University Department

Curriculum Vitae

Kay-Pong Daniel Yip Ph.D.

Business Address

Department of Molecular Pharmacology & Physiology

College of Medicine

University of South Florida

MDC 8, 12901 Bruce B. Downs Blvd.

Tampa, FL 33612

Phone : 813-***-****

Fax : 813-***-****

E-mail : abp97k@r.postjobfree.com

Education

1980-1984 Chinese University of Hong Kong

B.S. Biology (Honors)

19841986 Chinese University of Hong Kong

M.Phil. Biology

1986-1991 University of Southern California

Ph.D. Physiology and Biophysics

1992 Complex Systems Summer School

Santa Fe Institute, New Mexico

Honors and Awards

1992 Clifford and Evelyn Cherry Fellowship Award

American Heart Association Greater Los Angeles Affiliate

19921993 American Heart Association Postdoctoral Fellowship

1994-1996 National Kidney Foundation Young Investigator Grant

Appointments

19911992 Postdoctoral Fellow

Department of Physiology & Biophysics

University of Southern California (USC)

19921993 Postdoctoral Fellow

Department of Medicine

Division of Nephrology

University of California Los Angeles (UCLA)

1993-1999 Research Assistant Professor

Department of Molecular Pharmacology, Physiology & Biotechnology

Brown University

1999-2003 Assistant Professor

Department of Physiology and Biophysics

University of South Florida

2003-present Associate Professor

Department of Molecular Pharmacology & Physiology

University of South Florida

Fields of Scientific Interest

Pressure natriuresis and hypertension

Regulation of intracellular pH, Ca2+ and exocytosis in intact renal tubules

Integrin signal transduction in smooth muscle cells of renal arterioles

Nonlinear phenomena in renal hemodynamics

Societies Membership

American Physiological Society

American Society of Nephrology

National Agency Assignments

Member, NIH NIDDK Special Study Section of Kidney Research Center Grants,

2001, 2007

Ad Hoc Member, NIH NIDDK Study Section of Cell and Molecular Biology of Kidney,

2004

Member, American Heart Association Peer Review Committee, Cardiorenal Region II

2007 - present

Editorial Assignments

Editorial Board : American Journal of Physiology - Renal Physiology 2004 - Present

Ad Hoc Reviewer:

American Journal of Physiology - Cell Physiology

American Journal of Physiology - Heart and Circulatory Physiology

American Journal of Physiology - Regul. Integr. Comp. Physiology

Biochemical and Biophysical Research Communications

Bulletin of Mathematical Biology

Canadian Journal of Physiology and Pharmacology

Circulation Research

Kidney International

University of South Florida Services

University-wide

2004, 2005 Reviewer, Internal Award Program Division of Research Grants

College of Medicine

1999-2003 College of Medicine Academic Computing Committee

2003-2005 College of Medicine Research Committee

2005 Search Committee for Biomedical Science Faculty

2006-present College of Medicine Core Facilities Committee

2006-present Secretary, College of Medicine Graduate Education Committee

Department

2001-2006 Director, Physiology Seminar Series

2002-2006 Graduate Education Committee, Department of Physiology

2006 Search Committee for Department Chair - Department of

Molecular Pharmacology & Physiology

2006-2007 Co-Director, Molecular Pharmacology and Physiology Seminar

Series

2006-2008 Faculty Search Committee, Department of Molecular

Pharmacology & Physiology

2006-present Appointment, Promotion, and Tenure Committee,

Department of Molecular Pharmacology & Physiology

2006-present Graduate Education Committee, Department of Molecular

Pharmacology & Physiology

2007-present Director, Molecular Pharmacology and Physiology Seminar

Series

Research Support

Active :

Principal Investigator

American Heart Association Grant-in-Aid, SouthEast 07/01/08-6/31/10

Integrin-mediated mechanotransduction in renal blood flow autoregulation

NIH R01 DK 60501 07/01/03-06/30/08

Regulation of aquaporin-2 trafficking in collecting duct

Pending :

Principal Investigator

NIH R01 DK 080778 Integrin-mediated mechanotransduction in renal blood flow autoregulation

Completed :

Principal Investigator

National Kidney Foundation Young Investigator Grant 07/01/94-06/31/96

Cellular mechanisms of pressure natriuresis in rat proximal tubules

NIH R01 HL 59156 08/01/98-07/31/02

Mechanisms of pressure natriuresis in proximal tubules

American Heart Association Grant-in-Aid, Florida/Puerto Rico Affiliate 07/01/01-06/31/03

Role of intracellular calcium in regulating water permeability

in kidney inner medullary collecting duct

Co-Principal Investigator

NIH R01 HL 69629 08/01/02-07/31/06

Decoupling of the principal renal autoregulatory mechanisms

Sponsor

American Heart Association Pre-doctoral Fellowship 07/01/05-06/30/07

Role of integrins in renal circulation

Courses taught

Professional :

