Hai-Chao Han, PhD

Professor

Department of Mechanical Engineering

The University of Texas at San Antonio

San Antonio, TX78249

Phone: 210-***-****

E-mail: abphe5@r.postjobfree.com

EDUCATION

Ph.D. in Solid Mechanics /Biomechanics, Xi'an Jiaotong University, China 1991

Jointly trained at University of California at San Diego, CA, USA 1988-1991

M.S. in Solid Mechanics, Xi'an Jiaotong University, China 1987

B.S. in Applied Mechanics, Xi'an Jiaotong University, China 1984

EXPERIENCE

Professor 2011--

Department of Mechanical Engineering, University of Texas at San Antonio

Biomedical Engineering Program, UTSA-UTHSCSA

Associate Professor 2008-2011

Department of Mechanical Engineering, University of Texas at San Antonio

Biomedical Engineering Program, UTSA-UTHSCSA

Assistant Professor 2003-2008

Department of Mechanical Engineering, University of Texas at San Antonio

Biomedical Engineering Program, UTSA-UTHSCSA

Research Engineer II 1999-2002

GT/Emory Center for the Engineering of Living Tissues

School of Mechanical Engineering, Georgia Institute of Technology

Postdoctoral Fellow, Bioengineering 1997-1999

School of Mechanical Engineering, Georgia Institute of Technology

Visiting Research Scientist, Bioengineering 1996-1996

School of Mechanical Engineering, Georgia Institute of Technology

Associate Professor, Biomechanics 1993-1995

School of Civil Engineering & Mechanics, Xi'an Jiaotong University, China

Lecturer, Biomechanics 1991-1992

Department of Engineering Mechanics, Xi'an Jiaotong University, China

Research Associate, Bioengineering 1988-1991

Department of AMES/Bioengineering, University of California at San Diego, USA

HONORS

Citations: Over 400 citations (SCI, Google Scholar)

ASME J Biomechanical Engineering Top 10 most downloaded paper (Nov, 2009)

Who s Who in America (2009-).

Visiting Professorship (2009-), Shanghai JiaoTong University, China

Honorary Adjunct Professorship (2008-), Xi an JiaoTong University, China

CAREER Award (2007), National Science Foundation

Hai-Chao Han PhD

Visiting Professorship (2004), Forth Military Medicine University, China

Annual Review Poster Award (2004), Biomedical Engineering Society (co-author)

Best Paper Award (1995), Chinese J Reparative & Reconstructive Surgery

Outstanding Contribution Award (1995), Shaanxi Province, China

Young Investigator Award (1995), National Nature Science Foundation of China

Takeshi Kunio Young Investigator Award (1994), Xi'an Jiaotong University

Advance in Science and Technology Contribution Award (1994), Army, China

Young Teacher Award (1993), State Educational Commission of China

Uchida International Grant (1993), Japan Foundation of Cardiovascular Research

Tang Zhaotian Award (1991), Xi'an Jiaotong University

MEMBERSHIP IN PROFESSIONAL SOCIETIES

Fellow, American Heart Association (AHA)

Member, American Association of Mechanical Engineering (ASME)

Member, Biomedical Engineering Society (BMES)

Member, American Society of Biomechanics (ASB)

Executive Board Member, Chinese Society of Biomechanics (1995-1999)

Member, American Society of Engineering Education (ASEE)

Proposal Review panelist: NSF, AHA, NIH (ad hoc)

Editorial Board Member, Journal of Medical Biomechanics 2011-2013

Associate Editor, ASME Journal of Biomechanical Engineering 2011-2014

Reviewer for J Biomech, J Biomch Eng, Ann Biomed Eng, Biotech & Bioeng, Biomech Modeling

Mechanobiology, Atherosclerosis, J Mol Cell Cardiol, Am J Physiol, Cardiovasc Res,

Circulation, etc.

