CURRICULUM VITAE

I. Date of preparation

July, 2011

II. Personal data

Name: Ira Abram Tabas

Birth date: April 22, 1953

Birthplace: Philadelphia, Pennsylvania

Citizenship: USA

Office address: Department of Medicine, PH 8East-105F, Columbia University

th630 West 168 Street, New York, NY 10032

Contact information: Tel: 212-***-****; Fax: 212-***-****; E-mail: abos9l@r.postjobfree.com

III. Academic training

Undergraduate: Tufts University (Medford, MA), 1975, B.S.

Graduate: Washington University (St. Louis, MO), 1981, M.D., Ph.D.

(Biochemistry)

Ph.D. Thesis: "The Processing of Asparagine-Linked Oligosaccharides During

Glycoprotein Biosynthesis"; Dr. Stuart Kornfeld, Sponsor

M.D. Licensure: State of New York (#150522)

IV. Traineeship

Internship/Residency: Internal Medicine, Columbia-Presbyterian Medical Center, New

York, NY (1981-1983)

Clinical Fellowship: Endocrinology/Metabolism, Columbia-Presbyterian Medical

Center, New York, NY (1983-1985)

Research Fellowship: Laboratory of Dr. Alan Tall, Department of Medicine, Columbia

University, New York, NY, 1983-1985

V. Board certification

Internal Medicine, 1985

Endocrinology/Metabolism, 1987

1

VI. Professional organizations and societies

Arteriosclerosis, Thrombosis, and Vascular Biology as Council of the American Heart

Association; appointed member of the Membership/Credentials Committee (1990-1992,

1997-1999); Program Committee (1992-1994; 2000-2002; 2009-present), and Executive

Board (2010)

American Society of Biochemists and Molecular Biologists

American Association for the Advancement of Science

American Society for Cell Biology

Society of Leukocyte Biology

New York Lipid Club

American Society for Clinical Investigation

Interurban Clinical Club

Association of American Physicians

VII. Academic appointments

Assistant Professor of Medicine, Columbia University College of Physicians and Surgeons,

New York, NY (1985-1992

)

Assistant Professor of Anatomy & Cell Biology, Columbia University College of Physicians

and Surgeons, New York, NY (1988-1992

)

Associate Professor of Medicine and Anatomy & Cell Biology (Tenured), Columbia

University College of Physicians and Surgeons, New York, NY (1992-1997

)

Professor of Medicine and Anatomy & Cell Biology (

Tenured), Columbia University

College of Physicians and Surgeons, New York, NY (1997-present

)

Professor of Physiology and Cellular Biophysics (Tenured), Columbia University College

of Physicians and Surgeons, New York, NY (2004-present

)

Vice-Chairman of Research, Department of Medicine, Columbia University (2004-present)

VIII. Hospital appointments

AssistantAttending Physician of Medicine, Columbia-Presbyterian Medical Center, New

York, NY (1985-1992

)

Associate Attending Physician of Medicine, Columbia-Presbyterian Medical Center, New

York, NY (1992-present

)

Attending Physician of Medicine, Columbia-Presbyterian Medical Center, New York, NY

(1997-present

)

2

IX. Honors

Phi Beta Kappa, Tufts University, Medford, MA (1974)

Summa cum laude, Tufts University, Medford, MA (1975)

Letter of Commendation, Washington School of medicine, St. Louis, MO (1977)

Mosby Scholarship Book Award, Washington University School of Medicine (1981)

Alpha Omega Alpha, Washington University School of Medicine, St. Louis (1981)

Pfizer Research Award for Young Faculty (1985-1987)]

Silberberg Assistant Professorship of Medicine, Columbia University (1988-1993)

American Heart Association Established Investigator Award (1988-1993)

Doctor Harold and Golden Lamport Research Award (1990)

Elected to the American Society for Clinical Investigation (1992)

Scientific Board of the Stanley J. Sarnoff Endowment for Cardiovascular Science, Inc.

(1992-1996)

Editorial Board of Journal of Biological Chemistry (1995-2000)

Elected to Interurban Clinical Club (1996-present)

Elected to Association of American Physicians (1998-present)

Deputy Editor, Journal of Clinical Investigation, (2002-2007)

American Heart Association/ATVB Council Special Recognition Award (2003)

Keynote Lecture, 2010 National Lipid Association Scientific Session

2011 Alumni Achievement Award, Washington University School of Medicine

Chosen for Board of Reviewing Editors for Science (2011 - )

Chairman, 2012 Deuel Lipid Conference

Distinguished Science Lecture, Polytechnic Institute of NYU (2011)

Awarded Terman Lectureship, Albert Einstein College of Medicine (2011)

X. Fellowship and grant support

Past:

Fellowship: NIH training grant (NHLBI), 1983-85, trainee

Pfizer Research Award for Young Faculty, 1985-1987, Principal Investigatr, $50,000 per

annum

3

Project of NIH SCOR Grant in Atherosclerosis (NHLBI), 1986-1990, Co-Investigator,

$104,000 per annum

Project of NIH SCOR Grant in Atherosclerosis (NHLBI), 1991, Responsible Investigator,

$90,000 per annum

Biomedical Research Support Grant (NIH), 1990-1991, Principal Investigator $5,000

American Heart Association Established Investigatorship Award, 1988-1993, rincipal

Investigator, $35,000 per annum

New York Heart Association Grant-in-Aid, Principal Investigator, 1992-1995, $42,000 per

annum

Research Supplement for Minority Individuals in Postdoctoral Training (Dr. Anselm K.

Okwu)

American Heart Association, New York City Affiliate, Participating Laboratory Award (Dr.

