CURRICULUM VITA

Jean Frederic Welter

M.D., M.Sc., Ph.D.

Research Associate Professor

Skeletal Research Center

Department of Biology,

Case Western Reserve University

Millis Science Center, Room 112A

2080 Adelbert Road

Cleveland, Ohio 44106-7080

Tel.: 216-***-**** (Office), 216-***-**** (Lab),

Fax: 216-***-****

E-mail: abosx4@r.postjobfree.com

January, 2011

Educational Background:

1996 Ph.D. (Physiology & Biophysics), Case Western Reserve University, Cleveland, OH,

U.S.A.

1990 M.Sc. (Experimental Surgery), Dean's Honors List McGill University, Montreal,

Quebec, Canada

1984 Permanent ECFMG certificate, Foreign Medical Graduate Examination in the Medical

Sciences (F.M.G.E.M.S.)

1984 Doktor der gesamten Heilkunde (M.D.), School of Medicine, Leopold Franzens

Universitat, Innsbruck, Austria

Professional Experience:

2007 - Research Associate Professor, Department of Biology CaseWestern Reserve

University, Cleveland, OH

2004 - 2007Senior Research Associate, Skeletal Research Center Case Western Reserve

University, Cleveland, OH

1998 - 2004Assistant Professor, Department of Orthopadics, Case Western Reserve

University, Cleveland, OH

1996 - 1998Instructor, Department of Orthopadics, Case Western Reserve University,

Cleveland, OH

1990 - 1996Ph.D. Candidate, Department of Physiology & Biophysics, Case Western Reserve

University, Cleveland, OH

1989 - 1990Post-Doctoral Fellow, Department of Orthopadics, Case Western Reserve

University, Cleveland, OH

1988 - 1989 PGY-1 Surgery Resident, Surgery Residency Program, Case Western Reserve

University, Cleveland, OH

1985 - 1988Research Fellow, Montreal Children's Hospital Research Institute (Orthopadic

Research Laboratory), Montreal, PQ, Canada

Professional Affiliations:

2010 - Present Tissue Engineering and Regenerative Medicine International Society

2008 - Present Osteoarthritis Research Society International

2007 - Present Biomedical Engineering Society

2003 - Present International Cartilage Repair Society

2001 - Present American Society for Bone and Mineral Research

1998 - Present American Society for Biochemistry & Molecular Biology

1997 - Present Orthopadic Research Society

1989 - Present American Association for the Advancement of Science

Honors and Awards:

2006 ICRS poster award Cum Laude

2003, 2005 Arthritis Foundation travel ward

1991 - 1993 Research Fellowship, Cell Physiology Training Program. Department of

Physiology & Biophysics, Case Western Reserve University, Cleveland, OH

1990 McGill University, Dean's Honors List

1989 - 1990 Research Fellowship, NIH Training Program in Musculoskeletal Research.

Department of Orthopadics, Case Western Reserve University, Cleveland, OH

1985 - 1988 Fellow of the McGill University - Montreal Children's Hospital Research

Institute

Teaching Experience:

2011 Marine Gu, undergraduate senior project co-advisor

2011 Eduardo Arellano, summer laboratory project co-advisor

2010 - 2011 Marcin Citak, undergraduate senior project co-advisor

2009 Jason Walker, summer undergraduate student

2008 - 2009 Ashley McKee, undergraduate senior project co-advisor

2008 Michael Pelyak, ENGAGE fellowship sponsor

2006 - 2011 EBME 325, Introduction to Tissue Engineering, guest lecturer. Department of

Biomedical

Engineering, CWRU

2005 - 2006 Ross Anderson, undergraduate senior project co-advisor

2005 - 2008 Bioreactors for MSC differentiation; Cell-Based Therapies and Tissue

Engineering (CTTE) short course

2003 - 2004Mukund Deglurkar, M.B.B.S., M.S., F.R.C.S. Research Fellow, MD candidate,

University of Wales

2003 - 2004Reid Wenger, D.D.S., Research Fellow

2002 Rabia Ahmed, summer undergraduate student.

1997 - 1998Shmuel Tsurel, M.D.; Research Fellow

1991 - 1994 Introduction to Microcomputers. Department of Physiology & Biophysics, CWRU

Funded Research:

* Intra-articular delivery of injectable sustained-release microsphere drug formulations.

