WILLIAM M. YARBROUGH

CURRICULUM VITAE

WORK ADDRESS: Medical University of South Carolina

Department of Cardiothoracic Surgery

Ashley River Tower

** ********* ***** - ***** ****

Charleston, South Carolina 29425

Phone: 843-***-****

E-MAIL ADDRESS abpl83@r.postjobfree.com

CITIZENSHIP: United States

EDUCATIONAL BACKGROUND:

College: Duke University, B.S.

Durham, North Carolina. 1995

Post-Graduate: University of South Carolina

School of Medicine, M.D.

Columbia, South Carolina. 1999

EMPLOYMENT EXPERIENCE:

Intern, General Surgery Medical University of South Carolina

Charleston, South Carolina

July 1, 1999 June 30, 2000

Junior Resident, General Surgery Medical University of South Carolina

Charleston, South Carolina

July 1, 2000 June 30, 2001

National Institute of Health Medical University of South Carolina

Institutional Postdoctoral Research Fellowship Charleston, South Carolina

(NIH-HL 07260) July 1, 2001 June 30, 2003

Senior Resident, General Surgery Medical University of South Carolina

Charleston, South Carolina

July 1, 2003 June 30, 2005

Administrative Chief Resident, General Surgery Medical University of South Carolina

Charleston, South Carolina

July 1, 2005 June 30, 2006

Resident, Cardiothoracic Surgery Stanford University Medical Center

Stanford, California

July 1, 2006 June 30, 2009

Assistant Professor, Cardiothoracic Surgery Medical University of South Carolina

Charleston, South Carolina

July, 2009 Present

MEDICAL LICENSE: South Carolina #23969

(Expires 6/30/2011)

California #A93635

(Expires 8/31/2011)

BOARD CERTIFICATION: American Board of Surgery

#51711 (Expires 7/1/2017)

American Board of Thoracic Surgery

#7723 (Expires 12/31/2020)

AWARDS/HONORS:

1) Surgery Medal

University of South Carolina School of Medicine

2) Surgical Intern of the Year

Medical University of South Carolina Department of Surgery

Charleston, South Carolina. 2000

3) Dabney R. Yarbrough Resident Research Award

Medical University of South Carolina

Department of Surgery

Charleston, South Carolina. 2003

4) Third Edward D. Churchill Research Scholarship, 2009-2011

American Association for Thoracic Surgery

MANUSCRIPT PUBLICATIONS:

1. Yarbrough WM, Spinale FG. Large animal models of congestive heart failure: a

critical step in translating basic observations into clinical applications. J Nucl Cardiol.

2003 Jan-Feb;10(1):77-86. Review.

2. Yarbrough WM, Mukherjee R, Brinsa TA, Dowdy KB, Scott AA, Escobar GP, Joffs C,

Lucas DG, Crawford FA Jr, Spinale FG. Matrix metalloproteinase inhibition modifies

left ventricular remodeling after myocardial infarction in pigs. J Thorac Cardiovasc

Surg 2003 Mar;125(3):602-10.

3. Mukherjee R, Brinsa TA, Dowdy KB, Scott AA, Baskin JM, Deschamps AM, Lowry AS,

Escobar GP, Lucas DG, Yarbrough WM, Zile MR, Spinale FG. Myocardial infarct

expansion and matrix metalloproteinase inhibition. Circulation. 2003 Feb 4;107(4):618-

25.

4. Yarbrough WM, Mukherjee R, Escobar GP, Mingoia JT, Sample JA, Hendrick JW,

Dowdy KB, McLean JE, Lowry AS, O'Neill TP, Spinale FG. Selective targeting and

timing of matrix metalloproteinase inhibition in post-myocardial infarction remodeling.

Circulation. 2003 Oct 7;108(14):1753-9

5. Yarbrough WM, Mukherjee R, Escobar GP, Mingoia JT, Sample JA, Hendrick JW,

Dowdy KB, McLean JE, Stroud RE, Spinale FG. Direct inhibition of the

sodium/hydrogen exchanger after prolonged regional ischemia improves contractility

on reperfusion independent of myocardial viability. J Thorac Cardiovasc Surg. 2003

Nov;126(5):1489-97.

6. Yarbrough WM, Mukherjee R, Escobar GP, Hendrick JW, Sample JA, Dowdy KB,

McLean JE, Mingoia JT, Crawford FA, Spinale FG. Modulation of calcium transport

improves myocardial contractility and enzyme profiles after prolonged ischemia-

reperfusion. Ann Thorac Surg. 2003 Dec;76(6):2054-61.

7. Yarbrough WM, Mukherjee R, Escobar GP, Sample JA, McLean JE, Dowdy KB,

Hendrick JW, Gibson WC, Hardin AE, Mingoia JT, White PC, Stiko A, Armstrong RC,

Crawford FA, Spinale FG. Pharmacologic inhibition of intracellular caspases after

myocardial infarction attenuates left ventricular remodeling: a potentially novel

pathway. J Thorac Cardiovasc Surg. 2003 Dec;126(6):1892-9.