Yoshimune Shiratori)

Postdoctoral Fellowship Award in Atherosclerosis (Dr. Paul Skiba)

Schering-Plough Research Grant, 1989-1995, Responsible Investigator, $50,000 per annum

Individual National Research Supplement Award for Postdoctoral Training (Dr. G. Andrew

Keesler)

Postdoctoral Fellowship Award in Nutrition (Dr. Sudhir Marathe)

NIH R01 grant (NHLBI), Principal Investigator, 1992-1997, $120,000 perannum

Project of NIH SCOR Grant in Atherosclerosis (NHLBI), Responsible Investigator, 1991-

1996, $105,000 per annum

Council for Tobacco Research Award, Principal Investigator, 1995-1998, $5,000 per

annum

Postdoctoral Fellowship Award in Atherosclerosis (Dr. Wei Tang)

Research grant from Berlex Laboratories, 2003-2004, $100,000 per annum

AHA Heritage Affiliate Postdoctoral Training Grant, 2004-2005

(Dr. Tracie DeVries)

Merck Sponsored Research Project,

Principal Investigator, 2004-2006, $100,000 per annum

NIH SCOR Grant in Vascular Biology (NHLBI), Responsible Investigator or Project and

Pathology Core, 2002-2007, $282,000 per annum

NIH Individual Post-Doctoral Training Grant 2005-2007 (Dr. Tracie Seimon)

AHA Heritage Affiliate Postdoctoral Training Grant, 2005-2007

(Dr. Wahseng Lim)

AHA Scientist Development Grant, 2004-2007 (Dr. Yankun Li)

NIH Postdoctoral Fellowship Award in Atherosclerosis (Dr. Jenelle Timmins)

Boehringer-Ingelheim Sponsored Research Project, Principal Investigator, 2007, $150,000

per annum

NIH P01 grant (NHLBI), Responsible Investigator, 2001-2006, $312,000 pr annum

NIH R01 grant (NHLBI), Principal Investigator, 2002-2007, $250,000 perannum

NIH R01 grant (NHLBI), Principal Investigator, 2003-2008, $250,000 perannum

Department of Defense grant, Principle Investigator, 2006-2010, $250,000 per annum

AHA Scientist Development Grant, 2007-2010 (Dr. Tracie Seimon)

AHA Heritage Affiliate Postdoctoral Training Grant,

2007-2009 (Dr. Edward Thorp)

Fulbright Scholarship (Dorien Schrijvers)

NIH R01 grant (NHLBI), Principal Investigator, 2006-2011, $162,000 perannum

NIH K99 grant (NHLBI), mentor for Dr. Edward Thorp, 2009-2011

4

Present:

NIH P01 grant (NHLBI), Responsible Investigator, 2006-2011, $312,000 pr annum

NIH P01 grant (NHLBI), Principle Investigator, 2007-2012, $350,000 perannum

NIH R01 grant (NHLBI), Principal Investigator, 2008-2013, $250,000 perannum

NIH R01 grant (NHLBI), Principal Investigator, 2011-2015, $290,000 perannum

NHLBI Programs of Excellence in Nanotechnology, Project Investigator, 2010-2015,

$260,000 per annum

AHA Scientist Development Grant, mentor for Dr. Lale Ozcan, 2011-2013

AHA Pre-doctoral Training Grant, mentor for Ying Wang, 2011-2014

XI. Departmental and university committees

Faculty advisor for Columbia University College of Physicians and Surgeons medical

students (1986-1994)

Member of the Columbia University Research Advisory Committee for first year medical

student summer research projects (1990)

Member of the Department of Medicine Resident Selection Committee (1990-present)

Organizer of the Department of Medicine Young Faculty Research Conference (1990-1992)

Member of Department of Medicine Subcommittee on Research (1991) and Committee for

Organizing Departmental Retreat (1995)

Member of Doctoral Program Subcommittee on Nutrition (1991-present)

Co-Director of Basic Research Track of the CPMC Internal Medicine Residency Program

(1992-1997),

Scientific Advisory and Executive Committee, Medical Scientist Training (MD-PhD)

Program, Columbia University (1993-present)

Member, Curriculum Committee of the College of Physicians & Surgeons (1997-2002)

Co-Associate Director, Medical Scientist Training (MD-PhD) Program, Columbia

University (2001-present)

Chairman, Committee on Promotions of the Department of Medicine (1997-2004)

Member of Search Committees for Director of Pathology, St. Luke's Roosevelt Hosp.

(1992), Chairperson of the Department of Pharmacology, Columbia University (1994-

1995), Chairperson-Division of Cardiology, Columbia University (1999), Director of the

Irving Center for Cancer Research (2004), Chairperson-Division of Oncology (2005)

Member, Dean's Scientific Advisory Committee (2007 - present)

Vice-Chair of Research, Department of Medicine (2007 - present)

XII. Teaching experience and responsibilities

Specific courses:

Medical Student Preceptor (1989, 1991, 1994, 1996), 6 students

Abnormal Human Biology, Atherosclerosis session preceptor (1987-present), 30 students

Cellular Membranes graduate course (Department of Anatomy & Cell Biology), LDL

receptor and intracellular cholesterol metabolism sessions (1987-present), 30 students

Pharmacology graduate student course, LDL receptor session (1989-1993), 20 students

Histology medical student course, microcirculation session (1989-1994), 200 students

5

Advanced pathophysiology course for fourth year medical, atherosclerosis sessions (1990-

1996), 40 students

Pathology graduate student course (Molecular Mechanisms of Disease), organizer and

lecturer of Atherosclerosis section (1991-present), 15 students

Science Basic to the Practice of Medicine (formerly Biochemistry of Disease) medical

student course, Atherosclerosis session (1992-present), 120 students

Pathophysiology course for 2nd-year medical students, Atherosclerosis session (1997-

present), 120 students

Molecular and Cellular Biology of Nutrients, Apoptosis section (2001-) 15 students

Molecular and Cellular Cardiology Lecture Series, Transgenic Models secton (1998-), 15

fellows

Molecular Pathophysiology of the Cardiovascular System (2007-), 15 students

General teaching activities:

