Medical Project
Resume:
CURRICULUM VITAE
I. Date of preparation
July, 2011
II. Personal data
Name: Ira Abram Tabas
Birth date: April 22, 1953
Birthplace: Philadelphia, Pennsylvania
Citizenship: USA
Office address: Department of Medicine, PH 8East-105F, Columbia University
th630 West 168 Street, New York, NY 10032
Contact information: Tel: 212-***-****; Fax: 212-***-****; E-mail: ****@********.***
III. Academic training
Undergraduate: Tufts University (Medford, MA), 1975, B.S.
Graduate: Washington University (St. Louis, MO), 1981, M.D., Ph.D.
(Biochemistry)
Ph.D. Thesis: "The Processing of Asparagine-Linked Oligosaccharides During
Glycoprotein Biosynthesis"; Dr. Stuart Kornfeld, Sponsor
M.D. Licensure: State of New York (#150522)
IV. Traineeship
Internship/Residency: Internal Medicine, Columbia-Presbyterian Medical Center, New
York, NY (1981-1983)
Clinical Fellowship: Endocrinology/Metabolism, Columbia-Presbyterian Medical
Center, New York, NY (1983-1985)
Research Fellowship: Laboratory of Dr. Alan Tall, Department of Medicine, Columbia
University, New York, NY, 1983-1985
V. Board certification
Internal Medicine, 1985
Endocrinology/Metabolism, 1987
1
VI. Professional organizations and societies
Arteriosclerosis, Thrombosis, and Vascular Biology as Council of the American Heart
Association; appointed member of the Membership/Credentials Committee (1990-1992,
1997-1999); Program Committee (1992-1994; 2000-2002; 2009-present), and Executive
Board (2010)
American Society of Biochemists and Molecular Biologists
American Association for the Advancement of Science
American Society for Cell Biology
Society of Leukocyte Biology
New York Lipid Club
American Society for Clinical Investigation
Interurban Clinical Club
Association of American Physicians
VII. Academic appointments
Assistant Professor of Medicine, Columbia University College of Physicians and Surgeons,
New York, NY (1985-1992
)
Assistant Professor of Anatomy & Cell Biology, Columbia University College of Physicians
and Surgeons, New York, NY (1988-1992
)
Associate Professor of Medicine and Anatomy & Cell Biology (Tenured), Columbia
University College of Physicians and Surgeons, New York, NY (1992-1997
)
Professor of Medicine and Anatomy & Cell Biology (
Tenured), Columbia University
College of Physicians and Surgeons, New York, NY (1997-present
)
Professor of Physiology and Cellular Biophysics (Tenured), Columbia University College
of Physicians and Surgeons, New York, NY (2004-present
)
Vice-Chairman of Research, Department of Medicine, Columbia University (2004-present)
VIII. Hospital appointments
AssistantAttending Physician of Medicine, Columbia-Presbyterian Medical Center, New
York, NY (1985-1992
)
Associate Attending Physician of Medicine, Columbia-Presbyterian Medical Center, New
York, NY (1992-present
)
Attending Physician of Medicine, Columbia-Presbyterian Medical Center, New York, NY
(1997-present
)
2
IX. Honors
Phi Beta Kappa, Tufts University, Medford, MA (1974)
Summa cum laude, Tufts University, Medford, MA (1975)
Letter of Commendation, Washington School of medicine, St. Louis, MO (1977)
Mosby Scholarship Book Award, Washington University School of Medicine (1981)
Alpha Omega Alpha, Washington University School of Medicine, St. Louis (1981)
Pfizer Research Award for Young Faculty (1985-1987)]
Silberberg Assistant Professorship of Medicine, Columbia University (1988-1993)
American Heart Association Established Investigator Award (1988-1993)
Doctor Harold and Golden Lamport Research Award (1990)
Elected to the American Society for Clinical Investigation (1992)
Scientific Board of the Stanley J. Sarnoff Endowment for Cardiovascular Science, Inc.
(1992-1996)
Editorial Board of Journal of Biological Chemistry (1995-2000)
Elected to Interurban Clinical Club (1996-present)
Elected to Association of American Physicians (1998-present)
Deputy Editor, Journal of Clinical Investigation, (2002-2007)
American Heart Association/ATVB Council Special Recognition Award (2003)
Keynote Lecture, 2010 National Lipid Association Scientific Session
2011 Alumni Achievement Award, Washington University School of Medicine
Chosen for Board of Reviewing Editors for Science (2011 - )
Chairman, 2012 Deuel Lipid Conference
Distinguished Science Lecture, Polytechnic Institute of NYU (2011)
Awarded Terman Lectureship, Albert Einstein College of Medicine (2011)
X. Fellowship and grant support
Past:
Fellowship: NIH training grant (NHLBI), 1983-85, trainee
Pfizer Research Award for Young Faculty, 1985-1987, Principal Investigatr, $50,000 per
annum
3
Project of NIH SCOR Grant in Atherosclerosis (NHLBI), 1986-1990, Co-Investigator,
$104,000 per annum
Project of NIH SCOR Grant in Atherosclerosis (NHLBI), 1991, Responsible Investigator,
$90,000 per annum
Biomedical Research Support Grant (NIH), 1990-1991, Principal Investigator $5,000
American Heart Association Established Investigatorship Award, 1988-1993, rincipal
Investigator, $35,000 per annum
New York Heart Association Grant-in-Aid, Principal Investigator, 1992-1995, $42,000 per
annum
Research Supplement for Minority Individuals in Postdoctoral Training (Dr. Anselm K.
Okwu)
American Heart Association, New York City Affiliate, Participating Laboratory Award (Dr.
