Health University
Resume:
DAVID W PYATT
Summit Toxicology, L.L.P.
Superior, CO 80027
Office 720-***-****
Cell 303-***-****
Email abpxt9@r.postjobfree.com
Education:
Ph.D., Toxicology, University of Colorado Health Sciences Center, 1996.
B.S., Science Education, North Carolina State University, 1981.
B.S., Biological Sciences, North Carolina State University, 1980.
Current Academic Appointments
Adjunct Assistant Professor of Toxicology, Molecular Toxicology and Environmental
Health Sciences Program, School of Pharmacy, University of Colorado, CO.
Instructor, Graduate Programs in Environmental Sciences, University of Colorado
at Denver and Health Sciences Center, Downtown Denver Campus, Denver, CO.
Assistant Clinical Professor, Department of Occupational and Environmental Health,
School of Public Health, University of Colorado, Denver, CO.
Professional Experience
Jan 2005-Present, Principal, Summit Toxicology, L.L.P., Lafayette, CO.
September 2003-Sept 2004, Managing Health Scientist, ChemRisk, Boulder, CO.
January 1998-Dec 2004, Assistant Research Professor of Toxicology, Molecular
Toxicology and Environmental Health Sciences Program, University of Colorado
Health Sciences Center, Denver, CO.
May 2001-Oct 2002, Senior Toxicologist, Exponent, Boulder CO.
October 1996-1997, Research Associate (Post-doctoral researcher), Molecular
Toxicology and Environmental Health Sciences Program, University of Colorado
Health Sciences Center, Denver, CO.
August 1991-September 1996, Research Assistant, University of Colorado Health
Sciences Center, Denver, CO.
June 1993-Present, Adjunct Staff, Center for Creative Leadership, Colorado
Springs, CO.
November 1990-August 1991, Environmental Scientist, United States
Environmental Protection Agency, Region VIII, Denver, CO.
April 1990-November 1990, Chemist, Public Service Company, Denver, CO.
August 1983-August 1989, Instructor, Chemistry and Geology, Boulder Valley
Public Schools, Boulder, CO.
June 1984-August 1988, Instructor, General mountaineering, Colorado Outward
Bound School, Denver, CO.
University Teaching Experience
Instructor, Occupational Toxicology, Continuing Medical Education Program (CME)
offered through the University of Colorado School of Public Health, (Fall 2009-Present).
Instructor, EHOH 6616, Environmental and Occupational Toxicology, University of
Colorado School of Public Health, (Spring 2009).
Course Director and Instructor, ENVS 6230-001, Environmental Epidemiology,
Environmental Sciences Program, University of Colorado Health Sciences Center,
Denver Campus, (2008-present).
Course Director and Instructor, ENVS 6220-002, Principles of Toxicology,
Environmental Sciences Program, University of Colorado Health Sciences Center,
Denver Campus, (2006-present).
Instructor, "Principles of Immunology", IOS-6, School of Pharmacy, University of
Colorado Health Sciences Center, PharmD Program (1996-2004).
Course Director and Instructor, "Toxicology and Industrial Health", Department of
Biometrics and Preventive Medicine, School of Medicine, University of Colorado Health
Sciences Center (2000).
Course Director and Instructor, "Applied Toxicology and Risk Assessment", Molecular
Toxicology and Environmental Health Sciences Program, School of Pharmacy,
University of Colorado (1998-Present).
Instructor, "Toxicological Pathology", Molecular Toxicology and Environmental Health
Sciences Program, School of Pharmacy, University of Colorado (1997-2001).
Course Director and Instructor, "Principles of Immunology, Immunopathology and
Immunopharmacology", School of Pharmacy, University of Colorado Health Sciences
Center, an on-line course for the non-traditional PharmD Program (1997- 1999).
Selected Lectures and Presentations:
Leukemia and Formaldehyde Annual Science Meeting with FCI and FormaCare,
Miami, FL, Jan. 2010.
Benzene and Childhood Leukemia Benzene, 2009, Health Effects and Mechanisms of
Bone Marrow Toxicity, Munich, Germany, Sept, 2009.
