Project University
Resume:
G. A. Weiss
Gregory Alan Weiss
Curriculum Vitae
Professor of Chemistry, Molecular Biology and Biochemistry
Vice Chair, Chemistry
Department of Chemistry Fax: 949-***-****
**** ******* ******es 2 Tel: 949-***-****
University of California at Irvine Email: ******@***.***
Irvine, California, 92697-2025 Web: chem.ps.uci.edu/~gweiss/
Personal
Born July, 1970 in New York City, NY.
Married to Kim M. Weiss.
Education
Postdoctoral Fellow, Protein Engineering, Genentech, Inc., 1997-2000.
Ph.D. and A.M., Chemical Biology,
Harvard University, 1992-1997
.
B.S.,
Chemistry, U.C. Berkeley, 1988-1992
.
Research Experience
2009
- Professor of Chemistry, Molecular Biology and Biochemistry,
University of California, Irvine (with tenure)
2006
-2009Associate Professor of Chemistry, Molecular Biology and Biochemistry,
University of California,
Irvine (with tenure)
2000
-2006Assistant Professor of Chemistry, Molecular Biology and Biochemistry
University of California,
Irvine
1997
-2000Postdoctoral Fellow with Dr. James A. Wells, Genentech, Inc
.
1992
-1997 Graduate Student with Professor Stuart L. Schreiber, Harvard University
1990
-1992Undergraduate Researcher with Professor Paul A. Bartlett, U.C. Berkeley
1989
-1990Research Assistant, Lawrence Livermore National Laboratory
Awards and Other Professional Activities
2012- Member, NIH NANO study section
2010- Vice Chair, Graduate Affairs, UC Irvine Department of Chemistry
2010- Co-Chair, Global Young Academy (elected twice by scientists in >50 countries)
2010- Associate Editor, Current Protocols in Chemical Biology
2009- Co-Director, Chemical and Structural Biology Program of the Chao Family
Comprehensive Cancer Center
2009- Member, Scientific Advisory Board, Molecular Express, Inc.
2008- Chair, Scientific Advisory Bo ard, Phylogica Ltd.
2012 Member, NCI Macromolecular Crystallography site visit and review team
2009, 2010 US Representative, Annual Meeting of New Champions, World Economic Forum,
Dalian & Tianjin, China (selected by the US National Academy of Sciences)
2008-2009 Co-Chair, Organizing Committee, National Academy of Sciences Indo -US Kavli
Frontiers in Science Symposium
2008-2009 Member, NSF Proposal Review Panels
2007-2008 Class of 2007 Outstanding Professor from the U.C. Irvine School of Physical
Sciences (selected by the graduating seniors)
2006-2009 UC Biotechnology Research Education Program, Executive Committee member
2001-2012 Ad Hoc Member, NIH study sections (>16 times including ALY, F04A, F04B, F32,
1
G. A. Weiss
NANO, and SBCA study sections)
2004 U.C. Irvine, School of Physical Sciences, Innovation Award
2004 U.C. Irvine, School of Physical Sciences, Award for Contributions to
Undergraduate Education
2002-2005 Arnold & Mabel Beckman Foundation Young Investigator
2001-2008 Faculty of 1000, Founding Member, Chem ical Biology of the Cell Section
1997 Ruth Kirschstein National Research Service Award (post -doctoral fellowship,
funding returned to NIH)
1993-1996 NIH Biochemistry Training Grant
1992 High Honors at undergraduate graduation
1992 Phi Beta Kappa
1992 American Institute of Chemists Award
1990-1992 Department of Chemistry Scholarship, U.C. Berkeley
1988-1992 Chancellor s Scholarship, U
.C. Berkeley
Memberships
2002- Institute for Genomics and Bioinformatics, U.C. Irvine
2001- Faculty of 1000, Chemical Biology of the Cell Section
2000- Chao Family Comprehensive Cancer Center, U.C., Irvine
2000- Center for Viral Research, University of California, Irvine
1993- American Chemical Society
1989- American Association for the Advancement of Science
Science.