8. Mukherjee R, Yarbrough WM, Reese ES, Leiser JS, Sample JA, Mingoia JT, Hardin

AE, Stroud RE, McLean JE, Hendrick JW, Spinale FG. Myocyte contractility with

caspase inhibition and simulated hyperkalemic cardioplegic arrest. Ann Thorac Surg.

2004 May;77(5):1684-9.

9. Deschamps AM, Yarbrough WM, Squires CE, Allen RA, Dowdy KB, McLean JE,

Mingoia JT, Sample JA, Mukherjee R, Spinale FG. Trafficking of the membrane type-1

matrix metalloproteinase (MT1-MMP) in ischemia and reperfusion: Relation to

interstitial MT1-MMP activity. Circulation. 2005 Mar 8;111(9):1166-74

10. Yarbrough WM, Mukherjee R, Squires CE, Reese ES, Leiser JS, Stroud RE, Sample

JA, Hendrick JW, Mingoia JT, McLean JE, Hardin AE, Dowdy KB, Spinale FG.

Caspase inhibition attenuates contractile dysfunction following cardioplegic arrest and

rewarming in the setting of left ventricular failure. J Cardiovasc Pharmacol. 2004

Dec;44(6):645-50.

11. Blom AS, Mukherjee R, Pilla JJ, Lowry AS, Yarbrough WM, Mingoia JT, Hendrick JW,

Stroud RE, McLean JE, Affuso J, Gorman RC, Gorman JH 3rd, Acker MA, Spinale FG.

Cardiac support device modifies left ventricular geometry and myocardial structure

after myocardial infarction. Circulation. 2005 Aug 30;112(9):1274-83.

12. Deschamps AM, Apple KA, Leonardi AH, McLean JE, Yarbrough WM, Stroud RE,

Clark LL, Sample JA, Spinale FG. Myocardial interstitial matrix metalloproteinase

activity is altered by mechanical changes in LV load: interaction with the angiotensin

type 1 receptor. Circ Res. 2005 May 27;96(10):1110-8.

13. Apple KA, Yarbrough WM, Mukherjee R, Deschamps AM, Escobar PG, Mingoia JT,

Sample JA, Hendricks JW, Dowdy KB, McLean JE, Stroud RE, O Neill TP, Spinale

FG. Selective targeting of matrix metalloproteinase inhibition in post-infarction

myocardial remodeling. J Cardiovasc Pharmacol. 2006 Feb;47(2):228-35.

14. Flack EC, Lindsey ML, Squires CE, Kaplan BS, Stroud RE, Clark LL, Escobar PG,

Yarbrough WM, Spinale FG. Alterations in cultured myocardial fibroblast function

following the development of left ventricular failure. J Mol Cell Cardiol. 2006

Apr;40(4):474-83.

15. Ruddy JM, Yarbrough W, Brothers T, Robison J, Elliott B. Abdominal aortic

aneurysm and significant coronary artery disease: strategies and options. South Med

J. 2008 Nov;101(11):1113-116

16. Yarbrough WM, Bates MJ, Deuse T, Tang DG, Robbins RC, Reitz BA, Mallidi HR.

Alternative technique for salvage of donor lungs with insufficient atrial cuffs. Ann

Thorac Surg. 2009 Oct;88(4):1374-6.

17. Yarbrough WM, Mukherjee R, Stroud RE, Meyer EC, Escobar GP, Sample JA,

Hendrick JW, Mingoia JT, Spinale FG. Caspase inhibition modulates left ventricular

remodeling following myocardial infarction through cellular and extracellular

mechanisms. J Cardiovasc Pharmacol. 2010 Apr;55(4):408-16.

BOOK CHAPTERS:

1. Payne KJ, Yarbrough WM, Ikonomidis JS, Reeves ST. Transesophageal

echocardiography of the thoracic aorta. From, A practical approach to

transesophageal echocardiography. Perrino AC and Reeves ST. Lippincott Williams

and Wilkins. Copyright 2003

PRESENTATIONS AT PEER REVIEWED REGIONAL / NATIONAL MEETINGS:

1. Yarbrough WM, Mukherjee R, Brinsa TA, Dowdy KB, Scott AA, Escobar GP, Joffs C,

Lucas DG, Crawford FA, Spinale FG. Targeting matrix metalloproteinases alters the

course of post-myocardial infarction remodeling: identification of novel therapeutic

strategies. C. Walton Lillehei Resident Forum Session. 82nd Annual Meeting of The

