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CURRICULUM VITAE

Name: Wei Zhang, Ph.D.

Title and Affiliation:

a.Primary Appointment: Professor of Pathology (with tenure), Professor of Cancer Biology,

Department of Pathology, Division of Pathology and Laboratory Medicine, The University of

Texas M. D. Anderson Cancer Center.

b.Joint Appointment: Professor, Department of Cancer Biology, The University of Texas M.

D. Anderson Cancer Center

.

c.Joint Appointment:

Professor, University of Texas Health Science Center, Graduate

School of Biomedical Science

.

Project Director: National Foundation for Cancer Research

Office Address:

Department of Pathology

Box 85,

1515 Holcombe Boulevard

Houston, TX 77030

Tel/Fax: 713-***-****/713-***-****

e-mail: ******@**********.***

Education:

University of Texas Graduate School of Biomedical Sciences. Ph.D.

University of Texas Graduate School of Biomedical Sciences, M.S.

Beijing University, Beijing, China. B.S.

Editorship

Editorial Board Member, Clinical Cancer Res., (2001-)

Editorial Academy member, International J of Oncology (2004- )

Editorial Board Member, Neuro-Oncology (2004-2009 )

Editorial Board Member and Core Reviewer, BMC Genomics (2003-2010)

Associate Editor, BMC Genomics (2010--)

Editorial Board Member, Histology and Histopathology (2003-)

Editorial Board Member, Cancer Biology and Therapy (2002- )

Editorial Board Member, Technology in Cancer Research and Treatment (2002-)

Editorial Board Editor, Chinese J Clinical Oncology (2004-2008)

Associate Editor, Chinese J Clinical Oncology (2008-)

Editorial Board Member, Molecular Cancer (2003-)

Section Editor, Molecular Pathology, Archives of Pathology and Laboratory Medicine (2006-

)

Editorial Board Member, Current Cancer Therapy Rrviews, (2005)

Associate Editor, Comparative and Functional Genomics. (2007-)

Editorial Board Member, Cancer Letters. [

Ad Hoc membership:

Member on NHLBI Shared Microarray Facilities RFA-HL-02-007, National Heart, Lung, and

Blood Institute (2002)

Mail reviewer on NIH special reviewing panel ZRG1 SSS-P 09 S (Sept 2002)

Member, NIH Assays and Methods Development Study Section (Nov 9-10, 2004)

Member, NIH Assays and Methods Development Study Section (Aug 9-10, 2005)

Member, NIH Assays and Methods Development Study Section (Nov 2-3, 2005)

Member, NIH Assays and Methods Development Study Section (Mar16-17, 2006)

Member, NIH Cell Signaling and Dynamics (CSD) Study Section (June 8-9, 2006)

Member, NIH Cancer Genetics (CG) Study Section (June 19-20, 2006)

Member, NIH Assays and Methods Development Study Section (July 6, 2006)

Member, NIH Device and Detection Sciences Study Section (July 7, 2006)

Member, NIH Cell Signaling and Dynamics (CSD) Study Section (Oct 12-13, 2006)

Member, NIH Cancer Genetics (CG) Study Section (Feb 13-14, 2007)

Member, NIH Molecular Oncology PO1 Study Section (June 4-5, 2007)

Member, NIH Cancer Genetics (CG) Study Section (Oct 1-2, 2007)

Member, NIH Molecular Oncology PO1 Study Section (Oct 2-3, 2007)

Member, NIH Instrumentation and Systems Development (ISD) study section (February 6-7,

2008)

Member, NIH ZRG1 ONC-P (02)-Cancer Biomarkers Study Section (Feb 27, 2008)

Member, NIH Cancer Genetics (CG) Study Section (June 2008)

Member, NIH Comparative Systems Genetics of Cancer study section (July 2008)

Regular Member, NIH Cancer Genetics (CG) study section (Oct 9-10, 2008)

Regular Member, NIH Cancer Genetics (CG) study section (February 9-10, 2009)

Member, NIH ZRG1-OBT P(95) Topics in Cancer Genetics study section (June 8-9)

Regular Member, NIH Cancer Genetics (CG) study section (June 8-9, 2009)

Member, ZRG1 OBT-A (58) R (July 2009)

Regular Member, NIH Cancer Genetics (CG) study section (Oct 1-2, 2009)

Member, NIH ZRG1 CBSS-P (08) F Tumor Biomarkers study section (Oct 1-2, 2009)

Member, NIH Shared Instrumentation study section (Oct 28-29, 2009)

Regular Member, NIH Cancer Genetics (CG) study section (February, 2010)

Regular Member, NIH Cancer Genetics (CG) study section (June, 2010)

Other US government agency:

Reviewer for American Institute of Biological Sciences [The U.S. Army Medical Research

and Materiel Command (USAMRMC)] (2001)

Reviewer for American Institute of Biological Sciences [The U.S. Army Medical Research

and Materiel Command (USAMRMC)] (2002)

Reviewer for American Institute of Biological Sciences [The U.S. Army Medical Research

and Materiel Command (USAMRMC)] (A Center of Excellence grant) (2004)

Reviewer for American Institute of Biological Sciences [The U.S. Army Medical Research

and Materiel Command (USAMRMC)] (Center of Excellence grant) (2006)

Reviewer for American Institute of Biological Sciences [The U.S. Army Medical Research

and Materiel Command (USAMRMC)] (2008)

Reviewer for the New York State Department of Health and Empire State Stem Cell Board's

NYSTEM program (October 2008)

Reviewer for American Institute of Biological Sciences [The U.S. Army Medical Research

and Materiel Command (USAMRMC)] (September 2009)

Reviewer for American Institute of Biological Sciences [The U.S. Army Medical Research

and Materiel Command (USAMRMC)] (2010)

Others:

Invited Grant Reviewer for Canadian Institute of Health Research (2000)

Invited reviewer for the Sealy Center for Environmental Health and Medicine

Multidisciplinary/multi-investigator pilot project program (2001)

Invited reviewer for Innovation and Technology Support Programme of the Government of the

Hong Kong Special Administrative Region (2001)

Reviewer for grants of The National Medical Research Council (Singapore) (2003)

Reviewer for grants of The National Medical Research Council (Singapore) (2004)

Invited reviewer for the State of Pennsylvania Department of Health Summer 2005 Final

Performance Review

Reviewer, The Health Research Board in Ireland (2005)

Reviewer, Alberta Heritage Foundation for Medical Research, Canada (2006)

Invited reviewer for the State of Pennsylvania Department of Health Summer 2006 Final

Performance Review (November, 2006)

External reviewer for the Partnership research and training collaboration program between

Memorial Sloan-Kettering Cancer Center (MSKCC) and the City College of New York (CCNY)

(2006, 2007)

External reviewer, NIEHS Center/SCEHM, University of Texas Medical Branch (2007)

Invited reviewer for the State of Pennsylvania Department of Health Summer 2006 Final

Performance Review (April 23-24, 2007).

External reviewer, The Luxembourg National Research Fund (FNR) (May 2007)

Invited reviewer for the State of Pennsylvania Department of Health 2007 Final

Performance Review (July, 2007).

Invited reviewer for the State of Pennsylvania Department of Health 2007 Final

Performance Review (December, 2007).

Invited reviewer for the State of Pennsylvania Department of Health 2007 Final

Performance Review (May 2008).

Reviewer for the National Medical Research Council (Singapore) (2008)

Arizona Cancer Center U54 NIH/NCI developmental grant (2008)

Reviewer for Shriver Sarcoma Initiatives (2008-2009]

Invited reviewer for the State of Pennsylvania Department of Health Final Performance

Review (July, 2009)

Reviewer for grants of The National Medical Research Council (Singapore) (December, 2009)

Invited reviewer for the State of Pennsylvania Department of Health Final Performance

Review (March, July, 2010)

Current grant support

NIH/NCI 2 RO1 CA98503-6. 2004-2014. Dissecting Glioma Through Genomics and Tissue-

Specific Transgenic Mouse Model PI: Wei Zhang, co-PI: Gergory N. Fuller. This RO1 will be

renewed for 5 years beginning in August 2010

NIH R01 CA141432 (Zhang W; Fuller GN). 08/01/2010-7/31/2014. Oncogene cooperation in

glioma genesis and progression.

NIH U24 CA143835. PI: Ilya Shmulevich; Co-PI: Wei Zhang. 01/01/10 31/12/15. Center for

Systems Analysis of the Cancer Regulome.

NIGMS/NIH. R01 GM072855-01 (PI: Shmulevich, I). Computational and Experimental

Investigations of Genetic Regulatory Networks. PI of MDACC subcontract

National Foundation for Cancer Research grant. PI: Zhang, W. co-PI: Stanley R. Hamilton.

NGAL in colon cancer.

National Foundation for Cancer Research grant. Hope Fund PI: Zhang, W. Genomic

characterization of MPNST.