335: 319-324. Reviews include: H.P. Lu (2012). Science 335: 300-301. M. Papatriantafyllou
(2012). Nat. Rev. Mol. Cell Biol. 13: 138. I. Kaganman (2012). Nat. Methods 9: 226. B.
Halford
(2012). Chem. Eng. News 90: 28.
2
5
G. A. Weiss
9. Weiss, G.A., Lowman, H.B. (2000). Anticalins versus antibodies: made-to-order binding
proteins for small molecules. Chem. Biol. 7: R177-R184. Review. Not peer-reviewed.
8. Weiss, G.A., Watanabe, C.K., Goddard, A., Zhang, A., Sidhu, S.S. (2000). Rapid mapping
of
functional protein epitopes by combinatorial alanine-scanning. Proc. Natl. Acad. Sci.
USA. 97:
8950-8954.
7. Weiss, G.A., Sidhu, S.S. (2000). Design and evolution of artificial M13 coat proteins.
J. Mol.
Biol. 300: 213-219.
6. Weiss, G.A., Sidhu, S.S., Wells, J.A. (2000). Mutational analysis of the major coat
protein of
M13 identifies residues that control protein display. Protein Sci. 9: 647-654.
5. Sidhu, S.S., Weiss, G.A., Wells, J.A. (2000). High copy display of large proteins on
M13
phage for functional selections. J. Mol. Biol. 296: 487-495.
Graduate and Undergraduate Publications
4. Evensen, E., Joseph-McCarthy, D., Weiss, G.A., Schreiber, S.L. (2007). Ligand design
by a
combinatorial approach based on modeling an d experiment: application to HLA-DR4. J.
Comput. Aided Mol. Des. 21: 395-418.
3. Weiss, G.A., Valentekovich, R.J., Collins, E.J., Garboczi, D.N., Schreiber, S.L.,
Wiley, D.C.
(1996). Covalent HLA-B27/peptide complex induced by specific recognition of an aziridine
mimic of arginine. Proc. Natl. Acad. Sci. USA 93: 109**-*****.
2. Weiss, G.A., Collins, E.J., Garboczi, D.N., Wiley, D.C., Schreiber, S.L. (1995). A
tricyclic ring
system replaces the variable regions of peptides presented by three alleles of h uman MHC
U.S. provisional filed.
Sidhu, S.S. & Weiss, G.A. (2001). A combinatorial method for mapping functional protein
domains by scanning phage display libraries with libraries of p eptide variants.
Application: WO
0144463 A1 20010621.
Sidhu, S.S. & Weiss, G.A. (2001). Improved transformation efficiency in phage display
through
modification of a coat protein. Application: PCT/US99/16596.
Sidhu, S.S., Weiss, G.A. & Wells, J.A. (2000). Improving the efficiency of phage display
libraries by use of amino acid-substituted modification of the phage coat protein and
electroporation with low-conductance DNA solutions. Application: WO 99 -US16596 19990722.
Wiley, D.C., Schreiber, S.L., Valentekovich, R.J., Weiss, G.A. & Shambayati, S. (1996).
Preparation of reactive peptide ligands and covalent peptide -ligand complexes.
Application:
WO 97-US17483 970930.
Bartlett, P.A., Lauri, G. & Weiss, G.A. (1992). Tricyclics for automated design (TRIAD).
Software copyright, held by Regents of the University of California
6
G. A. Weiss
Funding
ACTIVE
Principal Investigator Dates of Proposed Project Role
G.A. Weiss 08/01/12 to 07/31/16 PI
Source: NIH, NIGMS (1 R01 GM100700-01A1) Total Direct Costs: $760,000
Title of Project (or Subproject)
Membrane Protein Co- Crystallization with Highly Crystalline and Soluble Proteins
In this research project, new types of protein libraries will be sifted to identify high
affinity binders or
unnatural ligands to membrane proteins.
ACTIVE
Principal Investigator Dates of Proposed Project Role
G.A. Weiss 8/1/06 to 7/31/12 PI
Source: NIH, NIGMS (1 R01 GM078528-01) Total Direct Costs: $891,000
Title of Project (or Subproject)
Engineering Soluble Aggregation -Prone and Membrane-Bound Proteins
This proposal describes new approaches to expedite the structural genomics of challenging
proteins.