Yoshimune Shiratori)
Postdoctoral Fellowship Award in Atherosclerosis (Dr. Paul Skiba)
Schering-Plough Research Grant, 1989-1995, Responsible Investigator, $50,000 per annum
Individual National Research Supplement Award for Postdoctoral Training (Dr. G. Andrew
Keesler)
Postdoctoral Fellowship Award in Nutrition (Dr. Sudhir Marathe)
NIH R01 grant (NHLBI), Principal Investigator, 1992-1997, $120,000 perannum
Project of NIH SCOR Grant in Atherosclerosis (NHLBI), Responsible Investigator, 1991-
1996, $105,000 per annum
Council for Tobacco Research Award, Principal Investigator, 1995-1998, $5,000 per
annum
Postdoctoral Fellowship Award in Atherosclerosis (Dr. Wei Tang)
Research grant from Berlex Laboratories, 2003-2004, $100,000 per annum
AHA Heritage Affiliate Postdoctoral Training Grant, 2004-2005
(Dr. Tracie DeVries)
Merck Sponsored Research Project,
Principal Investigator, 2004-2006, $100,000 per annum
NIH SCOR Grant in Vascular Biology (NHLBI), Responsible Investigator or Project and
Pathology Core, 2002-2007, $282,000 per annum
NIH Individual Post-Doctoral Training Grant 2005-2007 (Dr. Tracie Seimon)
AHA Heritage Affiliate Postdoctoral Training Grant, 2005-2007
(Dr. Wahseng Lim)
AHA Scientist Development Grant, 2004-2007 (Dr. Yankun Li)
NIH Postdoctoral Fellowship Award in Atherosclerosis (Dr. Jenelle Timmins)
Boehringer-Ingelheim Sponsored Research Project, Principal Investigator, 2007, $150,000
per annum
NIH P01 grant (NHLBI), Responsible Investigator, 2001-2006, $312,000 pr annum
NIH R01 grant (NHLBI), Principal Investigator, 2002-2007, $250,000 perannum
NIH R01 grant (NHLBI), Principal Investigator, 2003-2008, $250,000 perannum
Department of Defense grant, Principle Investigator, 2006-2010, $250,000 per annum
AHA Scientist Development Grant, 2007-2010 (Dr. Tracie Seimon)
AHA Heritage Affiliate Postdoctoral Training Grant,
2007-2009 (Dr. Edward Thorp)
Fulbright Scholarship (Dorien Schrijvers)
NIH R01 grant (NHLBI), Principal Investigator, 2006-2011, $162,000 perannum
NIH K99 grant (NHLBI), mentor for Dr. Edward Thorp, 2009-2011
4
Present:
NIH P01 grant (NHLBI), Responsible Investigator, 2006-2011, $312,000 pr annum
NIH P01 grant (NHLBI), Principle Investigator, 2007-2012, $350,000 perannum
NIH R01 grant (NHLBI), Principal Investigator, 2008-2013, $250,000 perannum
NIH R01 grant (NHLBI), Principal Investigator, 2011-2015, $290,000 perannum
NHLBI Programs of Excellence in Nanotechnology, Project Investigator, 2010-2015,
$260,000 per annum
AHA Scientist Development Grant, mentor for Dr. Lale Ozcan, 2011-2013
AHA Pre-doctoral Training Grant, mentor for Ying Wang, 2011-2014
XI. Departmental and university committees
Faculty advisor for Columbia University College of Physicians and Surgeons medical
students (1986-1994)
Member of the Columbia University Research Advisory Committee for first year medical
student summer research projects (1990)
Member of the Department of Medicine Resident Selection Committee (1990-present)
Organizer of the Department of Medicine Young Faculty Research Conference (1990-1992)
Member of Department of Medicine Subcommittee on Research (1991) and Committee for
Organizing Departmental Retreat (1995)
Member of Doctoral Program Subcommittee on Nutrition (1991-present)
Co-Director of Basic Research Track of the CPMC Internal Medicine Residency Program
(1992-1997),
Scientific Advisory and Executive Committee, Medical Scientist Training (MD-PhD)
Program, Columbia University (1993-present)
Member, Curriculum Committee of the College of Physicians & Surgeons (1997-2002)
Co-Associate Director, Medical Scientist Training (MD-PhD) Program, Columbia
University (2001-present)
Chairman, Committee on Promotions of the Department of Medicine (1997-2004)
Member of Search Committees for Director of Pathology, St. Luke's Roosevelt Hosp.
(1992), Chairperson of the Department of Pharmacology, Columbia University (1994-
1995), Chairperson-Division of Cardiology, Columbia University (1999), Director of the
Irving Center for Cancer Research (2004), Chairperson-Division of Oncology (2005)
Member, Dean's Scientific Advisory Committee (2007 - present)
Vice-Chair of Research, Department of Medicine (2007 - present)
XII. Teaching experience and responsibilities
Specific courses:
Medical Student Preceptor (1989, 1991, 1994, 1996), 6 students
Abnormal Human Biology, Atherosclerosis session preceptor (1987-present), 30 students
Cellular Membranes graduate course (Department of Anatomy & Cell Biology), LDL
receptor and intracellular cholesterol metabolism sessions (1987-present), 30 students
Pharmacology graduate student course, LDL receptor session (1989-1993), 20 students
Histology medical student course, microcirculation session (1989-1994), 200 students
5
Advanced pathophysiology course for fourth year medical, atherosclerosis sessions (1990-
1996), 40 students
Pathology graduate student course (Molecular Mechanisms of Disease), organizer and
lecturer of Atherosclerosis section (1991-present), 15 students
Science Basic to the Practice of Medicine (formerly Biochemistry of Disease) medical
student course, Atherosclerosis session (1992-present), 120 students
Pathophysiology course for 2nd-year medical students, Atherosclerosis session (1997-
present), 120 students
Molecular and Cellular Biology of Nutrients, Apoptosis section (2001-) 15 students
Molecular and Cellular Cardiology Lecture Series, Transgenic Models secton (1998-), 15
fellows
Molecular Pathophysiology of the Cardiovascular System (2007-), 15 students
General teaching activities:
Attending on Internal Medicine ward service (1985-present), 2-3 students and 3 housestaff
physicians
Attending on Endocrinology ward service (1987-present), 1-2 students and 1 fellow
Attending in Combined Endocrine/Diabetes, Thyroid, and Lipid Clinics (1987-present), 1-2
students and 1-2 clinical fellows
Ph.D. Thesis sponsor:
Lori Bottalico, Department of Anatomy/Cell Biology, Columbia University (1989-1992)
Scott Schissel, Department of Anatomy/Cell Biology, Columbia University (1993-1997)
Andrew Leventhal, Department of Anatomy/Cell Biology, Columbia University (2000-
2004) Winner of the 2004 Samuel W. Rover and Lewis Rover Award for Scholarship
and Outstanding Achievement in Anatomy and Cell Biology
Ying Wang, Department of Physiology, Columbia University (2010 - )
Masters thesis sponsor:
Sungtae Lim, Institute of Human Nutrition, Columbia University (1989)
Woan-Chyng Su, Institute of Human Nutrition, Columbia University (1990)
Ph.D. Advisory/Examination committees:
Deborah A. Lazzarino, Department of Anatomy/Cell Biology, Columbia University (Ph.D.