School of Medicine, Brown University, BIO 117 Medical Physiology (1994, 1996)

BMS 6500 Medical Physiology 1999 – present

BMS 6020 Medical Neuroscience 2000 – 2002

BCC 8190 Critical Care Senior Clerkship 2005

Graduate : Department of Molecular Pharmacology & Physiology, USF

GMS 6494 Introduction of Physiology Research 1999 – presentGMS 6410 Cardiovascular Regulation 2001 – presentGMS 6433 Membrane Biology 2001 – presentGMS 7939 Physiology seminar 2001 – presentGMS 7930 Cell and Molecular Physiology 2002 – 2003GMS 6431 Cell Physiology 2002 – 2003GMS 6512 Ion Channel Disease & Pharmacology 2002 – presentGMS 6401 Kidney, Fluids and Electrolytes 2002 – presentGMS 6001 Foundation in Biomedical Sciences 2004 – presentGMS 6461 Systemic Physiology and Pharmacology 2003 – presentGMS 7931 Advanced Concepts in System Physiology 2005 – presentGMS 6410 Cardiovascular Regulation 2006 – present

Post-Doctoral Fellows

NAME INSTITUTION OF ORIGIN

Wah-Lun Chan Ph.D. Chinese University of Hong Kong 1997-1998

Guangsheng Xiang M.D. Wurzburg University, Germany 2000-2001

Abu Ahmed Ph.D. Keyushu University, Japan 2000-2002

Graduate Student

Lavanya Balasubramanian Department of Physiology & Biophysics 2002-2007

University of South Florida

Doctoral Dissertation Committees

Zhi Li Department of Molecular Pharmacology, Physiology and

Biotechnology, Brown University, 1996-2000

Christopher Thanos Department of Molecular Pharmacology, Physiology and

Biotechnology, Brown University, 1997-2001

Qingli Zhang Department of Physiology & Biophysics, USF, 1999-2003

Patrick Stocker Department of Physiology & Biophysics, USF, 1999-2005

Cristina Jaen Department of Physiology & Biophysics, USF, 1999-2006

Lavanya Balasubramanian (Major Professor)

Department of Physiology & Biophysics, USF, 2001-2007

Sarah Norring Department of Molecular Physiology & Physiology, USF,

2006 - present

Invited Addresses and Seminars

UCLA, Department of Medicine, Division of Nephrology : Bifurcation of kidney dynamics in hypertension, 1992

Brown University, Department of Physiology : Bifurcation of kidney dynamics in hypertension, 1994

University of Florida, Department of Physiology : Cellular mechanisms of proximal tubule pressure natriuresis, 1998

University of South Florida, Department of Physiology and Biophysics : Cellular mechanisms of proximal tubule pressure natriuresis, 1998

Johns Hopkins University, Department of Medicine, Division of Pulmonary Care : Application of confocal fluorescence microscopy in perfused renal arterioles and tubules, 2000

NIH Laboratory of Kidney and Electrolyte Metabolism : Application of confocal fluorescence microscopy in perfused renal arterioles and tubules, 2000

2001 Experiment Biology symposium invited speaker : Application of optical methods in the study of proximal tubule pressure natriuresis, 2001

2001 FASEB Summer Research Conference invited speaker: Novel techniques applied to kidney - Optical methods for measuring blood flow and tubular reabsorption in single nephron, 2001

University of Southern California, Department of Physiology and Biophysics : Coupling of vasopressin induced Ca2+ mobilization and apical exocytosis in rat inner medullary collecting duct, 2001

2003 Experimental Biology Satellite Symposium invited speaker: Nephron and Numbers : The Past and Future of Renal Systems Biology, 2003

2004 FASEB Summer Research Conference invited speaker: Flash photolysis of caged nitric oxide inhibits proximal tubular fluid reabsorption in free flow nephron, 2004

University of Florida, Department of Medicine Division of Nephrology : Bifurcation of renal hemodynamics and pressure natriuresis, 2005

Mathematical Biosciences Institute of Ohio State University, Workshop : The Kidney: Cellular, Tubular, and Vascular Physiology, 2007 ( by invitation only)

The 5th International Conference of Aquaporin ( Nara, Japan) invited speaker : Calcium signaling in aquaporin trafficking, 2007

Microscopy and Microanalysis 2007 invited speaker : Calcium signaling and Aquaporin-2 trafficking in kidney collecting duct, 2007

Chinese University of Hong Kong, Department of Physiology : Trafficking of aquaporin-2 in kidney inner medullary collecting duct, 2007

2008 Experiment Biology symposium invited speaker : Integrin-mediated mechanotransduction in myogenic response of afferent arterioles, 2008

Publications

Peer Reviewed papers

Tam, S.C., K.P. Yip, K.P. Fung, and S.T. Chang. Hypotensive and renal effects of the edible mushroom, Pleurotus sajorcaju. Life Sci. 38:11551161, 1986.