ACTIVE
Principal Investigator Dates of Proposed Project Role
G.A. Weiss 9/1/08 to 8/1/13 PI
Source: NIH, NCI (1 R01 CA133592-01) Total Direct Costs: $871,500
Title of Project (or Subproject)
Single Molecule Enzymology with Carbon Nanocircuits
This project leverages advances in single molecule nanocircuits to investigate the
kinetics and
mechanisms of individual m olecules, comparing wild-type and mutants.
ACTIVE
Co-Investigator Dates of Proposed Project Role
G.A. Weiss (PI: W.E. Robinson, Jr.
) 01/01/10 to 07/01/14Co-I
Source: UC Multi-Campus Research Program Total Direct Costs: Weiss: $282,357
Title of Project (or Subproject)
California Center for Antiviral Drug Discovery
In the Weiss laboratory, this award funds discovery of new anti-HIV compounds targeting
HIV Vif.
ACTIVE
Co-Investigator Dates of Proposed Project Role
G.A. Weiss (PI: G. Fuji)
07/01/11 to 03/31/12Co-I
Source:NIH, NCI SBIR (50779) Total Direct Costs: $47,323 (ADC)
Title of Project (or Subproject)
Viratrodes: Biosensors for the Detection of Circulating Tumor Cells and Cancer Biomarkers
In this project, biosensors for detecting and quantifying circulating tumor cells in
prostate and other
cancers will be developed.
ACTIVE
Co-Principal Investigator
Dates of Proposed Project Role
G.A. Weiss
(PI: F. Freeman) 03/1/08 to 02/28/14Co-PI
Source: NSF (CHE-0755547) Total Direct Costs: $460,000
Title of Project (or Subproject)
REU Site: Chemistry Summer Undergraduate Research Fellowships (Chem-SURF)
This award supports a Research Experience for Undergraduates site designed to bring
undergraduates from non-research universities to experience cutting edge chemical
research to UC
Irvine. The funding exclusively supports undergraduate education.
ACTIVE
7
G. A. Weiss
Co-Investigator Dates of Proposed Project Role
G.A. Weiss (PI: R. Martin) 08/01/11 to 07/31/16 Co-I
Source:NIH, NEI (1R01EY021514-01A1) Total Direct Costs: $250,000 (ADC)
Title of Project (or Subproject)
Solid-state NMR methods for investigating native and aggregated eye lens proteins
This grant funds studies aimed at understanding the basis for protein aggregati on in
genetic cataract
disease.
Principal Investigator
Dates of Proposed Project Role
G.A. Weiss
04/01/11 to 03/31/12PI
Source: American Association for the Advancement Total Direct Costs: Weiss: $23,000
of Science (111912)
Title of Project (or Subproject)
Training in Nanobiotechnology for Detection of Environmental Viruses
This project initiates a long-term collaboration between investigators from Morocco and
the US to
develop new methods for identifying and diagnosing pathogenic vi ruses found in
environmental
samples.
Principal Investigator
Dates of Proposed Project Role
G.A. Weiss
8/1/08 to 7/31/10PI
Source:
NIH
(1 S10 RR025588-01) Total Direct Costs: $500,000
Title of Project (or Subproject)
Purchase of a MALDI TOF/TOF
This proposal will fund purchase of a multi -user MS instrument in the Department of
Chemistry at UCI.
Principal Investigator
Dates of Proposed Project Role
G.A. Weiss
9/1/06 to 2/28/09PI
Source: California HIV/AIDS Research Program Total Direct Costs: $100,000
(IDEA award, ID06-I-181)
Title of Project (or Subproject)
Dissection of HIV Nef by Combinatorial Mutagenesis
This project proposes to expand the anti -HIV arsenal through the development of
inhibitors targeting
HIV Nef.
Co-Investigator Dates of Proposed Project Role
G.A. Weiss
(PI: Fuji) 08/1/08 to 07/31/09Co-I
Source: NIH (1 R43 AI074163) Total Direct Costs: $100,000
Title of Project (or Subproject)
Development of Virus Electrodes for Fungal Pathogen Detection
This proposal describes new sensors for Aspergillus infection based upon covalent virus
surfaces with
phage-displayed binders to infection markers .