Attending on Internal Medicine ward service (1985-present), 2-3 students and 3 housestaff

physicians

Attending on Endocrinology ward service (1987-present), 1-2 students and 1 fellow

Attending in Combined Endocrine/Diabetes, Thyroid, and Lipid Clinics (1987-present), 1-2

students and 1-2 clinical fellows

Ph.D. Thesis sponsor:

Lori Bottalico, Department of Anatomy/Cell Biology, Columbia University (1989-1992)

Scott Schissel, Department of Anatomy/Cell Biology, Columbia University (1993-1997)

Andrew Leventhal, Department of Anatomy/Cell Biology, Columbia University (2000-

2004) Winner of the 2004 Samuel W. Rover and Lewis Rover Award for Scholarship

and Outstanding Achievement in Anatomy and Cell Biology

Ying Wang, Department of Physiology, Columbia University (2010 - )

Masters thesis sponsor:

Sungtae Lim, Institute of Human Nutrition, Columbia University (1989)

Woan-Chyng Su, Institute of Human Nutrition, Columbia University (1990)

Ph.D. Advisory/Examination committees:

Deborah A. Lazzarino, Department of Anatomy/Cell Biology, Columbia University (Ph.D.

advisory committee and examination, 1987-1990)

Shing-Jong Lin, Department of Physiology, Columbia University (Ph.D. examination, 1989)

Maria Davila-Bloom, Institute of Human Nutrition, Columbia University (Ph.D.

examination, 1989)

Fan Yuan, Department of Engineering, The City University of New York (Ph.D.

examination, 1990-1993)

Lester S. Johnson, Department of Pathology, Columbia University, Ph.D. thesis committee

(1990-1993)

Steven Rumsey, Institute of Human Nutrition, Ph.D. thesis committee (1992-1993)

6

Thomas E. Phalen, Albert Einstein College of Medicine, Ph.D. thesis defense committee

(1993)

Sripriya Chari, Integrated Program in Cellular, Molecular, and Biophysical Studies,

Qualifying Examination (1993)

Zhenglun Zhu, Department of Anatomy/Cell Biology, Columbia University (Ph.D. advisory

committee and examination, 1991-1993)

Lori Masucci, Institute of Human Nutrition, Ph.D. thesis committee (1993-1996)

Cory Huang, Department of Pathology, Ph.D. thesis committee (1995)

Mingyue Zhou, Institute of Human Nutrition, Ph.D. thesis committee (1995-)

Hong-yuan Yang, Institute of Human Nutrition, Ph.D. thesis committee (1995-)

Donata Paresce, Department of Pathology, Ph.D. thesis committee (1997)

Furcy Paultre, Institute of Human Nutrition, Ph.D. thesis committee (1997-)

Chris William, Integrated Program. Ph.D. qualifying exam (1997)

Nrgo Storey, Department of Biochemistry, Dalhousie University, Ph.D. examination, 1997

Peter Sartipy, Wallenberg Laboratory, University of Gothenburg, Sweden, opponent, 2000

Ying Lui, Institute of Human Nutrition, Ph.D. thesis committee (1999-)

Biophysica Acta (1985-present)

Ad hoc grant reviewer for National Science Foundation (1989-present)

Sub-group reviewer for American Heart Association Established Investigator and Clinical

Scientist Award grants (1991 & 1992)

Member of American Heart Association grant-in-aid study section (1992-1993)

Member Scientific Board of the Stanley J. Sarnoff Endowment for Cardiovascular Science,

Inc. (1992-1996)

Vice-chairman of American Heart Association grant-in-aid study section (1994)

Consultant for Merck, Schering-Plough, Warner-Lambert, Berlex, Eli Lilly, Pfizer, Talaria

Biotech, ReddyUS, Amersham/GE, and Bristol-Myers-Squibb, Novartis, Sankyo

Institutional representative for the American Society of Clinical Investigation (1998-

2000)

Co-Editor of October 2000 and 2001 issues of Current Opinion in Lipidoloy

Organizer and Chairman, Keystone Conference on the Cellular Biology of Atherosclerosis

(2005)

External Advisory Committee, Deuel Research Conferences (2004-2012)

Scientific Board, Kern Lipid Conference (2005-2010)

General Council and Review Panel for Future Leaders Grant Program, The Leadership

Council for Improving Cardiovascular Care (2005-)

7

Editorial Board of BBA - Molecular and Cell Biology of Lipids (2008-) ]TJ

EMC

/P >BDC

0.0005 Tc -0.0005 Tw 0 -1.

particles with and without apoprotein E. Biochemistry 33:151**-*****.

*37. Schissel, S.L., Beatini, N., Zha, X., Maxfield, F.R., and Tabas, I (1995) Effect and

cellular site of action of cysteine protease inhibitors on the cholesterl esterification

pathway in

macrophages and Chinese hamster ovary cells. Biochemistry 34:104**-*****.

*38. Shiratori, Y., Houweling, M., Zha, X., and Tabas, I. (1995) Stimulation of

CTP:phosphocholine cytidylyltransferase by free cholesterol loading of m9(acrophages

involves

signaling through protein dephosphorylation. J. Biol. Chem. 270:298**-*****.

39. Wang, N., Tabas, I., Winchester, R., Ravalli, S., Rabbani, L.E., and Tall, A. (1996)

Interleukin-8 is induced by cholesterol loading of macrophages and expressed in

macrophage

foam cells in human atheroma. J. Biol. Chem. 271:8837-8842.

*40. Skiba, P.J., Zha, X., Maxfield, F.R., Schissel, S.L., and Tabas, I (1996) The distal

pathway of lipoprotein-induced cholesterol esterification, but not sphingomyelinase-

induced

cholesterol esterification, is energy-dependent. J. Biol. Chem. 271:133**-*****.

2+

*41. Schissel, S.L., Schuchman, E.H., Williams, K.J., and Tabas, I. (1996) Zn -stimulated

sphingomyelinase is secreted by macrophages and other cell types and is a product of the

acid

sphingomyelinase gene. J. Biol. Chem. 271:184**-*****.