National Foundation for Cancer Research grant. PI: Zhang, W. 10/1/09-10/1/11.

Identification of Prognostic Markers for Colorectal Cancer.

Goldhirsh Foundation. PI: Wei Zhang. Validating the IGFBP2-ILK-NFkB pathway in glioma

development and progression by a glial specific mouse model.

James S. McDonnell Foundation. PI: Zhang W. Control of glioma cell migration by IIp45 and

HDAC6.

Liddy Shriver Sarcoma Initiative and the Reid R. Sacco Memorial Foundation. (PI: Wei

Zhang and Jilong Yang). 08/01/10-07/31/11. Targeting EGFR and IGF-1R in MPNST.

NIH/NCI. 2 R01 ES011740-06A2. PI: Qingyi Wei. 02/01/08 - 01/31/13. Molecular Epidemiology

of DNA Repair in Head and Neck Cancer. Role on grant: co-investigator.

NIH/NCI 1R21 CA129671 01A1 (PI: Jianhua Hu).

08/01/2009-07/31/2011. Nonparametric

analysis of reverse-phase protein lysate array data. Role: Co-investigator.

Past grant support

Characterization of leiomyodsarcoma and GIST by Genomics. NIH/NCI. RO1 CA098570-01. PI:

Wei Zhang, co-PI: Raphael Pollock.

NCI First Award, Texas Higher Education coordinating Board ATP grant and ARP grant, RGK

Foundation, DOD Breast Concept grant, Univeristy Cancer Foundation Award, Anthony Bullock

III Research fund. NFCR award, Goldhirsh Foundation grant, Commonwealth Foundation for

Cancer Research Grant.

BIBLIOGRAPHY:

A. Books

Computational and Statistical Approaches to Genomics. Zhang W and Shmulevich I Kluwer

Academic, 2002.

Genomic and Molecualr Neuro-Oncology. Zhang W and Fuller GN, Jones and Bartlett

Publishers, 2003.

Microarray Quality Control. Zhang W, Shmulevich I, and Astola J. Wiley, 2004.

Genomic and Molecular Neuro-Oncology. Zhang W and Fuller GN, eds. Translated into Chinese

by Pu P et al. Tianjin Science and Technology Translation Publishing Company, 2005.

Computational and Statistical Approaches to Genomics. Second Edition. Zhang W and

Shmulevich I. Springer, 2006

B. Published and accepted articles in referred journals:

Gossett, L.A., Zhang, W. and Olson, E. Dexamethasone-dependent Inhibition of

Differentiation of C2 Myoblasts Bearing Steroid-Inducible N-ras Oncogene. J. Cell. Biol.

106:2127-2137, 1988.

Wessel, G.M., Zhang, W., Tomlinson, C.R., Lennarz, W.J., and Klein, W.H. Selective

Transcriptional Dependence on the Extracellular Matrix During Sea Urchin Development.

Development. 106:355-365, 1989.

Wessel, G. M., Zhang, W., and Klein, W.H. Myosin Heavy Chain Accumulates in Dissimilar

Cell Types of the Macromere Lineage in the Sea Urchin Embryo. Developmental Biology.

140:447-454, 1990.

Gan, L.*, Zhang, W.*, and Klein, W.H. Repetitive DNA Sequence Linked to the Sea Urchin

Spec Genes Contain Transcriptional Enhancer-Like Elements. Developmental Biology. 139:186-

196, 1990. *Co-first authors.

Zhang, W., Hu, G., and Deisseroth, A. B. Improvement of PCR Sequencing by Formamide.

Nucleic Acids Res. 19:6649, 1991.

Zhang, W. and Deisseroth, A. B. Effects of Nucleotide Concentration on Specificity of

Sequence Amplification. BioTechnique. 11:60-61, 1991.

Zhang, W., Hu, G., Estey, E., Hester, J., and Deisseroth, A. B.. Altered Conformation of

the p53 Protein in Myeloid Leukemia Cells and Mitogen-stimulated Normal Blood cells.

Oncogene. 7:1645-1647, 1992.

Zhang, W., Hu, G., and Deisseroth, A. B. Polymorphism at Codon 72 of the p53 Gene in

Human Acute Myelogenous Leukemia. Gene. 117:271-275, 1992.

Zhang, W., Reading, C., and Deisseroth, A. B. Improved PCR sequencing with formamide.

Trends in Genetics. 8:332, 1992.

Hu, G., Zhang, W., and Deisseroth, A. B. p53 Gene Mutation in Acute Myelogenous Leukemia.

Brit. J. Hematol. 81:489-494, 1992.

Kornblau, S.M., Xu, H.-J., del Giglio, A., Hu, S.-X., Zhang, W., Calvert, L., Beran, M.,

Estey, E., Andreeff, M., Trujillo, J., Cork, A., Smith, T.L., Benedict, W.F., and

Deisseroth, A. B. Clinical Implications of Decreased Retinoblastoma Protein Expression in

Acute Myelogenous Leukemia. Cancer Res. 52:4587-4590, 1992.

Zhang, W., Hittelman, W., Van, N., Andreeff, M., and Deisseroth, A. B. The

Phosphorylation of Retinoblastoma Gene Product in Human Myeloid Leukemia Cells During the

Cell Cycle. Biochem. Biophys. Res. Commun. 184:212-216, 1992.

Zhang, W., Drach, J., Andreeff, M., and Deisseroth, A.B. Proliferation of Hematopoietic

Cells is Accompanied by Suppressed Expression of Heat Shock Protein 70. Biochem. Biophys.

Res. Commun. 183:733-738, 1992.

Kantarjian, H., Talpaz, M., Wetler, M., O'Brien, S., Estey, E., Plunkett, W., Zhang, W.,

Keating, M. J., and Deisseroth, A. B. Chronic myelogenous leukemia in blastic phase: A

model of heterogeneity and resistance in acute leukemia. Blut 34:214-221, 1992.

Zhang, W., Funk, W., Wright, W., Shay, J., and Deisseroth, A. B. Novel DNA Binding of p53

Mutants and Their Role in Transcriptional Activation. Oncogene 8: 2555-2559, 1993.

Zhang, W., Cork, A., Trujillo, J., Calvert, L., Hu, G., Andersson, B., and Deisseroth, A.

B. Mutations of the p53 Gene Are Associated with Genetic Instability and Immortalization

in Myelogenous Leukemia. Cancer Res., Therapy and Control. 3:139-144, 1993.

Zhang, W., Shay, J., and Deisseroth, A. B.. Inactive p53 Mutants may Enhance the

Transcriptional Activity of Wild-type p53. Cancer Res. 83:4772-4775, 1993.

Zhang, W., Guo, X.-Y., Hu, G.-Y., Liu, W.-B., Shay, J. W., and Deisseroth, A. B. A

Temperature Sensitive Mutant of human p53. EMBO J. 13:2535-2544, 1994.

Zhang, W., Randhawa, G. S., Guo, X. -Y., and Deisseroth, A. B. DNA binding and

transcriptional activation abilities are necessary but not sufficient for the

antiproliferative function of p53. Cell Growth & Differentiation 5:705-710, 1994.

Kornblau, S.M., Xu, H.-J., Zhang, W.,, Beran, M., Smith, T.L., Benedict, W.F., and

Deisseroth, A. B. Clinical Implications of Decreased Retinoblastoma Protein Expression in

Acute Myelogenous Leukemia. Blood 84:256-261, 1994.

Zhang, W. and Deisseroth, A. B. Conformational Change of p53 Protein in Growth Factor-

Stimulated Human Myelogenous Leukemia Cells. Leukemia and Lymphoma 14:251-255, 1994.

Zhang, W., Guo, X.-Y., and Deisseroth, A. B. The requirement of the carboxyl terminus of

p53 for DNA binding and transcription activation depends on the specific p53 binding DNA

element. Oncogene 9:2513-2521, 1994.

Zhang, W., McClain, C. D., Gau, J-P., Guo, X.-Y., and Deisseroth, A. B.

Hyperphosphorylation of p53 by Okadaic Acid Attenuates its Transcriptional Activation

Function. Cancer Res. 54:4448-4453, 1994.

Zhang, W., Grasso, L., McClain, C. D., Gambel, A. M., Cha, Y., Travali, S., Deisseroth,

A. B., and Mercer, W. E. p53-independent Induction of WAF1/Cip1 in human myeloid leukemia

cells is correlated with growth arrest accompanying monocyte/macrophage differentiation.

Cancer Res. 55:668-674, 1995.

Zhang, W., Xu, H-J., Kornblau, S., Drach, J., Hu, S-X, Andreeff, M., Benedict, W., and

Deisseroth, A. B. Growth Factor Stimulation Reveals Two Mechanisms of Retinoblastoma Gene

Inactivation in Human Myelogenous Leukemia Cells. Leukemia and Lymphoma 16:191-198, 1995.