Session Co-Chair: Sino-American Workshop on Biomedical Engineering, China 2004,2007,2010

ASME Summer Bioengineering Conference 2006-, BMES 2009-

World Congress of Biomechanics 2010

RESEARCH INTERESTS

Cardiovascular Biomechanics

Cardiac mechanics, aneurysm rupture, artery buckling, artery tortuosity, left ventricular remodeling,

arterial wall remodeling, intimal hyperplasia, endothelial and smooth muscle cells, vascular grafts,

and tissue engineering

PUBLICATIONS

Peer Reviewed Journal Articles:

1. Han HC (1989). The linear increase law of optimum age of scientific creativity. Scientometrics. 15(3/4):

309-312.

2. Han HC, Fung YC (1991). Residual strain in porcine and canine trachea. J Biomech. 24(5): 307-315.

3. Han HC, Fung YC (1991). Species dependence of the zero-stress state of aorta: pig versus rat. ASME J

Biomech Eng. 113: 446-451.

4. Han HC, Fung YC (1995). Longitudinal strain in canine and porcine aortas. J Biomech. 28(5): 637-642.

5. Han HC, Fung YC (1996). Direct measurement of transverse residual strains in aorta. Am J Physiol. 270:

H750-H759.

6. Huang M, Han HC, Zhao L (1996). The residual strain in canine arteries. Chin J Biomed Eng. (English

edition). 5(1): 1-10.

7. Han HC, Zhao L, Huang M, Hou LS, Huang YT, Kuang ZB (1998). Postsurgical change of the opening

angle of canine autogenous vein graft. ASME J Biomech Eng 120(2): 211-216.

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Hai-Chao Han PhD

8. Chesler NC, Conklin BS, Han HC, Ku DN (1998). Simplified ex vivo artery culture techniques for porcine

arteries. J Vasc Invest. 4 (3): 123-127.

9. Han HC, Ku DN (2001). Contractile responses in arteries subjected to hypertensive pressure in seven-day

organ culture. Ann Biomed Eng. 29(6): 467-475.

10. Oshinski JN, Han HC, Ku DN, Pettigrew RI (2001). Quantitative prediction of improvement in cardiac

function after revascularization using magnetic resonance imaging and modeling initial results.

Radiology. 221(2): 515-522.

11. Han HC, Oshinski JN, Ku DN, Pettigrew RI (2002). A left ventricle model to predict post-

revascularization ejection fraction based on cine magnetic resonance images. ASME J Biomech Eng.

124(1): 52-55.

12. Han HC, Ku DN, Vito RP (2003). Arterial wall adaptation under elevated longitudinal stretch in organ

culture. Ann Biomed Eng. 31(4): 403-411.

13. Han HC (2004). An echocardiogram-based 16-segment model for predicting left ventricular ejection

fraction improvement. J Theor Biol 228(1): 7-15.

14. Han HC, Lerakis S (2004). The relation between viable segments and the left ventricular ejection fraction

improvement. J Med Eng Technol 28(6): 242-253.

15. Davis NP, Han HC, Wayman B, Vito RP (2005). Sustained axial loading lengthens arteries in organ

culture. Ann Biomed Eng. 33(7): 869-879.

16. Han HC, Martin RP, Lerakis G, Lerakis S, (2005). Prediction of the left ventricular ejection fraction

improvement using echocardiography and mechanical modeling. J Am Society of Echocardiography 18(7):

718-721.

17. Han HC, Marita S, Ku DN (2006). Changes of opening angle in hypertensive and hypotensive arteries in

three-day organ culture. J Biomech 39 (13): 2410-2418.

18. Challa V, Han HC (2007). Spatial variations in wall thickness, material stiffness, and initial shape affect

wall stress and shape of intracranial aneurysms. Neurol Res. 29(6): 569-577.