Co-Investigator Dates of Proposed Project Role
G.A. Weiss (PI: G. Fuji
)
12/1/06 to 08/30/08Co-I
Source: NIH (1R43CA11955-01) Total Direct Costs: Weiss: $105,021
Title of Project (or Subproject)
Selection and Characterization of PS MA Ligands from Phage-Displayed Libraries
This proposal applies phage-displayed combinatorial libraries to target a prostate cancer
specific marker with anti-cancer therapies and diagnostic imaging agents.
8
G. A. Weiss
Co-Investigator Dates of Project Role
G.A. Weiss (PI: P. Collins
)
05/01/04 to 08/31/08Co-I
Source: NSF (EF-0404057) Total Direct Costs: Weiss: $300,000
Title of Project (or Subproject)
Direct Electronic Sensing of Biomolecular Activity and Signaling
This proposal describes electronic architectures for molecular sensing based on carbon
nanotube nanoelectronic devices.
Co-Investigator Dates of Project Role
G.A. Weiss (PI: P. Felgner) 6/15/04 to 12/14/06 Co-I
Source: NIH (1R43AI058365-01) Total Direct Costs: Weiss: $215,000
Title of Project (or Subproject)
Vaccinia Proteome Reagents from Phage Display
This proposal describes plans to identify receptors with high affinity and specificity
for every
protein in the vaccinia proteome.
Principal Investigator Dates of Project Role
G.A. Weiss
12/1/05 to 11/30/06PI
Source: Pacific Southwest Regional Center of Total Direct Costs: $25,000
Excellence for Biodefense (NIAID, NIH)
Title of Project (or Subproject)
Molecular Evolution of Viruses for Bio defense Sensors
This pilot project aims to develop ultra -sensitive devices for the detection of
biodefense agents
including botulinum toxin.
Principal Investigator Dates of Project Role
G.A. Weiss
6/1/04 to 5/30/06PI
Source: ACS Petroleum Research Fund Type G Total Direct Costs: $35,000
Title of Project (or Subproject)
Library Approaches to Exploring Terpene Cyclase Enzyme Mechanisms
The overarching aim of this proposal is to decipher how terpene cyclase enzymes
accomplish
complex organic synthesis.
Principal Investigator Dates of Project Role
G.A. Weiss
9/1/02 to 8/31/05PI
Source: Arnold and Mabel Beckman Foundation Total Direct Costs: $240,000
Young Investigator Award (BF-30212)
Title of Project (or Subproject)
Molecular Recognition by Libraries of HIV Nef and Streptavidin
This proposal funds research to dissect molecular recognition between canonically strong
and weak receptor-ligand interactions, streptavidin-biotin and Nef-CD4, respectively.
Principal Investigator Dates of Project Role
G.A. Weiss
8/3/04 to 8/2/05PI
Source: UCI School of Physical Sciences Total Direct Costs: $20,000
Innovation Fund
Title of Project (or Subproject)
Targeting Ovarian and Prostate Cancer Markers with Phage -Displayed Libraries
This proposal funds identification of ligands to cancer -specific markers.
9
G. A
. Weiss
PREVIOUS
Principal Investigator Dates of Project Role
G.A. Weiss
05/01/03 to 05/02/04PI
Source: Camille & Henry Dreyfus Foundation Total Direct Costs: $27,500
Special grant program in the Chemical Sciences
Title of Project (or Subproject)
Equipment for Undergraduate Chemical Biology Laboratory
This proposal funds acquisition of equipment for an upper division, undergraduate
laboratory for students to learn cutting edge experimental techniques in chemical
biology.
Principal Investigator Dates of Project Role
G.A. Weiss
07/01/00 to 06/30/04PI
Source: UCI School of Physical Sciences Total Direct Costs: $550,000
Title of Project (or Subproject)
Start-up Funding
Start-up funds have been used to construct phage display libraries, hire students and
post-docs and purchase equipment.