The critical interaction between hematopoietic progenitors cells (HPC) and the bone
marrow microenvironment in normal hematopoiesis and hematopoietic toxicology
Continuing Education Course, SOT Annual Meeting in Seattle WA, 2008.
Biomonitoring equivalents: Communication Issues, Society of Risk Analysis, Annual
Meeting in San Antonio, TX. 2007.
The relationship between hematotoxicity and the development of chemically induced
acute myelogenous leukemia Third International Symposium on Secondary Leukemia
and Leukemogenesis, Rome, Italy, 2006.
Children s Susceptibility to Chemical Leukemogenesis BTX VCCEP Panel, Estes Park,
2004.
"The Ethical Use of Animal Testing in Toxicology Research", Department of Preventive
Medicine and Biometrics, University of Colorado Health Science Center, Dec. 2003.
The Use of Non-Toxic Sugars for Long-term Storage of Hematopoietic Progenitor
Cells, Harvard University, Aug. 2002.
Assays to Evaluate Hematopoietic Function, Louisiana State University, Dec. 2001.
Dithiocarbamates as Confounders in Butadiene Epidemiology, Exponent, Inc. 2001
"Toxicology of Mercury and Other Heavy Metals", School of Dentistry, University of
Colorado Health Sciences Center (Sept. 2000).
"Toxicology and Risk Assessment in Product Safety Testing", Massachusetts Society for
Medical Research (Oct. 1999).
"Occupational and Regulatory Toxicology", Department of Preventive Medicine and
Biometrics, University of Colorado Health Science Center (Aug. 1999).
"Environmental Risk Assessment and Risk Management", Navy Civil Engineering and
Core Officer School (September 1998).
"NF- B in CD34 Positive Human Bone Marrow Cells", University of Colorado
Experimental Hematology Program (May 1998).
"Principles of Toxicology". Western States Chiropractic College (Nov. 1995 and Nov.
1996).
"Toxicology and Pathology of the Kidney". University of Colorado Health Sciences
Center (Mar. 1994).
"Toxicological Profile of the Rocky Mountain Arsenal". University of Colorado Health
Sciences Center (Feb.1993).
"Toxicology and Risk Assessment". University of Colorado at Denver (Dec. 1991,1992).
Scholarships/Awards
Invited Member of SOT Speaker s Bureau, Society of Toxicology, 2008
Biomonitoring Specialty Award, Society of Toxicology, 2008
Excellence in Teaching Award, School of Pharmacy, University of Colorado Health
Sciences Center, 2002.
Excellence in Teaching Award, School of Pharmacy, University of Colorado Health
Sciences Center 2001.
President s Teaching Award, runner-up, University of Colorado Health Sciences
Center, 2001, 2002, 2003.
Outstanding Research Award, Graduate Student Research Forum, University of Colorado
Health Sciences Center, Denver, CO. 1996.
Graduate Student Travel Award, Annual Meeting of the Society of Toxicology,
Baltimore, MD 1995.
Outstanding Research Award, Graduate Student Research Forum, University of Colorado
Health Sciences Center, Denver, CO. 1995.
Poster Presentation Award, Annual Mountain West Society of Toxicology Meeting,
Albuquerque, NM. 1994.
"Special Achievement" Award, Environmental Protection Agency
Region VIII 1991.
"Teacher of the Year" Award, Nevin Platte Jr. HS 1987, 1988.
"Beyond The Usual" Award, Nevin Platte Jr. HS 1986.
"Outstanding New Teacher" Award, Athens Drive HS 1982.
Professional Memberships:
* Society of Toxicology
* International Society of Experimental Hematology
* American Association for the Advancement of Science
Research Interests:
Immunotoxicology
Biochemical mechanisms of immunological disorders induced by exposure to
heavy metals. Chemical and drug induced alterations in developing immune
systems.
Experimental Hematology
Biological alterations associated with benzene induced leukemogenesis
Drug induced idiosyncratic aplastic anemia and agranulocytosis
Consulting Activities
US EPA, Region 8
US EPA, Office of Drinking Water, Washington, D.C.
