and Molecular Biology Program

Elisabeth Starnes, Cellular and Molecular Biology Program

Doctoral Thesis Committees

Liqian Zhang, Department of Biological Chemistry

Wei Zhu, Department of Anatomy and Cell Biology

Evelisse Gonzalez, Cellular and Molecular Biology Program

Yifei Wu, Cellular and Molecular Biology Program

Narayani Moorthy, Cellular and Molecular Biology Program

Ping Ye, Department of Microbiology and Immunology

Mojgan Naghavi, Karolinska Institute, Stockholm, Sweden

Jennifer Fuller, Program in Immunology

Jennifer McGregor, Program in Immunology

Tamara Tucker, Cellular and Molecular Biology Program

Ron Merhavi, School of Music

Christoph Carter, Cellular and Molecular Biology Program

Kevin Vannella, Immunology Program

Laboratory Research Instruction for Internal Medicine Residents

Dr. Vivian Lin (now Senior Director of Clinical Affairs at NanoBio)

Dr. William Geisler (now an Assistant Professor of Infectious Diseases at the University of Alabama)

Dr. Emily Wong (now an Infectious Diseases physician)

Dr. Jeffery Anderson (now Clinical Assistant Professor at the University of North Carolina)

Dr. Rajan RaviKumar (now an Assistant Professor of Internal Medicine at the University of Michigan)

Dr. Emily Stoneman (now Infectious Diseases faculty at the University of Michigan)

Post-Doctoral Fellows

Nina Clark, M.D., Infectious Diseases Fellow (now an Assistant Professor of Medicine at the University of Illinois)

John Hilfinger, Ph.D. (now Executive Vice President at TSRL)

Igho Ofotokun, M.D., Infectious Diseases Fellow (now an Assistant Professor of Medicine at Emory University)

Joanne Cleary, Ph.D. (now a scientist in the Department of Obstetrics and Gynecology at the University of Michigan)

Nirit Mor-Vaknin, Ph.D. (now a Research Assistant Professor at the University of Michigan)

Ferdinand Kappes, Ph.D.

Rafael Contreras, Ph.D.

Ph.D. Advisor

Glenn Fu, School of Public Health (Winner of the Third Annual (1994) Prize for Student Research from the Department of Epidemiology); (currently Director of Molecular Biology at Incyte)

Catherine Browning, Department of Microbiology and Immunology (now a medical writer)

Neil Faulkner, Cellular and Molecular Biology Program, Medical Scientist Training Program (currently a Hematologist at Wayne State University)

Brian Lane, Cellular and Molecular Biology Program, Medical Scientist Training Program (won prize for outstanding research by a graduating medical student, 2002); (currently a Urologist with Michigan Medical Professional Corporation (mmpc))

Kajal Sitwala, Cellular and Molecular Biology Program, Medical Scientist Training Program (currently a Hematopathologist at the Marshfield Clinic)

Michael Khodadoust, Immunology Program, Medical Scientist Training Program (currently an Internal Medicine Resident at Stanford University)

Michael Swanson, Immunology Program (currently a Postdoctoral Fellow at the University of North Carolina)

Marta Gonzalez, Immunology Program

Committee, Organizational, and Volunteer Service

Biosafety Level 3 Facility Committee, University of Michigan Medical Center, 1989-presentSearch Committee for Director of Infection Control/Infectious Diseases faculty member, Department of Internal Medicine, 1991Pharmacy and Therapeutics Committee, University of Michigan Hospitals,

1991-1999

Organizing Committee, Advances in Internal Medicine Course, Department of Internal Medicine, Spring of 1989 and 1992Washtenaw County AIDS Task Force, Washtenaw County Michigan, 1993-1994

Virology Search Committee, University of Michigan School of Public Health, 1994-1995Seminar Organizing Committee, Organogenesis Center, 1996-1999

Chair of Seminar Organizing Committee, Organogenesis Center, 1997-1999

Antibiotic Subcommittee, University of Michigan Hospitals, 1996-1999Cellular and Molecular Biology 850 Lecture Series Organizing Committee, 1997-2004Steering Committee, Molecular Mechanisms of Microbial Pathogenesis Training Program, 1998-presentOrganizer, Virology Research Group, 1996-2001

Epidemiology Search Committee, School of Public Health, 2001-2003 Infectious Diseases Faculty Search Committee, 2001-present

University of Michigan Medical School Admissions Committee, 2003-present

Search Committee for Chair, Department of Biological and Material Sciences, University of Michigan Dental School, 2004

Graduate Student Affairs Committee, Program in Immunology, 2007-2010

Consulting Positions

FDA Vaccines and Related Biological Products Advisory Committee

2002-2006

Research Committee, Infectious Diseases Society of America

2009-present

Visiting Professorships, Seminars, and Extramural Invited Presentations

(since 1998)

Regulation of Retroviral Transcription by Cellular Factors Infectious Diseases Seminar SeriesMemorial Sloan-Kettering Cancer Center, New York, New YorkJanuary 1998