advisory committee and examination, 1987-1990)
Shing-Jong Lin, Department of Physiology, Columbia University (Ph.D. examination, 1989)
Maria Davila-Bloom, Institute of Human Nutrition, Columbia University (Ph.D.
examination, 1989)
Fan Yuan, Department of Engineering, The City University of New York (Ph.D.
examination, 1990-1993)
Lester S. Johnson, Department of Pathology, Columbia University, Ph.D. thesis committee
(1990-1993)
Steven Rumsey, Institute of Human Nutrition, Ph.D. thesis committee (1992-1993)
6
Thomas E. Phalen, Albert Einstein College of Medicine, Ph.D. thesis defense committee
(1993)
Sripriya Chari, Integrated Program in Cellular, Molecular, and Biophysical Studies,
Qualifying Examination (1993)
Zhenglun Zhu, Department of Anatomy/Cell Biology, Columbia University (Ph.D. advisory
committee and examination, 1991-1993)
Lori Masucci, Institute of Human Nutrition, Ph.D. thesis committee (1993-1996)
Cory Huang, Department of Pathology, Ph.D. thesis committee (1995)
Mingyue Zhou, Institute of Human Nutrition, Ph.D. thesis committee (1995-)
Hong-yuan Yang, Institute of Human Nutrition, Ph.D. thesis committee (1995-)
Donata Paresce, Department of Pathology, Ph.D. thesis committee (1997)
Furcy Paultre, Institute of Human Nutrition, Ph.D. thesis committee (1997-)
Chris William, Integrated Program. Ph.D. qualifying exam (1997)
Nrgo Storey, Department of Biochemistry, Dalhousie University, Ph.D. examination, 1997
Peter Sartipy, Wallenberg Laboratory, University of Gothenburg, Sweden, opponent, 2000
Ying Lui, Institute of Human Nutrition, Ph.D. thesis committee (1999-)
Biophysica Acta (1985-present)
Ad hoc grant reviewer for National Science Foundation (1989-present)
Sub-group reviewer for American Heart Association Established Investigator and Clinical
Scientist Award grants (1991 & 1992)
Member of American Heart Association grant-in-aid study section (1992-1993)
Member Scientific Board of the Stanley J. Sarnoff Endowment for Cardiovascular Science,
Inc. (1992-1996)
Vice-chairman of American Heart Association grant-in-aid study section (1994)
Consultant for Merck, Schering-Plough, Warner-Lambert, Berlex, Eli Lilly, Pfizer, Talaria
Biotech, ReddyUS, Amersham/GE, and Bristol-Myers-Squibb, Novartis, Sankyo
Institutional representative for the American Society of Clinical Investigation (1998-
2000)
Co-Editor of October 2000 and 2001 issues of Current Opinion in Lipidoloy
Organizer and Chairman, Keystone Conference on the Cellular Biology of Atherosclerosis
(2005)
External Advisory Committee, Deuel Research Conferences (2004-2012)
Scientific Board, Kern Lipid Conference (2005-2010)
General Council and Review Panel for Future Leaders Grant Program, The Leadership
Council for Improving Cardiovascular Care (2005-)
7
Editorial Board of BBA - Molecular and Cell Biology of Lipids (2008-) ]TJ
EMC
/P >BDC
0.0005 Tc -0.0005 Tw 0 -1.
particles with and without apoprotein E. Biochemistry 33:151**-*****.
*37. Schissel, S.L., Beatini, N., Zha, X., Maxfield, F.R., and Tabas, I (1995) Effect and
cellular site of action of cysteine protease inhibitors on the cholesterl esterification
pathway in
macrophages and Chinese hamster ovary cells. Biochemistry 34:104**-*****.
*38. Shiratori, Y., Houweling, M., Zha, X., and Tabas, I. (1995) Stimulation of
CTP:phosphocholine cytidylyltransferase by free cholesterol loading of m9(acrophages
involves
signaling through protein dephosphorylation. J. Biol. Chem. 270:298**-*****.
39. Wang, N., Tabas, I., Winchester, R., Ravalli, S., Rabbani, L.E., and Tall, A. (1996)
Interleukin-8 is induced by cholesterol loading of macrophages and expressed in
macrophage
foam cells in human atheroma. J. Biol. Chem. 271:8837-8842.
*40. Skiba, P.J., Zha, X., Maxfield, F.R., Schissel, S.L., and Tabas, I (1996) The distal
pathway of lipoprotein-induced cholesterol esterification, but not sphingomyelinase-
induced
cholesterol esterification, is energy-dependent. J. Biol. Chem. 271:133**-*****.
2+
*41. Schissel, S.L., Schuchman, E.H., Williams, K.J., and Tabas, I. (1996) Zn -stimulated
sphingomyelinase is secreted by macrophages and other cell types and is a product of the
acid
sphingomyelinase gene. J. Biol. Chem. 271:184**-*****.