Owen-Schaub, L.B., Zhang, W., Cusack, J., Angelo, L. S., Santee, S. M., Fujiwara, T.,

Roth, J. A., Deisseroth, A. B., Zhang, W.-W., Kruzel, E., and Radinsky, R. Wild-type and a

temperature-sensitive mutant of human p53 induce Fas/APO-1 expression. Mol Cell Biol.

15:3032-3040, 1995.

Zhang, W., Kornblau, S. M., Kobayashi, T., Gambel, A., McClain, C. D., Claxton, D., and

Deisseroth, A. B. High levels of constitutive WAF1/Cip1 protein are associated with

chemoresistance in acute myelogenous leukemia. Clinical Cancer Res. 1:1051-1057, 1995.

Jung, J. M., Li, H., Kobayashi, T., Kyritsis, A., Bruner, J., Langford, L., Levin, V.,

and Zhang, W. The inhibition of human glioblastoma cell growth by WAF1/Cip1 can be

attenuated by mutant p53. Cell Growth & Differentiation. 6:909-913, 1995.

Fueyo, J., Gomez-Manzano, C., Yung, W. K. A., Zhang, W., Lee, P. S. Y., Majumder, S.,

Pershouse, M., Levin, V. A., and Kyritsis, A. P. A frequency polymorphism of the p16/CDKN2

gene. Mol. Cell. Probe 9:465-466, 1995.

Kobayashi, T., Consoli, U., Andreeff, M., Shiku, H., Deisseroth, A.B., and Zhang, W.

Activation of WAF1/Cip1 by a temperature sensitive mutant of human p53 does not lead to

apoptosis. Oncogene 11:2311-2316, 1995.

Jung, J.M., Bruner, J.M., Ruan, S.-B., Langford, L., Kyritsis, A.P., Kobayashi, T.,

Levin, V.A., and Zhang, W. Increased levels of p21WAF1/Cip1 in human brain tumors.

Oncogene 11:2021-2028, 1995.

Zhang, W., Randhawa, G., Gau, J.-P., Shay, J. W., and Deisseroth, A. B. The first intron

of human H-ras oncogene is regulated by p53: Mediation of specific activation by a p53-

binding element. Int. J. Oncol. 7:1021-1028, 1995.

Kyritsis, A. P., Zhang, B.-H., Zhang, W., Xiao, M., Takeshima, H., Bondy, M. L.,

Cunningham, J. E., Levin, V. A., Bruner, J. Mutations of the p16 gene in gliomas. Oncogene

12:63-67, 1996.

Zhang, W., Piatyszek, M. A., Kobayashi, T., Estey, E., Andreeff, M., Deisseroth, A. B.,

and Shay, J. W. Detection of telomerase activity in human acute myelogenous leukemia and

modulation of the activity by differentiation-inducing agents. Clinical Cancer Res. 2:799-

803, 1996.

Munker, R., Kobayashi, T., Elstner, E., Norman, A. W., Uskokovic, M., Zhang, W.,

Andreeff, A., and Koeffler, H. P. A new series of vitamin D analogs is highly active for

clonal inhibition, differentiation, and induction of WAF1 in myeloid leukemia. Blood.

88:2201-2209, 1996.

Fueyo, J., Gomez-Manzano, C., Bruner, J. M., Saito, Y., Zhang, B., Zhang, W., Levin, V.

A., Yung, W. K. A., and Kyritsis, A. P. Hypermethylation of the CpG island of p16/CDKN2

correlates with gene inactivation in glioma. Oncogene 13:1615-1619, 1997.

Kobayashi, T., Clodi, K., Yang, Y., Ruan, S., Shiku, H., Andreeff, M., Shay, J., and

Zhang, W. Inhibition of telomerase activity correlates with a decrease in the RNA

component of telomerase during differentiation. Int. J. Oncol 11:13-17, 1997.

Consoli, U., Li, H., Huang, P., Kobayashi, T., Andreeff, M., Levin, V., and Zhang, W.

Perturbation of G2 arrest and enhancement of DNA break and micronucleation in irradiated

glioblastoma cells by pentoxifylline. Oncology Report 4:673-678, 1997.

Grau, A.M., Zhang, L., Wang, W, Ruan, S.-B., Evans, D.B., Abbruzzese, J.L., Zhang, W.,

and Chiao, P.J. Induction of p21/WAF1 expression and growth inhibition by transforming

growth factor-b involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma

cells. Cancer Res. 57:3929-3934, 1997.

Ruan, S.-B., Fuller, G., Levin, V., Bruner, J., and Zhang, W. Expression of p21/WAF1/Cip1

in brain metastases. J. Neuro-Oncology 37:223-228, 1998.

Kobayashi, T., Ruan, S.-B., Jabbur, J. R., Consoli, U., Clodi, K., Shiku, H., Owen-

Schaub, L., Andreeff, M., Reed, J., and Zhang, W. Differential p53 phosphorylation and

activation of apoptosis-promoting genes Bax and Fas/APO-1 by radiation and ara-C

treatment. Cell Death and Differentiation 5:584-591, 1998.

Kobayashi, T., Ruan, S.B., Clodi, K., Kliche, K-O., Shiku, H., Andreeff, M., and Zhang,

W. Overexpression of bax gene sensitizes K562 erythroleukemia cells to apoptosis induced

by selective chemotherapy agents. Oncogene 16:1587-1591, 1998.

Sinicrope, F. A., Roddey, G., Lemoine, M., Ruan, S.-B., Stephens, L. C., Frazier, M.,

Shen, Y., and Zhang, W. 1998. Loss of p21WAF1/Cip1 protein expression accompanies

progression of sporadic colorectal neoplasms but not hereditary nonpolyposis colorectal

cancers. Clinical Cancer Res. 4:1251-1261.

Ruan, S.B., Okcu, M.F., Ren, J.P., Clodi, K., Andreeff, M., Chiao, P., Levin, V., and

Zhang,W. Overexpressed p21/WAF1/Cip1 renders glioblastoma cells resistant to chemotherapy

agents BCNU and cisplatin. Cancer Res. 58:1538-1543. 1998.

Wu, X., Kemp, B., Amos, C.I., Honn, S.E., Walsh, G.L., Zhang, W., and Spitz, M.R.

Correlation among telomerase activity, p53 protein overexpression, and constitutional

genetic instability in non-small cell lung cancer. British J. Cancer. 80:453-457, 1999

Rhee, C.H., Hess, K., Jabbur, J., Ruiz, M., Chen, S., Yang, Y., Chenchik, A., Fuller,

G.N., and Zhang, W. Heterogeneous gene expression profiles in three human glioblastoma

cell lines. Oncogene 18:2711-2717, 1999.

Ruan, S.B., Okcu, M.F., Andreeff, M., Levin, V., Hsieh, J.T., and Zhang, W. Attenuation

of p21/WAF1/Cip1 expression mediated by antisense adenovirus vector sensitizes glioma

cells to chemotherapeutic agents BCNU and cisplatin. Clinical Cancer Res. 5:197-202, 1999.

Shim, C., Zhang, W., Rhee, C.H., and Lee, J.H. Profiling of differentially expressed

genes in human cervical cancer by complementary DNA expression array. Clinical Cancer

Res.4:3045-3050, 1998.

Rhee, C.H., Ruan, S.B., Chen, S., Chenchik, A., Levin, V, Yung, A., Fuller, G.N., and

Zhang, W. Characterization of cellular pathways involved in glioblastoma response to the

chemotherapeutic agent 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) by gene expression

profiling. Oncology Reports 6:393-401, 1999.

Fuller, G.N., Rhee, C.H., Hess, K., Caskey, L., Wang, R., Bruner, J.M., Yung, W.K.A., and

Zhang, W. Reactivation of insulin-like growth factor binding protein 2 expression in

glioblastoma multiforme: a revelation by parallel gene expression profiling. Cancer Res.

59:4228-4332, 1999.

Chiao PJ, Hunt KK, Grau AM, Abramian A, Fleming J, Zhang W, Breslin T, Abbruzzese JL,

Evans DB Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of

cell cycle. Ann N Y Acad Sci 880:31-7, 1999.

Caskey, L., Fuller, G.N. Bruner, J., Yung, A.W. K., Sawaya, R., Holland, E., and Zhang,

W. Toward a molecular classification of gliomas: from pathological to genomic

methodologies. Histology and Histopathology 15:971-981, 2000.

Sawa H, Kobayashi T, Mukai K, Zhang W, Shiku H. Bax overexpression enhances cytochrome c

release from mitochondria and sensitizes KATOIII gastric cancer cells to chemotherapeutic

agent-induced apoptosis. Int. J. Oncol. 16:745-749, 2000.

Feng L, Achanta G, Pelicano H, Zhang W, Plunkett W, and Huang P. Role of p53 in Cellular

Response to Anticancer Nucleoside Analog-Induced DNA Damage. Int. J. Mol. Medicine 5:597-

604, 2000.