Yip, K.P., N.H. HolsteinRathlou, and D.J. Marsh. Chaos in blood flow control in genetic and renovascular hypertensive rats. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol.30): F400F408, 1991.

Marsh, D.J., K.P. Yip, O. Kallskog, and N.H. HolsteinRathlou. Oscillations and more complex dynamics in tubuloglomerular feedback. Kidney Int. 39: (Suppl.32) S94S97, 1991.

Buchanan, T.A., G.F. Sipos, S. Gadalah, K.P. Yip, D.J. Marsh, W. Huseh, and R.N. Bergman. Glucose tolerance and insulin action in rats with renovascular hypertension. Hypertension 18:341347, 1991.

Yip, K.P., N.H. HolsteinRathlou, and D.J. Marsh. Dynamics of TGFinitiated nephronnephron interactions in normotensive rats and SHR. Am. J. Physiol. 262 (Renal Fluid Electrolyte Physiol.31): F980F989, 1992.

Yip, K.P., N.H. HolsteinRathlou, and D.J. Marsh. Mechanisms of temporal variations of single nephron blood flow in rat. Am. J. Physiol. 264. (Renal Fluid Electrolyte Physiol.33): F427-F434, 1993.

Smedley, G.T., K.P. Yip, A.J. Wagner, S. Dubovitsky, and D.J. Marsh. A laser doppler velocimetry instrument for invivo measurements of blood flow in single renal arteriole. IEEE Trans. Biomed. Eng. 40:290-297, 1993.

Yip, K.P., D.J. Marsh, and N.-H. Holstein-Rathlou. Low dimensional chaos in renal blood flow in genetic and experimental hypertension. Physica D 80: 95-104, 1995.

Chen, Y.M., K.P. Yip, D.J. Marsh and N.-H. Holstein-Rathlou. Magnitude of TGF-initiated nephron-nephron interactions is increased in SHR. Am. J. Physiol. 269 (Renal Fluid Electrolyte Physiol. 38): F198-F204, 1995.

Yip, K.P. and I. Kurtz. NH3 permeability of principal cells and intercalated cells measured by confocal fluorescence imaging. Am. J. Physiol. 269 (Renal Fluid Electrolyte Physiol. 38): F545-F550, 1995.

Yip, K.P. and N.-H. Holstein-Rathlou. Chaos and nonlinear phenomena in renal vascular control. Cardiovas. Res. 31:359-370, 1996.

Zhang, Y, A.K. Mircheff, C.B. Hensley, C.E. Magyar, D.G. Warnock, R. Chambrey, K.P. Yip, D.J. Marsh, N.-H. Holstein-Rathlou, and A.A. McDonough. Rapid redistribution of renal sodium transporter during natriuresis induced by acute hypertension. Am. J. Physiol. 270 (Renal Fluid Electrolyte Physiol. 39): F1004-F1014, 1996.

Yip, K.P. and D.J. Marsh. [Ca2+]i in rat afferent arteriole during constriction measured with confocal fluorescence microscopy. Am. J. Physiol. 271 (Renal Fluid Electrolyte Physiol. 40): F1004-F1011,1996.

Yong, S.J., J.S. Jacob, K.P. Yip, G. Gardner, E. Seitelman, M. Whitney, S. Montgomery, and E. Mathiowitz. Controlled release of plasmid DNA. J. Control Release 47:123-134,1997.

Yip, K.P. and D.J. Marsh. An Arg-Gly-Asp peptide stimulates constriction in rat afferent arteriole. Am. J. Physiol. 273 (Renal Physiol. 42) : F768-F776, 1997.

Sun, A.M., Y. Liu, L.D. Dworkin, C.M. Tse, M. Donowitz, and K.P. Yip. Na+/H+ exchanger isoform (NHE2) is expressed in the apical membrane of the medullary thick ascending limb. J. Memb. Biol. 160: 85-90, 1997.

Quayle, A.J., E. Porter, A.A. Nussbaum, Y.M. Wang, C. Brabec,, K.P. Yip and S.C. Mok. Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Am. J. Path. 152:1247-1258, 1998.

Cutaia, M.V., N. Parks, J. Centracchio, S. Rounds, K.P. Yip, and A. Sun. The effect of hypoxia exposure on Na/H antiport activity, isoform expression, and cell membrane localization in pulmonary endothelial cells. Am. J. Physiol. 275 (Lung Cell. Mol. Physiol. 19) : L442-L451, 1998.