19. Han HC (2007). A biomechanical model of artery buckling. J Biomech. 40(16): 3672-3678. (E-

publication Aug. 8, 2007)

20. Jin Y, Han HC, and Lindsey ML (2007). Editorial: ACE Inhibitors to Block MMP-9 Activity: New

Functions for Old Inhibitors. J Molecular Cellular Cardiology. 40 (6): 664-666.

21. Lin J, Lopez E, Jin Y, Van Remmen H, Bauch T, Han HC, Lindsey ML (2008). Age-related cardiac

muscle sarcopenia: combining experimental and mathematical modeling to identify mechanisms.

Experimental Gerontology. 43(4): 296-306.

22. Han HC (2008). Nonlinear buckling of blood vessels: A theoretical study. J Biomech. 41(12): 2708-2713.

23. Lee Y, Drury-Stewart D, Vito RP, Han HC (2008). Morphologic adaptation of arterial endothelial cells

under axial stretch in organ culture. J Biomech. 41(15): 3274-77.

24. Han HC (2009). The mechanical buckling of curved arteries. Molecular & Cell Biomech. 6(2): 93-100.

25. Kim YS, Galis ZS, Rachev A, Han HC, Vito RP (2009). Matrix metalloproteinase-2 and -9 are associated

with high stresses predicted using a nonlinear heterogeneous model of arteries. ASME J Biomech Eng

131(1): 011009.

26. Yao Q, Hayman DM, Dai Q, Lindsey ML, Han HC (2009). Alterations in pulse pressure stimulate arterial

wall matrix remodeling. J Biomech Eng. 131(10) 101011.

27. Han HC (2009). The theoretical foundation for artery buckling under internal pressure. J Biomech Eng.

131(12): 124501.

28. Han HC (2009). Blood vessel buckling within surrounding tissue generates tortuosity. J Biomech. 42(16):

2797-2801.

29. Han HC (2010) Letter to the Editor: Response to comment on A biomechanical model of artery

buckling. J Biomech 43(4):802-803.

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Hai-Chao Han PhD

30. Lee YU, Luo J, Sprague EA, Han HC (2010). Comparison of artery organ culture and co-culture models

for studying endothelial cell migration and its effect on smooth muscle cell proliferation and migration.

Ann Biomed Eng 38(3):801-12.

31. Martinez R, Fierro CA. Shireman PK, Han HC (2010). Mechanical buckling of veins under internal

pressure. Ann Biomed Eng 38(4):1345-53.

32. Wang Y, Yang J, Han HC, Lindsey ML, Jin Y (2010) A conceptual cellular interaction model of left

ventricular remodeling post-MI: dynamic network with exit-entry competition strategy BMC System

Biology 4(suppl 1):S5 (1-10).

33. Lee YU, Hayman D, Sprague EA, Han HC (2010). Effects of axial stretch on intimal thickness and cell

proliferation in arteries in organ culture. Cell & Mol Bioeng. 3(3): 286-295.

34. Han HC, Liu Q, Cui F (2010). Response to Comment on "A biomechanical model of artery buckling" and

subsequent comments. J Biomech. 43(14): 2864.

35. Lee AY, Han HC (2010). A thin-walled nonlinear model for vein buckling. Cardiovasc Eng & Tech.

1(4):282-289.

36. Han HC (2011). Determination of the critical pressure of artery buckling using the potential energy

approach. Ann Biomed Eng 39(3):1032-40.

37. Jin Y, Han HC, Berger J, Dai Q, Lindsey ML (2011) Combining experimental and mathematical modeling

to reveal mechanisms of macrophage-dependent left ventricular remodeling. BMC System Biology, 5:60.

38. Datir P, Lee AY, Lamm SD, Han HC (2011). Effect of geometric variations on the buckling of arteries.

Int J Appl Mech 3(2): 385-406.