US EPA, NCEA, IRIS program
State of Colorado, Department of Environmental Quality
ISSI, Inc. (environmental consulting company)
Scientia Veritas, Inc. (environmental consulting company)
Geotrans (environmental consulting company)
Geneva Pharmaceuticals, Inc.
Bavarian Department of the Environment
Organ-Recovery Systems, Inc.
Texas Commission on Environmental Quality (TCEQ)
Sandoz, Inc.
The Nature Conservancy
The American Petroleum Institute
American Chemical Council
Formaldehyde Council, Inc.
Various law firms
Student Advising Activities
Graduate Student Advisory Committee
Rhonda Baker (PhD)
Sandhya Buchanon (PhD)
Anatole Konowal (MS)
Research Advisor
Brenda Mehos (PharmD)
Jennifer McKermen (PharmD)
Jung Chang (PharmD)
Jean Zudrow (PhD)
Patrick Kerzic (PhD)
Academic Funding Sources:
Geneva Pharmaceutical, Inc. "Acute Toxicity of Glycine HCl", $49,801 (completed).
Cellular Engineering for Suspended Animation, DOD, $784,000 (completed).
A Novel In Vitro Culture System to Evaluate Developmental Immunotoxicity, $10,000
(completed).
Cellular Preservation of HPC with Non-Toxic Sugars, NIH $125,000 (completed).
Ad hoc Editorial Review:
Environmental Health Perspectives (2007)
The American Journal of Medical Sciences (2007)
American Journal of Hematology (2007)
Journal of Occupational & Environmental Hygiene (2006)
Chemosphere (2004)
Blood (1998, 2002)
Journal of Toxicology and Environmental Health (2003, 2004, 2006, 2007, 2008)
Toxicological Sciences (2003)
Occupational and Environmental Medicine (2002, 2007, 2009)
Toxicology and Applied Pharmacology (1998, 2001, 2002)
Experimental Hematology (2001, 2002)
Current Pharmaceutical Biotechnology (1998)
Cell Biology and Toxicology (1998)
Toxicology (1997, 2008)
Critical Reviews in Toxicology (2009)
Chemico-Biologic Interactions (2009, 2010)
Toxicological Sciences (2008, 2010)
Manuscripts (peer reviewed):
Natelson, E. and Pyatt, D., 2010 Temozolomide-Induced Myelodysplasia Advances in
Hematology, In press.
Pyatt, D., Hays, S., and Aylward, L. 2010 Benzene and Childhood Leukemia Chemico-
Biological Interactions, In press.
Buchanan, S., Elliott, G. Toner, T., Pyatt, D. and Carpenter, J. 2010 "Mechanistic Study
on Loss of Clonogenic Potential of a Lyophilized CD34+ Cell Line during Processing and
Following Ambient Storage" Submitted PloS Biology.
Buchanan, S., Pyatt, D.W. and Carpenter, J. 2009 "Preservation of Differentiation and
Clonogenic Potential of Lyophilized Human Hematopoietic Stem and Progenitor Cells
Loaded with Trehalose following Ambient Storage" In press.
Pyatt, D.W., Natelson, E. and Golden, R. 2008 Is Inhalation Exposure to Formaldehyde
a Biologically Plausible Cause of Lymphohematopoietic Malignancies? Regulatory
Toxicology and Pharmacology, V51, p119-133.
Buchanan, S., Pyatt, D.W. and Carpenter, J. 2008 Successful Lyophilization and
Ambient Temperature Storage of Human Umbilical Cord Blood Stem Cells.
Lakind, J.S., Holgate, S.T., Ownby, D., Mansure, A., Helms, P., Pyatt, D.W. and Hays,
S.M. 2007 A critical review of the use of clara cell secretory protein [CC16] as a
biomarker of acute of chronic pulmonary effects. Biomarkers, 2007, p1-23.
Pyatt, D.W., Aylward, L., and Hays, S. 2007 Is age an independent risk factor for
chemically induced acute myelogenous leukemia in children? Journal of Toxicology and
Environmental Health, Part B, 10: 1-22, 2007.