Pearson AS, Chiao P, Zhang L, Zhang W, Larry L, Katz RL, Evans DB, and Abbruzzese JL. The

detection of telomerase activity in patients with adenocarcinoma of the pancreas by fine

needle aspiration. Int. J of Oncol 17:0-00, 2000.

Kobayashi T, Sawa H, Morikawa J, Zhang W, and shiku H: Bax-induction activates apoptosis

cascade via mitochondrial cytochrome c release and Bax-overexpression enhances apoptosis

induced by chemotherapeutic agents in DLD-1 colon cancer cells. Jpn. J. Cancer Res.,

91:12, 2000.

Jabbur J.R., Huang P., and Zhang, W. DNA damage-induced phosphorylation of p53 at serine

20 correlates with p21 transactivational induction in vivo. Oncogene 19:6203-6208, 2000.

Jabbur J, Huang P, and Zhang W. Enhancement of the antiproliferative function of p53 by

phosphorylation at serine 20: an inference from site-directed mutagenesis studies. Int. J

Mol. Medicine. 2001 7:163-168, 2001.

Hess, KR, Zhang W, Baggerly KA, Stivers DN, Coombes KR. Microarrays: handling the deluge

of data and extracting reliable information. Trend in Biotechnology 19:463-468, 2001.

Zhang W, Laborde P, Coombes K, Berry D, Hamilton S. Cancer Genomics: promises and

complexities. Clin. Cancer Res. 7:2159-2167, 2001.

Taylor E, Cogdell D, Coombes K, Hu L, Ramdas L, Hamilton S, and Zhang W. Sequence

verification as quality control step for production of cDNA microarray. Biotechniques

31:62-65, 2001.

Ramdas L, Wang J, Hu L, Cogdell D, Taylor E and Zhang W. Comparative Evaluation of Laser-

based Microarray Scanners. Biotechniques 31:546-553, 2001.

Lee S-H, Cho YS, Shim CS, Choi JJ, Oh SH, Kim JW, Zhang W, and Lee JH. Aberrant

expression of Smad3 and Smad4 results in resistance against growth inhibitory effect of

transforming growth factor beta (TGF-beta) in human cervical carcinoma cell lines. Int. J

cancer. 94:500-507, 2001.

Lee S-H, Zhang W, Choi JJ, Cho YS, Lee SH, Kim JW, Hu L, Xu J, Liu J, and Lee JH.

Overexpression of thymosin beta 10 gene in human ovarian cancer cells disrupts F-actin

stress fiber and leads to apoptosis. Oncogene 20:6700-6706, 2001.

Baggerly KA, Coombes KR, Hess KR, Stivers DN, Abruzzo LV, and Zhang W. Accurately

measuring differentially expressed genes in cDNA microarray experiments. J Computational

Biology 8:639-659, 2001.

Hess KR, Fuller GN, Rhee HR, and Zhang W. Statistical pattern analysis of gene expression

profiles of glioblastoma tissues and cell lines. Int. J. Mol Med 8:183-8, 2001.

Ramdas L, Coombes KR, Baggerly KA, Abruzzo L, Highsmith WE, Krogmann T, Hamilton SR, and

Zhang W. Linearity of cDNA microarray expression measurement: caveats, serial dilutions,

and quality control. Genome Biology 2(11):research0047.1-0047.7, 2001.

Jabbur JR and Zhang W. p53 Antiproliferative Function is Enhanced by Aspartate

substitution at Threonine 18 and Serine 20. Cancer Biology and Therapy 1:275-281, 2002.

Ballal K, Zhang W, Plunkett W, and Huang P. p53 supresses genetic mutation in cells under

DNA replication stress caused by imbalance of cellular dNTP pools. J Mol Medicine 80:25-

32, 2002.

Hu L, Wang J, Baggerly K, Wang H, Fuller GN, Hamilton SR, Coombes KR, Zhang W. Obtaining

Reliable Information from Minute Amounts of RNA Using cDNA Microarrays. BMC Genomics 3:16,

2002.

Shmulevich I, Dougherty ER, Kim S, and Zhang W. Probabilistic Boolean network: a rule-

based uncertainty model for gene regulatory networks. Bioinformatics 18:261-274, 2002.

Shmulevich I, Hunt K, El-Naggar A, Taylor E, Ramdas L, Laborde P, Hess KR, Pollock R,

Zhang W. Tumor Specific Gene Expression Profiles in Human Leiomyosarcoma: an Evaluation of

Intra-Tumor Heterogeneity. Cancer 94:2069-2075, 2002, 2002

Hu L, Cogdell D, Jia Y, Hamilton SR, and Zhang W. Monitoring of microarray production

with a common oligonucleotide and specificity with selected targets. Biotechniques 32:528-

534, 2002.

Shmulevich I and Zhang W. Binary analysis and optimization-based normalization of gene

expression data. Bioinformatics 18:555-565, 2002.

Fuller GN, Hess KR, Rhee CH, Yung WKA, Sawaya RA, Bruner JM, and Zhang W. Molecular

classification of human diffuse gliomas by multidimensional scaling analysis of gene

expression profiles parallels morphology-based classification, correlates with survival,

and reveals clinically-relevant novel glioma subsets. Brain Pathology 12:108-116, 2002.

Zhang W, Wang H, Song SW, and Fuller GN. Insulin-like growth factor binding protein 2:

gene expression microarrays and hypothesis-generation paradigm. Brain Pathology 12:87-94,

2002.

Wang HM, Wang H, Zhang W, and Fuller GN. Tissue microarrays: applications in

neuropathology research, diagnosis, and education. Brain Pathology 12:95-107, 2002.

Kobayashi T, Sawa H, Morikawa J, Ueno S, Katayama N, Zhang W., Shiku H. Bax-induction

alone is sufficient to activate apoptosis cascade in wild-type Bax-bearing K562 cells, and

the initiation of apoptosis requires simultaneous caspase activation. Int. J. Oncology

20:723-728, 2002.

Choi W, Song SW, and Zhang W. Understanding cancer through proteomics. Technology in

Cancer Research and Treatment. 1:211-230, 2002.

Shmulevich I, Dougherty ER, and Zhang W. Gene perturbation and intervention in

probabilistic Boolean network. Bioinformatics 18:1319-31, 2002.

Shmulevich, I., Dougherty, E. R., and Zhang, W. Control of stationary behavior in

Probabilistic Boolean Networks by means of structural intervention. Journal of Biological

Systems 10:431-445, 2002.

Dunmire V, Wu C, Symmans WF, and Zhang W. Increased yield of total RNA from fine needle

aspirates in RNAlater for use in expression microarray analysis. Biotechniques 33:890-2,

894, 896, 2002.

Jabbur JR, Tabor AD, Cheng X, Wang H, Uesugi M, Lozano G, and Zhang W. Phosphorylation at

threonine 18 of p53 alters hydrogen bonding attenuating mdm2 binding and TAFII31

recruitment. Oncogene 21:7100-7113, 2002.

Kim S, Dougherty ER, Shmulevich I, Hess KR, Hamilton SR, Trent JM, Fuller GN, and Zhang

W. Finding strong gene sets for classification of gliomas. Mol. Cancer Therapeutics 1:1229-

1236, 2002.

Fuller CE, Wang H, Zhang W, Fuller GN, and Perry A. High-throughput molecular profiling

of high-grade astrocytomas: the utility of fluorescence in situ hybridization on tissue

microarrays (TMA-FISH). J Neuropathol Exp Neurol. 61:1078-84, 2002.

Lee SH, Kim J-W, Lee, HW, Cho Y, Oh S, Jung C, Zhang W, Lee JH. Interferon regulatory

factor-1 (IRF-1) is a mediator for interferon-g induced attenuation of telomerase Activity

and human telomerase reverse transcriptase (hTERT) expression. Oncogene 22:381-91, 2003.

Shmulevich I, Dougherty ER, and Zhang W. From Boolean to probabilistic Boolean networks

as models of genetic regulatory networks. Proceedings of the IEEE 90:1778-1792, 2002.

Wang J, Hu L, Hamilton SR, Coombes KR, and Zhang W. Evaluating the performance of two RNA

amplification strategies for cDNA microarray experiments. Biotechniques 34:394-400, 2003.

Kobayashi T, Yamaguchi M, Kim S, Morikawa J, Ogawa S, Ueno S, Suh E, Dougherty E,

Shmulevich I, Shiku H, and Zhang W. Microarray reveals differences in both tumor and

vascular specific gene expression in de novo CD5+ and CD5- diffuse large B-cell lymphomas.

Cancer Res. 63:60-66, 2003.

Shmulevich I, Astola J, Cogdell D, Hamilton SR, and Zhang W. Data extraction from

composite oligonucleotide microarrays Nucleic Acid Research 31:e36, 2003.