Principal Investigator Dates of Project Role
G.A. Weiss
07/01/01 to 06/30/02PI
Source: U.C. Cancer Research Coordinating Total Direct Costs: $50,000
Committee
Title of Project (or Subproject)
Ovarian Cancer Binding by Phage -Displayed Peptides
This project investigated using phage -displayed peptides to recognize and potentially
diagnose ovarian cancer.
Invited Seminars
142. Arizona State University
Tempe, AZ, November 30, 2012
141.
University of Twente Twente, Netherlands, November 2, 2012
140. Scripps Research Institute
La Jolla, CA, October 18, 2012
139. California State University, Long Beach Long Beach, CA, October 4, 2012
138. University of Sydney
Sydney, Australia, September 2, 2012
137. University of Queensland
Brisbane, Australia, August 31, 2012
136. University of Melbourne
Melbourne, Australia, August 29, 2012
135. University of Western Australia
Perth, Australia, August 24, 2012
134. Phylogica Perth, Australia, August 23, 2012
133. University of Pretoria
Pretoria, South Africa, May 24, 2012
132. Global Young Academy General Assembly meeting Johannesburg, South Africa, May
21, 2012
131. UC Irvine Cancer Research Symposium Irvine, CA, May 5, 2012
130. Phage Display at the Protein Engineering Summit (keynote) Boston, MA, May 1, 2012
129. Mainz University Mainz, Germany, April 3, 2012
128. Leibniz-Institut fUr Molekular Pharmakologie im Forshungsverbund Berlin, Germany,
March 29, 2012
127. Lepoldina Nationale Akademie der Wissenschaften Halle, Germany, March 26, 2012
126. California Lutheran University Thousand Oaks, CA, March 19, 2012
125. Structure and Engineering of Difficult Proteins San Francisco, CA, February 19-20,
2012
124. AAAS Annual Meeting Vancouver, Canada, February 18, 2012
123. California State University,
Los Angeles Los Angeles, CA, December 2, 2011
122. Chao Family Comprehensive Cancer Center Palm Springs, CA, November 12, 2011
10
G. A
. Weiss
121. University of California,
Riverside Riverside, CA, November 7, 2011
120. San Diego State University
San Diego, CA, October 31, 2011
119. IAP: Global Network of Science Academies
Mexico City, Mexico, October 18, 2011
118. Los Alamos National Laboratory Los Alamos, New Mexico, August 18, 2011
117. Scripps Research Institute
La Jolla, CA, April 18, 2011
116. Bowdoin College
Brunswick, Maine, April 8, 2011
115. GlaxoSmithKline Waltham, MA, April 6, 2011
114. Western Washington University
Bellingham, Washington, January 14, 2011
113. University of Texas,
Southwestern Medical Center Dallas, Texas, November 16, 2010
112. Orange Coast College
Costa Mesa, CA, October 27, 2010
111. California State University,
San Bernardino San Bernardino, CA, October 21, 2010
110.
Whittier College
Whittier, CA, October 8, 2010
109. California State University, Fullerton Fullerton, CA, September 2, 2010
108. U.C. Irvine, Minority Scientists Program
Irvine, CA, August 20, 2010
107. U.C. Irvine,
CEO Roundtable Executive Retreat
Sausalito, CA, May 1, 2010
106. Entrepreneur s Forum
Irvine, CA, April 23, 2010
105.
Cypress College
Cypress, CA, April 22, 2010
104. V Nicaraguan Biotech Conference (vi a Skype) Managua, Nicaragua, April 22, 2010
103. Iowa State University
Ames, Iowa, April 8, 2010
102. Dow Corning
Midland, MI, March 23, 2010
101. InterAcademy Panel General Assembly
London, UK, January 15, 2010
100.
Wake Forest University Comprehensive Cancer Center
Winston-Salem, North Carolina,
December 3, 2009
99
.
University of Arizona Tucson, AZ, October 30, 200998
. Leibniz-Institut fUr Molekular Pharmakologie im Forshungsverbund Berlin, Germany,
October 12, 2009.
