Internal Medicine Medical
Resume:
CURRICULUM VITAE
of
David Eugene Dostal, Professor
Date of Birth: 3 January 1955
Birth Place: Topeka, Kansas
Spouse: Barbara J. Dostal, married May 21, 1983
Children: Joseph Aaron (01/05/91) and Johnathan Alan (10/21/94)
Parents: Deward L. Dostal and Marie J. Dostal
Home Address: 206 Lakeview Rd
Temple, TX 76502
Work address: Cardiovascular Research Institute
Department of Molecular Cardiology
Texas A&M University System-HSC
1901 South 1st Street
VA Building 205, CTVHSC
Temple, TX 76504
Tel: 254-***-****
abptp8@r.postjobfree.com
Education: 1969
-73 Gregory High School, Gregory, SD
Degrees Received: B.S
., 1976, Chemistry, University of SD, Vermillion
M.A
., 1978, Developmental Biology, University of SD, Vermillion
Ph.D., 1986, Physiology, University of Missouri at Columbia, research performed
at the Harry S Truman VA Memorial Hospital.
Dissertation Title: Vascular hyperresponsiveness in renal arterial rings produced
by renal prehypertensive rabbit plasma.
Postdoctorate, 1986-1990, Pharmacology, Charlottesville, VA
FELLOWSHIPS AND HONORS
NIH Teaching Training Grant (1980-84), University Missouri-Columbia
Award for Outstanding Teaching in the Medical Sciences (1984), University of Missouri-
Columbia
NIH Research Training Grant (1984-86), University of Missouri-Columbia
NIH Postdoctoral Hypertension Training Grant (1986-87), NRSA Postdoctoral Training Grant
(1987-1990)
Sigma Xi (1988-92)
Member of American Heart Association, High Blood Pressure Research, Basic Cardiovascular
Sciences
Member of the International Society for Heart Disease (ISHR)
TEACHING EXPERIENCE
1984-86 Elements of Physiology for Undergraduate/Graduate Students: Classroom lecture (15
hrs/yr) on pituitary hormones and regulation of cardiovascular and renal systems. 250
students per term (three terms/yr). University of Missouri, Columbia.
1980-84 Elements of Physiology Laboratory: Lab lectures (135 hrs/yr), demonstrations,
coordinated and supervised junior teaching assistants for three terms each year.
Page -1 - David E. Dostal, Ph.D.
rev. 03/01/11
Coordinated and supervised catheterization of anesthetized dogs used for demonstration
of cardiovascular and respiratory reflexes. 125 students per term (three terms/yr).
University of Missouri, Columbia.
1983-84 Medical Student Cardiovascular Laboratory: Lab lectures and demonstrations (12
hrs/yr)
involving cardiovascular respiratory experiments. Supervised arterial and venous
catherization of dogs, use of polygraphs and interpretation ECGs, respiratory and
cardiovascular reflex data. 12 students per term (one term/yr). University of Missouri,
Columbia.
1987-90 Pharmacology for Undergraduate Students: Classroom lectures (3 hrs/yr) on
cardiovascular and lipid/cholesterol lowering drugs. 80 students per term (one term/yr).
University of Virginia, Charlottesville.
1989-90 Pharmacology for Graduate Students: Classroom lectures (6 hrs/yr) on diuretics,
antihypertensives, cardiac inotropes, antianginals, and antiarrythmics. 12 students per
term (one term/yr). University of Virginia, Charlottesville.
1998-99 Physiology 571 for Graduate Students: Classroom lectures (6 hrs/yr) on cardiac
mechanics, vascular physiology, and cardiovascular regulation. Penn State University,
State College.
2000 Cardiac Mechanics and Molecular Signaling for Cardiology Fellows: Classroom lectures
(3
hrs) on molecular and biochemical regulation of cardiac function. Scott & White Hospital,
College of Medicine, Temple, TX.
2001
-02Cardiac Mechanics, Molecular Signaling, Bioinformatics and Microarray Chip
Technology
for Cardiology Fellows: Classroom lectures (1.5 h). Scott & White Hospital, College of
Medicine, Temple, TX.
2002-05 Cardiac Mechanics, Electrocardiography, Integrated Cardiovascular Regulation for
Medical Students: Classroom lectures (7 hr). Texas A&M University System, College of
Medicine, College Station, TX.