Park MJ, Park IC, Bae IJ, Zhang W, Seo KM, Lee SH, Hong SI, Eun CK, Rhee CH. Arsenolite

(solid As4O6), a novel inhibitor of angiogenesis. International J Oncology. 22(6):1271-

1276, 2003.

Davis DW, McConkey DJ, Zhang W, Herbst RS. Antiangiogenic tumor therapy. Biotechniques

34(5):1048-50, 1052, 1054 passim, 2003.

Morikawa J, Li H, Kim S, Nishi K, Ueno S, Suh E, Dougherty E, Shmulevich I, Shiku H,

Zhang W, and Kobayashi T. Identification of signature genes by microarray for acute

myeloid leukemia without maturation and acute promyelocytic leukemia with

t(15;17)(q22;q12)(PML/RARa) International J Oncology 23(3):617-25, 2003

Shmulevich I, Lahdesmaki H, Dougherty ER, Astola J, and Zhang W. The Role of Certain Post

Classes in Boolean Network Models of Genetic Networks. Proc Natl Acad Sci USA. 100:10734-

10739, 2003.

Wang H, Wang H, Shen W, Huang H, Hu L, Ramdas L, Zhou Y, Liao WSL, Fuller GN, and Zhang

W. Insulin-like Growth Factor Binding Protein 2 Enhances Glioblastoma Invasion via

Activation of Invasion Enhancing Genes. Cancer Res. 63:4315-4321, 2003.

Kobayashi T, Kim S, Zhang W. Gene expression profiling of de novo CD5-positive diffuse

large B-cell lymphoma. Rinsho Ketsueki (in Japanese). 44(3):144-8, 2003.

Wang H, Shen SS, Wang H, Diwan AH, Zhang W, Fuller GN, and Prieto VG. Expression of

insulin-like growth factor binding protein 2 in melanocytic lesions. J. Cutaneous

Pathology. 30:599-606, 2003.

Zhang W, Ramdas L, Shen WP, Song WS, Hu L, Hamilton SR. Apoptotic Response to 5-

Fluorouracil Treatment is Mediated by Reduced Polyamines, Non-Autocrine Fas Ligand and

Induced Tumor Necrosis Factor Receptor 2. Cancer Biol Ther. 2(5):572-8, 2003.

Koh JS, Trent J, Chen L, El-Naggar A, Hunt K, Pollock R, and Zhang W. Gastrointestinal

stromal tumors (GIST): overview of pathologic features, molecular biology, and therapy

with imatinib. Histology and Histopathology 19:565-574, 2004.

Mircean C, Tabus I, Kobayashi T, Yamaguchi M, Shiku H, Shmulevich I, Zhang W. Pathway

analysis of informative genes from microarray data reveals that metabolism and signal

transduction genes distinguish different subtypes of lymphomas. International Journal of

Oncology 24:497-504, 2004.

Giurcaneanu CD, Tabus I, Shmulevich I, Zhang W. Clustering genes and samples from glioma

microarray data. The First South-East European Symposium on Interdisciplinary approaches

in fractal analysis, Bucharest, Romania, May 7-10, 2003.

Giurcaneanu CD, Tabus I, Shmulevich I, Zhang W. Stability-based cluster analysis applied

to microarray data. ISSPA 2003, Seventh International Symposium on Signal Processing and

its Applications, 1-4 July 2003, Paris, FRANCE.

Lahdesmaki H, Hao X, Sun B, Hu L, Yli-Harja O, Shmulevich I & Zhang W. Distinguishing key

biological pathways between primary breast cancers and their lymph node metastases by gene

function-based clustering analysis. International Journal of Oncology 24:1589-1596, 2004.

Hao X, Sun B, Hu L, Ladhdesmaki H, Dunmire V, Feng Y, Zhang SW, Wang H, Wu C, Wang H,

Fuller GN, Symmans WF, Shmulevich I, and Zhang W. Distinctive gene and protein expression

between primary breast cancers and their lymph node metastases revealed by combined cDNA

microarray and tissue microarray. Cancer Published on line in Feb 2004. 100:1110-22, 2004.

Song SW, Fuller GN, Khan A, Kong S, Shen W, Taylor E, Ramdas L, Lang F, and Zhang W.

IIp45, a novel IGFBP-2 binding protein, inhibits glioma cell invasion. Proc Natl Acad Sci

USA (Track II) 100:13970-75, 2003.

Shmulevich I, Gluhovsky I, Hashimoto RF, Dougherty ER, and Zhang W. Steady-state analysis

of genetic regulatory networks modeled by probabilistic Boolean networks. Comparative and

Functional Genomics 4:601-608, 2003.

Xu ZX, Zhao RX, Ding T, Tran T, Zhang W, Pandolfi PP, and Chang KS. PML Induces Apoptosis

by Inhibition of Survivin Expression. J Biol Chem, 279: 1838-1844, 2004.

Hashimoto RF, Kim S, Shmulevich I, Zhang W, Bittner ML, and Dougherty ER. A directed-

graph algorithm to grow genetic regulatory subnetworks from seed genes based on strength

of connection. Bioinformatics 20:1241-7, 2004.

Raza SM, Fuller GR, Rhee CH, Huang S, Hess KR, and Zhang W, and Sawaya R. Identification

of necrosis-associated genes in glioblastoma by cDNA microarray analysis. Clin Cancer Res

10:212-221, 2004.

Fujioka S, Schmidt C, Sclabas GM, Pelicano HM, Yao A, Niu J, Zhang W, Evans DB,

Abbruzzese JL, Huang P, Chiao PJ. NF-kB induces p53-dependent pro-apoptotic signaling J

Biol Chem 279:27549-59. e-pub April 2004.

Ramdas L, Cogdell DE, Jia YJ, Taylor E, Dunmire V, Hu L, Hamilton SR, and Zhang W.

Optimization of Signal Intensities for Low Expressing Genes on Oligonucleotide

Microarrays. BMC Genomics 5:35, 2004.

Wang H, Wang H, Zhang W, Huang H, Liao W, and Fuller GN. Activation of Akt and Up-

regulation of NFkB Correlates with Histologic Grade in Human Diffuse Gliomas: An

Immunohistochemical Tissue Microarray Study of 259 Tumors. Lab Investigation 84:941-951,

2004.

Fuller GN, Mircean C, Tabus I, Sawaya R, Bruner JA, Taylor E, Shmulevich I, Zhang W.

Molecular Voting For Glioma Classification Reflecting Heterogeneity in the Continuum of

Cancer Progression. Oncology Reports 1. 14: 651-656, 2005.

Sun BC, Zhang SW, Zhao X, Zhang W., and Hao X. Vasculogenic Mimicry Is Associated with

Poor Survival in Patients with Mesothelial Sarcomas and Alveolar Rhabdomyosarcomas. Int. J

Oncol. 25:1609-14, 2004.

Niemisto A, Dunmire V, Yli-Harja O, Zhang W, and Shmulevich I. Automated quantification

of in vitro angiogenesis through image analysis. IEEE Transactions on Medical Imaging

24(4):549-53, 2005.

Niemisto A, Hu L, Yli-Harja O, Zhang W, Shmulevich I. Quantification of in vitro cell

invasion through image analysis. Conf Proc IEEE Eng Med Biol Soc. 2004;3:1703-6.

Mircean C, Shmulevich I, Cogdell D, Choi W, Jia Y, Tabus I, Hamilton SR, and Zhang W.

Robust estimation of protein expression ratios with lysate microarray technology.

Bioinformatics 21(9):1935-42. Epub 2005. Jan 12; [Epub ahead of print]

Chinthariapalli S, Smith III R, Samudio I, Zhang W, Safe S. 1,1-Bis(3'-indolyl)-1-(p-

substituteddphenyl)methanes induce peroxisome proliferator-activated receptor g-mediated

growth inhibition, transactivation and differentiation markers in colon cancer cells.

Cancer Res. 64(17):5994-6001, 2004.

Sclabas GM, Frederick WAI, Fujioka S, Schmidt C, Yang W, Yokoi K, Evans DB, Denny A,

Abbruzzese J, Hess KR, Zhang W, Fidler IJ, and Chiao P. Overexpression of TrkB receptor

tyrosine kinase in highly metastatic human pancreatic cancer cells. Clin. Cancer Res. 2005

Jan 15;11(2 Pt 1):440-9.

Mircean C, I. Tabus, J. Astola, T. Kobayashi, H. Shiku, M. Yamaguchi, I. Shmulevich, W.

Zhang. Quantization and similarity measure selection for discrimination of lymphoma

subtypes under k-nearest neighbor classification.Proceedings of SPIE Photonics West,

Biomedical Optics, San Jose, CA, Jan. 24-29, 2004.

Symmans WF, Fiterman DJ, S K Anderson, M Ayers, R Rouzier, V Dunmire, J Stec, V Valero, N

Sneige, C Albarracin, Y Wu, J S Ross, P Wagner, R L Theriault, B Arun, H Kuerer, K R Hess,

W Zhang, G N Hortobagyi and L Pusztai. A single-gene biomarker identifies breast cancers

associated with immature cell type and short duration of prior breastfeeding. Endocrine

Related Cancer 12: 1059-1069, 2005.