*42. Schissel, S.L., Tweedie-Hardman, J., Rapp, J.H., Graham, G., Williams, K.J., and

Tabas, I. (1996) Rabbit aorta and human atherosclerotic lesions hydrolyze the

sphingomyelin of

retained low-density lipoprotein. Proposed role for arterial-wall sphinomyelinase in

subendothelial retention and aggregation of atherogenic lipoproteins. J. Clin. Invest.

98:1455-

1464.

11

*43. Tabas, I., Marathe, S., Keesler, G.A., Beatini, N., and Shiratori,Y. (1996) Evidence

that the initial up-regulation of phosphatidylcholine biosynthesis in fre cholesterol-

loaded

macrophages is an adaptive response that prevents cholesterol-induced celular necrosis.

Proposed role of an eventual failure of this response in foam cell necrosis in advanced

atherosclerosis. J. Biol. Chem. 271:227**-*****.

*44. Keesler, G.A., Gabel, B., Koschinsky, M., and Tabas, I. (1996) Te binding activity

of

the macrophage lipoprotein(a)/apoprotein(a) receptor is up-regulated by colesterol via a

translational mechanism and recognizes distinct kringle domains on apoprotein(a). J.

Biol.

Chem. 271:320**-*****.

*45. Tang, W., Keesler, G.A., and Tabas, I. (1997) The structure of the gene for m8(urine

CTP:phosphocholine cytidylyltransferase (Ctpct). Relationship of exon structure to

functional

domains and identification of transcriptional start sites and potential upsream

regulatory

elements. J. Biol. Chem. 272:131**-*****.

46. Zha, X., Tabas, I., Leopold, P.L., Jones, N.L., and Maxfield, F.R. (1997) Evidence

for

prolonged cell-surface contact of acetyl-LDL before entry into macrophages. Arterio.

Thromb.

Vasc. Biol. 17:1421-1431.

*47. Schissel. S.L., Jiang, X.C., Tweedie-Hardman, J., Jeong, T.S., Camejo, E.H., Najib,

J.,

Rapp, J.H., Williams, K.J., and Tabas, I. (1998) Secretory sphingomyelinase, a product of

the

acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH.

Implications

for atherosclerotic lesion development. J. Biol. Chem. 273:2738-2746.

48. Zha, X., Pierini, L.M., Leopold, P.L., Skiba, P.J., Tabas, I., and Maxfield, F.R.

(1998)

Sphingomyelinase treatment induces ATP-independent endocytosis. J. Cell Biol. 140:39-47.

*49. Marathe, S., Schissel, S.L., Yellin, M.J., Beatini, N., Mintzer, R, Williams, K.J.,

and

Tabas, I. (1998) Human vascular endothelial cells are a rich and regulatable source of

secretory

sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell

signaling.

J. Biol. Chem. 273:4081-4088.

50. Jeong, T.S., Schissel, S.L., Tabas, I., Pownall, H.J., Tall, A.R.,Jiang, X.C. (1998)

Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout-out

mice

reflects combined production and catabolic defects and enhances reactivity with mammalian

sphingomyelinase. J. Clin. Invest. 101:905-912.

*51. Khelef, N., Buton, X., Beatini, N., Wang, H., Meiner, V., Chang, T-Y., Farese, R.V.,

Jr., Maxfield, F.R., and Tabas, I. (1998) Immunolocalization of ACAT in macrophages. J.

Biol.

Chem. 273:112**-*****.

*52. Schissel, S.L., Keesler, G.A., Schuchman, E.H., Williams, K.J., and Tabas. I. (1998)

The cellular trafficking and zinc-dependency of secretory and lysosomal sphingomyelinase,

two

products of the acid sphingomyelinase gene. J. Biol. Chem. 273:182**-*****.

12

53. Mazany, K., Peng, T., Tabas, I, and Williams, K.J. (1998) Human chondroitin 6-

sulfotransferase: cloning, gene structure, and chromosomal localization. Biochim.

Biophys.

Acta. 1407:92-97.

54. Mukherjee, S., Zha, X., Tabas, I., Maxfield, F.R. (1998) Cholesterol distribution in

living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol

analog.

Biophysical Journal 75:1915-1925.

*55. Tang, W., WalshA., and Tabas, I (1999) Macrophage-targeted CTP:phosphocholine

cytidylyltransferase (1-314) transgenic mice. Biochim. Biophys. Acta. 1437:301-316.

56. Bakovic, M., Waite, K., Tang, W., Tabas, I., Vance, D.E. (1999) Transcriptional

activation of the murine CTP:phosphocholine cytidylyltransferase gene (Ctpct). Combined

action of upstream stimulatory and inhibitory cis-acting elements. Biochim. Biophys.

Acta.

1438:147-165.

*57. Marathe, S., Kuriakose, G., Williams, K.J., and Tabas I. (1999) Sphingomyelinase, an

enzyme implicated in atherogenesis, is present in atherosclerotic lesions and bins to

extracellular matrix. Arterio. Thromb. Vasc. Biol. 19:2648-2658.

*58. Buton, X., Mamdouh, Z., Ghosh, R., Du, H., Kuriakose, G., Beatini, N., Grabowski,

G.A., Maxfield, F.R., and Tabas, I. (1999) Unique cellular events occuring during the

initial

interaction of macrophages with matrix-retained or methylated aggregated LDL. Prolonged

cell-

surface contact during which LDL-cholesteryl ester hydrolysis exceeds LD-protein

degradation. J. Biol. Chem. 274:321**-*****.

*59. Khelef, N., Soe, T.T., Quehenberger, O., Beatini, N., Tabas, I., Mxfield, F.R.

(2000)

A portion of acyl-CoA:cholesterol acyltransferase localizes near the trans-Golgi network

and the

endocytic recycling compartment in macrophages. Arterio. Thromb. Vasc. Biol. 20:1769-

1776.