Yip, K.P., C.-M. Tse, A.A. McDonough, and D.J. Marsh. Redistribution of Na+/H+ exchanger isoform NHE3 in proximal tubules induced by acute and chronic hypertension. Am. J. Physiol. 275 (Renal Physiol. 44) : F565-F575, 1998.

Pushkin, A, K.P. Yip, I. Clark, N. Abuladze, T.-H. Kwon, S. Tsuruoka, G. J. Schwartz, S. Nielsen, and I. Kurtz. NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase . Am. J. Physiol. 277 (Renal Physiol. 44) : F974-F981, 1999.

Yip, K.P., A. J. Wagner, and D. J. Marsh. Detection of Na+/H+ exchanger activity inhibition in proximal tubules induced by acute hypertension. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 279 : R1412-R1419, 2000.

Chou, C.-L., K.P. Yip, L. Michea, K. Kador, J. Ferraris, J.B. Wade, and M.A. Knepper. Regulation of aquaporin-2 trafficking by vasopressin in renal collecting duct: roles of ryanodine-sensitive Ca2+ stores and calmodulin. J. Biol. Chem. 275:368**-*****, 2000.

Chon, K.H., K.P. Yip, B.M. Camino, D.J. Marsh, and N.-H. Holstein-Rathlou. Modeling nonlinear determinism in short time series from noise driven discrete and continuous systems. Int. J. Bifurcation Chaos 10 : 2745-2766, 2000.

Chan W.L, N.-H. Holstein-Rathlou, and K.P. Yip. Integrin mobilizes intracellular Ca 2+ in renal vascular smooth muscle cells. Am. J. Physiol. Cell Physiol. 280 : C593-C603, 2001.

Holstein-Rathlou, N-H., K.P. Yip, O.V. Sosnovtseva, and E. Mosekilde. Synchronization phenomena in nephron-nephron interaction. Chaos 11: 417:426, 2001.

Yip, K.P. Coupling of intracellular calcium mobilization and apical exocytosis in perfused rat inner medullary collecting duct. J. Physiol. (Lond.) 538 : 891-899, 2002.

Zou, R., C. W.A., K.P. Yip, N.-H. Holstein-Rathlou, and K.H. Chon. Time-varying properties of renal autoregulatory mechanisms. IEEE Trans. Biomed. Eng. 49: 1112-1120, 2002.

Yip, K.P., S. Tsuruoka, G.J. Schwartz, and I. Kurtz. Role of NBC3 in mediating bicarbonates transport and pHi regulation in the outer medullary collecting duct. Am. J. Physiol. Renal Physiol. 283 : F1098-F1104, 2002.

Yip, K.P. and I. Kurtz. Confocal fluorescence microscopy measurement of pH and calcium in living cells. Meth. Cell Bio. 70 : 417-427, 2002.

Zhang, W.-M., K.P. Yip, M.-J. Lin, L.A. Shimoda, W.-L. Li, and J. S. K. Sham. Endothelin-1 activates Ca2+ sparks in pulmonary arterial smooth muscle cells: local Ca2+ signaling between inositol triphosphate- and ryanodine-receptors. Am. J. Physiol. Lung Cell. Mol. Physiol. 285 ;L680-L690, 2003.

Walstead C. and K.P. Yip Acute arterial hypertension inhibits proximal tubular fluid reabsorption in normotensive rat but not in SHR. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 286 : R726-R733, 2004.

Lin, M.-J.,G. P. H. Leung, W.-M. Zhang, X.-R. Yuang, K.P. Yip, C.-M. Tse, and J.S.K. Sham. Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells-a novel mechanism of hypoxic pulmonary hypertension. Circ. Res. 95: 496-505, 2004.

Thanos, C.G., K.P. Yip, and E. Mathiowitz. Intestinal uptake of polymer microspheres in the rabbit studies with confocal microscopy. J. Bioactive Compatible polymers 19 :247-266, 2004.

Chon, K.H., R. Raghavan, Y.-M. Chen, D.J. Marsh, and K.P. Yip. Interactions of TGF-dependent and myogenic oscillations in tubular pressure. Am. J. Physiol. Renal Physiol. 288 : F298-F307, 2005.

Marsh, D.J., O. Sosnovtseva, A.N. Pavlov, K.P. Yip, and N.-H. Holstein-Rathlou. Frequency encoding in renal blood flow regulation. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 288 : R1160-R1167, 2005.

Ditlevsen, S., K.P. Yip, and N.-H. Holstein-Rathlou. Parameter estimation in a stochastic model of the tubuloglomerular feedback mechanism in a rat nephron. Math Biosci. 194 : 49-69, 2005.

Yip, K.P. Flash photolysis of caged nitric oxide inhibits proximal tubular fluid reabsorption in free flow nephron. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 289: R620-R626, 2005.

Yang, X.-R., M

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