Book Chapters:

39. Ku DN, Han HC (2003), Assessment of function in tissue engineered vascular grafts. In Functional Tissue

Engineering, Springer-Verlag. New York, NY, Chapter 19, 258-267. (Book Chapter)

40. Northcutt A. Datir P, Han HC (2010). Computational simulations of buckling of oval and tapered

arteries. Tributes to Yuan-Cheng Fung on His 90th Birthday. Ed: Chien S, Chen P, Schmid-

Sch nbein GW, Tong P, and Woo SLY, World Scientific Publishing Co. (Book Chapter).

Additional Peer-Reviewed Journal Articles in Chinese

41. Chen ST, Han H (1987). The Fourier Eigen Transform. Chin J Appl Mech. 4(1): 33-37.

42. Zhao L, Huang YT, Han H, Huang M, Han LP, Zhang LF, Zhang R, Li J (1993). Mechanical and

hemodynamical changes of autogenous vein grafts. Chin J Reparative Reconstructive Surg. 7(2): 91-94.

43. Han H (1994). An analysis of stress and strain representations. J Xi'an Jiaotong Univ. 28(1): 45-50.

(English Abstract in Ei '9409).

44. Huang M, Han H, Zhao L (1994). The zero-stress state of canine aorta. Chin J Appl Biomech. 9(1): 52-55.

45. Han H (1994). A review of the residual strain in living organs. Advances in Mechanics. 24(1): 124-131.

46. Han H, Li G, Kuang ZB, Zhao L, Huang YT (1994). Tensile test of autogenous vein graft. Chin J Appl.

Mech. 11(3): 122-123.

47. Han H, Huang M, and Yang Z (1994). The zero-stress state of human extremital arteries and veins. Chin J

Biomed Eng. 13(3): 244-250. (English Abstract in EI '9505).

48. Shen Q, Zong W, Jiang D, Han H (1994). An isometric muscle contraction test device using capacitive

transducer. Chin J Biomed Instrument. 18(6): 329-332.

49. Liao DH, Han H, Li LS (1995). An in vitro fatigue test of human tibia. Chin J Appl Biomech. 10(4): 238-

244.

50. Xu H, Zhu M, Pei J, Zang Y, Han H (1997). [The establishment and evaluation of abdominal aorta

thrombosis model in rat]. Chin J Appl Physiol. 13(1): 89-90. (English Abstract in Medline).

51. Xu H, Zhu M, Pei J, Zang Y, Han H (1997). [Changes in the contraction and relaxation of abdominal aorta

after thrombosis in rats]. Chin J Appl Physiol. 13(3): 260,267.

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Hai-Chao Han PhD

52. Xu H, Zhu M, Han H, Pei J, Wang Y, Zang Y, Hu S, (1997). Effect of calcitonin gene-related peptide on

the relaxation of isolated abdominal aorta of rat following thrombosis. J FMMU 18(6): 532-535.

53. Liao DH, Han HC, Huang M, Kuang Z, Zhao L (1997) A study of stress-strain relation of autogenous

vein grafts: circumferential versus longitudinal. J Med Biomech, 12(3):134-137.

54. Liao D, Han H, Kuang Z (1998). Finite element analysis of human tibia in vitro. J Biomed Eng [Chinese].

15(1): 53-57.

55. Liao D, Kuang Z, Han H (1999). Simulation of endothelial cell behavior by 2-D steady flow on a wavy

surface. J Xi'an Jiaotong Univ. 33(2): 59-63.

56. Han HC, Xu H, Zhu M, Zang YM (1999). The zero-stress state of rat abdominal aorta following

thrombosis. Chin J Biomed Eng. 18(2): 184-186. (English Abstract in Ei)

57. Liao DH, Han HC, Zhao L, Huang M, Huang YT, Kuang ZB (2000). The stress-strain relations of

autogenous vein grafts and its histologic correlation. Chin J Biomed Eng. 19(3): 261-266.