Chen LL, Trent JC, Wu EF, Fuller GN, Ramdas L, Zhang W, Raymond AK, Prieto VG, Oyedeji

CO, Hunt KK, Pollock RE, Feig BW, Hayes K, Choi H, Macapinlac HA, Hittleman W, Velasco MA,

Patel S, Burgess MA, Benjamin RS, Frazier ML. A missense mutation in KIT kinase domain I

correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res 64:5913-

5919, 2004.

Mircean C, I. Tabus, J. Astola, T. Kobayashi, H. Shiku, M. Yamaguchi, I. Shmulevich, W.

Zhang. Quantization and similarity measure selection for discrimination of lymphoma

subtypes under k-nearest neighbor classification.Proceedings of SPIE Photonics West,

Biomedical Optics, San Jose, CA, Jan. 24-29, 2004.

Niemisto, A., L. Hu, O. Yli-Harja, W. Zhang, I. Shmulevich, "Quantification of in Vitro

Cell Invasion through Image Analysis," in Proceedings of the 26th Annual International

Conference of the IEEE Engineering in Medicine and Biology Society (EMBS'04), San

Francisco, California, USA, Sep. 1-5, 2004.

Lee E, Mircean C, Shmulevich I, Wang H, Liu J, Niemisto A Kavanagh J, Lee JH, and Zhang

W. Insulin-like growth factor binding protein 2 promotes ovarian cancer cell invasion. Mol

Cancer Feb 2;4(1):7 [Epub ahead of print].

Trent J, Dupart J, and Zhang W. Imatinib mesylate: Targeted therapy of gastrointestinal

stromal tumor. Current Cancer Therapy Reviews 1:93-108, 2005.

Choi W, Gerner E, Ramdas L., Dupart J, Carew J., Huang P, Zhang W, and Hamilton SR.

Combination of 5-fluouracil with diethylnorspermine markedly activates SSAT expression,

depletes polyamines, and synergistically induces apoptosis in colon cancer cells. J. Biol

Chem. 280(5):3295-304, 2005.

Song SW, Fuller GN, Zheng H, and Zhang W. Inactivation of the invasion inhibitory protein

gene IIp45 in gliomas by alternative splicing. Cancer Res. 65:3562-7, 2005.

Wang GK and Zhang W. Signaling network of cancer invasion. Histology and Histopathology

20:593-602, 2005.

Kim J-H, Tuziak T, Hu L, Gold D, Wang Z, Bondaruk J, Fuller GN, Dinney C, Grossman HB,

Baggerly K, Zhang W, Czerniak B. Alterations in Transcription Clusters of Key Cellular

Functions Underlie Development of Bladder Cancer from in situ Preneoplastic Conditions

along Papillary and Non-papillary Pathways. Lab Investigation. 85:532-49, 2005.

Lahdesmaki H, Shmulevich I, Dunmire V, Zhang W. In silico microdissection of microarray

data from mixed cell populations. BMC Bioinformatics. 6(1):54, 2005.

Neto AG, McCutcheon IE, Vang R, Spencer ML, Zhang W, Fuller GN. Elevated expression of

p21 (WAF1/Cip1) in hormonally active pituitary adenomas. Ann Diagn Pathol. 2005 Feb;9(1):6-

10.

McDonald JM, See S, Tremont I, Colman H, Gilbert M, Groves M, Burger P, Louis DN,

Giannini C, Fuller GN, Passe S, Blair H, Jenkins RB, Yang H, Ledoux A, Tipnis U, Zhang W,

Hess K, Aldape K. Prognostic impact of histology and 1p/19q status in anaplastic

oligodendroglioma. Cancer 104(7):1468-77, 2005.

Lin Q, Lai R, Li C, Chirieac LR, Grammatikakis I, Thomazy VA, Rassidakis GZ, Zhang W,

Fujio Y, Kunisada K, Hamilton SR, and Amin HM. Constitutive activation of JAK3/STAT3 in

colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces

apoptosis and cell cycle arrest of colon carcinoma cells. Am J Pathology 167(4):969-80,

2005.

Ueno S, Yamaguchi M, Kimura M, Odagiri H, Shiraki K, Uemoto S, Nakamura N, Zhang W, Shiku

H, and Kobayashi T. Expression of CD29 on lymphoma cells and/or CD36 on microvascular

endothels correlates with high serum LDH level in diffuse large B-cell lymphomas (DLBCLs)

and is frequent in de novo CD5-positive DLBCLs International Journal of Oncology

27(5):1241-1246, 2005.

Hu J, Kapoor M, Zhang W, Hamilton SR, Coombes K. Analysis of dose-response effects on

gene expression data with comparison of microarray platforms. Bioinformatics 1;21(17):3524-

9, 2005.

Tabus I, Hategan A, Mircean C, Rissanen J, Shmulevich I, Zhang W, Astola J. Nonlinear

modeling of protein expression in protein arrays. IEEE Transactions on Signal Processing.

54:2394-2407, 2006.

McDonald JM, Dunmire V, Cogdell D, Sawaya R, Bruner J, Fuller GN, Aldape K, and Zhang W.

Attenuated expression of the DFF40/CAD/DFFB gene is a hallmark of oligodendrogrliomas with

deletion of chromosome 1p. Mol Cancer 4:35, 2005.

Niemisto A, Dunmire V, Yli-Harja O, Zhang W, Shmulevich I, Analysis of angiogenesis using

in vitro experiments and stochastic growth models. Physical Review E 72:62902-5, 2005.

McDonald JM, Dunlap S, Cogdell D, Dumnire V, Wei Q, Starzinski-Powitz A, Sawaya R, Bruner

J, Fuller GN, Aldape K, and Zhang W. Shrew 1 gene, commonly deleted on chromosome 1p36 in

oligodendrogliomas, functions to inhibit cell adhesion. Cancer Bio and Therapy. 5(3):300-

4, 2206. Cover art of the March issue

Jiang R, Mircean C, Shmulevich I, Cogdell D, Jia Y, Aldape K, Sawaya R, Bruner J, Fuller

GN, and Zhang W. Pathway alterations during glioma progression revealed by reverse phase

protein lysate arrays. Proteomics 6:2964-2971, 2006. (featured on the cover of April

issue).

Nykter M, Hunt KK, Pollock RE, El-Naggar AK, Taylor E, Shmulevich I, Yli-Harja O, and

Zhang W. Unsupervised analysis uncovers changes in histopathologic diagnosis in supervised

genomic studies. Technology in Cancer Research and Treatment. 5:177-182, 2006.

Choi Y, Shimogawa H, Murakami K, Ramdas L, Zhang W, Qin J, and Uesugi M. Chemical genetic

identification of a STAT-linked pathway that modulates the insulin-like growth signaling.

Chemistry and Biology 13(3):241-9, 2006. .

Wang H, Wang H, Zhang W., Fuller GN. Overexpression of IGFBP5, But Not IGFBP3, Correlates

With the Histologic Grade Of Human Diffuse Glioma: A Tissue Microarray and

Immunohistochemical Study. Technology in Cancer Research and Treatment . 5(3):195-200,

2006.

Korbling M, Reuben JM, Gao H, Lee BN, Harris DM, Cogdell D, Giralt SA, Khouri IF, Saliba

RM, Champlin RE, Zhang W, Estrov Z. RhG-CSF mobilized and apheresis-collected endothelial

progenitor cells: a novel blood cell component for therapeutic vasculogenesis. Transfusion

46:1795-1802, 2006.

Choi W, Proctor L, Xia Q, Feng Y, Gerner EW, Chiao PJ, Hamilton SR, Zhang W. Inactivation

of IkB contributes to transcriptional activation of spermidine/spermine N(1)-

acetyltransferase. Mol Carcinogenesis. 45(9):685-93, 2006.

Wang G, Hu L, Fuller GN, Zhang W. An interaction between insulin-like growth factor

binding protein 2 and integrin a5 is essential for IGFBP2-induced cell mobility J. Biol.

Chem. 281(20):14085-91, 2006.

Steinert DM, Oyarzo M, Wang X, Choi H, Thall PF, Medeiros LJ, Raymond AK, Benjamin RS,

Zhang W, Trent JC. Expression of Bcl-2 in gastrointestinal stromal tumors: correlation

with progression-free survival in 81 patients treated with imatinib mesylate. Cancer.

106(7):1617-23, 2006.

Wang H, Rosen DG, Wang H, Fuller GN, Zhang W, and Liu J. Insulin-like growth factor

binding protein 2 and 5 are differentially regulated in ovarian cancer of different

histologic types. Modern pathology 19(9):1149-56, 2006.