Hays, S.M., Becker, R., Leung, H.W., Aylward, L.L., and Pyatt, D.W. 2007.
Biomonitoring equivalents: A screening approach for interpreting biomonitoring results
from a public health risk perspective. Reg. Toxicol. Pharmacol. 47(1):96-109.
Buchanan, S., Pyatt, D.W. and Carpenter, J. 2006 Freeze-drying human hematopoietic
stem and progenitor cells loaded with trehalose. Accepted, Nature Biotechnology.
Golden, B., Pyatt D.W. and Shields, P. 2006 Formaldehyde as a potential human
leukemogen: an assessment of biologic plausibility Critical Reviews in Toxicology,
V36:135-153.
Hays, S.M. and Pyatt, D.W. 2006 Risk assessment for children exposed to
decabromodiphenyl (Oxide) ether (Deca) in the United States. Integrated Environmental
Assessment and Management, V2 (1):2-12.
Buchanan, S., Menze, M., Hand, S., Pyatt, D.W. and Carpenter, J. 2005
Cryopreservation of human hematopoietic stem and progenitor cells loaded with
trehalose: Transient permeabilization via the ATP-Dependent P2Z receptor channel.
Cell Preservation Technology, V3(4):212-222.
Pyatt, D.W., Hays, S. and Cushing, C. 2005 Do children have increased susceptibility
for developing secondary acute myelogenous leukemia? Chemico-Biological
Interactions, V153-154:223-229.
Zheng, T., Pyatt, D.W., Gross, S., Le, A. and Irons, R. D. 2004 Hydroquinone modulates
GM-CSF in TF.1 cells . Leukemia, 18(7):1296-304.
Buchanan, S., Gross, S., Mehmet, T., Carpenter, J. and Pyatt, D. W. 2004 A novel
methodology for cell preservation using non-toxic sugars . Journal of Stem Cells and
Development, V13(3):295-305.
Hays, Sean, M., Cushing, C., Leung, H-W., Pyatt, D., Holicky, K. and Paustenbach, D.
2003 Exposure of infants and children in the U.S. to the flame retardant
decabromodiphenyl oxide (DBDPO) . Journal of Children s Health, V1(4):449-475.
Kerzic, P., Pyatt, D.W., Zheng, T. and Irons, R.D. 2003 "Inhibition of NF-kappa B by
hydroquinone, a benzene metabolite, sensitizes human bone marrow progenitor cells to
TNF- induced apoptosis". Toxicology,V187(2-3):127 137.
Irons, R.D., Pyatt, D.W., Yang, J., Zheng, T., Stillman, W.S., Le, A. and Gustaphson,
D.2001 Comparative toxicology of dithiocarbamates and butadiene metabolites in
human lymphoid and bone marrow cells. Chemical- Biological Interactions, V135-
136:615-625.
Baker, R.K., Pyatt, D.W., Irons, R.D. and Kroll, D.J. 2001 "Benzene Metabolites
Antagonize Etoposide Stabilized Cleavable Complexes of DNA-Topoisomerase- ".
Blood, V98:830-833.
Irons, R.D., Pyatt, D.W., Gross, S. A. and Stillman, W.S. 2001 Hematopoietic stem and
progenitor cells as targets for biologically reactive intermediates . Advances in
Experimental and Medical Biology, V500:441-9.
Irons, R.D., Pyatt, D. W., Stillman, W. S., Som, D., Claffey, D. and Ruth, J. 2000
"Comparative toxicity of butadiene and it's putative metabolites in human CD34+ bone
marrow cells. Toxicology, V150:99-106.
Pyatt, D.W., Yang, J, Stillman, W.S. and Irons, R.D. 2000 Dithiocarbamates inhibit
hematopoiesis via a copper dependent mechanism. Biochemical and Biophysical
Research Communications, V274(2):513-518.
Pyatt, D.W., Mehos, B., Yang, J. and Irons, R.D. 2000 Effects of the anti-rheumatic
herbal medicine, Tripterygii, on CD34+ bone marrow cell function and survival.