CSCRM/BRCP:

7/1/096/30/2012. Principal Investigator

* Tissue engineered cartilage repair. (PI: Arnold Caplan) NIH/NIAMS-NIBIB P01 AR053622

7/01/08 - 06/30/10Core director and sub-project Co-principal investigator

* Engineering cartilage: an integrated approach to biological joint repair. NIH R01

AR050802. 4/5/2005 - 3/31/2010. Principal investigator.

* Chondrogenic preconditioning of cell/scaffold constructs for the repair of large

cartilage defects. Arthritis Foundation Biomedical Research Grant. 07/01/2002 -

06/30/2005. Principal investigator.

* Clinical tissue engineering center (CTEC), BRTT, PI: George Muschler,

04/01/2005 -

03/31/2008Co-investigator.

* Tissue-engineered skin with built-in capillary flow networks. NIH R01 EB006203. PI:

Harihara Baskaran,

03/01/2006 - 02/28/2010, Co-investigator.

* Tissue engineering of cartilage subtypes. NIH R01 DE015322. PI: James Dennis,

08/01/2004 - 7/31/2008, Co-investigator.

* Strength and resorption of biodegradable skull implants. NIH R01-DE13740. PI: David

Dean, Co-investigator. Start date pending. Co-investigator.

* Effects of processing techniques for tantalum trabecular bone implant surfaces. Zimmer,

Inc. PI: Victor Goldberg,

07/01/2003 - 06/30/2005, Co-investigator.

* State-of-the-Art pH Monitoring in Bioreactors. NSF STTR Phase I. PI: John Robecheck,

07/01/03 - 06/30/04, Co-investigator.

* Tissue engineered implants for cartilage regeneration. Ohio Board of Regents/Case

Western Reserve University Presidential Research Initiative. 01/01/2001 - 12/31/2002.

Principal investigator

* Gene transcription in mechanically loaded bone cells. NIH R03 AR 45777. 10/1/1998 -

9/30/2001. Principal investigator

Pending/Planned Proposals:

* R01 AR061650-02 (PI: Caplan) Functional Cartilage Tissue Engineering with Sequential

Growth Factor Treatment. 09/01/2011 - 08/31/2016Co-Investigator

R21 EB014426-01

(PI: Welter) A unique application of ultrasound: evaluating engineered

tissue in a bioreactor

07/01/2011 - 06/30/2013

* R21 (PI: Bukulmez) C-type Natriuretic Peptide (CNP) Regulates Osteoblastic Function

07/01/2011 - 06/30/2013Co-Investigator

* 1R43-AR058078-01: Intra-articular delivery of controlled release betamethasone. SBIR

phase I, 12/01/2009-5/31/2010. Co-Principal Investigator.

* Acoustic properties of tissue engineered cartilage. PRI

Ongoing Collaborations:

At Case Western Reserve University:

Harihara Baskaran: Mass transport studies in tissue-engineered cartilage and skin.

Metabolic engineering of anaerobic bacteria.

Charles Malemud: Apoptosis in OA.

Victor Goldberg: Porous ingrowth bone implants, bone grafts and bone graft substitutes.

David Dean: Tissue engineering of cranial implants.

Tariq Haqqi: Oxidative stress and MSC performance.

C.C. Liu: Glucose consumption by differentiating mesenchymal stem cells

Off Campus:

Lisa Freed (Massachusetts Institute of Technology): Cartilage tissue engineering.

John Robecheck, (Sensirox, Inc), Jay Johnson (UDRI): Development of micro-pH sensors.