2003-05 Integrin and Cytoskeletal Signaling: Advanced Topics in Cell Signaling MSCI 689:
Classroom lectures (6 hrs). Texas A&M University System, College of Medicine, College
Station, TX.
2003 Clinical Aspects of Congestive Heart Failure: BMEN 689 Biomedical Case Studies
Classroom lectures (1 hr). Texas A&M University, Department of Biomedical Engineering,
College Station, TX.
2004-05 Cardiac Hypertrophy and Heart Failure: MSCI 689 Cardiovascular Sciences:
Classroom
lectures (1 hr) Texas A&M University System, College of Medicine, College Station, TX.
2004 Dept. of Medicine Current Concepts of Cell Adhesion in Disease States: Subspecialty
Fellows Course: Research in Health and Disease: Classroom lectures (2 hr) Scott &
White Memorial Hospital, College of Medicine, Temple, TX.
2005 Excitation-Contraction Coupling, Cardiac Mechanics, Electrocardiography First year
Medical Students: Classroom lectures (6 hr). Texas A&M University System, College of
Medicine, College Station, TX.
2006-09 MEID 905: Structure and Function of Human Organ Systems, Cardiac Physiology, 8
credit-hour course, 83 medical students, classroom lectures (6 hr), College of Medicine,
College Station, TX.
2005
-11 MSCI 689: Advanced Topics in Cell Signaling, 3 credit-hour graduate student
course, 3
students, classroom lectures on stress-activated kinases, cell cycle signaling pathways
(6
hr), Temple, TX.
2009
-10SBTM 612 Techniques Course II. 3 credit-hour graduate student course, 7 students,
classroom lectures (6 hr), laboratory (4 hr) on echocardiography and heart failure,
Temple, TX.
2010
-11 SBTM 615 Pathobiology and Therapeutics. 4 credit-hour graduate student course.
Faculty
facilitator for heart failure block. Temple, TX.
2010 MEID 905: Structure and Function of Human Organ Systems, Cardiac Physiology Block,
8
credit-hour course, 150 medical students (M2), classroom lectures (6 hr), College of
Medicine, Temple, TX.
Page -2 - David E. Dostal, Ph.D.
rev.
03/01/11
ACADEMIC APPOINTMENTS:
1975
-76Teaching Assistant, Department of ChemistryUniversity of South Dakota, Vermillion
1976
-78Graduate Teaching Assistant, Department of Biology
University of South Dakota, Vermillion
1980
-84Graduate Teaching Assistant, Department of Physiology
University of Missouri, Columbia
1984
-86Graduate Research Assistant, Department of Physiology
University of Missouri, Columbia
1986
-87Postdoctoral Fellow, Department of Hypertension
University of Virginia, Charlottesville
1987
-90Postdoctoral Fellow, Department of Pharmacology
University of Virginia, Charlottesville
1990
-96Associate Scientist/Assistant Professor, The Henry Hood Center for Research
Geisinger Clinic, Danville, PA
1996
-97Research Scientist II/Assistant Professor, The Henry Hood Research Program,
Geisinger Clinic, Danville, PA
1997
-98Assistant Professor, The Henry Hood Research Research Program, Pennsylvannia
State
University College of Medicine, Danville, PA
1998
-99Research Associate Professor, Department of Molecular and Cellular Physiology,
Penn
State University College of Medicine, Danville, PA.
1999
-02Research Associate Professor, Department of Molecular Cardiology, Cardiovascular
Institute, Texas A&M Health Science System - CTVHCS, Temple, TX.
2003
-09Associate Professor, Department of Internal Medicine, Texas A&M Health Science
System, Temple, TX.
2003
-2007Associate Professor, cross-appointment, Department of Medical Physiology,Texas
A&M
Health Science System, Temple, TX.
2009
-Pres Professor, cross-appointment, Department of Systems Biology and Translational
Medicine, Texas A&M Health Science System, Temple, TX.