Molecular Pharmacology, V57:1-7.
Pyatt, D.W., Stillman, W.S., Yang, J., Cano, L.L. and Irons, R.D. 2000 Hydroquinone,
an active metabolite of benzene, inhibits PMA-induced activation of NF- B in primary
human CD19+ B lymphocytes. Cell Biology and Toxicology, V16 (1):41-51.
Pyatt, D.W., Stillman, W.S., Yang, J., Zheng, T., Gross, S. and Irons, R.D. 1999 An
essential role for NF- B in human CD34+ bone marrow cell survival. Blood, V93
(10):1-8.
Pyatt, D.W., Stillman, W.S. Gruntmeir, J. and Irons, R.D. 1998
Dimethyldithiocarbamate (DMDTC) inhibits activation of human CD4+ T
lymphocytes. Toxicology, V128:83-90.
Pyatt, D.W., Stillman, W.S. and Irons, R.D. 1998 Hydroquinone, a reactive metabolite
of benzene, inhibits NF- B in primary human CD4+ T lymphocytes. Toxicology and
Applied Pharmacology,V149:178-184.
Irons, R.D. and Pyatt, D.W. 1997 Dimethyldithiocarbamate is a Potential Confounder in
Butadiene Epidemiology. Carcinogenesis, V19(4):539-542.
Gross, S., Helm, K., Gruntmeir, J., Pyatt, D.W., Stillman, W.S. and Irons, R.D. 1997
Characterization and phenotypic analysis of differentiating CD34+ human bone marrow
cells in liquid culture. European Journal of Haematology, V.59:318-326.
Pyatt, D.W., Stillman, W.S. and Irons, R.D. 1996 Reactive oxygen species mediate stem
cell factor synergy with GM-CSF in a sub-population of primitive hematopoietic
progenitor cells. Molecular Pharmacology, V49:1097-1103.
Pyatt, D.W., Stillman, W.S. and Irons, R.D. 1996 Inorganic lead activates the nuclear
transcription factor, NF-kB, in primary human CD4+ T-Lymphocytes. Biochemical and
Biophysical Research Communications, V227:380-385.
Book Chapters:
Pyatt, D.W. 2004 Benzene and Hematopoietic Malignancies, Industrial Solvents and
Human Health, Part 1, Clinics in Occupational and Environmental Medicine, V4, No. 1,
p.529-555.
Abstracts:
Hays, S., Aylward, L., Pyatt, D. 2010 Using the Biomonitoring Equivalent for Benzene
to Help Interpret Biomonitoring Data SOT, 2010 Annual Meeting.
Pyatt, D., Hays, S., Aylward, L. 2009 Benzene and Childhood Leukemia Benzene,
2009, Health Effects and Mechanisms of Bone Marrow Toxicity, Munich, Germany,
Sept, 2009.
Hays, S., Aylward, L., Pyatt, D. 2009 Biomonitoring Equivalent for Benzene Benzene,
2009, Health Effects and Mechanisms of Bone Marrow Toxicity, Munich, Germany,
Sept, 2009.
Pyatt, D., Aylward, L., and Hays, H. 2008. Biomonitoring equivalents: Case studies
Abstract #1197, Toxicologist 108(2):776.
Pyatt, D. 2008 The critical interaction between hematopoietic progenitors cells (HPC)
and the bone marrow microenvironment in normal hematopoiesis and hematopoietic
toxicology 47th SOT Annual Meeting in Seattle WA, CE Course, AM03.
Golden, R. and Pyatt, D. 2007. Can inhaled formaldehyde result in hematopoietic
malignancies? Abstract No. 1964, Toxicologist 96(1):405.