Yao, P.M. and Tabas, I. (2000) Free cholesterol loading of macrophages induces

*60.

apoptosis involving the Fas pathway. J. Biol. Chem. 275:238**-*****.

*61. Wong, M-L., Xie, B., Beatini, N., Phu, P., Marathe, S., Johns, A., Hirsch E.,

Williams,

K.J., Licinio, J., and Tabas, I. (2000) Acute systemic inflammation up-regulates

secretory

sphingomyelinase in vivo: a possible new link between inflammatory cytokines and

atherogenesis. Proc. Natl. Acad. Sci. U.S.A. 97:8681-8686.

*62. Marathe, S., Miranda, S.R.P., Devlin, C., Johns, A., Kuriakose, G. Williams, K.J.,

Schuchman, E.H., and Tabas, I. (2000) Creation of a mouse model for non-neurological (type

B)

Niemann-Pick mouse model by stable, low-level expression of lysosomal sphingomyelinase in

the absence of secretory sphingomyelinase: relationship between brain intra-lysosomal

enzyme

activity and central nervous system function. Hum. Molec. Gen. 9:1967-1976.

*63. Zhang, D., Tang, W., Yao, P.M., Yang, C., Xie, B., Jackowski, S., and Tabas, I.

(2000)

Macrophages deficient in CTP:phosphocholine cytidylyltransferase-a are viable under

normal

13

culture conditions but are highly susceptible to free cholesterol-induce death. Molecular

genetic

evidence that the induction of phosphatidylcholine biosynthesis in free holesterol-loaded

macrophages is an adaptive response. J. Biol. Chem. 275:353**-*****.

*64. Marathe, S., Choi, Y., Leventhal, A., and Tabas, I. (2000) Lipoproteins from

apolipoprotein E knockout mice become potent inducers of macrophage foam cell formation

when treated with sphingomyelinase. Arterio.Thromb.Vasc.Biol. 20:2607-2613.

*65. Sakr, S., Eddy, R.J., Barth, H., Wang, F., Greenberg, S., Maxfield, F.R., and Tabas,

I.

(2001) The uptake and degradation of matrix-bound lipoproteins by macrophages require an

intact actin cytoskeleton, Rho family GTPases, and myosin ATPase activity. J. Biol. Chem.

276:376**-*****.

*66. Yao, P.M. and Tabas, I. (2001) Free cholesterol loading of macrophages is associated

with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis

pathway. J. Biol. Chem. 276:424**-*****.

Leventhal, A.R., Chen, W., Tall, A.R., and Tabas, I. (2001) Acid sphingomyelinase-

*67.

deficient macrophages have defective cholesterol efflux and trafficking. J. Biol. Chem.

276:449**-*****.

Chen, W., Sun, Y., Welch, C., Gorelik, A., Leventhal, A.R., Tabas, I., Tall, A.R. (2001)

68.

Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late

endosomes/lysosomes and a defect in Niemann-Pick Type C macrophages. J. Biol. Chem.

276:435**-*****.

*69. Devlin, C.M., Kuriakose, G., Hirsch, E., and Tabas, I. (2002) Genetic alterations of

interleukin-1 receptor antagonist in mice markedly affect non-HDL lipoprotein cholesterol

levels

and foam cell lesion size. Proc. Natl. Acad. Sci. U.S.A. 99: 6280-6285.

*70. Feng, B. and Tabas, I. (2002) ABCA1-mediated cholesterol efflux is defective in free

cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a

process requiring full npc1 activity. J. Biol. Chem. 277:432**-*****.

*71. Feng, B, Yao, P.M., Li, Y., Devlin, C., Zhang, D., Harding, H., Sweney, M., Rong,

J.X., Kuriakose, G., Fisher, E.A., Marks, A.R., Ron, D., Tabas, I. (200) The endoplasmic

reticulum as the site of cholesterol-induced cytotoxicity in macrophages. Nature Cell

Biology

5:781-792.

*72. Feng, B., Zhang, D., Kuriakose, G., Devlin, C.M., Kockx, M., and Tbas, I. (2003)

Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage

apoptosis in murine atherosclerosis. Proc. Natl. Acad. Sci. U.S.A. 100:104**-*****.

*73. Patel, M., Morrow, J., Maxfield, F.R., Strickland, D.K., Greenberg S., and Tabas, I.

(2003) The cytoplasmic domain of LDL receptor-related protein, but not that of the LDL

receptor, triggers phagocytosis. J. Biol. Chem. 278:447**-*****.

14

*74. Leventhal, A.R., Leslie, C.C., and Tabas, I. (2004) Suppression of macrophage

eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-

fatty acyl

esterification and the Niemann-Pick C pathway of lipid trafficking. J. Biol. Chem.

279:8084-

8092.

75. Liang, C.P., Han, S.A., Okamoto, H., Carnemolla, R., Tabas, I., Accili, D., Tall,

A.R.

(2004) Increased CD36 Protein as a Response to Defective Insulin Signaing in Macrophages.

J.

Clin. Invest. 113:764-773.

*76. Li, Y., Ge, M., Ciani, L., Kuriakose, G., Westover, E.J., Dura, M., Covey, D.F.,

Freed,

J.H., Maxfield, F.R., Lytton, J., and Tabas, I. (2004) Enrichment of endoplasmic

reticulum with

cholesterol inhibits SERCA2b activity in parallel with increased order o membrane lipids.

Implications for depletion of ER calcium stores and apoptosis in cholesterol-loaded

macrophages. J. Biol. Chem. 279:370**-*****.

77. Jacobs, R.J., Devlin, C., Tabas, I., Vance, D.E. (2004) Targeted deletion of hepatic

CTP:phosphocholine cytidylyltransferase-a in mice decreases plasma high density and very

low

density lipoproteins. J. Biol. Chem. 279:474**-*****.