*42. Schissel, S.L., Tweedie-Hardman, J., Rapp, J.H., Graham, G., Williams, K.J., and
Tabas, I. (1996) Rabbit aorta and human atherosclerotic lesions hydrolyze the
sphingomyelin of
retained low-density lipoprotein. Proposed role for arterial-wall sphinomyelinase in
subendothelial retention and aggregation of atherogenic lipoproteins. J. Clin. Invest.
98:1455-
1464.
11
*43. Tabas, I., Marathe, S., Keesler, G.A., Beatini, N., and Shiratori,Y. (1996) Evidence
that the initial up-regulation of phosphatidylcholine biosynthesis in fre cholesterol-
loaded
macrophages is an adaptive response that prevents cholesterol-induced celular necrosis.
Proposed role of an eventual failure of this response in foam cell necrosis in advanced
atherosclerosis. J. Biol. Chem. 271:227**-*****.
*44. Keesler, G.A., Gabel, B., Koschinsky, M., and Tabas, I. (1996) Te binding activity
of
the macrophage lipoprotein(a)/apoprotein(a) receptor is up-regulated by colesterol via a
translational mechanism and recognizes distinct kringle domains on apoprotein(a). J.
Biol.
Chem. 271:320**-*****.
*45. Tang, W., Keesler, G.A., and Tabas, I. (1997) The structure of the gene for m8(urine
CTP:phosphocholine cytidylyltransferase (Ctpct). Relationship of exon structure to
functional
domains and identification of transcriptional start sites and potential upsream
regulatory
elements. J. Biol. Chem. 272:131**-*****.
46. Zha, X., Tabas, I., Leopold, P.L., Jones, N.L., and Maxfield, F.R. (1997) Evidence
for
prolonged cell-surface contact of acetyl-LDL before entry into macrophages. Arterio.
Thromb.
Vasc. Biol. 17:1421-1431.
*47. Schissel. S.L., Jiang, X.C., Tweedie-Hardman, J., Jeong, T.S., Camejo, E.H., Najib,
J.,
Rapp, J.H., Williams, K.J., and Tabas, I. (1998) Secretory sphingomyelinase, a product of
the
acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH.
Implications
for atherosclerotic lesion development. J. Biol. Chem. 273:2738-2746.
48. Zha, X., Pierini, L.M., Leopold, P.L., Skiba, P.J., Tabas, I., and Maxfield, F.R.
(1998)
Sphingomyelinase treatment induces ATP-independent endocytosis. J. Cell Biol. 140:39-47.
*49. Marathe, S., Schissel, S.L., Yellin, M.J., Beatini, N., Mintzer, R, Williams, K.J.,
and
Tabas, I. (1998) Human vascular endothelial cells are a rich and regulatable source of
secretory
sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell
signaling.
J. Biol. Chem. 273:4081-4088.
50. Jeong, T.S., Schissel, S.L., Tabas, I., Pownall, H.J., Tall, A.R.,Jiang, X.C. (1998)
Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout-out
mice
reflects combined production and catabolic defects and enhances reactivity with mammalian
sphingomyelinase. J. Clin. Invest. 101:905-912.
*51. Khelef, N., Buton, X., Beatini, N., Wang, H., Meiner, V., Chang, T-Y., Farese, R.V.,
Jr., Maxfield, F.R., and Tabas, I. (1998) Immunolocalization of ACAT in macrophages. J.
Biol.
Chem. 273:112**-*****.
*52. Schissel, S.L., Keesler, G.A., Schuchman, E.H., Williams, K.J., and Tabas. I. (1998)
The cellular trafficking and zinc-dependency of secretory and lysosomal sphingomyelinase,
two
products of the acid sphingomyelinase gene. J. Biol. Chem. 273:182**-*****.
12
53. Mazany, K., Peng, T., Tabas, I, and Williams, K.J. (1998) Human chondroitin 6-
sulfotransferase: cloning, gene structure, and chromosomal localization. Biochim.
Biophys.
Acta. 1407:92-97.
54. Mukherjee, S., Zha, X., Tabas, I., Maxfield, F.R. (1998) Cholesterol distribution in
living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol
analog.
Biophysical Journal 75:1915-1925.
*55. Tang, W., WalshA., and Tabas, I (1999) Macrophage-targeted CTP:phosphocholine
cytidylyltransferase (1-314) transgenic mice. Biochim. Biophys. Acta. 1437:301-316.
56. Bakovic, M., Waite, K., Tang, W., Tabas, I., Vance, D.E. (1999) Transcriptional
activation of the murine CTP:phosphocholine cytidylyltransferase gene (Ctpct). Combined
action of upstream stimulatory and inhibitory cis-acting elements. Biochim. Biophys.
Acta.
1438:147-165.
*57. Marathe, S., Kuriakose, G., Williams, K.J., and Tabas I. (1999) Sphingomyelinase, an
enzyme implicated in atherogenesis, is present in atherosclerotic lesions and bins to
extracellular matrix. Arterio. Thromb. Vasc. Biol. 19:2648-2658.
*58. Buton, X., Mamdouh, Z., Ghosh, R., Du, H., Kuriakose, G., Beatini, N., Grabowski,
G.A., Maxfield, F.R., and Tabas, I. (1999) Unique cellular events occuring during the
initial
interaction of macrophages with matrix-retained or methylated aggregated LDL. Prolonged
cell-
surface contact during which LDL-cholesteryl ester hydrolysis exceeds LD-protein
degradation. J. Biol. Chem. 274:321**-*****.
*59. Khelef, N., Soe, T.T., Quehenberger, O., Beatini, N., Tabas, I., Mxfield, F.R.
(2000)
A portion of acyl-CoA:cholesterol acyltransferase localizes near the trans-Golgi network
and the
endocytic recycling compartment in macrophages. Arterio. Thromb. Vasc. Biol. 20:1769-
1776.
