Plant Molecular Biology

Nikolai Slavov

Departments of Physics and Biology E-mail abph31@r.postjobfree.com

MIT, Cambridge, MA 02139 http://alum.mit.edu/www/nslavov/

Information

Princeton University, Princeton, NJ, USA

Education

Ph.D. in Molecular Biology 03.2006-05.2010

Dissertation: Universality, speci city and regulation of S. cerevisiae growth rate response in

di erent carbon sources and nutrient limitations

Mentor: David Botstein

M.A. in Molecular Biology 09.2004-03.2006

MIT, Cambridge, MA, USA

B.S., Biology, Major GPA: 4.93/5.00 09.2001-06.2004

Postdoctoral Researcher 02.2011-present

Academic

Mentor: Alexander van Oudenaarden, MIT, Cambridge, USA

Appointments

Described conserved metabolic dynamics during the eukaryotic cell division cycle (CDC).

Demonstrated metabolic dynamics during exponential cell growth at constant rate.

Experimentally identi ed trade-o s of aerobic glycolysis.

Postdoctoral Researcher 05.2010-01.2011

Mentors: David Botstein and Amy Caudy, Princeton, NJ, USA

Discovered metabolic cycling without cell division cycling in phosphate-limited yeast cultures

University College Dublin, Dublin, Ireland 09.2006-02.2007

Research

Mentor: Kenneth Dawson

Experience

Identi ed the molecular mechanisms of nanoparticle-induced apoptosis in the astrocytoma cell line 1321N1

Lund University, Lund, Sweden 05.2006-09.2006

Mentor: Sara Linse

Media Lab, MIT, MA, USA 09.2002-09.2004

ns Developed a low-cost chlorophyll uorescence sensor for plant research and environment sensing

Method and Logic in Quantitative Biology, Princeton 09.2009-01.2010

Teaching &

Introduction to major advances in quantitative biology based on the primary literature

Residential

Residential Graduate Student at Forbes College, Princeton 09.2009-06.2010

Advising

Advised students, organized language tables, sport events and trips

02-05.{2006, 2007, 2010}

Integrated Quantitative Introduction to Natural Sciences

Participated in implementing an interdisciplinary curriculum emphasizing quantitative problem solving

09-12.{2002, 2003}

Terrascope, MIT

Selected for 2 subsequent years to lead student groups solving complex real-world problems

Slavov N., Botstein D. (2012) Decoupling Nutrient Signaling from Growth Rate Causes Aerobic

Publications

Glycolysis and Deregulation of Cell Size and Gene Expression, Molecular Biology of the Cell, 24,

doi: 10.1091/mbc.E12-09-0670

Slavov N., van Oudenaarden A.(2012) How to Regulate a Gene: To Repress or to Activate?,

Molecular Cell, vol. 46, issue 5, 551-552

Slavov N., Airoldi E.M., van Oudenaarden A., Botstein D. (2012) A Conserved Cell Growth

Cycle Can Account for the Environmental Stress Responses of Divergent Eukaryotes, Molecular

Biology of the Cell, vol. 23, no. 10 1986-1997

Slavov N., Macinskas J., Caudy A., Botstein D. (2011) Metabolic Cycling without Cell Division

Cycling in Respiring Yeast, PNAS, vol. 108, no. 47, 190**-*****

Slavov N., Botstein D. (2011) Coupling among Growth Rate Response, Metabolic Cycle and

Cell Division Cycle in Yeast, Molecular Biology of the Cell, vol. 22, no. 12, 1997-2009

Slavov N., Botstein, D. (2010) Universality, Speci city and Regulation of S. cerevisiae Growth

Rate Response in Di erent Carbon Sources and Nutrient Limitations, Dissertation

Slavov N. (2010) Inference of Sparse networks with Unobserved Variables. Application to Gene

Regulatory Networks, JMLR, W&CP, vol.9, 757-764

Silverman SJ., Slavov N., Allegra PA., Parsons L. Briehof R., Thiberge S., Zenklusen D., Gandhi

SJ., Larson D., Singer R., Botstein D. (2010) Metabolic cycling in single yeast cells from unsyn-

chronized steady-state populations limited on glucose or phosphate, PNAS, vol. 107, no. 15,

6946-6951

Slavov N., Dawson KA. (2009) Correlation Signature of the Macroscopic States of the Gene

Regulatory Network in Cancer, PNAS, vol. 106, no.11, 4079-4084 ( In This Issue article)

Tagkopoulos I., Slavov N., Kung S. (2005) Multi-Class Biclustering and Classi cation Based

on Modeling of Gene Regulatory Networks, 89-96, 5th IEEE Symposium on Bioinformatics and

Bioengineering (BIBE 05).

IRCSET Postgraduate Research Scholarship 06.2007

Honors and

Finalist in the Young European Entrepreneur Competition 10.2006

Awards

Princeton Graduate Fellowship 04.2004

Eureka Fellowship for Academic Excellence 07.2001

Bronze Medal in the 31st International Chemistry Olympiad (IChO ) 07.1999

National Diploma of Excellence and Exceptional Achievements in Chemistry 06.1999

Slavov N., Schwab D., Budnik B., Airoldi E., van Oudenaarden A. (2013) Exponentially grow-

Manuscripts in

ing cells can support a constant growth rate by very di erent metabolic strategies

Review &

Slavov N., Botstein, D., Caudy A. (2013) Extensive regulation of metabolism and growth

Preparation

during the cell division cycle

Slavov N., Parsons, L., Briehof, R., Silverman, SJ., van Oudenaarden A., Botstein D. (2013)

Systematic Counting of mRNAs and the Phase of Cell Division Cycle in Single Cells from Fluo-

rescent in situ Hybridization Images

Slavov N., Malioutov, D. Briehof, R., Silverman, SJ., Botstein D. (2013) Coordinating Cell

Division Cycle and Metabolic Activities in Respiring Single Cells

Slavov N. (2013) Inferring Trajectory of High Dimensional Nonlinear Dynamical Systems from

Time-disordered Low Dimensional Observations. Application to Intrinsic Metabolic Cycle in

Single Cells.

Slavov N., Carey, J., Linse, S. (2013) Mechanism for Transducing the Kinetic Pro les of Ca+2

Transients into Di erential Regulation of CaM Target Proteins

Corresponding author

Programming: C/C++, MatLab, Perl, FORTRAN, Python, R & Bioconductor, Mathematica,

Skills &

NI LabVIEW, HTML, L TEX A

Experience

OS and Software: Linux, Solaris, Windows, Cygwin, Mac OS X, POV-ray, TeXnicCenter,

Texmaker, Adobe suit

Scienti c: Precision-measurements of metabolic, O2 & CO2 uxes; measuring gene regula-

tion: mRNA, protein levels and posttranslational modi cations (tandem mass tag mass-spec);

microscopy, ow cells and Fluorescence in situ hybridization (FISH); statistical analysis and mod-

eling of high-dimensional genomic data; simulation and characterization of non-linear dynamical

systems, stochastic & deterministic modeling, cultivation of continuous (chemostat) cultures,

standard genetic and biochemical techniques, patch-clamping

Languages: Bulgarian (native), English ( uent), Russian (passive)

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