Regulation of HIV-2 Transcription Seminar Series, Harvard School of Public HealthFebruary 1998

Regulation of HIV-2 Transcription Co-organizer and SpeakerKeystone Symposium: HIV Pathogenesis and Treatment Park City, UtahMarch 1998

Regulation of HIV-2 Transcription by Intriguing Cellular Factors Molecular Medicine SeriesOregon Health Sciences University, Portland, OregonMay 1998

Regulation of HIV-2 Transcription by Intriguing Cellular Factors Seminar Series, University College, London, EnglandJune 1998

Regulation of HIV-2 Transcription by Intriguing Cellular Factors Molecular and Cellular Biology Seminar, Arizona State UniversityTempe, ArizonaOctober 1998 Regulation of HIV-2 Transcription Department of Virology Seminar SeriesKarolinska Institute, Stockholm, SwedenOctober 1998 HIV-2 Infection University of LisbonLisbon, PortugalOctober 1998

Regulation of HIV-2 Transcription by Cellular Factors Second ICGEB Virology SymposiumNew Delhi, IndiaNovember 1998 Infection with HIV-2 Internal Medicine Grand RoundsUniversity of Illinois at ChicagoDecember 1998

"Regulation of HIV-2 Transcription by Intriguing Cellular Factors"Internal Medicine Research ConferenceTulane UniversityNew Orleans, LouisianaApril 1999"GLI-2 Synergizes with Tat to Activate HIV Transcription"International Symposium on HIV, Leukemia, & Opportunistic CancersMarrakesh, MoroccoMay 1999

Regulation of HIV Transcription by Intriguing Cellular Factors City of Hope Medical CenterDuarte, CaliforniaJuly 1999

Regulation of HIV Replication by Intriguing Cellular Factors University of the Virgin IslandsSt. Thomas, Virgin IslandsFebruary 2000

Regulation of HIV Transcription San Marino Conference on Immunology, Oncology, and VirologyRepublic of San MarinoJune 2000 Regulation of HIV Transcription and Replication New Jersey Medical SchoolNewark, New JerseyOctober 2000 Regulation of HIV by Intriguing Cellular Factors University of California at IrvineIrvine, CaliforniaNovember 2000

The Role of IL-8 and GRO-α in HIV Replication GlaxoSmithKlinePhiladelphia, PennsylvaniaJanuary 2001 IL-8, Gro-α, and Kaposi’s Sarcoma University of Minnesota Dental SchoolMinneapolis, MinnesotaFebruary 2001

HIV and Cellular Factors Harvard School of Public HealthBoston, MassachusettsApril 2001 DEK Expression is Regulated by PP2A Indiana University Cancer Center SymposiumIndianapolis, IndianaApril 2001

Regulation of DEK Expression 4th International Conference on Gene Regulation, Oncogenesis, and AIDSAthens, GreeceSeptember 2002 Regulation of DEK Expression Universit Libre de BruxellesBrussels, BelgiumOctober 2002

Adventures with the Exotic DEK Protein Department of Biochemistry, University of MinnesotaMinneapolis, MinnesotaApril 2003

