Swati Rane

**** **** ****** *****, *** AA**** Nashville, TN 37232

Phone: 615-***-**** Fax: 615-***-**** E-Mail: abphe7@r.postjobfree.com

Web: http://www.vuiis.vanderbilt.edu/~ranesd

Research Interests

Functional magnetic resonance imaging (method development and application to neuro-degenerative

diseases) - Resting state blood oxygen level dependent (BOLD), multi-echo BOLD at high fields (3T/ 7T)

Cerebral blood volume measurement Contrast imaging, Vascular Space Occupancy (VASO)

Lymphatic system - ASL based method development for study of lymphatic system

Diffusion tensor Imaging (DTI)

Clinical Applications: Alzheimer s disease, Schizophrenia, Breast cancer related lymphedema

Research Experience

Vanderbilt University Sept. 2009 - present

Research Fellow, Vanderbilt University Institute of Imaging Science

Development and application of cerebral blood volume measurement techniques (VASO, multi-echo fMRI,

DSC MRI) at high magnetic field strengths

Development of functional cerebral blood volume measurement approaches, test of feasibility for applications

in neurodegenerative disorders, suitable for high field strengths (3T and 7T).

Application of functional MRI methods to understand patho-physiology of Alzheimer s disease

Multi-parametric MR imaging (fMRI, VASO, DTI, Chemical Exchange and Saturation Transfer (CEST) and T1rho) to

identify hemodynamic, genetic and cognitive biomarkers to identify early onset of Alzheimer s disease

Application of functional MRI methods to understand patho-physiology of Schizophrenia

Implementation of a combined protocol for steady state imaging and dynamic susceptibility contrast imaging

approached with a single dose of contrast agent (Magnevist) to identify abnormal blood volume and flow in

the hippocampus in Schizophrenia, Experimental evaluation of the relaxivity of Magnevist

Development of novel MR methods to quantify lymphatic flow

Development of a non-invasive MR imaging protocol, based on spin labeling methods, to study lymphatic flow

and lymph node structure to identify risk of secondary lymphedema, following surgery, especially breast tissue

removal

Development of VASO approaches to study muscle function:

Development of a fat suppressed, flow compensated VASO method to study skeletal muscle contraction and

recovery and comparison with standard NIRS approach

Georgia Institute of Technology Aug. 2005 Aug. 2009

Graduate (PhD) Thesis: Development and improvement of diffusion tensor imaging technique by employing

very long diffusion time

Texas A&M University Aug. 2003 Aug. 2005

Graduate (MS) Thesis: Study, simulation and comparison of different parallel imaging techniques for a

Swati

Rane

commercially available 8 channel receiver and a 64 channel receiver developed at Texas A&M University

Other: Study effect of heat on crystalline structure of paraffin solids

Teaching Experience

Vanderbilt University

BMED 331: NeuroImaging (Graduate) Fall 2010

Lectures on DTI, PET including imaging principles and clinical relevance

Georgia Institute of Technology

BMED 2300: Problem based learning II (Undergraduate) Fall 2006

Texas A&M University (Undergraduate)

ELEN 248: Introduction to Digital Systems Spring 2005

ELEN 325: Electronics Summer 2004

ELEN 214: Electrical Circuit Theory Spring 2004

Education

Georgia Institute of Technology Aug. 2005 Aug. 2009

Ph.D., Bioengineering, G.P.A. = 3.88/4.00

Thesis Title: Diffusion Tensor Imaging and Tractography at Very Long Diffusion Time

Texas A&M University Aug. 2003 Aug. 2005

M.S., Electrical Engineering, G.P.A. = 3.63/4.00

Emphasis: Parallel Magnetic resonance Imaging: characterization and Comparison

Pune Institute of Compute Technology, Pune University Aug. 1999 Aug. 2003

B.E., Electronics and Telecommunication, G.P.A. = 4.00/4.00 (Rank 1/72)

Skills

Philips Medical Systems, Cleveland OH 2010

SDM Training Module

PPE Training Module

Siemens MED Training Center, Cary NC 2006

IDEA Sequence Programming Course (for VB13)

IDEA Imaging Calculation Programming Course (for VB13)

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Other

MATLAB, C, C++, FSL, AFNI, SPM, DTIStudio

Professional Activities

Peer Reviewer

Magnetic resonance Imaging

International Society for Magnetic Resonance In Medicine (ISMRM), 2012

The Open Neuroimaging Journal, Special Issue: Neuroimaging in Non-Human Primates, Nov. 2011