2010
-Pres Professor, Internal Medicine/College of Medicine, Texas A&M Health Science
System,
Temple, TX
SERVICE
TO THE VETERANS ADMINISTRATION
VA Research Experience
1980
-86 Basic hypertension research with Dr. J. Alan Johnson (Career Scientist) at the
Harry S
Truman VA Hospital in Columbia, Missouri
1999-11 Basic research in the Cardiovascular Research Institute (Division of Molecular
Cardiology)
at Central Texas Veterans Health Care System (CTVHCS) in Temple
VA Research Grants
1993
-04Consultant/Reviewer for Veterans Administration (North Eastern and Western
branches)
2002-11 Research member for Veterans Integrated Service Networks in Texas (VISN-17)
2009-11 Reviewer for the Department of Veterans Affairs Cardiovascular Studies A (CARA)
Merit
Review Subcommittee
VA Committees for Central Texas Veterans Health Care System (CTVHCS)
1999 Planning committee for "A Star For Texas" fundraiser for the Cardiovascular Research
Institute, Temple, TX
1999
-11Radiation Safety/Medical Radioisotope Committee
1999
-02Laboratory Safety Oversight Committee
1999
-09
Research and Development (R&D) Committee
Page -3 - David E. Dostal, Ph.D.
rev. 03/01/11
1998
-01Task Force for the Cardiovascular Research Institute (CVRI
)
2000
-03 Building and Design Committee for construction of new CVRI
2000
-11Research Liason to Radiation Safety Officer
2001
-02Assistant Radiation Safety Officer for Research
2001-11 Chairman of Radiation Safety Protocol Review Committee (RPRC)
2001
-03 Strategic Research Planning Committee for the Temple Texas VA Research Building
2001 Groundbreaking Committee for Cardiovascular Research Institute
2002-11 Research Committee VISN-17 (Texas Veterans Administration)
2005 Organizer for VISN-17 Annual Research Conference on Current Concepts and
Controversies in Hypertension
2004-08 Alternate Radiation Safety Officer (RSO)
2009-11 Vice-chair of Subcommittee for Scientific Review (SSR)
2011 Research and Development (R&D) Committee
OTHER COMMITTEES AND GRANT REVIEW EXPERIENCE
1989
-91Consultant/Reviewer for Tobacco and Health Research Institute grants, Lexington,
KY
1992
-96Consultant/Reviewer
for Whitaker Foundation grants
1994-97 Peer-Review Committee for the American Heart Association, PA Affiliate
1996-98 Chairman of Information Technology Committee for American Heart Association
1996-98 Board of Directors of the American Heart Association, PA Affiliate
1996-97 Animal Care and Use Committee at Geisinger Clinic
1997-99 Computer Committee at Weis Center for Research
1998 Ad hoc Consultant/Reviewer for National Institutes of Health (CV-B)
1999-07 Board of Directors of American Heart Association (Temple-Belton, TX)
1999-03 Peer Reviewer for American Heart Association grants (Western Review Consortium)
2000-08 Institutional Research Committee at Scott & White
2000-08 Member of Scott & White Research Advisor Committee
2000-11 Member and Co-chair of Internal Medicine Mentor s Committee at Scott & White
2000
-08 Reviewer for Scott & White New Programs Research Initiative Applications
2000
Institutional Focus Group for Research, Scott & White
2001
-08 Project Administrative Review Committee (PAR) for Scott & White
2001
-03 Research and Education Planning Committee (REPC) for Scott & White
2001
-03 Reviewer for National Institutes of Health (Special Review Committee)
2001 Vision Committee for Education and Research, Scott &White
2001
-11Graduate Faculty Member of the Texas A&M University-HSC-GSBS
2001
-06Institutional Animal Care and Use Committee (IACUC
), TAMHSC
2001
-07Institutional Animal Care and Use Committee (IACUC), Scott & White
2000
-04 Peer Reviewer for Small Business Innovation Research (SBIR) and Technology
Transfer
(STTR) Grants, National Institutes of Health (HEM-1)
2001
-03Reviewer/Chairman for Special Emphasis Review Panel for National Institutes of
Health
2002
-03 Reviewer for HLBP Workgroup for National Institutes of Health
2003-05 Confocal/multiphoton Microscope oversight committee for COM at College Station
2004-05 Chair of CVRI Core Facilities and Instrumentation Committee
2004-11 Representative of Research Lab Operations, Radiation Safety Committee, TAMU
Health
Science Center, Temple campus
2004-11 Chair of Cardiovascular Research Institute Scientific Program Committee
2004-08 Member of Internal Medicine Research Committee (IRC)
2004-11 Reviewer for CCHF NIH study section
2005 Member of the Space Review Task Force, College of Medicine, Texas A&M HSC
2005-11 AAS Advisory Committee for Temple College
2005-08 Member of Scott & White Tissue Bank Oversight Committee
2006-08 Member of Imaging Oversight Committee for COM at Temple
2006-08 Member of the Educational Technology Advisory Group (ETAG) for COM
2006-10 Member of Scott & White Data Safety and Monitoring Board for Cancer Research
Inst.