Trent JC, Ramdas L, Dupart JJ, Hunt K, Oyedeji C, Taylor EE, Hu L, Chen LL, Benjamin RS,

Pollock R, and Zhang W. Imatinib Mesylate Induces Expression of Insulin-like Growth Factor

Binding Protein 3 in Gastrointestinal Stromal Tumor. Cancer 107(8):1898-908, 2006.

Pelicano H, Sasaki R, Feng L, Ramdas L, Hu L, Keating MJ, Zhang W, Plunket W and Huang P.

Mitochondrial Respiration Defect in Cancer Cells Leads to Activation of Akt Pathway. J.

Cell Biol. 175(6):913-23, 2006.

Sun BC, Zhang SW, Zhang DF, Du J, Guo H, Zhao XL, Zhang W, and Hao XS, Vasculogenic

mimicry is associated with high tumor grade, invasion and metastasis, and short survival

in patients with hepatocellular carcinoma. Oncology Report 16(4):693-8, 2006.

Yount G, Taft R, Luu T, Rachlin K, Hall J, Wendell C, Moore D, Aldape K, Zhang W.

Independent Motile Microplast Formation Correlates with Cell Invasiveness. J Neuro-

Oncology 81(2):113-21, 2007.

Lee E, Jo M, Park J, Zhang W, and Lee JH. Alternative splicing variants of IRF-1 lacking

exons 7, 8, and 9 in cervical cancer. Biochem Biophys Res Commun 347(4):882-8, 2006.

Choi W, Cogdell D, Feng Y, Hamilton SR, and Zhang W. Activation of CES-2 gene expression

by phosphorylated p53. Cancer Biology and Therapy. 5(11):1450-6, 2006.

Akkiprik M, Nicorici D, Cogdell D, Jia Y, Tabus I, Yli-Harja O, Yu D, Sahingul A, and

Zhang W. Dissection of Signaling Pathways in 14 Breast Cancer Cell Lines by Protein Lysate

Array. Technology in Cancer Res Treatment (microarray special issue) 5:543-552, 2006.

Guo M, Sneige N, Silva E, Cogdell D, Jan YJ, Lin E, and Luthra R, Zhang W. Distribution

of eight oncogenic types of human papillomavirus (HPV) and HPV16 viral load and

integration status in cervical carcinoma and cervical intraepithelial neoplasia. Modern

Pathology 20:256-66, 2007.

Feng Y, Sun B, Li X, Zhang L, Niu Y, Xiao C, Fang Z, Ning L, Zhang L, Wang Y, Cheng J,

Zhang W, Hao X. Differentially Expressed Genes between Primary Cancer and Paired Lymph

Node Metastases Predict Clinical Outcome of Node-positive Breast Cancer Patients. Breast

Cancer Res Treatment. 103(3):319-29, 2007.

Price N, Trent J, El-Naggar A, Cogdell D, Taylor EE, Hunt K, Pollock R, Hood L,

Shmulevich I, and Zhang W. Highly Accurate Two-Gene Diagnostic Classifier for

Differentiating Gastrointestinal Stromal Tumors and Leiomyosarcomas. Proc. Natl. Acad.

Sci. USA 104:3414-19, 2007.

Fan YH, Hu ZB, Li C, Wang LE, Guo Z, Qiao Y, Zhang L, Zhang W, Mao L, and Wei QY.

Expression levels of cell cycle checkpoint protein ATM is associated with cellular DNA

repair capacity in peripheral blood lymphocytes: a multivariate analysis. J Proteome Res.

6(4):1560-7, 2007.

Jiang R, Choi W, Asad Khan, Kenneth Hess, Gerner G, Casero R, Yung WK, Hamilton SR, Zhang

W. Activation of Polyamine Catabolism by N1, N11-diethylnorspermine Leads to Cell Death in

Glioblastoma. Int J Oncol 31(2):431-40, 2007.

Li X, Cao X, Li X, Zhang W, Feng Y. The Expression Level of IGFBP5 mRNA is a Prognostic

Factor for Breast Cancer. Cancer Science 98(10):1592-6, 2007.

Natarajan-Mendes K, Nicorici D, Cogdell D, Tabus I, Yli-Harja O, Guerra R, Hamilton SR,

and Zhang W. Dissection of Signaling Pathways in 90 Cancer Cell Lines by Protein Lysate

Array. J Proteome Res. 6:2753-67. 2007.

Chen KX, Hu Z, Wang LE, Zhang W, Sturgis EM, and Wei Q. Potential Gene-Gene Interaction

between Polymorphic P53BP1 and p53 Genes on Risk of Squamous Cell Carcinoma of the Head

and Neck A Case-Control Analysis. Clin Cancer Res. 13(14):4300-5, 2007.

Dunlap SM, Celestino J, Wang H, Jiang R, Holland E, Fuller GN, and Zhang W. Insulin-like

growth factor binding protein 2 promotes glioma development and progression. Proc Natl

Acad. Sci. USA 104(28):11736-41, 2007.

Sun X, Zhang W, Ramdas L, Stivers DN, Jones DM, Kantarjian HM, Estey EH, Vadhan-Raj S,

Medeiros LJ, Bueso-Ramos CE. Comparative analysis of genes regulated in acute

myelomonocytic leukemia with and without inv(16)(p13q22) using microarray techniques, real-

time PCR, immunohistochemistry, and flow cytometry immunophenotyping. Modern Pathology

20(8):811-20, 2007.

Armistead PM, Salganick J, Roh JS, Steinert DM, Patel S, Munsell M, El-Naggar A, Benjamin

RS, Zhang W, and Trent JC. Expression of Receptor Tyrosine Kinases and Apoptotic Molecules

in Rhabdomyosarcoma: Correlation with overall survival in 105 patients. Cancer

110(10):2293-303, 2007.

Jiang R, Choi W, Hu L, Gerner EW, Hamilton SR, and Zhang W. Activation of polyamine

catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and

downregulates mTOR protein level in glioblastoma cells. Cancer Biology and Therapy

6(10):1644-8, 2007.

Chen K, Hu Z, Wang L, Sturgis EM, El-Naggar AK, Zhang W and Wei Q. Single Nucleotide

Polymorphisms at the TP53-Binding or Responsive Promoter Regions of BAX and BCL2 Genes and

Risk of Squamous Cell Carcinoma of the Head and Neck. Carcinogenesis. 28(9):2008-12, 2007.

Trent J, Lazar AJF, Zhang W. A molecular approach to resolve diagnostic dilemmas: The

Case of Gastrointestinal Stromal Tumor and Leiomyosarcoma. Future Oncology 3(6):629-637,

2007.

Yang J and Zhang W. WWOX tumor suppressor gene. Histology and Histopathology. 23(7):877-

82, 2008.

Nakamizo A, Amano T, Zhang W, Zhang XQ, Dunmire V, Ramdas L, Liu TJ, Shono T, Sasaki T,

Benedict WF, Sawaya R, and Lang FF. Critical Role of Phosphorylation of Thr18 and Ser20 in

p53-Mediated Apoptosis. Neuro-Oncology 10(3):275-91, 2008.

Wang H, Arun BK, Wang H, Fuller GN, Zhang W, Middleton LP, and Sahin AA. IGFBP2 and

IGFBP5 overexpression contributes to metastasis in T1 breast carcinomas. The Breast

Journal. 14(3):261-7, 2008.

Kleinbaum EP, Lazar AJF, Tamborini E, Chen LL, Strong L, Choi H, Benjamin RS, Zhang W,

Trent JC. Familial Gastrointestinal Stromal Tumor With Loss Of Heterozygosity Of a KIT

Exon 11 Deletion: Clinical, Histopathologic, Molecular, and Therapeutic Findings.

International Journal of Cancer 122(3):711-718, 2008.

Guo M, Gong Y, Deavers M, Silva E, Jan YJ, Zhang W, Cogdell D, Lin E, Luthra R and Sneige

N. Comparison of in situ hybridization with PCR for detecting human papillomavirus DNA in

cervical intraepithelial neoplasia and cervical carcinoma. Journal of Clinical

Microbiology 46(1):274-80, 2008.

Song FJ, He M, Li HX, Qian BY, Wei Q, Zhang W, Chen K, and Hao XS. A cancer incidence

survey in Tianjin - the third largest city in China - between 1981 and 2000. Cancer Causes

and Control. 19(5):443-50, 2008.

Li HX, Hao XS, Zhang W, Wei Q, Chen K. The hOGG1 Ser326Cys polymorphism and lung cancer

risk: a meta-analysis. Cancer Epidemiology Biomarkers & Prevention 17(7):1739-45, 2008.

Chen LL, Holden JA, Choi H, Zhu J, Wu EF, Jones KA, Ward JH, Andtbacka R, Randall RL,

Scaife CL, Hunt KK, Prieto VG, Raymond AK, Zhang W, Trent JC, Benjamin RS, and Frazier ML.