Yao, P.M. and Tabas, I. (2000) Free cholesterol loading of macrophages induces
*60.
apoptosis involving the Fas pathway. J. Biol. Chem. 275:238**-*****.
*61. Wong, M-L., Xie, B., Beatini, N., Phu, P., Marathe, S., Johns, A., Hirsch E.,
Williams,
K.J., Licinio, J., and Tabas, I. (2000) Acute systemic inflammation up-regulates
secretory
sphingomyelinase in vivo: a possible new link between inflammatory cytokines and
atherogenesis. Proc. Natl. Acad. Sci. U.S.A. 97:8681-8686.
*62. Marathe, S., Miranda, S.R.P., Devlin, C., Johns, A., Kuriakose, G. Williams, K.J.,
Schuchman, E.H., and Tabas, I. (2000) Creation of a mouse model for non-neurological (type
B)
Niemann-Pick mouse model by stable, low-level expression of lysosomal sphingomyelinase in
the absence of secretory sphingomyelinase: relationship between brain intra-lysosomal
enzyme
activity and central nervous system function. Hum. Molec. Gen. 9:1967-1976.
*63. Zhang, D., Tang, W., Yao, P.M., Yang, C., Xie, B., Jackowski, S., and Tabas, I.
(2000)
Macrophages deficient in CTP:phosphocholine cytidylyltransferase-a are viable under
normal
13
culture conditions but are highly susceptible to free cholesterol-induce death. Molecular
genetic
evidence that the induction of phosphatidylcholine biosynthesis in free holesterol-loaded
macrophages is an adaptive response. J. Biol. Chem. 275:353**-*****.
*64. Marathe, S., Choi, Y., Leventhal, A., and Tabas, I. (2000) Lipoproteins from
apolipoprotein E knockout mice become potent inducers of macrophage foam cell formation
when treated with sphingomyelinase. Arterio.Thromb.Vasc.Biol. 20:2607-2613.
*65. Sakr, S., Eddy, R.J., Barth, H., Wang, F., Greenberg, S., Maxfield, F.R., and Tabas,
I.
(2001) The uptake and degradation of matrix-bound lipoproteins by macrophages require an
intact actin cytoskeleton, Rho family GTPases, and myosin ATPase activity. J. Biol. Chem.
276:376**-*****.
*66. Yao, P.M. and Tabas, I. (2001) Free cholesterol loading of macrophages is associated
with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis
pathway. J. Biol. Chem. 276:424**-*****.
Leventhal, A.R., Chen, W., Tall, A.R., and Tabas, I. (2001) Acid sphingomyelinase-
*67.
deficient macrophages have defective cholesterol efflux and trafficking. J. Biol. Chem.
276:449**-*****.
Chen, W., Sun, Y., Welch, C., Gorelik, A., Leventhal, A.R., Tabas, I., Tall, A.R. (2001)
68.
Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late
endosomes/lysosomes and a defect in Niemann-Pick Type C macrophages. J. Biol. Chem.
276:435**-*****.
*69. Devlin, C.M., Kuriakose, G., Hirsch, E., and Tabas, I. (2002) Genetic alterations of
interleukin-1 receptor antagonist in mice markedly affect non-HDL lipoprotein cholesterol
levels
and foam cell lesion size. Proc. Natl. Acad. Sci. U.S.A. 99: 6280-6285.
*70. Feng, B. and Tabas, I. (2002) ABCA1-mediated cholesterol efflux is defective in free
cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a
process requiring full npc1 activity. J. Biol. Chem. 277:432**-*****.
*71. Feng, B, Yao, P.M., Li, Y., Devlin, C., Zhang, D., Harding, H., Sweney, M., Rong,
J.X., Kuriakose, G., Fisher, E.A., Marks, A.R., Ron, D., Tabas, I. (200) The endoplasmic
reticulum as the site of cholesterol-induced cytotoxicity in macrophages. Nature Cell
Biology
5:781-792.
*72. Feng, B., Zhang, D., Kuriakose, G., Devlin, C.M., Kockx, M., and Tbas, I. (2003)
Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage
apoptosis in murine atherosclerosis. Proc. Natl. Acad. Sci. U.S.A. 100:104**-*****.
*73. Patel, M., Morrow, J., Maxfield, F.R., Strickland, D.K., Greenberg S., and Tabas, I.
(2003) The cytoplasmic domain of LDL receptor-related protein, but not that of the LDL
receptor, triggers phagocytosis. J. Biol. Chem. 278:447**-*****.
14
*74. Leventhal, A.R., Leslie, C.C., and Tabas, I. (2004) Suppression of macrophage
eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-
fatty acyl
esterification and the Niemann-Pick C pathway of lipid trafficking. J. Biol. Chem.
279:8084-
8092.
75. Liang, C.P., Han, S.A., Okamoto, H., Carnemolla, R., Tabas, I., Accili, D., Tall,
A.R.
(2004) Increased CD36 Protein as a Response to Defective Insulin Signaing in Macrophages.
J.
Clin. Invest. 113:764-773.
*76. Li, Y., Ge, M., Ciani, L., Kuriakose, G., Westover, E.J., Dura, M., Covey, D.F.,
Freed,
J.H., Maxfield, F.R., Lytton, J., and Tabas, I. (2004) Enrichment of endoplasmic
reticulum with
cholesterol inhibits SERCA2b activity in parallel with increased order o membrane lipids.
Implications for depletion of ER calcium stores and apoptosis in cholesterol-loaded
macrophages. J. Biol. Chem. 279:370**-*****.
77. Jacobs, R.J., Devlin, C., Tabas, I., Vance, D.E. (2004) Targeted deletion of hepatic
CTP:phosphocholine cytidylyltransferase-a in mice decreases plasma high density and very
low
density lipoproteins. J. Biol. Chem. 279:474**-*****.