2007 College of Medicine Educational Technology Curriculum Subcommittee (EdTechSubCom)
Page -4 - David E. Dostal, Ph.D.
rev. 03/01/11
2007-08 Scott & White Research and Education Task Force Committee
2009-11 Member of the Texas A&M Health Science Center Research Advisory Committee
2008-11 Executive Committee of the Cardiovascular Research Institute
2009-11 Animal Research Ultrasound Committee, Chair (ARUC)
2009-11 Scott & White Institutional Biosafety Committee (IBC)
2010-11 Peer Reviewer for Basic Science Signaling Section-3 (National AHA)
2010-11 IACUC Chair for Texas A&M Health Science Center
2010-11 IACUC Chair for Scott & White Hospital
2010-11 Texas A&M Health Science Center Compliance Task force
MISCELLANEOUS SERVICE
1. Current Concepts and Controversies in Hypertension, April 21, 2005, VA Building 205,
Temple
Texas, affiliations included VISN-17 (Research Divisions that consist of the Dallas,
Temple,
Waco, Austin and San Antonio Veterans Administrations) Annual Research Conference. 65
attendees, primary organizer.
th
2. 12 Annual Internal Medicine Research Day, May 6, 2005, Scott & White Hospital, Rm 109,
Temple Texas, ~80 attendees, co-organizer.
3. 2005 Flow Cytometry Workshop: Principals and Application, Aug 19, 2005 VA Building
205,
Temple Texas, affiliations include Central Texas VA, Texas A&M University College of
Medicine,
and Scott & White Hospital, 24 attendees, primary organizer.
4. First Annual Cardiovascular Research Institute Retreat, Oct 27-28, Scott & White
Hospital, Rm
110, Temple Texas, affiliations include Central Texas VA, Texas A&M University College of
Medicine, and Scott & White Hospital, IBT, 93 attendees, primary organizer.
th
5. 13 Annual South Texas ACP Associates Research Program, May 3, 2006, Scott & White
Hospital, Mayborn auditorium, Temple Texas, affiliations include Texas A&M University
System -
HSC, Scott & White, Temple; UTMB, Austin; UTHSC-San Antonio; UTHSC-Harlington; BAMC-
Fort Sam Houston; WHMC-Lackland AFB, ~100 attendees, Scientific Director/Planning
Committee member .
th
6. 12 Annual Internal Medicine Research Day, May 5, 2006, Scott & White Hospital, Rm 109,
Temple Texas, ~80 attendees, co-organizer.
7.
MANUSCRIPT REVIEW EXPERIENCE
1986
-PresentAmerican Journal of Physiology; Bentham Publishing; Biotechniques; Blood
Vessels;
Page -5 - David E. Dostal, Ph.D.
rev. 03/01/11
Cardiac Journal; Circulation; Circulation Research; Experimental Cell Research;
Hypertension; Journal of Cardiovascular Pharmacology; Journal of Clinical Investigation;
Journal of Molecular and Cellular Biochemistry; Journal of Molecular and Cellular
Cardiology; Cardiology Journal of Pharmacology and Experimental Therapeutics; Life
Sciences; Molecular and Cellular Biochemistry, The Canadian Journal of Physiology and
Pharmacology
TRAINEES
Chiencheng Lin, PhD, Post Doctoral Fellow,
July 1993 - June 30, 1995
Donald Hoover, PhD, Visiting Scientist, April 1994 - Aug 29, 1994
Thomas Peeler, PhD, Visiting Scientist, June 1995 - Aug 1995
Rachel M. Hunt, PhD, Post Doctoral Fellow, July 1995 - June 30, 1996
Steven A. Leicht, Undergraduate student from Bucknell University, May 1996 - Aug 1996
Masafumi Watanabe, MD, Post-doctoral fellow, Sept 1996 - Oct 1997
Jun Fukuzawa, MD, PhD, Visiting Scientist from Japan, Sept 1997 - Oct 1998
Jacey Hornecker, Undergraduate student from Texas A&M, May 2000 - Aug 2000
Sumit Shah, Undergraduate student from Stanford, CA, May 2000 - Sept 2000
Neeshant Hajira, Undergraduate student from Boston University, MA, June 2000 - Aug 2000
Rajesh Kumar, PhD, Post-doctoral Fellow. Jan 2001 - Dec 2002
.