58. Hou L, Huang Y, Han H (2000), Bridging artery defect with autogenous vein under required

anastomosing tension a theoretical analysis based on related biomechanical evidence. J Biomed Eng

[Chinese]. 17 (3): 277-280. (English Abstract in Medline)

59. Liao DH, Kuang ZB, Li J, Han HC (2001). Simulation of endothelial cell behavior under 2-D pulsatile

flow on a wavy surface. Chinese J Biomed Eng. 20(6): 545-551.

60. Liao DH, Li J, Kuang ZB, Han HC (2002). Numerical simulation of the shear stress on the surfaces of

endothelial cells under static and 24h flow conditions. Chinese J Biomed Eng. 21(1): 21-27.

61. Hou L, Huang Y, Han H (2002). Compliance variation following the change of longitudinal stretch ratio.

A study on femoral artery and vein in a rabbit model. J Biomed Eng [Chinese] 19(2):207-11.

RESEARCH FUNDS:

Current:

1. CAREER Award (CBET-0644646), Han(PI) 3/1/2007-2/28/2012

NSF

CAREER: Biomechanics of artery buckling

The main goals of this project are to establish the biomechanical models of three forms artery

buckling (bending, kinking, and twisting) and to predict the buckling load.

Role: PI

2. R01HL095852 Han (PI) 3/1/2010-12/31/2014

NIH/NHLBI

Biomechanical mechanisms of artery tortuosity

The main goal of this project is to determine the biomechanical mechanisms of artery tortuosity

by investigating the interactions between vascular hemodynamics, buckling, and wall remodeling.

Role: PI

3. Oversea Scholar Collaborative Research Project 10928206 1/1/2010-12/31/2011

NNSFC (China)

Three-Dimensional tissue remodeling of arteries

Role: PI

4. 2R01 HL075360, PI: Lindsey 7/1/2010-6/30/2015

NHLBI

The Role of Macrophage-Derived MMP-9 in LV Remodeling

The goal of this project is to model the relationship between macrophage activation and the left

ventricular remodeling.

Role: Co-Investigator

5. HHSN268201000036C (N01-HV-00244), PI: Lindsey 8/15/2010-8/14/2015

NHLBI

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Hai-Chao Han PhD

UTHSCSA Cardiovascular Proteomic Center

Role: Co-Investigator (UTSA subcontract PI)

6. SC2HL101430, SCORE Pilot Project Award, Jin (PI) 9/1/2009-8/31/2012

NIH/NHLBI

Effects of Aging on LV Geometry and MMP-9 Expression Level

The main goal of this project is to establish a mathematical model of the MMP-9 driven left

ventricular matrix remodeling in aging mice.

Role: Mentor & Collaborator

Training Grants:

7. T32 HL07446, PI: McManus 07/1990- 08/2012

NIH /NHLBI

Pathobiology of Occlusive Vascular Disease

Role: Faculty Mentor

This grant supports one postdoctoral fellow in Dr. Han s lab

8. MARC-U*STAR Program (PI: Martinez) 6/1/2006-5/31/2012

NIGMS/NIH

UTSA MARC-U*STAR Program.

Role: Faculty Mentor

9. MBRS-RISE R25GM060655 (PI: Barea-Rodriguez) 8/1/2008-7/31/2012

NIH/NIGMS

UTSA MBRS RISE Program

Role: Faculty Mentor

Completed (last 3 years as PI only)

1. UTSA Collaborative Research Seed Grant Program (CRSGP) 11/15/2008-8/31/2009

Why do arteries become tortuous?

2. Advanced Research Program 003***-****-****, Sprague & Han (Co-PI) 5/1/2006-1/31/2009

Texas Higher Education Coordinating Board

Reendothelialization in a Novel Injured Arterial Model

3. GM008194-25S10080 MBRS-SCORE Pilot Project Han(PI) 8/1/2004-7/31/2008

NIH/NIGMS

The effect of axial stretch on intimal hyperplasia in the arterial wall

4. CAREER Award-- REU supplement 5/1/2008 2/28/2009

NSF

The goal of this grant was to support 2 undergraduate students each year to participate in the

CAREER project to get hands-on research experience.