Pyatt, D., S. Hays, L. Aylward, P. Kerzic, and Borgert, C.. 2007. The role of
hematotoxicity in chemically induced acute myeloid leukemia . Abstract No. 1963,
Toxicologist 96(1):405
Hays, S., L. Aylward, D. Pyatt, H. Leung and Becker, R. 2007. Interpreting human
biomonitoring data in a risk assessment context: Biomonitoring equivalents . Abstract
No. 427. Toxicologist 96(1):89
Pyatt, D., Golden, B and Borgert, C. 2006 The relationship between hematotoxicity and
the development of chemically induced acute myelogenous leukemia Third International
Symposium on Secondary Leukemia and Leukemogenesis, Rome, Italy
Buchanan, S., Toner, M., Pyatt, D., and Carpenter, J. 2006 Successful lyophilization and
storage of human hematopoietic stem and progenitor cells derived from umbilical cord
blood. American Association of Pharmaceutical Science, 2006 Annual Meeting
Pyatt, D.W. and Borgert, C.J. 2006 Is bone marrow damage and hematopoietic toxicity
a requirement for chemically-induced AML? Experimental Hematology, V34, No.9, S.1,
#126
Pyatt, D.W. and Golden, B. 2006 Can inhaled formaldehyde result in hematopoietic
malignancies? Experimental Hematology, V34, No.9, S., #127
Pyatt, D.W. and Hays, S. 2006 Age related differences in secondary malignancies in
children: Lessons learned from the pediatric clinical experience. Toxicological Sciences
V.97, S1, #114
Pyatt, D.W. and Hays, S., 2005 Biomarkers of Susceptibility Annual Meeting Society
of Risk Analysis
Hays, S. and Pyatt, D.W. 2005 Interpreting Biomarkers of Exposure Annual Meeting
Society of Risk Analysis
Pyatt, D.W., Hays, S. Cushing, C. 2005 Are there age related differences in Children s
Susceptibility for Developing Secondary Acute Myelogenous Leukemia? Toxicological
Sciences V.89, S1, #258
Paustenbach, D. J., Madl, A.K., Unice, K., Scott, P., Robinson, K. P. Scaramella, K.P.,
and Pyatt, D.W. 2005 Exposure Reconstruction of Historical Airborne Benzene
Concentrations: Case study of a Deck Crewman on board Crude Oil and Chemical
Tankers . Toxicological Sciences V.89, S1, #411
Pyatt, D.W., Hays, S. Cushing, C. 2004 Do Children Have Increased Susceptibility for
Developing Secondary Acute Myelogenous Leukemia? Recent Advances in Benzene
Toxicity, Munich, Germany, Oct 9-12
Madl, A., Pyatt, D.W., Widner, T. E., and Paustenbach, D. J. 2004 Airborne Benzene
Concentrations Associated with Chainsaw Use during Tree Trimming Operations .
International Society of Exposure Assessment
Buchanan, Sandhya, Menze, Michael, Hand, Steven C, Carpenter, John, and Pyatt, D.W.
2004 Permeabilization of Hematopoietic Progenitor Cells to Trehalose using P2Z
Purinoreceptor-Associated Pores for the Purpose of Cryopreservation . Experimental
Hematology, V.39, (9), #37.
Kerzic, P., Pyatt, D., Zheng, T., Le, A., and Irons, R. 2004 Selective inhibition of I
kappa kinase (IKK) by benzene metabolites . Experimental Hematology, V.39, (9), #234
Hays, Sean, M., Cushing, C., Leung, H-W., Pyatt, D., Holicky, K. and Paustenbach, D.
2003 Exposure of infants and children in the U.S. to the flame retardant
decabromodiphenyl oxide (DBDPO) . Society of Risk Assessment, Baltimore MD
Kerzic, P., Pyatt, D., Zheng, T., Le, A., and Irons, R. 2003 Direct Inhibition of I Kappa
Kinase Activity by Benzene Metabolites Sensitizes Bone Marrow Cells to Cytokine-
Induced Apoptosis . Toxicological Sciences V.72, S1, #1716
Cushing, C.A., Holicky, K., Pyatt, D.W., Staskai, D., Finley, B. L., Paustenback, D.J.,
Hay, S.M. 2003 Estimated Children s Exposure to Decabromodiphenyl Oxide in the
US. Toxicological Sciences V.72, S1, #1906
Freed, B.M., Ouyang, Y., Yang, J., Pyatt, D.W., McCue, J. 2003 Suppression of
Inflammatory Cytokine Production by Cigarette Smoke is Mediated by Acrolein
Toxicological Sciences V.72, S1, #841
Buchanan, S, Gross, S, Acker, J.P. Toner, M., Carpenter, J, and Pyatt, D.W. 2002 A
Novel Technique for Long-term Cryopreservation of HPC using Non-toxic Sugars.