78. Wang, L., Magdaleno, S., Tabas, I., and Jackowski, S. (2005) Early embryonic

lethality

in mice with targeted deletion of the CTP:phosphocholine cytidylyltransferasea gene

(pcyt1a).

Mol. Cell. Biol. 25:3357 3363

79. Mintzer, R.J., Appell, K.C., Cole, A., Johns, A., Pagila, R., Polooff, M.A., Tabas.

I.,

Snider, R.M., and Meurer-Ogden, J.A. (2005) A comparison of two high-throughput screening

formats to identify inhibitors of secreted acid sphingomyelinase. Journal of Biomolecular

Screening. 10:225-234.

80. Baez, J.M., Tabas, I., Cohen, D.E. (2005) Decreased lipid efflux nd increased

susceptibility to cholesterol-induced apoptosis in macrophages lacking

phosphatidylcholine

transfer protein. Biochemical J. 388:57-63

81. Wustner, D., Mondal, M, Tabas, I., and Maxfield, F.R. (2005) Direct observation of

rapid internalization and intracellular targeting of plasma membrane sterol in macrophage

foam

cells. Traffic. 6:396-412.

82. Devlin, C.M., Lee, S.J., Kuriakose, G., Spencer, C., Becker, L., Grosskopf, I., Ko,

C., Huang, L.S., Koschinsky, M.L., Cooper, A.D., Tabas, I. (2005) A cell surface-binding

apolipoprotein(a) peptide delays chylomicron remnant clearance and markedly increases

plasma

remnant lipoproteins and atherosclerosis in vivo. Arterio. Thromb. Vasc. Biol. 25:1704-

1710.

*83. Li, Y, Schwabe, R, DeVries-Seimon, T., Yao, P.M., Tall, A.R., Davis, R.J., Flavell,

R.,

Brenner, D.A., and Tabas, I (2005) Free cholesterol-loaded macrophages are an abundant

source

of TNF-a and IL-6. J. Biol. Chem. 280:217**-*****.

15

84. Jacobs, R.L., Stead, L.M., Devlin, C. Tabas, I., Brosnan, M.E., Brosnan, J.T., and

Vance, D.E. (2005) Physiological regulation of phospholipid methylation alters plasma

homocysteine in mice. J. Biol. Chem. 280:282**-*****.

*85. DeVries-Seimon, T., Li, Y., Yao, P.M., Stone, E., Wang, Y., Davis, R.J., Flavell,

R.,

and Tabas, I. (2005) Cholesterol-induced macrophage apoptosis requires both ER stress

pathways and engagement of the type A scavenger receptor. J. Cell Biol. 171:61-73.

*86. Li, Y., Gerbod-Giannone, M.C., Seitz, H., Cui, D., Thorp, E., Tall A.R., Matsushima,

G.K., and Tabas, I. (2006) Cholesterol-induced apoptotic macrophages elicit an

inflammatory

response in phagocytes that is partially attenuated by the Mer receptor. J. Biol. Chem.

281:6707-

6717.

87. Nelson, J., Jiang, X.C., Tabas, I., Tall, A.R., and Shea, S. (2006a sphingomyelin

and subclinical atherosclerosis: findings from the multi-ethnic study of atherosclerosis

(MESA).

Am. J. Epidemiol. 163:903-12

88. Gerbod-Giannone, M.C., Li, Y., Holleboom, A., Tabas, I., Tall, A.R. (2006) TNFa

induces ABCA1 via NF?B in macrophages and phagocytes ingesting apoptotic cells. Proc.

Natl.

Acad. Sci. U.S.A. 103:3112-3117.

89. Han, S., Liang, C.P., DeVries-Seimon, T., Ranalletta, M., Accili, D., Tabas, I., and

Tall,

A.R. (2006) Macrophage insulin receptor deficiency leads to increased poptosis and

necrotic

core areas in advanced atherosclerotic lesions. Cell Metabolism 3:257-266.

90. Boullier, A., Li, Y., Palinski, W., Quehenberger, O., Tabas, I., Witztum, J.L., and

Miller, Y.I. (2006) Minimally oxidized LDL offsets the apoptotic effects of extensively

oxidized

LDL and free cholesterol in macrophages. Arterio. Thromb. Vasc. Biol. 26: 1169 - 1176.

*91. Bao, L., Li, Y., Deng, S.X., Landry, D., and Tabas, I. (2006) Sitosterol-containing

lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent

macrophages. Implications for sterol structure-dependent mechanisms of cell death and for

atherosclerotic vascular disease in sitosterolemia. J. Biol. Chem. 281:336**-*****.

*92. Seimon, T.A., Obstfeld, A., Moore, K.J., Golenbock, D.T., and Tabas, I. (206)

Combinatorial pattern recognition receptor signaling alters the balance of lfe and death

in

macrophages. Proc. Natl. Acad. Sci. U.S.A. 103:197**-*****.

*93. Li, Y. and Tabas, I. (2007) The inflammatory cytokine response of cholesterol-

enriched macrophages is suppressed by stimulated pinocytosis. J. Leukoc. Biol. 81:

483 491.

*94. Cui, D., Thorp, E., Li, Y., Wang, N., Yvan-Charvet, L., Tall, A.R., Tabas, I. (2007)

Pivotal Advance: Macrophages become resistant to cholesterol-induced death after

phagocytosis of apoptotic cells. J. Leukoc. Biol. 82:1040-50.

16

95. Bao, S., Li, Y., Leia, X., Wohltmanna, M., Bohrera, A., Ramanadhama, S., Tabas, I.,

and Turk, J. (2007) Attenuated free cholesterol loading-induced apoptosis but preserved

phospholipid composition of peritoneal macrophages from mice that do not express group

VIA

phospholipase A2. J. Biol. Chem. 282:27100-14.