R. Tracy Ballock, (Cleveland Clinic Foundation): Investigation of Heuter-Volkmann effect

in vitro using a hydrostatic bioreactor.

Dwayne Bisgrove, Ph.D., System Biosciences (SBI): Lentiviral reporter/selection vectors

to report cell differentiation.

Service to Professional Community:

2010, 2011 Reviewer, NCRM pilot grant proposals

2009 Moderator, Progenitors and Stem Cells session, Orthopaedic Research Society meeting,

Las Vegas, NV

2009 Member, NIH Challenge Grant Review Panel #10, ZRG1 BDA-A (58) R

2008, 2011 Member, Arthritis Research Campaign (U.K.) study section

2008 Member, Special Emphasis Panel/Scientific Review Group 2009/01 MTE

2008 Ad hoc member, NIH Special Emphasis Panel/Scientific Review Group ZAR1 EHB-H (M1) 1

2006, 2007 Ad hoc member, NIH Special Emphasis Panel/Scientific Review Group ZAR1 EHB-J

(M1) (1)

2005 Ad hoc member, NIH Special Emphasis Panel/Scientific Review Group ZAR1 EHB-G (O1)

(1)

2005 Judge, MTEC-2005 presentation awards

2004, 2006-2010 Ad hoc reviewer for the National Medical Research Council (Singapore)

study section

2004, 2006, 2007 Judge, graduate student poster competition at Research ShowCASE

2003 Organizing committee for the 5th Bone Fluid Flow Workshop, Cleveland, OH. September

17 - 18

2002 - 2003 Ad hoc member, NIH biomedical engineering study section ZRG1 SSS-M 58

2001 - 2004 Member, Department of Orthopadics Research Committee

* Ad hoc reviewer for Acta Biomaterialia

* Ad hoc reviewer for Arthritis Research and Therapy

* Ad hoc reviewer for Biomaterials

* Ad hoc reviewer for BioTechniques

* Ad hoc reviewer for Bone

* Ad hoc reviewer for British Journal of Cancer

* Ad hoc reviewer for Cells, Tissues, Organs

* Ad hoc reviewer for Current Eye Research

* Ad hoc reviewer for Genomics

* Ad hoc reviewer for the Journal of Biological Chemistry

* Ad hoc reviewer for the Journal of Biomedical Materials Research

* Ad hoc reviewer for the Journal of Investigative Dermatology

* Ad hoc reviewer for the Journal of Orthopadic Research

* Ad hoc reviewer for the Orthopadic Research Society

* Ad hoc reviewer for Tissue Engineering

* Ad hoc reviewer for Yonsei Medical Journal

Patents:

Apparatus and method for tissue engineering. Provisional patent application filed

November 4, 2003; definitive application filed November 4, 2004.

Publications:

Invited Presentations:

Canine and Human Mesenchymal Stem Cells, Growth Factors, Bioreactors, and Animal Model

Studies. External Advisory Board and Co-Investigators meeting of NIH Grant R01-DE013740,

Strength and Resorption of Biodegradable Skull Implants. July 21, 2011

Intra-articular delivery of injectable sustained-release drug formulations. NCRM Retreat,

November 14, 2011

X marks the spot. Spatial and temporal distribution of Type X collagen in engineered

cartilage. MSCs Skeletal Research Center seminar series, Case Western Reserve University,

Cleveland, OH, November 15, 2010

Canine Mesenchymal Stem Cells, Growth Factors, Bioreactors, and Toxicity. External

Advisory Board and Co-Investigators meeting of NIH Grant R01-DE013740, Strength and

Resorption of Biodegradable Skull Implants. June 2, 2010

Crowding MSCs Skeletal Research Center seminar series, Case Western Reserve University,

Cleveland, OH, February 1, 2010

.

Cartilage tissue engineering. EBME 325 guest lecture,

Case Western Reserve University,

Cleveland, OH, November 30, 2009

Optimizing MSC differentiation; CTTE-2009 Cell-Based Therapies and Tissue Engineering

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