78. Wang, L., Magdaleno, S., Tabas, I., and Jackowski, S. (2005) Early embryonic
lethality
in mice with targeted deletion of the CTP:phosphocholine cytidylyltransferasea gene
(pcyt1a).
Mol. Cell. Biol. 25:3357 3363
79. Mintzer, R.J., Appell, K.C., Cole, A., Johns, A., Pagila, R., Polooff, M.A., Tabas.
I.,
Snider, R.M., and Meurer-Ogden, J.A. (2005) A comparison of two high-throughput screening
formats to identify inhibitors of secreted acid sphingomyelinase. Journal of Biomolecular
Screening. 10:225-234.
80. Baez, J.M., Tabas, I., Cohen, D.E. (2005) Decreased lipid efflux nd increased
susceptibility to cholesterol-induced apoptosis in macrophages lacking
phosphatidylcholine
transfer protein. Biochemical J. 388:57-63
81. Wustner, D., Mondal, M, Tabas, I., and Maxfield, F.R. (2005) Direct observation of
rapid internalization and intracellular targeting of plasma membrane sterol in macrophage
foam
cells. Traffic. 6:396-412.
82. Devlin, C.M., Lee, S.J., Kuriakose, G., Spencer, C., Becker, L., Grosskopf, I., Ko,
C., Huang, L.S., Koschinsky, M.L., Cooper, A.D., Tabas, I. (2005) A cell surface-binding
apolipoprotein(a) peptide delays chylomicron remnant clearance and markedly increases
plasma
remnant lipoproteins and atherosclerosis in vivo. Arterio. Thromb. Vasc. Biol. 25:1704-
1710.
*83. Li, Y, Schwabe, R, DeVries-Seimon, T., Yao, P.M., Tall, A.R., Davis, R.J., Flavell,
R.,
Brenner, D.A., and Tabas, I (2005) Free cholesterol-loaded macrophages are an abundant
source
of TNF-a and IL-6. J. Biol. Chem. 280:217**-*****.
15
84. Jacobs, R.L., Stead, L.M., Devlin, C. Tabas, I., Brosnan, M.E., Brosnan, J.T., and
Vance, D.E. (2005) Physiological regulation of phospholipid methylation alters plasma
homocysteine in mice. J. Biol. Chem. 280:282**-*****.
*85. DeVries-Seimon, T., Li, Y., Yao, P.M., Stone, E., Wang, Y., Davis, R.J., Flavell,
R.,
and Tabas, I. (2005) Cholesterol-induced macrophage apoptosis requires both ER stress
pathways and engagement of the type A scavenger receptor. J. Cell Biol. 171:61-73.
*86. Li, Y., Gerbod-Giannone, M.C., Seitz, H., Cui, D., Thorp, E., Tall A.R., Matsushima,
G.K., and Tabas, I. (2006) Cholesterol-induced apoptotic macrophages elicit an
inflammatory
response in phagocytes that is partially attenuated by the Mer receptor. J. Biol. Chem.
281:6707-
6717.
87. Nelson, J., Jiang, X.C., Tabas, I., Tall, A.R., and Shea, S. (2006a sphingomyelin
and subclinical atherosclerosis: findings from the multi-ethnic study of atherosclerosis
(MESA).
Am. J. Epidemiol. 163:903-12
88. Gerbod-Giannone, M.C., Li, Y., Holleboom, A., Tabas, I., Tall, A.R. (2006) TNFa
induces ABCA1 via NF?B in macrophages and phagocytes ingesting apoptotic cells. Proc.
Natl.
Acad. Sci. U.S.A. 103:3112-3117.
89. Han, S., Liang, C.P., DeVries-Seimon, T., Ranalletta, M., Accili, D., Tabas, I., and
Tall,
A.R. (2006) Macrophage insulin receptor deficiency leads to increased poptosis and
necrotic
core areas in advanced atherosclerotic lesions. Cell Metabolism 3:257-266.
90. Boullier, A., Li, Y., Palinski, W., Quehenberger, O., Tabas, I., Witztum, J.L., and
Miller, Y.I. (2006) Minimally oxidized LDL offsets the apoptotic effects of extensively
oxidized
LDL and free cholesterol in macrophages. Arterio. Thromb. Vasc. Biol. 26: 1169 - 1176.
*91. Bao, L., Li, Y., Deng, S.X., Landry, D., and Tabas, I. (2006) Sitosterol-containing
lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent
macrophages. Implications for sterol structure-dependent mechanisms of cell death and for
atherosclerotic vascular disease in sitosterolemia. J. Biol. Chem. 281:336**-*****.
*92. Seimon, T.A., Obstfeld, A., Moore, K.J., Golenbock, D.T., and Tabas, I. (206)
Combinatorial pattern recognition receptor signaling alters the balance of lfe and death
in
macrophages. Proc. Natl. Acad. Sci. U.S.A. 103:197**-*****.
*93. Li, Y. and Tabas, I. (2007) The inflammatory cytokine response of cholesterol-
enriched macrophages is suppressed by stimulated pinocytosis. J. Leukoc. Biol. 81:
483 491.
*94. Cui, D., Thorp, E., Li, Y., Wang, N., Yvan-Charvet, L., Tall, A.R., Tabas, I. (2007)
Pivotal Advance: Macrophages become resistant to cholesterol-induced death after
phagocytosis of apoptotic cells. J. Leukoc. Biol. 82:1040-50.
16
95. Bao, S., Li, Y., Leia, X., Wohltmanna, M., Bohrera, A., Ramanadhama, S., Tabas, I.,
and Turk, J. (2007) Attenuated free cholesterol loading-induced apoptosis but preserved
phospholipid composition of peritoneal macrophages from mice that do not express group
VIA
phospholipase A2. J. Biol. Chem. 282:27100-14.