*96. Thorp, E., Kuriakose, G., Shah, Y.M., Gonzalez, F.J., Tabas, I. (007) Pioglitazone

increases macrophage apoptosis and plaque necrosis in advanced atherosclerotic lesins of

non-

diabetic LDL receptor-null mice. Circulation 116:2182-2190.

*97. Lim, W., Timmins, J., Seimon, T.A., Sadler, A., Kolodgie, F., Virmani, R.,

Schindler,

C., and Tabas, I. (2008) Signal transducer and activator of transcription-1 is critical

for apoptosis

in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced

atherosclerotic lesions in vivo. Circulation 117:940-951.

*98. Iqbal, J., Dai, K., Seimon, T.A., Jungreis, R., Oyadomari, M., Ron, D., Tabas, I.,

Hussain, M. (2008) IRE1B restricts chylomicron production by selectively degrading MTP

mRNA. Cell Metabolism 7:445-55 (Dr. Tabas, co-communicating author)

*99. Thorp, E., Cui, D., Kuriakose, G., and Tabas, I. (2008) Mutatio of the Mertk

receptor

promotes apoptotic cell accumulation and plaque necrosis in advanced atherosclerotic

lesions of

apolipoprotein E-deficient mice. Arterio. Thromb. Vasc. Biol. 28:1421-8.

*100. Devlin, C.M., Leventhal, A.R., Kuriakose, G., Schuchman, E.H., Williams, K.J.,

Tabas, I. (2008) Acid sphingomyelinase promotes lipoprotein retention within early

atheromata

and accelerates lesion progression. Arterio. Thromb. Vasc. Biol. 20:2607-2613.

101. Senokuchi, T., Liang, C.P., Seimon, T.A., Han, S., Matsumoto, M., J.H., DePinho,

R.A., Accili, D., Tabas, I., and Tall, A.R. (2008) FoxOs promote apoptosis of insulin

resistant

macrophages during cholesterol-induced ER stress. Diabetes 57:2967-76.

102. Manning-Tobin, J.J., Moore. K.J., Seimon, T.A., Bell, S.A., Sharuk, M., Alvarez-

Leite, J.I., de Winther, M.P.J., Tabas, I., Freeman, M.W. (2009) Loss of SR-A and CD36

activity

reduces atherosclerotic lesion complexity without abrogating foam cell formation in

hyperlipidemic mice. Arterio. Thromb. Vasc. Biol. 29:19-26.

*103. Thorp, E., Li, Y., Bao, L., Yao, P.M., Kuriakose, G., Rong, J., Fsher, E.A., Tabas,

I.

(2008) Increased apoptosis in advanced atherosclerotic lesions of Apoe-/- mice lacking

macrophage Bcl-2. Arterio. Thromb. Vasc. Biol. 29:169-72.

104. Packard, R.R.S., Tabas, I., Libby, P., Lichtman, A.H. (2008) CD11c dendritic

cells

maintain antigen processing, presentation capabilities, and CD4 T-cel priming efficacy

under

hypercholesterolemic conditions associated with atherosclerosis. Circulation Res.103:965-

973.

*105. Li, Y., Zhang, Y., Dorweiler, B., Cui, D., Wang, T., Woo, C.W., Wolberger, C.,

Imai,

S., Tabas, I. (2008) Extracellular Nampt protects macrophages from ER stress-induced

apoptosis

17

via a non-enzymatic interleukin-6/STAT3 signaling mechanism. J. Biol. Chem. 283:34833

34843.

*106. Seimon, T., Wang, Y., Kuriakose, G., Han, S., Senokuchi, T., Tall, A., Tabas, I.

(2009) Deficiency of p38a in macrophages promotes apoptosis and plaque necrosis in

advanced

murine atherosclerotic lesions. J. Clin. Invest. 119:886-898.

107. Sun, Y., Ishibashi, M., Seimon, T., Sharma, S.M., Fitzgerald, K.A., Samokhin, A.O.,

Wang. Y., Sayers, S., Aikawa, M., Jerome, G.W., Ostrowski, M.C., Bromme, D., Libby. P.,

Tabas, I., Welch, C.L., Tall, A.R. (2009) Free cholesterol accumulation in macrophage

membranes activates Toll-like receptors, p38 MAP kinase and induces cathepsi K.

Circulation

Res. 104:455-465.

*108. Thorp, E., Li, G., Seimon, T.A., Kuriakose, G., Ron, D., Tabas, I. (2009) Reduced

apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/-

mice

lacking CHOP. Cell Metabolism 9:474-481.

*109. Timmins, J., Ozcan, L., Seimon, T.A., Li, G., Malagelada, C., Backs, J., Backs, T.,

Bassel-Duby, R., Olson, E.N., Anderson, M.E., and Tabas, I. (2009) Calium/calmodulin-

dependent protein kinase II links endoplasmic reticulum stress with Fas and mitochondrial

apoptosis pathways. J. Clin. Invest. 119:2925-2941.

*110. Li, G., Mongillo, M., Chin, K-T., Harding, H., Ron, D., Marks, A.R., and Tabas, I.

(2009) Role of ERO1a-mediated stimulation of inositol 1,4,5-triphosphate receptor

activity in

endoplasmic reticulum stress-induced apoptosis. J. Cell Biol. 186:783-792.

*111. Woo, C.W., Cui, D., Arrelano, J., Dorweiler,B., Harding, H., Fitzgerald, K.A., Ron,

D., and Tabas, I. (2009) Adaptive suppression of the ATF4-CHOP branch of the unfolded

protein

response by toll-like receptor signaling. Nature Cell Biol. 11:1473-1480.

112. Li, S., Sun, Y., Thorp, E., Jehle, A., Viswanathan, S., Kanter, J., Hasty, A.,

Bornfeldt,

K., Tabas, I., Tall, A.R. (2009) Defective phagocytosis of apoptotic cells by ob/ob

peritoneal and

atherosclerotic lesional macrophages: reversal of defects by PPAR?/d activation and fish

oils.

Circulation Res. 105:1072-1082.

