Good Morning,

A solid and broad background in pharmacology, informatics,

and project management has sustained my superior work at NLM, HerbMed and University

of Arizona. I am a creative, resourceful problem solver who has brought

projects from just a vision to final completion. I am a deep thinker with the

stamina to overcome challenges, and I enjoy being a team player. 'Handle paper

once' and a keen sense of prioritization and organization permit me to meet

work requirements in a timely and efficient fashion. In addition to my ample

experience, I have good oral and written presentation skills and tactful listening

and negotiating ability.

My philosophy of just-in-time knowledge is reflected in

several database projects and systems in which I have participated. Information

at the fingertips with intuitive acces and clarity and with minimal cluttering

is what I aspire to.

As a member of the

group at NLM, my overhaul of the indexing vocabulary for chemistry and pharmacology

merited bonuses and quality step increases every year I have been here. Additionally,

a couple of the projects I handled garnered mention in the NLM annual report

for 2002 and 2003. The training

presentation that I developed, about MeSH updates and how to use our system

for better PubMed searches, has been well received at national meetings of the

.

A fine earlier example of how I brought together science,

informatics and web publishing is my conceptualization and development of the

web site (http://www.herbmed.org)

during the late 1990's. Starting from scratch, I developed the database system

and implemented the output pathway and wrote the summaries themselves for over

ten thousand links into about botanical

medicines. I am a master at literature search with attention to detail and excellent

vocabulary of search terms for locating existing data in databases.

Before HerbMed, other projects that I conceptualized and

managed from vision to finished product included the 200 page book of "Dental

Self Help" and the 60 page book of "NYU Faculty Evaluation".

The former required a few years of research and then marketing and teaching.

The latter involved recruitment of hundreds of volunteers and then automated

processing of 15,000 completed surveys. The successful completion of both of

these projects demonstrate my good organization and managerial skills.

My scientific work explored molecular structure and chemical

interactions using modeling and informatics tools including: QSAR, dynamics,

sequence analysis, homology, database searching, etc. I identified an error

in a widely held model of how topoisomerase cuts DNA, provided the first model

of the human enzyme active site, and differentiated inhibitor subtypes with

mutant mapping.

I am a U.S. citizen and qualified for veteran's preference.

I look forward to discussing opportunities with you soon.

Warmest regards,

Soaring Bearlink to Courseworklink to Research & Teaching Interests

Soaring Bear

abpcgg@r.postjobfree.com

http://soaringbear.tripod.com

http://www.nlm.nih.gov/mesh/bear.html

8600 Rockville Pike 38a B2E17, Rockville Md 20894

phone: 301-***-****

Career Summary

- A decade of medical informatics and database experience

including development of the acclaimed

web site (http://www.herbmed.org) which has over ten thousand links into Medline,

and overhaul of the MeSH vocabulary of Medline for the chemistry and alternative

medicine sections.

- Effective project management, from vision to product: dental and faculty evaluation

books, herbmed website, political campaigns.

- A broad scientific & technical background - from pharmacology to proteomics

and from electronics to computer modeling. Master of literature search with

three decades investigation of herbal medicine. Pharmaceutical and proteomics

investigation for cancer drug discovery including QSAR, homology and molecular

modeling of inhibitors of the topoisomerase-DNA complex.

- Ph.D. 1998, Pharmaceutical Science; B.S. 1992, Biochemistry with honors (Magna

Cum Laude, 3.8/4, Phi Beta Kappa) while supporting myself with lab jobs.

- 5 years experience on the board of directors of community organizations, including

one in which I played a key role in recovery from a million dollar bankruptcy.

- Finance and management experience.

Education

PhD, 1998,, Univ. of

Arizona. "Modeling Topoisomerase-DNA Interactions and Design

of Trapping Inhibitors Used for Cancer."

BS, 1992, Magna Cum Laude,

3.8/4; Phi Beta Kappa; UAz.

Also: 3yrs NYU Finance; 1yr US Navy Electronics Technician school.

Experience

2000-present: National Library of Medicine (NIH), Information

Specialist keeping the controlled

vocabulary of Medline up-to-date in the areas of alternative medicines, chemistry

and biochemistry. I added new terms for thousands of plants, which brought mention

in the NLM annual report for 2002. My revamping of the data structure of pharmacological

effects to a more relational format was referred to in the 2003 NLM annual report.

This fine work has merited raises and bonuses each year I have been employed

at NLM.

1998-2000: Alternative Medicine

Foundation (Jackie Wootton), Conceptualization,

development and management of the HerbMed project from blank paper to a nationally

recognized Internet resource on the science of medicinal plants at http://HERBMED.org

Starting from scratch, I developed the database system and implemented

the output pathway and wrote the summaries themselves for over ten thousand

links into Medline.

1990-98: Dr.

William Remers, abpcgg@r.postjobfree.com

"Modeling Topoisomerase-DNA Interactions and

Design of Trapping Inhibitors Used for Cancer" using sequence &

structure analysis, dynamics, homology & QSAR: -identified error in widely

held view of how this enzyme cuts DNA; -first description of human enzyme active

site from homology model; -mutant mapping to the three dimensional structure;

-molecular modeling for medicinal chemistry drug design with structural biology

using: MSI's Insight, Homology, QSAR, Ludi; Tripos' Sybyl, CoMFA; UCSF-AMBER,

Mopac, Tsar, Daylight, Sequence Analysis, SMILES.