Session Chair

Imaging Methods: MRI and DTI, Neuroscience 2007, (Society for Neuroscience, SFN)

Talks

Functional imaging of neurological disorders Feb 6, 2012, Vanderbilt Psychiatry Neuroimaging Program

Neuroimaging Seminar

Post-processing strategies for perfusion based imaging Oct 5, 2011, Reconstruction and Post-Processing

Project (RAPP), Vanderbilt University

On the measurement of cerebral blood volume May 6, 2011, Vanderbilt University Institute of Imaging

Science Seminar

Other

Organizer: 9th VUIIS Annual Retreat, Florence, AL, USA

Seminar Coordinator (2011- 2012), Vanderbilt University Institute of Imaging Science

IBM Workshop Organizer: Title - Managing Different Generations, Region D Conference, Society of Women

Engineers (SWE), 2009

Student Representative for Undergraduate Curriculum Design, All India Council for Technical Education,

2001

Coordinator, Impetus and Concepts - Engineering Project Exhibit at Pune Institute of Technology

Member, ISMRM (2005 present), SFN (2005 2006), SWE

Awards

Honorable Mention, 9th Annual VUIIS Research Retreat, 2012

Summa Sum Laude, 20th ISMRM Meeting, 2012

Magna Cum Laude, 20th ISMRM Meeting, 2012

ISMRM Student Stipend Award, 2012, 2007, 2005

Electrical Engineering Graduate Scholarship, Texas A&M University, Fall 2003, Fall 2004

JN Tata Endowment Scholarship for graduate studies in USA

The Lila Poonawala Fellowship for graduate studies in USA

Govt. Of India National Merit Scholarship

Maharashtra State Govt. Student Scholarship

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Publications

Journal Publications

Rane S., Kose S., Gore J.C., Heckers S. Altered Fucntional and Structural Connectivity in a Schizophrenia Patients

with Complete Agenesis of the Corpus Callosum, The American Journal of Psychiatry (in press)

Rane S., Ally B.A., Hussey E., Wilson T., Thornton-Wells T., Gore J.C., Donahue M.J., Inverse correspondence

between hippocampal perfusion and verbal memory performance in older adults, Hippocampus (in press)

Rane S., and Gore J.C.,Measurement of T1 of human arterial and venous blood at 7T, Magnetic

resonance Imaging, (in press)

Rane S.D., and Duong T.Q., Comparison of in vivo and ex vivo Diffusion Tensor Imaging in Rhesus Macaques at

Short and Long Diffusion times, The Open NeuroImaging Journal, Special Issues: Neuroimaging of Non-Human

Primates, vol. 5, pp~172 - 178, November 2011, PMID: 22253659

Rane S.D., Nair G. and Duong T.Q., DTI at Long Diffusion Time Improves Fiber Tracking in Fixed Rhesus Monkey

Brains, NMR Biomed., vol.23(5), pp.~459 - 467, June 2010, PMID: 20175137

Ji J. X., Son J. B. and Rane S.D., PULSAR: A MATLAB Toolbox for Parallel Magnetic Resonance Imaging Using

Array Coils and Multiple Channel Receivers, Concepts in Magnetic Resonance Part B, Magnetic Resonance

Engineering, vol. 31B(1), pp.~24-36, February 2007,

Research Monograph

Rane Swati, Parallel Magnetic Resonance Imaging: Characterization and Comparison, VDM Verlag Dr. Mueller,

Jan. 7, 2008, ISBN (10 digit): 383-***-****

Peer-reviewed Conference Publications

Meda S., Cobb J., Wilson T., Hussey E., Ally B., Rane S., Donahue M., Thornton-Wells T., Quantitative 3T T1rho

imaging as an early biomarker of Alzheimer's Disease: A preliminary voxel-wise analysis in MCI, at-risk, and

control subjects, Alzheimer's Association International Conference on Alzheimer's Disease 2012, British Columbia,

Canada.

Godar J., Rane S., Towse T., Damon B., Improved quantification of muscle blood volume during exercise with

Vascular Space Occupancy (VASO) imaging, Proceedings of Experimental Biology 2012, San Diego, USA.