Sandhya Sanghi, PhD, Post-doctoral Fellow, Jan 2001- Aug June 2004
Jason Lange, MD, Resident, Scott & White Memorial Hospital, May 2001
.
Robert Denyer, MD, Cardiology Fellow, Scott & White Hospital, July 2001 - June 2002
.
Elizabeth Ebert, MD, Internal Medicine Resident, Scott & White, Sept 2001 - June 30,
2003
.
Song Min Hong, MD, Internal Medicine Resident, Scott & White, Nov 2001-June 30, 2004
.
Ronald Kantola, DO, Internal Medicine Resident, Scott & White, Dec 2001 - June 30, 2003
.
Sheldon Chaffer, MD, Internal Medicine Resident, Scott & White, Feb 2002 - June 30, 2004
.
Milan Sheth, DO, Cardiology Fellow, July 1, 2002 - June 30, 2004
.
Shivani Desai, Summer Student from Temple High School, June - July 2002
Coty Jewel, MD, Internal Medicine Resident/Research Fellow, Scott & White, July 2003 -
June 2005
Bethany Chaffin, Summer Student from Oklahoma University, May 15 2004 - Aug 20, 2004
Daniel Levesque, MD, Internal Medicine Resident, Aug 2003 - May 2005
Eric Walker, MD, Internal Medicine Resident Aug 2004 - May 2005
Jonathan Mock, MD, Internal Medicine Resident, July 2005 - 2007
Hind Lal, PhD
., Postdoctoral Fellow, September 2005 - June 2009
.
Hui Yan, MD/PhD, Research Associate, Sept 2005 - April 2006
Rakeshwar Guleria, PhD, Postdoctoral Fellow, April 2006 - July 2006
Suresh Verma, PhD, Postdoctoral Fellow, January 2007 - Present
John C. Reneau, MD/PhD, Medical Student (M1), May 2007 - June 2007
Honey B. Golden, Graduate Student/COM/Tamhsc, Aug 20, 2007 - 2010
Hitesh Singh, MD, Internal Medicine Resident, Scott & White, Sept 2007 - Present
April Holt, BA, Summer Internship for Temple College Biosciences, June 2008 - Aug 2008
Marcelo Medical Student (M1), summer research rotation,
May 2009 - Aug 2009
Swagoto Mukappaddahyah, Medical student
(M1), summer research rotation, May 2009 - Aug
2009
Nimrit Goraya MD, Nephrology Fellow,
Scott and White, Texas A&M HSC, Jan 2010 - July 2010
Suraj Sunder, Medical student, summer rotation May 2010Aug 2010
Ricardo Cristales, Summer Internship for Temple College Biosciences, June 2010 - Aug 2010
Hao Feng, PhD, Postdoctoral Fellow, Dec 2010 - Present
Kumar Dasuri, PhD, Postdoctoral Fellow, Nov 2010Present
Damir Nizmutdinov, MD/PhD, Postdoctoral Fellow, March 2011 - Present
HOBBIES, INTERESTS AND COMMUNITY ACTIVITIES
Computer: software development for Windows/Linux; computer repair
Home remodeling: carpentry, flooring, drywall
Automotive: engine rebuild, body work, machine/fabricate small parts
Music: choir, small vocal groups
Page -6 - David E. Dostal, Ph.D.
rev. 03/01/11
PUBLICATIONS
1. Bowers MA, III, Dostal DE, Heisinger JF. Failure of selenite to protect against
mercuric chloride in
early devlopmental stages of the Japanese ricefish (Oryzias latipes). Comp Biochem
Physiol
66C:175-178, 1979.
2. Wells AM, Johnson JA, Zeigler DW, Fowler WL, Jr, Dostal DE, Payne CG. Pressor and
vascular
responsiveness in renal prehypertensive rabbits with a non-filtering kidney. Proc Soc Exp
Biol Med
180:24-32, 1985.
3. Fowler WL, Jr, Johnson JA, Kurz KD, Zeigler DW, Dostal DE, Payne CG. Body fluid
volumes in rats
with mestranol-induced hypertension. Am J Physiol 250:H190-H195, 1986.