97. Cambridge Healthtech Institute Phage Display Conference Hannover, Germany, October
6, 2009
96
. New York University New York City, NY,
September 25, 200995
. Albert Einstein College of Medicine New York City, NY,
May 19, 200994
. Physical Optics Corporation Torrance, CA,
May 8, 200993
. U.C. Irvine Strategic Partners for the Evaluation of Cancer Signatures Symposium
Laguna
Beach, CA, January 16, 200992
. U.C. Irvine LifeChips International Symposium
Irvine, CA, January 9-10, 2009
91. The Telethon Institute for Children s Research
Perth, Australia, November 26, 200890
. Phylogica
Perth, Australia, November 24, 200889
. Genentech South San Francisco, CA, September 23, 200888
. CODA Genomics
Laguna Hills, CA, August 7, 200887
. IBC Beyond Antibodies Conference
La Jolla, CA, July 28, 200886
. Dow-Corning
Midland, MI, July 17, 200885
. Lawrence Berkeley National Laboratory
Berkeley, CA, July 15, 200884
. U.C. Irvine LifeChips Workshop on Cancer, Stem Cells, and Micro/nanotechnology
Irvine,
CA, May 30, 200883
. U.C. Irvine Campuswide Symposium on Basic Cancer Research
Irvine, CA, May 3, 200882
. Cambridge Healthtech Institute Phage Display Conference
Cambridge, MA, April 28,
2008
81
. U.C. Irvine, Department of Pathology
Irvine, CA, March 21, 200880
. Lund University
Lund,
Sweden, March 16, 200879
. Saddleback College
Mission Viejo, CA, March 7, 2008: Distinguished Guest Lecture
78. Materials Research Society Symposium MM: Biomolecular and Biologically Inspired
Interfaces and Assemblies
Boston, MA, November 26-30, 2007
77. U.C. San Diego
La Jolla, CA, November 5, 200776
. Georgia State University
Atlanta, GA, September 21, 200775
. Lawrence Livermore National Laboratory
Livermore, CA, March 5, 200711
G. A. Weiss
74. California State University, Fullerton Fullerton, CA, February 28, 200773
. NANOWorld,
Loyola Marymount University Los Angeles, CA, January 24, 200772
. AvidBiotics
San Francisco, CA, December 19, 200671
. UCLA
Los Angeles, CA, December 6, 200670
. University of California,
Riverside
Riverside, CA, November 8, 200669
. NSF Workshop in Physical Organic Chemistry
San Gabriel, CA, October 27-31, 2006
68. UniversitE de MontrEal
MontrEal, Canada, October 13, 200667
. San Diego State University
San Diego, CA, October 6, 200666
. University of Maryland
Rockville, Maryland, June 5, 200665
. Cambridge Healthtech Institute Phage Display Conference
Cambridge, MA, April 24-26,
2006
64
. Harvey Mudd College Claremont, CA, March 22, 200663
. Palm Springs Symposium on HIV/AIDS
Palm Springs, CA, March 2-4, 2006
62.
The Scripps Research Institute
La Jolla, CA, December 12, 200561
.
University of Minnesota Minneapolis, Minnesota, December 8, 200560
.
Harvard University Cambridge, MA, November 7, 200559
.
University of Massachusetts Medi cal Center Worcester, MA, November 4, 200558
. U.C. Irvine, Department of Chemistry
Irvine, CA, October 26, 200557
. Santa Clara University
Santa Clara, CA, October 7, 200556
. Michigan State University
East Lansing, MI, September 7, 200555
. Purdue University
Lafayette, IN, September 6, 200554
. Arnold & Mabel Beckman Foundation Young Investigator Symposium
Irvine, CA, August
27, 2005
53
. U.S. Food and Drug Administration
Irvine, CA, June 22, 200552
. Gordon Research Conference (Bioorganic Ch emistry)
Proctor, NH, June 16, 200551
. Tufts University
Medford, MA, May 19, 2005
50.
Cornell University
Ithaca, NY, May 18, 2005
49.
Stanford University
Stanford, CA, March 30, 2005
48.
American Chemical Society National Meeting
San Diego, CA, March 13, 2005
47. Univers
in. Int. J. Quant. Chem. S24: 277-289.
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