Rane S., Donahue M, Gore J, Quantitative measurement of functional cerebral blood volume changes with

multi-echo fMRI at 7T, 20th Scientific Meeting and Exhibition, ISMRM 2012, Melbourne, Australia

Rane S., Porchak T., Ally B., Hussey E., Thornton-Wells T., Meda S., Gore J., Donahue M., Multi-modal MRI analysis

for assessing memory impairment in the early stages of AD, 20th Scientific Meeting and Exhibition, ISMRM 2012,

Melbourne, Australia

Rane S., Donahue P., Jordi J., Gore J., Donahue M., Noninvasive characterization of lymphatic flow velocity

using principles of spin labeling, Summa Cum Laude, 20th Scientific Meeting and Exhibition, ISMRM 2012,

Melbourne, Australia

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Rane S., Kose S., Heckers S., Avison M., Gore J., Experimental evaluation of in vivo transverse relaxivity of

Magnevist in brain tissue, Magna Cum Laude, 20th Scientific Meeting and Exhibition, ISMRM 2012, Melbourne,

Australia

Wilson T., Ally B., Hussey E., Rane S., Thornton-Wells T., Meda S., Gore J., Donahue M., Arterial spin labeling

reproducibility and potential for predicting hemodynamic alterations in older adults at risk for Alzheimer s

disease, 20th Scientific Meeting and Exhibition, ISMRM 2012, Melbourne, Australia

Donahue M., Hussey E., Porchak T., Rane S., van Osch M., Hartkamp N., Hendrikse J., Ally B., Planning-free

regional arterial spin labeling provides evidence for flow asymmetry as a risk factor for dementia, 20th Scientific

Meeting and Exhibition, ISMRM 2012, Melbourne, Australia

Meda S., Cobb J., Wilson T., Hussey E., Ally B., Rane S., Donahue M., Thornton-Wells T., Multi-slice 3T T1rho

quantitative imaging as an early biomarker of Alzheimer s Disease: Preliminary voxel-based analysis in controls,

at-risk and MCI subjects, 20th Scientific Meeting and Exhibition, ISMRM 2012, Melbourne, Australia

Porchak T., Thornton-Wells T., Ally B., Hussey E., Smith S., Cobb J., Dula A., Rane S., Welch B., Anderson A., Gore J.

and Donahue M., Novel High-field MRI Applied to the Early Detection of Alzheimer's Disease-Related Pathology,

Alzheimer's Association International Conference on Alzheimer's Disease 2011, Paris, France

Kose S., Rane S., Woolard A., Armstrong K., Avison M., Gore J.C. and Heckers S., Cerebral blood volume in

hippocampal sector CA1 is increased in schizophrenia, Frontiers in Biomedical Imaging III 2011, Nashville, TN,

USA

Rane S., Donahue M. and Gore, J.C., Detection of Changes in Cerebral Blood Volume with fMRI at 7T, Frontiers

in Biomedical Imaging III 2011, Nashville, TN, USA

Rane S.D. and Duong T.Q., Ex vivo study of Diffusion Tensor Tractography at Long Diffusion Time shows Improved

Tensor Estimation and Longer Fiber Tracts, 15th Annual Meeting, HBM 2009, San Francisco, CA, USA

Rane S.D. and Duong T.Q., Evaluation of DTI Tractography at Long and Short Diffusion Times in ex vivo and in

vivo Rhesus Macaques, 17th Scientific Meeting and Exhibition, ISMRM 2009, Honolulu, HI, USA

Rane S. D., Duong T., Diffusion Tensor Imaging at Long Diffusion Time, Neuroscience 2007, Society for

Neuroscience, San Diego, CA

Rane Swati, Duong Timothy, Diffusion Tensor Imaging non-invasively reveals tissue ultrastructure, Georgia Tech

Graduate Technical Symposium 2007, Atlanta, GA

Rane S.D. and Duong T., Long Diffusion Time Improves DTI Tractography, 15th Scientific Meeting and Exhibition,

ISMRM 2007, Berlin, Germany

Rane S.D., Ma X., Duong T., Fidelity testing of DTI tractography algorithms on a simulated fiber: Comparison of

FACT and FMT methods, Neuroscience 2006, Society for Neuroscience, Atlanta, GA

Rane S.D. Ji J.X., A MATLAB Toolbox for Parallel Imaging using Multiple Phased-Array Coils, 13th Scientific

Meeting and Exhibition, ISMRM 2005, Miami, FL

Rane Swati D., Ji Jim X., A Software Package for simulating and analyzing Parallel Magnetic Resonance

Imaging, 22nd Annual Houston Conference on Biomedical Engineering Research, HSEMB 2005, Houston, TX

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Other

Rane S. et al., Characterizing the neuro-chemical basis of BOLD fMRI, Honorable Mention, 9th Annual Retreat,

Vanderbilt University Institute of Imaging Science, Florence, AL, USA

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