5. BME/RAPD (CBET-0602834), Han (PI) 6/1/2006-5/31/2010

NSF

The effect of pulse pressure on vascular remodeling

The main goal of this project is to elucidate the role of pulse pressure on arterial wall remodeling

6. F31HL096448 Predoctoral Fellowship, Hayman (PI) 5/1/2009-4/30/2011

NIH/NHLBI

Determining the effect of altered pulse pressure on artery structure and function

Role: Sponsor (Mentor)

7. Graduate Research Supplement, Han (PI) 9/1/2009 8/31/2010

NSF

This supplement is to support a new doctoral student, Justin Garcia to pursue his doctoral degree

in biomedical engineering.

Role: PI & Faculty Mentor

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Hai-Chao Han PhD

TEACHING EXPERIENCE

Organized Courses Taught:

ME 3813 Solid Mechanics (UG)

EGR 3323 Applied Engineering Analysis II (UG)

ME 4963 Introduction to Bioengineering (UG elective)

ME 5183 Mechanical Vibration (G)

ME 5453 Advance Strength of Material (G)

ME/BME 6893 Cardiovascular Biomechanics (G) (G Graduate, UG Undergraduate)

New Courses Developed

ME 4963 Introduction to Bioengineering, undergraduate elective

BME 6893 Cardiovascular Biomechanics, graduate course

Students supervision at UTSA

Undergraduate REU Students and Research Assistants trained:

Jesus Gomez, Kurtis Johnson, Cesar A. Fierro, Ansel Gaddy, Ricky Martinez, Emilio Gonzales

(San Antonio College), Krista Durney (Cooper Union), Monica Gireud (UT Austin), Daniel Sid,

Shawn Lamm, Moises Rodriguez, Matthew Taliaferro, Yellowwossen Moghes,

Graduate students advised:

Yong-Ung Lee, PhD. Biomedical Engineering, UTSA. Graduated in Aug. 2008

Danika Hayman, PhD. Biomedical Engineering, UTSA. Graduated in July 2011

Avione Northcutt, PhD. Biomedical Engineering, UTSA. Graduated in July 2011

Donghua Liao, MS. Solid Mechanics, XJTU. Graduated in May 1995

Vinay Challa, MS. Mechanical Engineering, UTSA. Graduated in Aug. 2005

Armando Silva, MS. Mechanical Engineering, UTSA. Graduated in June 2007

Marcello Pilia, MS. Biomedical Engineering, UTSA. Graduated in Dec 2008

Parag Datir, MS Biomedical Engineering, UTSA. Graduated in Aug. 2010

Ricky Martinez, MS Biomedical Engineering, UTSA. Graduated in July 2011

Yang Zhao, MS Biomedical Engineering, UTSA. Graduated in July 2011

Current Graduate students:

Justin Garcia, PhD student, BME

Andrew Voorhees, PhD student, BME

Justin Moreno, MS student, BME

Shawn Lamm, MS student, ME

Awards received by supervised students

Ricky Martinez, Finalist, Student Paper Competition, ASME Summer Bioeng Conf, 2008.

Shawn Lamm, Best Poster Award. SACNAS National Conference, Utah, 2008

Danika Hayman, NIH MBRS-RISE Predoctoral Scholarship (Sept. 2008)

Avione Northcutt, NIH MBRS-RISE Predoctoral Scholarship (Sept. 2008)

Danika Hayman, NIH F31 Predoctoral Fellowship (May 2009-April 2011)

Danika Hayman, Graduate Research Award, BMES Sept. 2009

Shawn Lamm, Travel Scholarship, SACNAS, Sept 2009

Danika Hayman featured in UTSA Today regarding receiving NIH F31 Fellowship

and BMES Graduate Research Award

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