CURRICULUM VITAE
TIM WILTSHIRE
PH.D
Personal Information
Office Address: 1015 Genetic Medicine
Division of Pharmacotherapy and Experimental Therapeutics,
UNC Eshelman School of Pharmacy
University of North Carolina at Chapel Hill
Chapel Hill, NC 27599
Office: 919-***-****
Lab: 919-***-****
Fax: 919-***-****
Email: ****@***.***
Home Address: 1000 Wood-Sage Dr.
Chapel Hill, NC 27516
Academic Appointments
Associate Professor 2007 present
Division of Pharmacotherapy and Experimental Therapeutics
UNC Eshelman School of Pharmacy
Faculty member 2007 present
Associate Director, Institute for Pharmacogenomics and Individualized Therapy
Adjunct Faculty 2010 present
Department of Genetics
UNC School of Medicine
Faculty member 2010 present
Lineberger Comprehensive Cancer Center
Professional Education and Training:
Bachelors of Science, major in Organic Chemistry. B.Sc. 1972 - 1975
The University of Canterbury (Christchurch, New Zealand)
Diploma in Teaching, Dip.Teach. 1975
High School Teacher training
Christchurch Teachers College (Christchurch, New Zealand).
Post-Graduate Diploma in Science, major in Biotechnology. Dip.Sci.(Hons) 1990 - 1991
The University of Otago (Dunedin, New Zealand).
Thesis Project: Comparison of oil levels in accessions of Myoporum laetum and development
of a
tissue culture protocol for M. laetum.
Advisor: Dr. Paula Jameson
Doctor of Philosophy in Biochemistry, Cellular and Molecular Biology. Ph.D. 1991 - 1996
The University of Tennessee, Knoxville, Tennessee.
Dissertation: Mammalian Meiosis: Events of meiotic prophase I in spermatogeneisis
Advisor: Dr. Mary Ann Handel
Postdoctoral Research
Post-Doctoral Fellow, Department of Physiology 1996 - 1998
The Johns Hopkins University School of Medicine
Advisor: Dr. Roger Reeves
Post-Doctoral Fellow, Center for Neurobiology and Behavior 1998 - 1999
University of Pennsylvania School of Medicine
Advisor: Dr. Maja Bucan
Other Employment:
High School Teacher (New Zealand trained teacher certification) 1980 - 1991
Teaching general science classes and chemistry and biology to advanced levels
Waikohu College Te Karaka 1980 - 1981
Motueka High School Motueka (Head of Biology and Outdoor Education) 1982 - 1991
Institute Research Fellow 2000
Genomics Institute of the Novartis Research Foundation, a division of Novartis
PharmaceuticalsStaff Scientist2001 - 2003
Genomics Institute of the Novartis Research FoundationGenetics Group Leader2003 - 2006
Genomics Institute of the Novartis Research FoundationSenior Research Investigator Genetics 2006 - 2007
Genomics Institute of the Novartis Research Foundation
San Diego, CA
Professional Activities and Services:
Course Instructor, Cloning and Analysis of Large DNA - Cold Spring Harbor Laboratory, NY
1996
Course Instructor, Positional Cloning Course - Cold Spring Harbor Laboratory, NY 1997National Cancer Institute - (Think Tank participant) September 12-14, 2004
Cancer Susceptibility and Resistance
National Cancer Institute - (Think Tank participant) December 6-7, 2005
Predictive Models of Cancer Susceptibility: Integrated Strategies
Host Susceptibility meeting, participant/consultant December 2006
National Toxicology Program (NIEHS)
NCI-Integrated Systems Genetics Meeting participant March 11-13 2008
Newport Beach, CA.
National Institutes of Health
Reviewer for NIEHS special emphasis panel 2007
Comparative Biology Elucidation of Environmental Pathways and Susceptibility
Reviewer for NIH GCAT Study sections, 2007, 2008
Genomics, Computational Biology and Technology
Reviewer for NIH ARRA Challenge Grant Program (RFA-OD-09-003) 2009
National Institutes of Health (NIH).
Journal Reviews
Reviewer for scientific journals: Genomics, Mammalian Genome, Genome Research, Nature
Genetics, Genetics, Trends in Genetics, Physiological Genomics, BMC Genomics, and PLoS
Biology, PLoS ONE.
Inventions
US Patent number 7,595,148
This invention provides novel methods and compositions for modulating T cell
differentiation and T
cell responses.