4. Zeigler DW, Johnson JA, Koivunen DG, Siripaisarnpipat S, Fowler WL, Jr, Dostal DE,
Payne CG.
Angiotensin receptors and pressor hyperresponsiveness in renal prehypertensive rabbits.
Am J
angiotensin II
receptor
couples to Stat1 and Stat3 activation through Jak2 kinase in neonatal rat cardiac
myocytes. J Mol
Cell Cardiol 29:2513-2524, 1997.
29. Brooks WW, Bing OHL, Conrad CH, O'Neill L, Crow MT, Lakatta EG, Dostal DE, Baker KM,
Boluyt
MO. Left ventricular gene expression during regression of hypertrophy with angiotensin
converting
enzyme inhibition in hypertrophied and failing myocardium from aged spontaneously
hypertensive
rats. Hypertension 30:1362-1368, 1997.
30. Dostal, DE, Hunt RA, Kule CE, Bhat GJ, Karoor VJ, McWhinney CD, Baker KM. Molecular
mechanisms of angiotensin II in modulating cardiac function: Intracardiac effects and
signal
transduction pathways. J Mol Cell Cardiol 29:2893-2902, 1997.
31. McWhinney CM, Dostal DE, Kempinski, AM, Baker KM. Angiotensin II activates Stat5
through Jak2
kinase in cardiac myocytes. J Mol Cell Cardiol 30:751-761, 1998
32. Dostal DE, Baker KM. Pathophysiology of the renin-angiotensin system in Heart
Failure: Molecular
control through endocrine, paracrine, and autocrine pathways, In: Heart Metabolism in
Failure, 1st
Edition (R.A. Altschuld and R.A. Haworth, Eds) in the series: Advances in Organ Biology,
vol. 4B
(E.E. Bittar, Ed.) Jai Press, Connecticut, 1998, 305-322.
33. Dostal DE, Baker KM. Angiotensin and Endothelin: Messengers that couple ventricular
stretch to the
+ +
Na/H exchanger and cardiac hypertrophy. Circ Res 83:870-873, 1998.
34. Dostal, DE, Hunt RA, Kule CE, Baker KM. Developmental regulation of the cardiac renin
-angiotensin
system: Expression and association with growth and apoptosis. In: Angiotensin II Receptor
Blockade: Physiological and Clinical Implications. (NS Dhalla, RE Beamish, EDs) Kluwer
Academic
Publishers, 1998, 403-414.
35. Dostal DE, Kempinski AM, Motel TJ, Baker K. Absolute quantification of messenger RNA
using
multiplex reverse-transcriptase polymerase reaction. In: RT-PCT Methods for Gene Cloning
and
Analysis, eds. PD Siebert and C McAndrews, Eaton Publishing, 1998, 71-90.
36. Booz GE, Dostal DE Baker KM. Conditioned medium from cardiac fibroblasts rapidly
stimulates
signal transduction events, and increases protein synthesis and angiotensinogen mRNA of
cardiac
myocytes. Amer J Cardiol 83:44H-47H, 1999.
37. Dostal DE, Baker KM. The cardiac renin-angiotensin system: Conceptual, or a regulator
of cardiac
function Circ Res 85:643-650, 1999.
38. Fukuzawa J, Booz GW, Hunt RA, Shimizu N, Karoor V, Baker KM, Dostal DE. Cardiotrophin
-1
increases angiotensiogen mRNA levels in rat cardiac myocytes through STAT3: an autocrine
lo op
for hypertrophy. Hypertension 35:1191-1196, 2000.
39. Dostal, DE. The cardiac renin-angiotensin system: Novel signaling mechanisms and role
in
mediating cardiac growth. Regul Peptides 91:1-11, 2000.
40. Dostal DE, Booz GW, Baker KM. Regulation of angiotensinogen gene expression and
protein in
Page -8 - David E. Dostal, Ph.D.
rev. 03/01/11
neonatal rat cardiac fibroblasts by glucocorticoid and -adrenergic Stimulation. Basic
Research in
Cardiology 95:485-491, 2000.
41. Dostal DE. Regulation of Cardiac Collagen: Angiotensin and cross-talk with local
growth factors.
Hypertension 37:841-844, 2001.
42. Booz, GW, Fukuzawa J, Dostal DE, Baker. Angiotensin and cytokine receptor crosstalk
in
modulation of cardiomyocyte hypertrophy. Heart 33 (02) 174-179, 2001.
