Medical Health

Adrián V. Hernández, M.D., M.Sc., Ph.D.

Department of Quantitative Health Sciences /Wb4

Telephone: 216-***-****

Fax: 216-***-****

********@***.***

Positions:

Project Staff, Health Outcome Research and Clinical Epidemiology,

Department of Quantitative Health Sciences,

The Cleveland Clinic, 2007-present

Education:

M.D., San Fernando Medical School, Universidad Nacional Mayor de San Marcos, Lima, Peru, 1998.

M.Sc., Clinical Epidemiology, Netherlands Institute for Health Sciences, Erasmus University Medical Center, Rotterdam, the Netherlands, 2002.

M.Sc., Clinical Research in Cardiovascular Diseases, COEUR (Cardiovascular Research Erasmus University Rotterdam), Erasmus University Medical Center, Rotterdam, the Netherlands, 2006

Ph.D., Clinical Epidemiology, Department of Public Health, Erasmus University Medical Center, Rotterdam, the Netherlands, 2006.

Key Interests:

Dr. Hernández’s current research interests include design and analysis of clinical trials, in particular covariate adjustment and subgroup analysis, prognostic research, and systematic reviews and meta-analysis. Dr. Hernández also has special interest in clinical and outcome research of several diseases, such as acute coronary syndromes, stroke, traumatic brain injury, and AIDS-related opportunistic infections.

Selected Publications:

1. McHugh GS, Engel DC, Butcher I, Steyerberg EW, Lu J, Mushkudiani N, HernandezAV, Marmarou A, Maas AI, Murray GD. Prognostic Value of Secondary Insults in Traumatic Brain Injury: Results from The IMPACT Study. J Neurotrauma 2007; 24: 287-93.

2. Butcher I, McHugh GS, Lu J, Steyerberg EW, Hernandez AV, Mushkudiani N, Maas AI, Marmarou A, Murray GD. Prognostic Value of Cause of Injury in Traumatic Brain Injury: Results from The IMPACT Study. J Neurotrauma 2007; 24: 281-6.

3. Westerhout CM, Hernandez AV, Steyerberg EW, Bueno H, White H, Theroux P, Moliterno DJ, Armstrong PW, Califf RM, Wallentin LC, Simoons ML, Boersma E. Predictors of stroke within 30 days in patients with non-ST-segment elevation acute coronary syndromes. Eur Heart J 2006; 27: 2956-61.

4. Hernandez AV, Westerhout CM, Steyerberg EW, Ioannidis JP, Bueno H, White H, Theroux P, Moliterno DJ, Armstrong PW, Califf RM, Wallentin LC, Simoons ML, Boersma E. Effects of platelet glycoprotein IIb/IIIa receptor blockers in non-ST-segment elevation acute coronary syndromes: Benefit and harm in different age subgroups.

Heart 2006 Oct 25; [Epub ahead of print].

5. Hernandez AV, Steyerberg EW, Butcher I, Mushkudiani N, Taylor GS, Murray GD, Marmarou A, Choi SC, Lu J, Habbema JD, Maas AI. Adjustment for strong predictors of outcome in traumatic brain injury trials: 25% reduction in sample size requirements in the IMPACT study. J Neurotrauma 2006; 23: 1295-303.

6. Hernandez AV, Boersma E, Murray GD, Habbema JD, Steyerberg EW. Subgroup analyses in therapeutic cardiovascular clinical trials: are most of them misleading?

Am Heart J 2006; 151: 257-64.

7. Hernandez AV, Steyerberg EW, Taylor GS, Marmarou A, Habbema JD, Maas AI. Subgroup analysis and covariate adjustment in randomized clinical trials of traumatic brain injury: a systematic review. Neurosurgery 2005; 57: 1244-53.

8. Collins JA, Hernandez AV, Hidalgo JA, Villena J, Sumire J, Delgado V, Salazar R; Almenara Hospital AIDS Working Group. High proportion of T-cell systemic non-Hodgkin lymphoma in HIV-infected patients in Lima, Peru. J Acquir Immune DeficSyndr 2005; 40: 558-64.

9. Hernandez AV, Eijkemans MJ, Steyerberg EW. Randomized controlled trials with time-to-event outcomes: how much does prespecified covariate adjustment increase power? Ann Epidemiol 2006; 16: 41-8.

10. Vidal JE, Hernandez AV, de Oliveira AC, Dauar RF, Barbosa SP Jr, Focaccia R. Cerebral toxoplasmosis in HIV-positive patients in Brazil: clinical features and predictors of treatment response in the HAART era. AIDS Patient Care STDS 2005; 19: 626-34.

11. Colombo FA, Vidal JE, Penalva de Oliveira AC, Hernandez AV, Bonasser-Filho F, Nogueira RS, Focaccia R, Pereira-Chioccola VL. Diagnosis of cerebral toxoplasmosis in AIDS patients in Brazil: importance of molecular and immunological methods using peripheral blood samples. J Clin Microbiol 2005; 43: 5044-7.

12. Vidal JE, Hernandez AV, Oliveira AC, Souza A, Madalosso G, Silva PR, Dauar R. Cerebral tuberculomas in AIDS patients: a forgotten diagnosis? Arq Neuropsiquiatr 2004; 62: 793-6.

13. Hernandez AV, Steyerberg EW, Habbema JD. Covariate adjustment in randomized controlled trials with dichotomous outcomes increases statistical power and reduces sample size requirements. J Clin Epidemiol. 2004; 57: 454-60.

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