Evolution from heterozygous to homozygous KIT mutation in gastrointestinal stromal tumor

correlates with the mechanism of mitotic nondisjunction and significant tumor progression.

Modern Pathology. 21(7):826-36, 2008.

Miyazaki K, Yamaguchi M, Suguro M, Ogawa S, Ueno S, Ji Y, Choi W, Zhang W, Katayama N,

Shiku H, Kobayashi T. Gene Expression Profiling of Diffuse Large B-cell Lymphoma

Supervised by CD21 Expression. Brit J Hematology. 142(4):562-70, 2008.

Zhang LN, Gu L, Qian BY, Zhang W, Wei Q, and Chen K. The association of genetic

polymorphisms of ER-a and the estradiol- synthesizing enzyme genes CYP17 and CYP19 with

breast cancer risk in Chinese women. Breast Cancer Res and Treat. 114(2):327-38, 2009.

Chen K, Song F, Calin G, Wei Q, Hao X, Zhang W. Polymorphisms in MicroRNA Targets: A Gold

Mine for Molecular Epidemiology. Carcinogenesis 29(7):1306-11, 2008

Conley AP, Trent J, and Zhang W. Recent Progress in the Genomics of Soft Tissue Sarcomas.

Current Opinions in Oncology 20:395-399, 2008.

Guo M, Lin CY, Gong Y, Cogdell DE, Zhang W, Lin E, Sneige N. Human papillomavirus

genotyping for the eight oncogenic types can improve pecificity of HPV testing in women

with mildly abnormal Pap results. Modern Pathology 21(8):1037-43, 2008.

Yang J, Du X, Lazar AJF, Pollock R, Hunt K, Chen K, Hao XS, Trent J, Zhang W. Genetic

Aberrations of Gastrointestinal Stromal Tumor. Cancer. 113:1532-1543. 2008.

Bhatia B, Jiang M, Patrawala L, Badeaux M, Schneider-Broussard R, Multani A, Jeter CR,

Suraneni M, Calhoun-Davis T, Hu L, Hu J, Tsavachidis S, Zhang W, Chang S, Hayward SW, and

Tang DG. Critical and distinct roles of p16INK4a and telomerase in regulating the

proliferative lifespan of the CD44+CK5+p63+ normal human prostate epithelial progenitor

cells. J Biol Chem. 283(41):27957-72, 2008

Chen KX, Song FJ, He H, Li HX, Qian BY, Zhang W, Wei Q, and Hao XS. Trends in Head and

Neck Cancer Incidence in Tianjin, China, between 1981 and 2002. Head and Neck. 31(2):175-

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Chen K, Zhao H, Hu Z, Wang LE, Zhang W, Sturgis E, Wei Q. CASP3 Polymorphisms and

Susceptibility to Squamous Cell Carcinoma of the Head and Neck. Clin Cancer Res.

14(19):6343-9, 2008.

Yang J, Du X, Chen KX, Ylipaa A, Lazar AJF, Trent J, Lev D, Pollock R, Hao XS, Hunt K,

and Zhang W. Genetic Aberration of Leiomyosarcomas. Cancer Letters, 275:1-8, 2009.

Akkiprik M, Feng Y, Wang H, Chen KX, Sahin A, Krithnamurphy S, Hu L,, Hao X, and Zhang

W. Multifunctional Roles of IGFBP-5 in Breast Cancer. Breast Cancer Res. 10(4):212, 2008.

Lee EJ, Jo MH, Park JS, Zhang W, Lee JH. The downregulation of Dkk3 by epigenetic

alteration leads to activation of a-catenin pathway in Cervical Cancer. International J of

Cancer. 124(2):287-97, 2009.

Lin Y, Jiang T, Zhou K, Xu L, Chen BS, Li GL, Qiu XG, Jiang TZ, Zhang W, Song SW. Plasma

IGFBP-2 levels predict clinical outcomes of patients with high-grade gliomas. Neuro-

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Hu L, Hittelman W, Lu T, Ji P, Arlinghaus R., Ilya Shmulevich, Hamilton SR, Zhang W. NGAL

decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion

through Rac1 in colon carcinoma cells. Lab Invest 89(5):531-48, 2009.

Wang YM, Ji P, Liu J, Broaddus R, Xue FX, Zhang W. Centrosome-associated regulators of

the G2/M checkpoint as targets for cancer therapy. Mol Cancer 8:8, 2009.

Akkiprik M, Hu L, Sahin A, Hao X, and Zhang W. The subcellular localization of IGFBP5

affects its cell growth and migration functions in breast cancer. BMC Cancer 9:103, 2009.

Huang A, Hu L, Kauffman S, Zhang W, Shmulevich I. Using cell fate attractors to recover

transcripitional factors linked to HL60 neutrophil differentiation. BMC Systems Biology,

3:20, 2009.

Zou C, Smith KD, Liu J, Lahat G, Myers S, Wang WL, Zhang W, McCutcheon IE, Slopis JM,

Lazar AJ, Pollock RE, and Lev D. Clinical, pathological and molecular variables predictive

of malignant peripheral nerve sheath tumor (MPNST) outcome. Ann Surg. 249(6):1014-22,

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Yang H, Gu J, Wang KK, Zhang W, Xing J, Chen Z, Ajani JA, Wu X. MicroRNA Expression

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15(18):5744-52, 2009.

Song FJ, Zheng H, Liu B, Wei S, Dai HJ, Calin GA, Hao XS, Wei Q, Zhang W, Chen KS. The

miR-502-binding Site SNP in SET8 Gene is Associated with Early Onset of Breast Cancer.

Clin. Cancer Res. 15(19):6292-300, 2009.

Moore L, Holmes K, Smith S, Wu Y, Tchougounova E, Uhrbom L, Sawaya R, Bruner JM, Fuller

GN, Zhang W. IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target

for high-grade gliomas. Proc Natl Acad Sci 106(39):16675-9, 2009.

Dupart JJ, Trent J, Lee HY, Hess K, Godwin A, Tuguchi T, and Zhang W. Insulin-like growth

factor binding protein-3 has dual effects on gastrointestinal stromal tumor cell viability

and sensitivity to the anti-tumor effects of imatinib mesylate in vitro. Mol Cancer 8:99,

2009

Zhou X, Ren Y, Moore L, You YP, Jia ZF, Wang BL, Wang GX, Xu P, Ruan JS, Pu PY, Zhang W*,

Kang CS*. Downregulation of miR-21 inhibits EGFR pathway and suppressed the growth of

human glioblastoma cells independent of PTEN status. Lab Invest 90(2):144-55, 2010. *co-

corresponding author.

Edelman LB, Toia G, Zhang W, and Price ND. Two-Transcript Gene Expression Classifiers in

the Diagnosis and Prognosis of Human Diseases. BMC Genomics 10(1):583, 2009

Leng X, Ding T, Lin H, Wang Y, Hu L, Hu J, Feig B, Zhang W, Pusztai L, Symmans WF, Wu Y,

and Arlinghaus RB. Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis.

Cancer Res. 69(22):8579-84, 2009.

Natarajan-Mendes K, Wang GK, Fuller GN, Zhang W. JNK mediates Insulin-like Growth Factor

Binding Protein 2 (IGFBP2)/Integrin a5-dependent glioma cell migration. Int J Oncol 37:

143-153, 2010

Wu Y, Song SW, Sun J, Bruner JM, Fuller GN, and Zhang W. IIp45 Inhibits Cell Migration

through Inhibition of HDAC6. J Biol Chem 2010 285: 3554-3560.

Yang J, Cogdell D, Yang D, Hu L, Li H, Zheng H, Du X, Pang Y, Trent J, Chen K, and Zhang

W. Deletion of the WWOX gene and frequent loss of its protein expression in human

osteosarcoma. Cancer Letters 291:31-38, 2010.

Song FF, Ji P, Zheng H, Song FJ, Wang Y, Hao X, Wei Q, Zhang W*, and Chen K*. Definition

of a Functional Single Nucleotide Polymorphism in the Cell Migration Inhibitory Gene MIIP

That Affects the Risk of Breast Cancer. Cancer Res. 70(3); 1024-32, 2010 *Co-corresponding

author

Ji P, Smith SM, Wang YM, Jiang R, Song SW, Bruner J, Sawaya R, Kuan J, Yu HT, Fuller GN

and Zhang W. Inhibition of gliomagenesis and attenuation of mitotic transition by MIIP.

Oncogene 29(24):3501-8, 2010. Epub 2010 Apr 26.

Wang YM, Yang D, Cogdell D, Hu L, Xue FX, Broaddus R, and Zhang W. Genomic

characterization of gene copy-number aberrations in endometrial carcinoma cell lines

derived from endometrioid-type endometrial adenocarcinoma. Tech Cancer Res Treat 9(2):179-

89, 2010.

Yang J,Yang D, Cogdell D, Du X, Li, H, Pang Y, Sun Y, Hu L, Sun B

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