Process Project

COVER LETTER

Dear Sir/Madam,

Please consider the attached resume as my application for the position Research Officer. I

respectfully submit this letter of application, for I believe my experience are well qualified to meet

the needs of the project.

I have completed my post graduation in Organic Chemistry with First class with distinction

from Pune University in July 2007. Having strong desire to work in challenging field of chemistry

and wanting to work on something helpful to the scientific community and humanity currently I

am working with Herbert-Brown Pharmaceuticals and Research lab. Mumbai as a Research Officer

in Research & Development department.

As a postgraduate student at Pune University I gained a concrete knowledge in theoretical

as well as practical aspects of Organic Chemistry. Especially the Laboratory sessions of Multistep

organic synthesis, photochemical reactions, organic product extractions & Chromatographic

separation methods developed a great deal of laboratory skills and provided me with enthusiasm

and zeal to work in the field of Organic Chemistry. During my academic career I have conducted

project of ‘Preparation of Bis-imido Schiff’s bases and their different metal complexes’ like Zn, Hg,

Fe, Mn, etc. derived from 5-chlorosalicyaldehyde and thio-semicarbazide having positive anti-

microbial activity towards enzymes like E-coli, Shingella, Ksabeilla, etc. Also I have present my

above project work in AVISHKAR-2006 an Inter University Research Project Competition for

UG/PG/Doctoral students during post graduation study which was arranged by University of Pune,

INDIA in 2006.

During my working experience as a Research Officer at Herbert-Brown Pharmaceuticals

and research lab. I came across some of the many difficulties faced during Organic synthesis.

Troubleshooting such difficulties & looking for alternative process through literature search in case

problem was not solved, gave me a good learning experience and developed me as a strong

organic chemist. Also working in a team during the process development of Active Pharmaceutical

Ingredients (API’s) developed in me a good amount of team working and interpersonal skills.

Besides my main responsibility, I also accomplished some research independently or in a team

mainly in process development of API’s, these practices give me skill in the application of the

same.

My studies in chemistry not only provide me strong background and research experience in

it but also in its application in many fields like medicinal & industrial field. Several courses and

project provide me broad view of organic chemistry which helpful for medicinal field. Moreover my

theoretical knowledge and Industrial Research experience would allow me to pursue cutting edge

research in field of Organic Chemistry.

Thanking you for considering my application and I look forward to your positive response.

Sincerely,

Santosh

CURRICULAM VITAE

Mr. SANTOSH SHIVAJI SHINGOTE

B-10, Sevasmruti CHS, SBI Society,

Shastrinagar, Near Jondhale high-school,

Dombivli (W), Mumbai.

Mobile No. +918*********

E-mail: ***************@**********.***

Have five and half years of professional experience in chemical laboratories in diversified areas

and roles. I am an expertise and analytical minded chemist with extensive experience in

analytical activities in various branches namely organic chemistry. Familiar with usage of all

modern chemical laboratory equipments and have done analysis on medium as well as large sized

chemical laboratories.

Objective:

To establish myself in the field of Research and Development of pharmaceutical science

where I can continuously learn and contribute directly to the growth of the organization &

which offers me challenges that help me polish my technical skills .

Highlights:

Multi step synthesis, purification and characterization of organic molecule by using various

techniques like NMR, IR, UV, GCMS and HPLC etc.

Demonstrated ability and extensive hands-on experience in designing and executing multi-

step synthesis, optimizing chemical processes and scale-up of synthetic methods.

Handled moisture sensitive, air sensitive reactions.

Experience of working on various organic transformations.

Handled preparative HPLC technique on milligram scale.

Handled membrane filtration unit which specially use for desaltation based on reverse

osmosis phenomenon.

Well versed with chemistry related software’s like Chem Draw.

Possessing excellent communication and interpersonal skills.

Capable of doing collaborative and independent research work.

Academic Qualification:

Master of Science (M.Sc.) in Organic Chemistry 1st Class with Distinction from Pune

University, India in July-2007.

Bachelors of Science (B.Sc.) in Chemistry 1st Class with Distinction from Pune

University, India in July-2005.