American Association For Thoracic Surgery, Washington, D.C., May 2002

2. Yarbrough WM, Mukherjee R, Brinsa TA, Thornton JL, Sample JA, Dowdy, KB,

O Neill TP, Escobar GP, Spinale FG. Selective matrix metalloproteinase inhibition

influences regional myocardial geometry and reduces LV dilation following myocardial

infarction. 75th Scientific Session of the American Heart Association, Chicago,

November 2002

3. Deschamps AM, Yarbrough WM, Sample JA, McLean JE, Mingoia JT, Dowdy KB,

Mukherjee R, Hendrick JW, Stroud RE, Spinale FG. Persistent and selective activation

of matrix metalloproteinases within the myocardial interstitial space following ischemia-

reperfusion. 75th Scientific Session of the American Heart Association, Chicago,

November 2002

4. Invited discussant at the 2003 Annual Scientific Meeting of the Southeastern Surgical

Congress, Residents Forum, discussing manuscript entitled The Cost of Trauma,

presented by Dr. Stephen Lanzarotti, Savannah, Georgia, February 2003

5. Yarbrough WM, Mukherjee R, Escobar GP, Sample JA, McLean JE, Dowdy KB,

Hendrick JW, Gibson WC, Hardin AE, Mingoia JT, White PC, Stiko A, Armstrong RC,

Crawford FA, Spinale FG. Pharmacologic inhibition of intracellular caspases following

ischemia-reperfusion attenuates left ventricular remodeling: a potentially novel

pathway. Cardiac Surgery Forum Session. 83rd Annual Meeting of The American

Association For Thoracic Surgery, Boston, May 2003

6. Yarbrough WM, Escobar GP, Mingoia JT, Sample JA, Hendrick JW, Dowdy KB,

Stroud RE, Crawford FA, Spinale FG. Na+/H+ exchanger inhibition following

prolonged ischemia improves contractility upon reperfusion independent of myocardial

viability. Surgical Forum. 89th Annual Clinical Congress Meeting of the American

College of Surgeons, Chicago, October 2003

7. Mukherjee R, Reese ES, Multani MM, Yarbrough WM, Dowdy KB, Mingoia JT,

Hendrick JW, Stroud RE, Hardin AE, McLean JE, Leiser JS, Blom AS, Pilla JJ, Affuso

J, Acker MA, Spinale FG. Passive restraint following myocardial infarction modifies left

ventricular and myocyte remodeling and improves isolated myocyte contractile

response. Heart Failure Society of America. Las Vegas, September 2003

8. Yarbrough WM, Reese ES, Leiser JS, Multani MM, Hardin AE, McLean JE, Sample

JA, Stroud RE, Hendrick JW, Mukherjee R, Spinale FG. Effects of caspase inhibition

on left ventricular myocyte contractile function following cardioplegic arrest and

rewarming in a model of pacing induced heart failure. Heart Failure Society of

America. Las Vegas, September 2003

9. Yarbrough WM, Mukherjee R, Escobar GP, Sample JA, McLean JE, Hendrick JW,

White PC, Stiko A, Armstrong RC, Spinale FG. Effects of Caspase Inhibition on Left

Ventricular Dilation Following Myocardial Infarction. Heart Failure Society of America.

Las Vegas, September 2003

10. Chapman RE, Lindsey ML, Squires C, Yarbrough WM, Leiser JS, Gardner KC, Reese

ES, Butler JE, Spinale FG. Alterations in myocardial fibroblast adhesion in left

ventricular remodeling and failure. Heart Failure Society of America. Las Vegas,

September 2003

11. Yarbrough WM, Sample JA, Mukherjee R, McLean JE, Hendrick JW, Escobar GP,

Dowdy KB, Mingoia JT, O Neill TP, Spinale FG. Selective inhibition of matrix

metalloproteinase species favorably modifies left ventricular remodeling post

myocardial infarction. Heart Failure Society of America. Las Vegas, September 2003

12. Lowry AS, Yarbrough WM, Mukherjee R, Allen RA, Deschamps AM, Escobar GP,

Sample JA, Hendrick JW, Spinale FG. Selective targeting of matrix metalloproteinase

(MMP) inhibition reduces myocardial MMP activity and LV remodeling post myocardial

infarction. Heart Failure Society of America. Las Vegas, September 2003

13. Deschamps AM, Yarbrough WM, Allen RA, Dowdy KB, McLean JE, Mingoia JT,

Sample JA, Mukherjee R, Spinale FG. The discordance between localized induction of

membrane type-MMPs and tissue inhibitors with ischemia and reperfusion: a potential

therapeutic target. Heart Failure Society of America. Las Vegas, September 2003

14. Deschamps AM, Yarbrough WM, Allen RA, Squires CE, McLean JE, Mingoia JT,

Sample JA, Mukherjee R, Spinale FG. Membrane trafficking of the membrane type-1

matrix metalloproteinase in ischemia and reperfusion: Relation to interstitial activity.

77th Scientific Session of the American Heart Association, New Orleans, November

2004

ino AC and Reeves ST. Lippincott Williams

and Wilkins. Copyright 2003

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