43. Barlucchi L, Leri A, Dostal DE, Fiordaliso F, Tada H, Hintze TH, Kajstura J, Nadal-
Ginard B, Anversa
P. Canine ventricular myocytes possess a renin-angiotensin system that is upregulated
with heart
failure. Circ Res 88:298-304, 2001
44. Dostal, DE, Tak T. Mechanoreceptors: elusive and important activators of cardiac
growth.
Netherlands Journal 9:65-67, 2001
45. Denyer R, Sanghi S, Kumar R, Dostal DE. Novel aspects of mechanical signaling in
cardiac tissue.
In Signal Transduction and Cardiac Hypertrophy. ed. NS Dhalla, Kluwer Academic Pub
lishers
(Boston), 2003, pp 181-198.
46. Shivakumar K, Dostal DE, Boheler K, Baker KM, Edward G. Lakatta. Differential
response of
cardiac fibroblasts from young adult and senescent rats to angiotensin II. AJP, 284:H1454-
459, 2003.
47. Watson LE, Sheth M, Lange J, Denyer RF, Dostal DE. Baseline echocardiographic values
for adult
male rats. J Amer Soc Echocardiography 17:161-167, 2004.
48. Baker, KM, Cherin M, Sanghi S, Booz GW, Dostal DE, Kumar R, Evidence of a novel
intracrine
mechanism in angiotensin II-induced cardiac hypertrophy. Regulatory Peptides 120:5-13,
2004
49. Sanghi S, Foster D, Jewell C, Dostal DE. Humoral and Mechanical Cross-Talk in the
Vasculature:
Perspectives in Vascular Disease. Vasc Dis Prevent 2:205-218, 2005
50. Sanghi S, Kumar R, Smith M, Baker KM, Dostal DE. Activation of Protein Kinase A by
Atrial
Natriuretic Peptide in Neonatal Rat Cardiac Fibroblasts: Role in Regulation of the Local
Renin -
Angiotensin System. Regulatory Peptides 132:1-8, 2005.
51. Sanghi S, Dostal DE. Mechanical Signaling and the Cardiac Renin-Angiotensin System.
In: The
Local Cardiac Renin Angiotensin System, eds. ED Frolich & RN Re, Springer, pp. 111-127,
2005.
52. Jewell C, Watson LE, Sanghi S, Dostal DE. Mineralocorticoid Receptor Antagonists: A
Chang ing of
the Guard. Cardiovascular and Hematological Agents in Medicinal Chemistry 4:129-153,
2006.
53. Dostal DE, Watson LE. Understanding diastolic heart failure with preserved ejection
fraction:
choosing the right model. Hypertension. 47(5):830-2, 2006.
54. Sanghi S, MacLaughlin EJ, Jewell CW, Chaffer S, Naus PJ, Watson LE and Dostal DE.
Cyclooxygenase-2 Inhibitors: A Painful Lesson. Cardiovascular & Hematological Disorders-
Drug
Targets, 6:85-100, 2006.
55. Alvaro D, Barbaro B, Franchitto A, Onori P, Glaser SS, Alpini G, Francis H, Marucci
L, Sterpetti P,
Ginanni- Corradini S, Onetti-Muda A, Dostal DE, De Santiis A, Attili AF, Benedetti A,
Gaudio E.
Estrogens and insulin like growth factor 1 modulate neoplastic cell growth in human
cholangiocarcinoma. Am J Pathol 169(3):877-88, 2006.
56. Lal H, Guleria R, Foster DM Lu G, Watson LE, Sanghi S, Dostal DE. Integrins: Novel
Theraeutic
Targets for Cardiovascular Diseases. Cardiovasc Hematol Agents Med Chem. 2007 5(2):109-
32,
2007
57. Watson LE, Mock J, Lal H, Lu G, Bourdeau RW, Tang WJ, Leppla SH, Dostal DE, Frankel
AE.
Differing Echocardiographic Effects of Anthrax Lethal and Edema Toxins. Front Biosci.
1;12:4670-
5, 2007.
58. Watson LE, Kuo S, Katki K, Dang T, Park SK, Dostal DE, Tang WJ, Leppla SH, Frankel,
A. Anthrax
toxins induce shock in rats by depressed cardiac ventricular function and reduced
preload. PLoS
ONE. 23;2:e466, 2007.