Publications:

A Process patent published for the “Novel one pot process for the preparation of

Irbesartan” Patent: 10/2008; Patent: Indian patent application No.2210/MUM/2008

Vitthal Gund, Bansi Lal, Pravin Bochiya, Sheikh Rubeena Parveen Kaiseruddin, Nipunge

Dnyaneshwar Sambhajirao, Santosh Shingote.

A process patent published for the “An improved process for preparation of Irbesartan”

Patent: 09/2008; Patent: Indian patent application No.1276/MUM/2008

Vitthal Gund, Bansi Lal, Pravin Bochiya, Shingote Santosh Shivaji, Nipunge

Dnyaneshwar Sambhajirao.

Apply for process patent for “Novel method of purification of Sodium Citicoline without ion

exchange resin” Indian patent application No 3279/MUM/2012

Vitthal Gund, Prasad Kulkarni, Santosh Shingote, Navnath Zaware.

Apply for process patent for “Process of preparation of 3-chloroiminodibenzyl” Indian

patent application No 185/MUM/2013

Vitthal Gund, Santosh Shingote, Mukund Bangal, Govardhan Parande.

Professional research experience:

Research Officer, Sept-2009 to till date

Herbert-Brown Pharmaceutical & Research Lab. Mumbai, India.

Design and execute the syntheses of the desired organic compounds; Scale up the new

processes to pilot plant; optimize the existing chemical processes;

Successfully designed and implemented process of synthesis of Sodium Citicoline and

scaled up to 75 kilograms. For above product apply for process patent of novel purification

method to avoid ion exchange resin column.

Improved the current process of Clomipramine hydrochloride antihypertensive drugs, for

it also apply for process patent.

Successfully implemented process of synthesis of Biphenyl Dibenzoic anhydride one of

the monomer which on further polymerization used in preparation of glass coatings which

involve cannula technique especially for air and moisture sensitive reactions.

Contribute for process implementation and it’s scale-up at plant scale up to 200

kilograms of an indoline derivative which was one of the key raw material of Silodosin an

API drug, during that work carried low temperature reaction like Vilsmayer-Hack reaction

using liquid nitrogen, dry ice on plant scale.

Research Associate, July2007 to Sept.2009

Calyx Chemicals & Pharmaceuticals Ltd. Mumbai, India.

Work for custom synthesis, designed and implemented the syntheses of complex organic

compounds for pharmaceutical company’s drug development. Below are some examples:

(2S)-Aminomethyl-4-benzylmorpholine dibenzoyl-D-tartaric acid salt.

3-Aminopyridine-2-carboxaldehyde.

4-Chloro 2-hydroxy 6-methylphenylboronic acid which was used for Suzuki coupling

reaction of dibenzyl preparation.

Process development of syntheses of some API drugs with their scale up at plant scale.

Irbesartan during above work file patent for its novel and improved one pot process preparation.

Losartan potassium.

Lumifantrine.

Extra curriculum activities:

Participated in ‘AVISHKAR-2007’ an Inter University Research Project Competition for

UG/PG/Doctoral students Science exhibition held in PVP College, Pravaranagar, Dist-

Ahmednagar arranged by University of Pune, INDIA in 2007.

References:

Dr. V. G. Gund, (General Manager, R&D) Dr. D. D. Patil (Head of Department)

Herbert-Brown Pharmaceutical & Research Lab. Department Of Chemistry,

W-258 A MIDC Phase II, Shivaji Udyog Nagar, RBNB College Shrirampur,

Dombivli (E), Mumbai, MH, India 421 203. Ahmednagar, MH, India 413 709.

Office Tel. 025*-*******/2871762 Office Tel.: 024**-******

Personal Mobile No. +91-983******* Personal Mobile No. +91-942*******

E-mail: ************@*****.*** E-mail: ********.*****@*****.***

Declaration:

I hereby declare that the above details furnished are true to the best of my Knowledge

and belief. I assure that my performance will to the best of my ability and to the satisfaction of

the concerned.

Date:

Place: Mumbai (Santosh Shingote)

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