*96. Thorp, E., Kuriakose, G., Shah, Y.M., Gonzalez, F.J., Tabas, I. (007) Pioglitazone
increases macrophage apoptosis and plaque necrosis in advanced atherosclerotic lesins of
non-
diabetic LDL receptor-null mice. Circulation 116:2182-2190.
*97. Lim, W., Timmins, J., Seimon, T.A., Sadler, A., Kolodgie, F., Virmani, R.,
Schindler,
C., and Tabas, I. (2008) Signal transducer and activator of transcription-1 is critical
for apoptosis
in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced
atherosclerotic lesions in vivo. Circulation 117:940-951.
*98. Iqbal, J., Dai, K., Seimon, T.A., Jungreis, R., Oyadomari, M., Ron, D., Tabas, I.,
Hussain, M. (2008) IRE1B restricts chylomicron production by selectively degrading MTP
mRNA. Cell Metabolism 7:445-55 (Dr. Tabas, co-communicating author)
*99. Thorp, E., Cui, D., Kuriakose, G., and Tabas, I. (2008) Mutatio of the Mertk
receptor
promotes apoptotic cell accumulation and plaque necrosis in advanced atherosclerotic
lesions of
apolipoprotein E-deficient mice. Arterio. Thromb. Vasc. Biol. 28:1421-8.
*100. Devlin, C.M., Leventhal, A.R., Kuriakose, G., Schuchman, E.H., Williams, K.J.,
Tabas, I. (2008) Acid sphingomyelinase promotes lipoprotein retention within early
atheromata
and accelerates lesion progression. Arterio. Thromb. Vasc. Biol. 20:2607-2613.
101. Senokuchi, T., Liang, C.P., Seimon, T.A., Han, S., Matsumoto, M., J.H., DePinho,
R.A., Accili, D., Tabas, I., and Tall, A.R. (2008) FoxOs promote apoptosis of insulin
resistant
macrophages during cholesterol-induced ER stress. Diabetes 57:2967-76.
102. Manning-Tobin, J.J., Moore. K.J., Seimon, T.A., Bell, S.A., Sharuk, M., Alvarez-
Leite, J.I., de Winther, M.P.J., Tabas, I., Freeman, M.W. (2009) Loss of SR-A and CD36
activity
reduces atherosclerotic lesion complexity without abrogating foam cell formation in
hyperlipidemic mice. Arterio. Thromb. Vasc. Biol. 29:19-26.
*103. Thorp, E., Li, Y., Bao, L., Yao, P.M., Kuriakose, G., Rong, J., Fsher, E.A., Tabas,
I.
(2008) Increased apoptosis in advanced atherosclerotic lesions of Apoe-/- mice lacking
macrophage Bcl-2. Arterio. Thromb. Vasc. Biol. 29:169-72.
104. Packard, R.R.S., Tabas, I., Libby, P., Lichtman, A.H. (2008) CD11c dendritic
cells
maintain antigen processing, presentation capabilities, and CD4 T-cel priming efficacy
under
hypercholesterolemic conditions associated with atherosclerosis. Circulation Res.103:965-
973.
*105. Li, Y., Zhang, Y., Dorweiler, B., Cui, D., Wang, T., Woo, C.W., Wolberger, C.,
Imai,
S., Tabas, I. (2008) Extracellular Nampt protects macrophages from ER stress-induced
apoptosis
17
via a non-enzymatic interleukin-6/STAT3 signaling mechanism. J. Biol. Chem. 283:34833
34843.
*106. Seimon, T., Wang, Y., Kuriakose, G., Han, S., Senokuchi, T., Tall, A., Tabas, I.
(2009) Deficiency of p38a in macrophages promotes apoptosis and plaque necrosis in
advanced
murine atherosclerotic lesions. J. Clin. Invest. 119:886-898.
107. Sun, Y., Ishibashi, M., Seimon, T., Sharma, S.M., Fitzgerald, K.A., Samokhin, A.O.,
Wang. Y., Sayers, S., Aikawa, M., Jerome, G.W., Ostrowski, M.C., Bromme, D., Libby. P.,
Tabas, I., Welch, C.L., Tall, A.R. (2009) Free cholesterol accumulation in macrophage
membranes activates Toll-like receptors, p38 MAP kinase and induces cathepsi K.
Circulation
Res. 104:455-465.
*108. Thorp, E., Li, G., Seimon, T.A., Kuriakose, G., Ron, D., Tabas, I. (2009) Reduced
apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/-
mice
lacking CHOP. Cell Metabolism 9:474-481.
*109. Timmins, J., Ozcan, L., Seimon, T.A., Li, G., Malagelada, C., Backs, J., Backs, T.,
Bassel-Duby, R., Olson, E.N., Anderson, M.E., and Tabas, I. (2009) Calium/calmodulin-
dependent protein kinase II links endoplasmic reticulum stress with Fas and mitochondrial
apoptosis pathways. J. Clin. Invest. 119:2925-2941.
*110. Li, G., Mongillo, M., Chin, K-T., Harding, H., Ron, D., Marks, A.R., and Tabas, I.
(2009) Role of ERO1a-mediated stimulation of inositol 1,4,5-triphosphate receptor
activity in
endoplasmic reticulum stress-induced apoptosis. J. Cell Biol. 186:783-792.
*111. Woo, C.W., Cui, D., Arrelano, J., Dorweiler,B., Harding, H., Fitzgerald, K.A., Ron,
D., and Tabas, I. (2009) Adaptive suppression of the ATF4-CHOP branch of the unfolded
protein
response by toll-like receptor signaling. Nature Cell Biol. 11:1473-1480.
112. Li, S., Sun, Y., Thorp, E., Jehle, A., Viswanathan, S., Kanter, J., Hasty, A.,
Bornfeldt,
K., Tabas, I., Tall, A.R. (2009) Defective phagocytosis of apoptotic cells by ob/ob
peritoneal and
atherosclerotic lesional macrophages: reversal of defects by PPAR?/d activation and fish
oils.