59. Lal H, Guleria R, Lu G, Foster DM, Smith M, Dostal DE. Stretch-Induced MAP Kinase
Activation in
Cardiac Myocytes: Differential Roles of 1-Integrin and Focal Adhesion Kinase. J Mol Cell
Cardiol.
43(2):137-47, 2007
60. Watson LE, Mock J, Lal H, Lu G, Bourdeau RW, Tang WJ, Leppla SH, Dostal DE, Frankel
AE.
Differing Echocardiographic Effects of Anthrax Lethal and Edema Toxins. Front Biosci.
1;12:4670-5,
Page -9 - David E. Dostal, Ph.D.
rev. 03/01/11
2007.
61. Lal H, Guleria R, Foster DM Lu G, Watson LE, Sanghi S, Dostal DE. Integrins: Novel
Theraeutic
Targets for Cardiovascular Diseases. Cardiovasc Hematol Agents Med Chem. 2007 5(2):109-
32,
2007.
62. Foster DM, Verma SK,Lal H, Reneau J, Smith M, Dostal DE. The Sodium Pump: Bridging
the basic
and Clinical Cardiovascular Sciences. Rec. Patents Endocrin, Metabol & Immune Drug
Discov. 1:
224-246, 2007.
63. Watson LE, Kuo S, Katki K, Dang T, Park SK, Dostal DE, Tang WJ, Leppla SH, Frankel,
A. Anthrax
toxins induce shock in rats by depressed cardiac ventricular function and reduced
preload. PLoS
ONE. 23;2:e466, 2007.
64. Lal H, Guleria R, Lu G, Foster DM, Smith M, Dostal DE. Stretch-Induced MAP Kinase
Activation in
Cardiac Myocytes: Differential Roles of 1-Integrin and Focal Adhesion Kinase. J Mol Cell
Cardiol.
43:137-47, 2007.
65. Francis H, Glaser S, DeMorrow S, Gaudio E, Ueno Y, Venter J, Dostal DE, Franchitto A,
Marzioni M,
Vaculin S, Katki K, Stutes M, Savage J, Alpini F. Small Mouse Cholangiocytes P roliferate
in
Response to H1 Histamine Receptor Stimulation by Activation of the IP/CaMK I/CREB
Pathway,
3
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66. Lal H, Verma SK, Golden HB, Foster DM, Smith M, Dostal DE. Stretch induced regulation
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67. Lal H, Verma SK, Foster DM, Smith M, Golden HB, Reneau J, Watson LE, Singh H, Dostal
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Integrins and Proximal Signaling Mechanisms in Cardiovascular Disease. Front Biosci.
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68. Golden HB, Watson LE, Lal H, Verma SK, Foster DM, Kuo, Shu-Ru, Sharma AC, Kuo, Shu-
Ru,
Frankel AE and Dostal DE.Anthrax Toxin: Pathologic Effects on the Cardiovascular System.
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69. Glaser S, Gaudio E, Rao A, Pierce L, Onori P, Franchitto A, Francis H, Dostal DE,
Venter J,
DeMorrow S, Mancinelli R, Carpino G, Alvaro D, Kopriva S, Savage J, Alpini G.
Morphological and
Functional Heterogeneity of the Mouse Intrahepatic Biliary Epithelium. Laboratory
Investigation
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70. Lal H, Verma SK, Golden HB, Foster DM, Holt AM and Dostal DE. Molecular Signaling
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71. Onori P, Wise C, Gaudio E, Franchitto A, Francis H, Carpino G, Lee V, Lam I, Miller
T, Dostal DE,
Glaser SS. Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-
dependent
signaling mechanisms of secretin receptor. Int J Cancer. 127(1):43-54, 2010.
72. Perepu RS, Garcia C, Dostal D, Sethi R. Enhanced death signaling in ozone exposed
ischemic -
reperfused hearts. Mol Cell Biochem (Epub ahead of print, D01: 10.1007/s11010-009-0265-
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73. Jewell CW, Houck PD, Watson LE, Dostal DE, Dehmer GJ. Enhanced external
counterpulsation is a
regenerative therapy Front Biosci (Elite Ed) 1;2:111-21; 2010
74. Chopra M, Das P, Golden H, Dostal DE, Watson LE, Sharma AC. Norepinephrine induces
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failure and inhibits antiapoptotic genes in a polymicrobial septic rat model. Life Sci.
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75. Verma SK, Lal H, Golde
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