Society of Cryobiology, 2002 Annual Meeting
Zheng, T, Gross, S, Pyatt, D, Kerzic, P, and Irons, R 2002 Alterations in a GM-CSF
Signaling Pathway by the Benzene Metabolite Hydroquinone Experimental Hematology
V.30, (6), #205
Kersic, P., Pyatt, D. W., Yang, J., Zheng, T., and Irons, R. D. 2002. Hydroquinone
inhibits NF-kB and Synergizes with TNF in the Induction of Apoptosis inCD34+
Hematopoietic Progenitor Cells. Experimental Hematology V.30, (6), #59
Buchanan, S Gross, S, Acker, J.P. Toner, M. Carpenter, J and Pyatt, D.W. 2002 A Novel
Technique for Long-term Cryopreservation of Hematopoietic Progenitor Cells using
Intracellular Trehalose. Experimental Hematology V.30, (6), #380
Lowney, Y., Tsuji, J., Pyatt, D.W., Yost, L., Cushing, C., and Paustenbach, D. 2002
Children s Exposure to Metals from CCA Treated Wood: Important Factors in
Assessing Inadvertent Ingestion Exposures. International Society of Exposure
Assessment
Gross, S. A., Pyatt, D. W. and Irons, R. D. 2001 Altered phosphorylation of PU.1 by the
benzene metabolite Hydroquinone. Experimental Hematology V. 22 (5), #278
Ouyang, Y., Zheng, J., Yang, Y., Pyatt, D.W., Irons, R.D. and Freed, B.M. 2001
Suppression of Human Cytokine Expression by the Vapor from Cigarette Smoke
Extracts is Mediated by Decreased NF- B and AP.1. The Toxicologist V, V60, (1), #131
Gross, S.A., Pyatt, D.W., Shpall, E.J., Bearman, S., and McNiece, I. 2000 "Ex vivo
expansion of CD3+ cells from umbilical cord blood for use as donor lymphocyte
infusions in relapse patients". Experimental Hematology, 28, p89 #185
Pyatt, D.W., Stillman, W.S., Yang, J. Le, A. and Irons, R.D. 2000 "Hematotoxicity of
Dithiocarbamates on CD34+ Human Bone Marrow Cells". The Toxicologist V54, 1-S,
#.1654
Pyatt, D.W., Stillman, W.S., Yang, J. Le, A. and Irons, R.D. 2000 "Hematotoxicity of the
Chinese Herbal Medicine, Tripterygium Wilfordii Hook f in CD34+ Human Bone
Marrow Cells". The Toxicologist V54, 1-S, #. 1655
Baker, R., Pyatt, D.W., Irons, R.D., and Kroll, D. 2000 "Catalytic Inhibition of
Topoisomerase II alpha by Benzene Metabolites". The Toxicologist V54, 1-S, #.1656
Gross, S.A., Shpall, E.J., Bearman, S., Pyatt, D.W., and McNiece, I. 1999 "Ex vivo
culture of cord blood T cells for use as donor lymphocyte infusions in relapsed patients".