*113. Devlin, C., Pipalia, N.H., Liao, X., Schuchman, E.H., Maxfield, F.R., Tabas, I.

(2009)

Marked improvement in lipid and protein trafficking in a lysosomal storage disease cell

by

correction of a secondary enzymatic defect. Traffic 11:601 615.

114. Yeboah, J., McNamara, C, Jiang, X.C., Tabas, I., Herrington, D.M., Burke, G.L., and

Shea, S. (2010) Association of plasma sphingomyelin levels and incident coronary heart

disease

events in an adult population: multi ethnic study of atherosclerosis. Arterio. Thromb.

Vasc. Biol.

30:628-633.

115. Nawrocki, A.R., Hofmann, S.M., Teupser, D., Basford, J.E., Durand, J.L., Rickes,

E.L.,

Jelicks, L.A., Tanowitz, H.B., Chang, C.H., Hui, D.Y., Woo, C.W., Kuriakose, G., Tabas,

I., and

18

Scherer, P.E. (2010) Adiponectin Effects on Atherogenesis in LDL Receptor Null Mice.

Arterio.

Thromb. Vasc. Biol. 30:1159-1165.

116. Chandak, P.G., Radovic, B., Aflaki, E., Kolb, D., Buchebner, M., Rathke, N.,

Frohlich,

E., Haemmerle, G.., Tabas, I., Zechner, R., Levak-Frank, S., and Kratky, D. (2010)

Efficient

phagocytosis requires triglyceride hydrolysis by adipose triglyceride liase. J. Biol.

Chem. 285:

201**-*****.

117. Tam, C., Idone, V., Devlin, C., Tabas, I., Andrews, N.W. (2010) Exocytosis of acid

sphingomyelinase upon cell injury triggers endocytosis and plasma membrane repair. J.

Cell.

Biol. 189:1027-38.

118. Yvan-Charvet, L., Pagler, T.A., Seimon, T.A., Thorp, E., Welch, C.L., Witztum, J.L.,

Tabas, I., and Tall, A.R. (2010) ABCA1 and ABCG1 protect against oxidative stress induced

macrophage apoptosis during efferocytosis. Circulation Res. 106:1861-1869.

119. Seimon, T.A., Kim, M.J., Blumenthal, A., Koo, J., Ehrt, S., Wainwright, H., Bekker,

L.G., Kaplan, G., Nathan, C., Tabas, I., Russell, D.G.. (2010) Induction of ER stress in

macrophages of tuberculosis granulomas. PLoS One. 2010 Sep 15;5:e12772 .

*120. Seimon, T.A., Liao, X., Magallon, J, Nguyen, M., Witztum, J.L., Tsimikas, S.,

Moore,

K.J., Golenbock, D., and Tabas, I. (2010) Atherosclerosis-relevant CD36 ligands trigger

Toll-like

receptor 2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress.

Cell

Metabolism 12:467-82.

*121. Li, G., Scull, C., Ozcan, L., and Tabas, I. (2010) NADPH oxidase links endoplasmic

reticulum stress, oxidative stress, and PKR activation to induce apoptosis. J. Cell Biol.

191:1113-1125.

122. Shechtman, C.F., Henneberry, A.L., Seimon T., Wilcox, L., Tinkelenberg, A.H.,

Albala,

A., Lee, E., Munkasci, A.B., Silverstein, S.C., Bussemaker, H.J., Tabas, I., and Sturley,

S.L.

(2011) Loss of ARV1 activates the unfolded protein response via disruption of lipid and

organelle homeostasis. J. Biol. Chem. 286: 119**-*****.

*123. Thorp, E., Iwawaki, T., Miura, M, and Tabas, I. (2011) A reporter for tracking the

unfolded protein response in vivo reveals patterns of temporal and cellular stress during

atherosclerotic progression. J. Lipid Res. 52: 1033-1038.

124. Ouimet, M., Mak, E., Franklin, V., Liao, X., Tabas, I., and Marcel, Y.L. (2011)

Lysosomal acid lipase regulates cholesterol efflux from macrophage foam cells via

autophagy.

Cell Metabolism. 13: 655 667.

125. Liang, C.P., Han, S., Li, G., Senokuchi, T., Tabas, I., Tall, A.R. (2011) Impaired

MEK

signaling and SERCA expression promotes ER stress and apoptosis in insulin resistant

macrophages and is reversed by exenatide treatment. Submitted for publication.

19

126. Richards, M.R., Black, A.S., Bonnet, D.J., Barish, G.D., Woo, C.W., Tabas, I.,

Tobias,

P.S., and Curtiss, L.K. (2011) TRIF deficiency is atheroprotective in hyperlipidemic LDL

receptor knockout mice. Submitted for publication.

*127. Woo, C.W., Kutzler, L., Kimball, S.R., and I. Tabas (2011) Toll-like receptor

activation suppresses endoplasmic reticulum stress-induced CHOP through activation of

eIF2B.

Submitted for publication.

*128. Liao, X., Sluimer, J.C., Wang, Y., Tabas, I. (2011) Macrophage autophagy plays a

protective role in advanced atherosclerosis. Submitted for publication.

*129. Thorp, E., Vaisar, T., Subramanian, M., Mautner, L., Blobel, C., and Tabas, I.

(2011)

TLR-induced cleavage of mer tyrosine kinase at proline 483 by ADAM17 requires ROS and

activation of PKCd and P38 MAPK. J. Biol. Chem., In press.

Reviews, chapters, and letters-to-editor:

1. Tabas, I., Li, E., Michael, M. and Kornfeld, S. (1979) Oligosaccharide processing

during

glycoprotein biosynthesis. IN From Gene to Protein: Information Transfer in Normal and

Abnormal Cells (Russell, T.R., Brew, K., Faber, H., and Schultz, J., eds.), Miami Winter

Symposium 16, Academic Press, New York, pp. 425-532.

2. Korn

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