Adventures with the Exotic DEK Protein

Johns Hopkins Medical School, Department of Molecular Pharmacology

Baltimore, Maryland

September 2003

Regulation of HIV Transcription by Intriguing Cellular Factors

Meeting of the Institute of Human Virology

Baltimore, Maryland

October 2003

Adventures with the Exotic DEK Protein University of Konstanz

Konstanz, Germany

October 2003

AIDS

University of Seville

Seville, Spain

October 2003

The Role of IL-8 and GRO-α in HIV Replication

Department of Pathology, Stanford University

Palo Alto, California

January 2004

Adventures with the Exotic DEK Protein

Laboratory of Dr. Robin Reed, Harvard Medical School

Boston, Massachusetts

February 2004

Regulation of HIV Replication by Cellular Factors

Committee on Microbiology, University of Chicago

Chicago, Illinois

May 2004

The Role of IL-8 and GRO-α in HIV Replication

Meeting of the Institute of Human Virology

Baltimore, Maryland

October 2004

Adventures with the Exotic DEK Protein: in the Footsteps of HMGB1

LIJ Institute for Medical Research

Manhasset, New York

January 2005

IL-8, GRO-, and HIV Replication

North Shore University Hospital

Manhasset, New York

January 2005

The Role of DEK in Inflammation

Pontificia Universidad Cat lica De Puerto Rico

Ponce, Puerto Rico

April 2005

Prosthetic Joint Infections

Texas Tech Health Sciences Center

Lubbock, TX

September 2005

Adventures with the Exotic DEK Protein

Chiron Vaccine Research Center

Siena, Italy

October 2005

The DEK Autoantigen is a Secreted Chemotactic Factor

Eli Lilly and Company

Indianapolis, IN

November 2005

Adventures with DEK

Emory University

Atlanta, GA

March 2006

Exploiting HIV to Dissect Cellular Mechanisms

University of Alabama

Birmingham, AL

June 2006

Adventures with the DEK Autoantigen

University of North Carolina

Chapel Hill, NC

October 2006

The Role of Vimentin in Microbial Pathogenesis

Novartis Vaccines

Siena, Italy

November 2006

Endogenous Retroviruses

bioMerieux Global Research and Development

Grenoble, France

February 2007

Unexpected Chemokines Emerging from Studies of HIV

Weizmann Institute

Rehovot, Israel

June 2007

Adventures at the Interface Between Virus and Cell

University of Miami, Department of Internal Medicine

Miami, Florida

September 2007

The Exotic DEK Protein Modulates Chromatin Structure

Centre de Regulacio Genomica

Barcelona, Spain

October 2007

The Secret Life of the Human Endogenous Retrovirus HERV-K

Karolinska Institute

Stockholm, Sweden

December 2007

The Secret Life of the Human Endogenous Retrovirus HERV-K

University of Wisconsin

Madison, WI

April 2008

The Secret Life of a Human Endogenous Retrovirus

Instituto Scientifico Universitario San Raffaele

Milan, Italy

October 2008

The Human Endogenous Retrovirus HERV-K

Dartmouth-Hitchcock Medical Center

Lebanon, NH

March 2009

The Secret Life of the Endogenous Retrovirus HERV-K

University of Cincinnati

Cincinnati, OH

May 2009

The Secret Life of an Endogenous Retrovirus

Blood Systems Research Institute/UCSF

San Francisco, CA

July 2009

Human Endogenous Retroviruses as Cancer Biomarkers

Ninth Frye Halloran Symposium on Neuro-Oncology

Massachusetts General Hospital

Boston, MA

November 2009

The Secret Life of a Human Endogenous Retrovirus

University of Toledo

Toledo, OH

March 2010

Human Endogeneous Retroviruses and Cancer

Novartis Vaccines

Siena, Italty

June 2010

PATENTS

Methods for Inhibition of HIV Replication Using a Small Molecule Inhibitor

U.S. #7,052,676

Date of Issue: November 3, 2005

Methods of Secretory Vimentin Detection and Modulation

U.S. #7,691,582

Date of Issue: April 6, 2010

Compositions and Methods for Detecting Cancer for Inhibiting Metastasis

U.S. #7,641,902

Date of Issue: January 5, 2010

DEK Protein Compositions and Methods of Using the Same

Application #12/090,164

Converted September 9, 2008

Approval pendingHERV Group II Viruses in Lymphoma and Cancer

Application #12/090,164

Filed September 7, 2007

Approval pending

Antiviral Treatment of Lymphoma and Cancer

#61/180,321

Filed May 21, 2009

Approval pending

Bibliography

Peer-Reviewed Journals and PublicationsMarkovitz, D.M., Beutner, K.R., Maggio, R.P., and Reichman, R.C. Failure of recommended treatment for secondary syphilis. JAMA 1986; 255(13):1767-1768.Gartner, S., Markovits, P., Markovitz, D.M., Kaplan, M.H., Gallo, R.C., and Popovic, M. The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 1986; 233:215-219.

Gartner, S., Markovits, P., Markovitz, D.M., Betts, R.F., and Popovic, M. Virus isolation from and identification of HTLV-III/LAV-producing cells in brain tissue from a patient with AIDS. JAMA 1986; 256(17):2365-2371.Hall, C.B., Dolin, R., Gala, L.C., Markovitz, D.M., Zhang, Y.C., Madore, P.H., Disney, F.A., Talpey, W.B., Green, J.L., Francis, A.B., and Pichichero, M.E. Children with Influenza A infection: treatment with Rimantadine. Pediatrics 1987; 80(2):275-282.Kenney, S., Kamine, J., Markovitz, D.M., Fenrick, R., and Pagano, J.S. An Epstein-Barr virus immediate-early gene product trans-activates gene expression from the human immunodeficiency virus long terminal repeat. Proc. Natl. Acad. Sci. USA 1988; 85:1652-1656.

Kenney, S., Kamine, J., Holley-Guthrie, E., Mar, E.C., Lin, J.C., Markovitz, D., and Pagano, J. The EBV immediate-early gene product, BMLF1, acts in trans by a posttranscriptional mechanism which is reporter gene dependent. J. Virology 1989; 63(9):3870-3877.

Markovitz, D.M., Kenney, S., Kamine, J., Smith, M.S., Davis, M., Huang, E-S., Rosen, C., and Pagano, J.S. Disparate effects of two Herpesvirus immediate-early gene trans-activators on the HIV-1 LTR. Virology 1989; 173:363-367.Markovitz, D.M., Hannibal, M., Perez, V.L., Gauntt, C., Folks, T.M., and Nabel, G.J. Differentia



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