1998 summer: Dr Kenneth Merz, Gaussian exploration of cobalt for

study of Vitamin B12 containing enzymes.

1997 summer:Dr Yvonne C. Martin, abpcgg@r.postjobfree.com

Compared the predictability of CoMFA QSAR method with forcefield dynamics methods

for ligand binding to 5 enzymes which exposed the need for better hydrogen bonding

parameters in molecular modeling software.

1988-89: Dr.

Victor Hruby, abpcgg@r.postjobfree.com

Chiral peptide synthesis intended for the study of glucagon and blood sugar

regulation; including preparation by Wittig, reaction under Argon, recrystallizaiton.

1989-90: Dr. John Law, abpcgg@r.postjobfree.com

Created step-by-step proceedure guide for a computer interfaced HPLC-DAD. Developed

gradient for purification of peptide hormone. Carried out entomylogical assay

of adipokinetic hormone on Manduca (tobacco hornworm) for the study of lipid

metabolism.

1987-88: Dr. Charles Weber. Performed analytical chemistry of protein, minerals

and fat content in plant materials.

1987-89: Dr. Ronald R. Watson, abpcgg@r.postjobfree.com

Medline & literature review of nutritive factors on immune function

and cancer.

1978-87: Research, publication & promotion of my 200 page book "Dental

Self Help," selling thousands of copies.

1972-present: Continuing database of medicinal plants.

1973: Supervised a dozen staff as assistant manager of a six-floor-600-car parking

structure.

1970-71: Co-chair of NYU faculty evaluation group: designed survey, promoted

distribution & arranged for retrieval of 15,000 completed forms, computational

evaluation, publication of the sixty page book of results for sale to students.

1970: Internal audit of the $10 million NYU student loan program.

1968-71: NYU Finance undergraduate which set the basis of my understanding economic

and business trends.

1969: Bank teller in a busy branch of Manufacturer's Hanover Trust.

1965-68: Navy Electronics Technician (radar repair).

Leadership: Elected to community food coop board and helped lead it through

a difficult million dollar bankruptcy. Elected representative to NYU senate

1970. Tucson Free Clinic board 1981. Yuba County Health Council 1985. Selective

Service advisory board 1969.

Teaching: Advanced training in improved information search techniques.

Seminars on my research progress 1992-8. Tutoring 1993. Scores of dental classes

that reached thousands of people 1980-87.

Other: extensive travel throughout Latin America (22 months of the past

30 years). Wildflower photography. Work on several political and petition campaigns.

Publications

"A new class of antitumor agent: 2-substituted-1,2-dihydro-3H-

dibenz [de,h] isoquinoline- 1,3-diones." Remers WA, Dorr RT, Sami SM, Alberts

DS, Bear S, Mayr CA, Solyom AM. Current Topics in Med Chem 2:45-61 1997.

"Homology structure analysis of topoisomerase 2 reveals

Gln->His evolution at the active site." Bear S.

MGMS web conference & ACS meeting fall 1996.

"Computer simulation of the binding of amonafide and

azonafide to DNA." Bear S & Remers WA. J Comp Aided Molec Design

10:165-75 1997, & ACS meeting spring 1997.

"Molecular Modeling of DNA-Drug Complexes as a Tool

in the Design of Antitumor Agents." Remers, WA, Bear S, Hill GC

& Rao SN. Part 1 of Computational Medicine, Public Health and Biotechnology

pt 1, ed by M Witten World

Scientific, 1995.

"Synthetic Antibacterial Agents." Remers WA &

Bear S Chapt 51 of Burger's Medicinal Chemistry and Drug Discovery, 5th

edit, vol 1, John Wiley & Sons Inc. 1996.

"Asymmetric Synthesis of Unusual Amino Acids: An Efficient

Synthesis of Optically Pure Isomers of B-Methylphenylalanine." Dharanipragada,

VanHulle, Bannister, Bear, Kennedy & Hruby. Tetrahedron

48(23): 473*-**-****.

* "Dental Self Help."

Bear S. 1980. 200 page book of prevention and remedies.

Course papers which have broadened my perspective include: Naringenin inhibition

of P450, Calmodulin structure, Silymarin protection of the liver, Supercritical

Fluid Chromatography & Extraction, Immune Complement, and Rifampicin.

References

William A. Remers

Dept. of Pharmacology and Toxicology

University of Arizona

Tucson, Arizona 85721

abpcgg@r.postjobfree.com

Telephone: 520-***-****

FAX: 520-***-**** Arnold R. Martin

Dept. of Pharmacology and Toxicology

University of Arizona

Tucson, Arizona 85721

abpcgg@r.postjobfree.com

Telephone: 520-***-****

FAX: 520-***-****

Yvonne Connolly Martin

Abbott Labs

D47E AP10-2

Abbott Park, Ill 60064-3500

abpcgg@r.postjobfree.com

Telephone: 847-***-****

Jackie Wootton

Alternative Medicine Foundation

5411 W. Cedar Lane

Bethesda, Md 20814

abpcgg@r.postjobfree.com

Telephone: 301-***-****

I hope to hear from you soon: abpcgg@r.postjobfree.com

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