State University Assistant

Alison Margolskee

Department of Mathematics, North Carolina State University, Raleigh, NC 27695 *******@****.***

Research Interests

Applied Mathematics (in particular, applications in the biological sciences)

Biological Interests: Physiology, Hormonal Regulation, Systems Biology

Mathematical Interests: Dynamical Systems, Monte Carlo Methods, Parameter Identi cation

and Uncertainty Quanti cation

Education

Carnegie Mellon University BSA in Mathematics and Art 2008

North Carolina State University MS in Applied Mathematics 2010

North Carolina State University PhD in Applied Mathematics May 2013 (Anticipated)

Awards

Outstanding Graduate Poster Award - the Society for Industrial and August 2012

Applied Mathematics - Life Sciences 2012 Conference, San Diego, CA

Departmental Fellowship - Department of Mathematics, North Carolina August 2008 May 2009

State University, Raleigh, NC

Science, Technology, Engineering and Mathematics (STEM) Grant August 2008 May 2009

Teaching / Research Experience

North Carolina State University, Raleigh, NC August 2009 Present

Graduate Research Assistant

Worked with mechanistic dynamic models of hormonal control of the human menstrual cycle. Performed

bifurcation analysis on sensitive parameters of an existing model. Developed a variation on previous

models to include key hormonal changes that occur with advancing age. Performed sensitivity analysis,

parameter identi cation and uncertainty quanti cation. Published manuscripts in peer reviewed journals

and presented at conferences.

Chimerix, Inc., Durham, NC May August 2012

Intern - Physiologically Based Pharmacokinetic Modeling

Developed physiologically based pharmacokinetic models to simulate absorption, distribution,

metabolism and excretion of the company s pharmaceuticals. Performed parameter identi cation of

unknown parameters. Performed Monte Carlo simulations, sampling physiological parameters from prior

distributions to predict population variability. Simulations successfully predicted clinical pharmacokinetic

results. Wrote internal reports and presented ndings at the company s research team meetings. Wrote

a draft manuscript of the work which is currently under internal review at Chimerix.

North Carolina State University, Raleigh, NC May August 2009

Graduate Research Participant - Summer Research Experience for Graduate Students

Program in Modeling & Industrial Applied Mathematics

Worked with dynamic models of hormonal control of the human menstrual cycle. Performed parameter

identi cation, optimizing model against hormone data from the literature.

North Carolina State University, Raleigh, NC August December 2008

Lecture Assistant - Calculus III

Held o ce hours and graded all student assignments, including exams.

1

Carnegie Mellon University, Pittsburgh, PA August 2006 May 2008

Supplemental Instruction Leader - Calculus II, Calculus III, and Di erential Equations

Received training in interactive learning techniques. Attended all lectures, and planned and led biweekly

Supplemental Instruction sessions for students in the assigned course.

North Carolina State University, Raleigh, NC June August 2007

Undergraduate Research Participant - Summer Research Experience for Undergradu-

ates Program in Modeling & Industrial Applied Mathematics

Developed physiologically based pharmacokinetic models for carbon tetrachloride exposure in rats. De-

veloped IV bolus, inhalation, and oral ingestion models. Performed sensitivity analysis and parameter

identi cation. Published a manuscript in a peer reviewed journal.

Carnegie Mellon University, Pittsburgh, PA May July 2006

Undergraduate Research Participant - Summer Undergraduate Mathematics Institute

Publications

A. Margolskee and T.K. Tippin, (In Preparation) PBPK modeling for oral absorption of CMX001 and

inhibition of CYP3A4-mediated clearance of Midazolam, Under internal review at Chimerix, Inc.

A. Margolskee and J.F. Selgrade, (In Review) A Lifelong Model for the Female Reproductive Cycle

with an AMH Treatment to Delay Menopause, Journal of Theoretical Biology

A. Margolskee and J.F. Selgrade, (2011) Dynamics and Bifurcation of a Model for Hormonal Control

of the Menstrual Cycle with Inhibin Delay, Mathematical Biosciences, 234:95-107.

B. Draper*, D. Marcin*, A. Margolskee*, R. Murden*, A. Attarian, M.V. Evans and K. Yokley, (2009)

Feasibility of Metabolic Parameter Estimation in Pharmacokinetic Models of Carbon Tetrachloride

Exposure in Rats, Toxicology and Environmental Chemistry, 91:521-546.

(* co- rst authors ordered alphabetically)

Presentations

A. Margolskee and T.K. Tippin, (2012) Physiologically Based Pharmacokinetic Modeling: Modeling

Intestinal Absorption of CMX001 and CYP3A4-Related Drug-Drug Interactions, Internal presentation

at Chimerix Inc., Durham, NC

A. Margolskee and J.F. Selgrade, (2012) A Model for Hormonal Regulation of the Menstrual Cycle

Applying to Women from Ages 20 to 51 Years, Poster presented at the Society for Industrial and

Applied Mathematics Life Sciences 2012 Conference (SIAM-LS 2012), San Diego, CA

A. Margolskee and J.F. Selgrade, (2011) Dynamics and Bifurcation of a Model for Hormonal Control

of the Menstrual Cycle with Inhibin Delay, Presented paper at the International Council for Industrial

and Applied Mathematics 2011, Vancouver, Canada

References

James F. Selgrade, Professor, Department of Mathematics, North Carolina State University

********@****.****.***, 919-***-****

Timothy K. Tippin, Director, DMPK, Chimerix Inc.

*******@********.***, 919-***-****

Mette S. Olufsen, Associate Professor, Department of Mathematics, North Carolina State University

********@****.***, 919-***-****

Hien T. Tran, Professor & Associate Head, Dept. of Mathematics, North Carolina State University

****@****.****.***, 919-***-****

2

Contact this candidate