Circulation Res. 105:1072-1082.
*113. Devlin, C., Pipalia, N.H., Liao, X., Schuchman, E.H., Maxfield, F.R., Tabas, I.
(2009)
Marked improvement in lipid and protein trafficking in a lysosomal storage disease cell
by
correction of a secondary enzymatic defect. Traffic 11:601 615.
114. Yeboah, J., McNamara, C, Jiang, X.C., Tabas, I., Herrington, D.M., Burke, G.L., and
Shea, S. (2010) Association of plasma sphingomyelin levels and incident coronary heart
disease
events in an adult population: multi ethnic study of atherosclerosis. Arterio. Thromb.
Vasc. Biol.
30:628-633.
115. Nawrocki, A.R., Hofmann, S.M., Teupser, D., Basford, J.E., Durand, J.L., Rickes,
E.L.,
Jelicks, L.A., Tanowitz, H.B., Chang, C.H., Hui, D.Y., Woo, C.W., Kuriakose, G., Tabas,
I., and
18
Scherer, P.E. (2010) Adiponectin Effects on Atherogenesis in LDL Receptor Null Mice.
Arterio.
Thromb. Vasc. Biol. 30:1159-1165.
116. Chandak, P.G., Radovic, B., Aflaki, E., Kolb, D., Buchebner, M., Rathke, N.,
Frohlich,
E., Haemmerle, G.., Tabas, I., Zechner, R., Levak-Frank, S., and Kratky, D. (2010)
Efficient
phagocytosis requires triglyceride hydrolysis by adipose triglyceride liase. J. Biol.
Chem. 285:
117. Tam, C., Idone, V., Devlin, C., Tabas, I., Andrews, N.W. (2010) Exocytosis of acid
sphingomyelinase upon cell injury triggers endocytosis and plasma membrane repair. J.
Cell.
Biol. 189:1027-38.
118. Yvan-Charvet, L., Pagler, T.A., Seimon, T.A., Thorp, E., Welch, C.L., Witztum, J.L.,
Tabas, I., and Tall, A.R. (2010) ABCA1 and ABCG1 protect against oxidative stress induced
macrophage apoptosis during efferocytosis. Circulation Res. 106:1861-1869.
119. Seimon, T.A., Kim, M.J., Blumenthal, A., Koo, J., Ehrt, S., Wainwright, H., Bekker,
L.G., Kaplan, G., Nathan, C., Tabas, I., Russell, D.G.. (2010) Induction of ER stress in
macrophages of tuberculosis granulomas. PLoS One. 2010 Sep 15;5:e12772 .
*120. Seimon, T.A., Liao, X., Magallon, J, Nguyen, M., Witztum, J.L., Tsimikas, S.,
Moore,
K.J., Golenbock, D., and Tabas, I. (2010) Atherosclerosis-relevant CD36 ligands trigger
Toll-like
receptor 2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress.
Cell
Metabolism 12:467-82.
*121. Li, G., Scull, C., Ozcan, L., and Tabas, I. (2010) NADPH oxidase links endoplasmic
reticulum stress, oxidative stress, and PKR activation to induce apoptosis. J. Cell Biol.
191:1113-1125.
122. Shechtman, C.F., Henneberry, A.L., Seimon T., Wilcox, L., Tinkelenberg, A.H.,
Albala,
A., Lee, E., Munkasci, A.B., Silverstein, S.C., Bussemaker, H.J., Tabas, I., and Sturley,
S.L.
(2011) Loss of ARV1 activates the unfolded protein response via disruption of lipid and
organelle homeostasis. J. Biol. Chem. 286: 119**-*****.
*123. Thorp, E., Iwawaki, T., Miura, M, and Tabas, I. (2011) A reporter for tracking the
unfolded protein response in vivo reveals patterns of temporal and cellular stress during
atherosclerotic progression. J. Lipid Res. 52: 1033-1038.
124. Ouimet, M., Mak, E., Franklin, V., Liao, X., Tabas, I., and Marcel, Y.L. (2011)
Lysosomal acid lipase regulates cholesterol efflux from macrophage foam cells via
autophagy.
Cell Metabolism. 13: 655 667.
125. Liang, C.P., Han, S., Li, G., Senokuchi, T., Tabas, I., Tall, A.R. (2011) Impaired
MEK
signaling and SERCA expression promotes ER stress and apoptosis in insulin resistant
macrophages and is reversed by exenatide treatment. Submitted for publication.
19
126. Richards, M.R., Black, A.S., Bonnet, D.J., Barish, G.D., Woo, C.W., Tabas, I.,
Tobias,
P.S., and Curtiss, L.K. (2011) TRIF deficiency is atheroprotective in hyperlipidemic LDL
receptor knockout mice. Submitted for publication.
*127. Woo, C.W., Kutzler, L., Kimball, S.R., and I. Tabas (2011) Toll-like receptor
activation suppresses endoplasmic reticulum stress-induced CHOP through activation of
eIF2B.
Submitted for publication.
*128. Liao, X., Sluimer, J.C., Wang, Y., Tabas, I. (2011) Macrophage autophagy plays a
protective role in advanced atherosclerosis. Submitted for publication.
*129. Thorp, E., Vaisar, T., Subramanian, M., Mautner, L., Blobel, C., and Tabas, I.
(2011)
TLR-induced cleavage of mer tyrosine kinase at proline 483 by ADAM17 requires ROS and
activation of PKCd and P38 MAPK. J. Biol. Chem., In press.
Reviews, chapters, and letters-to-editor:
1. Tabas, I., Li, E., Michael, M. and Kornfeld, S. (1979) Oligosaccharide processing
during
glycoprotein biosynthesis. IN From Gene to Protein: Information Transfer in Normal and
Abnormal Cells (Russell, T.R., Brew, K., Faber, H., and Schultz, J., eds.), Miami Winter
Symposium 16, Academic Press, New York, pp. 425-532.
2. Korn
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