University Development

John Terhorst, Ph.D.

R sum

e e

Adjunct Professor of Chemistry Mobile: 562-***-****

Vanguard University of Southern California O ce: 562-***-****

** **** ***** *****: ****@************.***

Costa Mesa, California 92626 Web: www.johnterhorst.com

Academic and Research Interests

Undergraduate education and computational chemistry: curriculum development, organic and physical or-

ganic chemistry, molecular modeling, conformational dynamics and conformer focusing, Monte Carlo free-energy

perturbation, molecular mechanics and force eld development, continuum solvent models.

Education

Ph.D. Chemistry, Yale University 2008 2011

M.S. Chemistry, Yale University 2006 2008

B.S. Chemistry, University of Redlands 2002 2006

B.S. Biology, University of Redlands 2002 2006

Honors, Awards, and Fellowships

Dox Research Fellowship, Yale University 2009

Distinguished Chemistry Fellowship, Yale University 2006 2011

Graduate summa cum laude, University of Redlands 2006

Phi Beta Kappa, Xi Chapter of Southern California 2006

Robert D. Engel Award, University of Redlands 2006

Edmund C. Jaeger Award, University of Redlands 2005

Tutor of the Year, University of Redlands 2005

Summer Research Fellowship, University of Redlands 2003 2005

Research Experience

Graduate Student, Chemical Theory and Computation, Yale University 2007 2011

Undergraduate Researcher, Organic Chemistry, University of Redlands 2004 2006

Undergraduate Researcher, Theoretical Chemistry, University of Redlands 2003 2004

Refereed Journal Articles

Terhorst, J.; Jorgensen, W. L. E /Z Energetics for Molecular Modeling and Design. J. Chem. Theory Comput.

2010, 6 (9), 2762 2769. doi:10.1021/ct1004017.

Longin, T. L.; Terhorst, J.; Lang, C. Simulations of Photopumping in Doubly Illuminated Liquid Membranes

Containing Photoactive Carriers. J. Phys. Chem. B 2010, 114 (48), 158**-*****. doi:10.1021/jp106802q.

Terhorst, J.; Jorgensen, W. L. An E cient, Approximated Generalized Born Potential for GB/SA Solvation in

Monte Carlo Free-Energy Perturbations. In preparation. 2012.

Terhorst, J.; Jorgensen, W. L. Substituent E ects on Tautomerizations of 2-Hydroxypyridine and 4-Hydroxypyri-

midine. In preparation. 2012.

Terhorst, J.; Jorgensen, W. L. Development of OPLS Torsion Parameters for Derivatives of Benzene, Pyridine,

Pyrrole, Furan, and Thiophene: Motivation from E orts in Drug Design. In preparation. 2012.

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Scienti c Software

MCPRO. Jorgensen, W. L.; Tirado-Rives, J. 2010 (contributor, proprietary): Implementation of new modules for

utilizing the GB/SA continuum solvent model in simulations with Monte Carlo free-energy perturbation.

BOSS. Jorgensen, W. L.; Tirado-Rives, J. 2011 (contributor, proprietary): Development of new OPLS-AA dihedral

parameters for functionalized heterocyles, and expansion of code for inclusion of solvent-by-solvent polarization

within the OPLS-AAP polarizable force eld.

DIHOPT. Terhorst, J.; Jorgensen, W. L. 2011 (chief author, open source): A Perl utility for automated discovery

and optimization of dihedral torsion coe cients for the OPLS-AA force eld.

Theses

Terhorst, J. Continuum Solvent Models and Force Field Development for Computer-aided Drug Design. ProQuest

UMI-3496989. Ph.D. Dissertation. 2011. Yale University, New Haven, CT. 153 pages.

Terhorst, J. Theoretical Studies of Photopumping in Photofacilitated Liquid Membranes and The [3+2] Cycload-

dition of Carbonyl Oxides in the Synthesis of 1,2-Dioxolanes. Honors Thesis. 2006. University of Redlands,

Redlands, CA. 96 pages.

Teaching Experience

Organic Chemistry II, Summer, 2012 and Spring, 2013.,P

CHEM 305

Organic Chemistry I, Summer, 2012.,P

CHEM 304

Fundamentals of General, Organic, and Biochemistry II, Spring, 2013.,P

CHEM 113

General Chemistry I, Spring, 2012.,P

CHEM 120

Introductory Organic Chemistry, Spring, 2010.,F,T

CHEM 220

Organic Chemistry of Life Processes, Fall, 2009 and Spring, 2010.,T

CHEM 221

General Chemistry I, Fall, 2007.,F

CHEM 114

Organic Chemistry Lab I/II, Fall, 2006 and Spring, 2007.,F

CHEM 222/223

Organic Chemistry I/II, Fall, 2004 through Spring, 2006.,T,G,A

CHEM 231/232

General Chemistry I/II, Fall, 2003 and Spring, 2004.,T

CHEM 131/132

Key: = Vanguard University, = Yale University, = University of Redlands, P = Professor, F = Teaching Fellow,

T = Private Tutor, G = Group Tutor, A = Teaching Assistant.

Technical Skills

Laboratory Skills and Expertise: Organic synthesis (total and concise routes), separation (thin-layer and col-

umn chromatography, extraction, recrystallization, distillation), characterization (GC-MS, HPLC, CE, NMR, IR,

UV/Vis), computational chemistry (MM, QM, MC, MC/FEP, GB/SA). Chemical Simulation and Visualiza-

tion: MCPRO, BOSS, Gaussian, GaussView, GAMESS, Spartan, Chimera, WebLab, PyMol, RasMol, Chem-

Draw. Productivity: Microsoft O ce, OpenO ce, Apple iWork, vim, GNUplot. Programming: Perl, FOR-

TRAN, HTML, shell scripting, L TEX, GNUprof. Operating Systems: Mac OS X, Linux (Debian/Ubuntu, Red-

A

hat/Fedora), Windows.

Professional A liations

American Association for the Advancement of Science 2011 Present

Phi Beta Kappa ( BK) 2006 Present

American Chemical Society 2003 Present

References

References and student teaching evaluations will be made available upon request. More information and auxiliary

documents, including teaching and research portfolios, can be found online at http://www.johnterhorst.com/.

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