Blood V94, No. 10, Supp 1, p.4695
Gross, S.A., Shpall, E.J., Bearman, S., Pyatt, D.W., and McNiece, I. 1999 "Ex vivo
expansion of cord blood T cells for use as donor lymphocyte infusions in relapsed CML
patients.'Division of Medical Oncology Poster Session, School of Medicine, University of
Colorado Health Sciences Center, Denver, CO
Pyatt, D.W., Yang, J., Zheng, J., Stillman, W.S., and Irons, R.D. 1999 "Inhibition of NF-
B in Primary Human CD19+ B Lymphocytes by Hydroquinone." The Toxicologist
V48, 1-S, P.824
Gross, S.A., Pyatt, D.W., Yang, J., Zheng, J., Stillman, W.S., and Irons, R.D. 1999
"Hydroquinone Alters the Phosphorylation State of the Transcription Factor PU.1 in
Human CD34+ Hematopoietic Progenitor Cells." The Toxicologist V.48, 1-S, p. 172
Pyatt, D.W., Stillman, W.S., Yang, J. and Irons, R.D. 1998 "A Potential Role for NF- B
in Human CD34+ Bone Marrow Cell Function and Survival." International Society of
Experimental Hematology, Experimental Hematology V. 26, N.8, p.735
Gross, S.A., Pyatt, D.W., Yang, J., Stillman, W.S., and Irons, R.D. 1998 "Hydroquinone
Alters DNA Binding Activity of the Transcription Factor PU.1 in Human CD34+
Hematopoietic Progenitor Cells." The Toxicologist V. 42,1-S, p.269
Pyatt, D.W., Stillman, W.S., and Irons, R.D. 1998 "Hydroquinone Inhibits NF- B in
Primary Human CD4+ T Lymphocytes." The Toxicologist V. 42,1-S, p. 270.
Irons, R.D., Pyatt, D.W., Gross, S., Gruntmeir, J. and Stillman, W.S. 1997
"Characterization of the Effects of Hematotoxic Agents on Differentiating CD34+ Human
Bone Marrow Cells in Liquid Culture." First International Symposium on
Hematotoxicology, Palazzo dei Congressi, Lugano, Switzerland
Pyatt, D.W., Stillman, W.S., Zheng J-H., and Irons, R.D. 1997 "Activation of NF- B in
Primary Human CD4+ Lymphocytes by Lead Acetate." The Toxicologist V.36, p.262
Luckey, S.W., Pyatt, D.W., and Irons, R.D. 1997 "Nuclear Factor- B Activation and
Regulation of IL-2 Receptor Alpha Chain Expression by Nickel Chloride in Primary
Human CD4+ Lymphocytes." The Toxicologist V.36, p.264
Pyatt, D.W., Stillman, W.S., and Irons, R.D. 1996 "Antioxidants selectively suppress
stem cell factor synergy in murine hematopoietic progenitor cells (HPC)." The
Toxicologist V.30, p.133
Pyatt, D.W., Stillman, W.S. and Irons, R.D. 1995 "Inorganic Lead Mimics Stem Cell
Factor is a Select Subpopulation of Murine Hematopoietic Cells". Graduate Student
Research Forum, University of Colorado Health Sciences Center, Denver, CO
Pyatt, D.W., Stillman, W.S., and Irons, R.D. 1995 "Hematopoietic Alterations Induced
By Lead in Bone Marrow Derived Progenitor Cells May Be Mediated By Reactive
Oxygen Intermediates". The Toxicologist V.15, p.221
Pyatt, D.W., Stillman, W.S., and Irons, R.D. 1995 "Reactive oxygen species are required
for Stem Cell Factor and Interleukin-3 mediated signal transduction in a subpopulation of
primitive hematopoietic progenitor cells in C57BL/6 mice." Research Forum, University
of Colorado School of Pharmacy, Denver, CO
Pyatt, D.W., Stillman, W.S., and Irons, R.D. 1995 "Reactive oxygen species mediate
stem cell factor synergy in murine hematopoietic progenitor cells." Mountain West
Society of Toxicology, Ft. Collins, CO
Pyatt, D.W., Stillman, W.S., and Irons, R.D. 1994 "Effects of In Vitro Lead Acetate
Pretreatment on Colony Forming Ability of Murine Bone Marrow Cells". Experimental
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Pyatt, D.W., Stillman, W.S., and Irons, R.D. 1994 "Lead Induced Alterations in Growth
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Toxicology, Albuquerque, NM
Dissertation
Pyatt, D.W. 1996. Hematopoietic and immunological alterations induced by in vitro
pretreatment with inorganic lead.
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