UNC-Chapel Hill
Member, UNC IACUC committee 2008 - present
Sub-committee responsibilities mouse genetics
Faculty Search Committee Genetics Dept.
UNC School of Medicine
UNC Eshelman School of Pharmacy
Member, Conflict of Interest committee (COIC)
Interviewer graduate program applicants
Institute of Pharmacogenomics and individualized Therapy
Associate Director for Pre-Clinical Studies
Professional Memberships
American Association for Advancement of Science (AAAS) 1993 - present
American Society of Human Genetics (ASHG) 2005 - present
International Mouse Genome Society 1997 - present
Elected member of Nominations committee 2010
Awards
Post-Primary Teachers Association New Zealand Teacher of the year award. 1986
Nominated by students
University of Tennessee - Science Alliance Graduate Student Award of Excellence, 1994 and
1995
University of Tennessee Chancellors Award 1996
.
7. Rakhra-Burris TK, Auman JT, Deverka P, Dressler LG, Evans JP, Goldberg RM, Havener
TM, Hoskins JM, Jonas DE, Long KM, Motsinger-Reif AA, Irvin WJ, Richards KL,
Roederer MW, Valgus JM, Riper M, Vernon JA, Zamboni WC, Wagner MJ, Walko CM,
Education Network, 8 International Meeting, November 2010.
Teaching
High School Subjects taught to lower grade levels, Biology, Chemistry, Physics, Earth
Sciences, and Mathematics. Subjects taught to advanced grade levels, Biology, Chemistry.
Outdoor Education, also taught to senior students.
Biology 101 labs University of Tennessee undergraduate program.
Biotechnology Lab class University of Tennessee graduate program.
Graduate Program (Ph.D. in Pharmaceutical Sciences)
Course Coordinator 2009 - present
DPET 838 Methods in Pharmacogenetics
Lecturer 2008 - present
DPET 832 Pharmacogenomics
Advisor 2008 -present
DPET 991 Research in DPET
Dissertation Committees
Division of Pharmacotherapy and Experimental Therapeutics
Cristina Santos (Major Advisor)
Amber Frick (Major Advisor)
Shawn Watson (Committee Chair)
Venita Gresham completed defense April, 2010
Graduate Program Curriculum of Genetics and Molecular Biology, University of North
Carolina
Samantha Segall (Major Advisor) completed defense September 2010
Yuying Xie (Threadgill major advisor) completed defense July 2010
Graduate Program Curriculum in Toxicology, Environmental Genetics Group, NIEHS
Monica High - completed defense March 2010 (Kleeberger - major advisor)
Jennifer Nicholls (Kleeberger - major advisor)
Graduate Program Department of Cell and Molecular Physiology
Shiliang Wang (Faber major advisor)
Department of Biostatistics, School of Public Health
Yi Gong (Zou - major advisor)
Post-Doctoral Advisor
Mat Pletcher - Senior Principal Scientist, Investigative Toxicology Pfizer Global
Research and
Development. Groton CT.
David DelanoProduct Manager, Epigenetics. Illumina Corp, San Diego, CA.
Steven Su Scientist, Merrimack Pharmaceuticals, Boston MA
Current post-doctoral fellows
Natasha Butz
Oscar Suzuki
Current Research Support
1R01MH077251-01A1 (Wiltshire) 7/01/2007 - 4/31/2012
NIMH $250,000
Organismal, Cellular and Genetic Networks in Anxiety and Depression
The major goals of this project are to collect and analyze anxiety and depression-related
genetic,
biochemical and clinical phenotype data related in inbred mouse strains.
1 R01 DOA022392-01(Tarantino) Co-PI -10% 7/01/2007 7/01/2011
NIDA $250,000
Fine Mapping Genes for Cocaine Locomotor Response in ENU Mutagenized Mice
The major goals of this project are to map, identify and characterize the gene underlying
a
cocaine locomotor response in an ENU mutant mouse.
5R01DA023690-02 (Tarantino, Wiltshire, coPIs) 8/01/2010 7/31/2011
NIDA $390,000
Organismal and Genetic Networks in Drug Reward and Reinforcement.
The major goals of this project are to collect and analyze drug reward and reinforcement-
related
genetic, biochemical and clinical phenotype data related in inbred mouse strains.
Completed Research Support
Novartis Grant SFP-1407. Internal special project funding support within Novartis to
develop
SNP mapping technologies.