organic/polymer chemist

MANAS KUMAR HALDAR, Ph.D.

Dept. of Pharmaceutical Sciences 701-***-**** (Office), 701-***-**** (Mobile)

North Dakota State University e-mail: ************@*****.***

Fargo, ND 58105

Visa Status – Permanent Resident

OBJECTIVE: Looking for a challenging position where my technical and analytical skills can make a

difference and simultaneously I can acquire additional expertise, while developing products/processes in a

team - oriented setting.

SUMMARY OF SKILLS/QUALIFICATIONS

• Synthetic Organic Chemist with medicinal chemistry knowledge.

• Multistep organic synthesis /characterization

• Monomer/polymer, lipid synthesis and characterization.

• Production of milligram to multigram target molecule

• Product development/ Process development

• Technology transfer from laboratory to plant

• Peptide synthesis and purification both by solution and solid phase.

• Excellent technical problem solving (trouble shooting) skill.

• Excellent verbal and written communication skills

EXPERIENCE

North Dakota State University, Fargo, ND 2008

– Present

Research Scientist

Building on extensive laboratory experience, define project focus for small molecule inhibitors,

solid phase/ solution phase peptide synthesis and lipid synthesis, design experimental approaches,

utilize different research techniques, and analyze/interpret data for presentation and/or publication.

Train and mentor graduate/undergraduate students in the techniques and good laboratory practices

for conducting organic synthesis as well as do solve their synthetic problems. Write proposals for

research funding.

Authored 9 papers (published in chemistry/med chem. Journals like ACS Nano, Analytical

•

Chemistry, BMCL etc), two books chapters, and filed one US patent.

Synthesis of small molecule inhibitor for HDACs, MMP and novel activator for sirtuins.

•

Synthesized lipids and monomer/polymer to facilitate isozyme detection of CA and MMP.

•

Demonstrated successful cancer sub typing employing specially designed and synthesized small

•

library of water soluble fluorescent polymers.

North Dakota State University 2004-2008

Post Doctoral Research Associate

Combined research expertise and deep knowledge of organic chemistry to design and synthesize

small molecule inhibitors of metallo enzymes such as methionine aminopeptidase-1, MMPs and

carbonic anhydrases. Also designed and synthesized different lipids for protein detection.

• Published 13 papers (which include JACS - 4, Chem. Comm. – 4) and granted one USA

patent.

• Developed, synthesized and validated the “Two Prong” inhibitor concept for isozyme

selective inhibition of Carbonic anhydrase and MMPs.

• Designed and synthesized new fluorescent probe for carbonic anhydrases.

• Facilitated isozyme recognition of carbonic anhydrase and Matrix metallo proteinase by

liposomes

National Taiwan University- Taipei, Taiwan ROC 2000-2004

Post-doctoral Fellow

Introduced to a entirely different field of chemistry from small molecule synthesis to fullerene chemistry and

material science- picked up fast and solved two existing problem which my earlier people could not solve.

• Synthesized chiral pyrrolidino- fullerene and established the exact structure by single crystal

X-ray crystallography (granted one USA patent for this).

• Transformed relatively unreactive biopolTM oligomers to reactive oligomers by introducing

different functional group on its chain. (Everything was ready for another patent).

• Synthesized water soluble fullerene derivatives under inert atmosphere and 100% moisture

free condition (kilo level) for PDT application.

Cheminova (I) limited (formerly Lupin Agrochemical) GIDC Panoli – Gujarat, INDIA 1996 - 2000

Executive, Research &Development

• Synergistic effect of subject matter expertise and process research resulted launch and an

increase of yield from 84% to 90% with concomitant reduction of effluent load by 10% for

Quinolphos at plant level.

• Conducted in-depth studies to improve quality/quantity of other products at reduced costs,

while encompassing environmental concerns such as product biodegradability and emissions

reduction.

EDUCATION

Ph.D. Synthetic Organic Chemistry, Indian Institute of Technology, Kharagpur, WB, India

MTech, Human resources development and Management, IIT, Kharagpur, WB, India

M.Sc. Organic Chemistry, IIT, Kharagpur, WB, India

TECHNICAL SKILLS

NMR (Multinuclear and multidimensional); Automated Flash chromatography, IR, Fluorescence, UV,

Dynamic Light Scattering (DLS), Pepetide synthesizer, DSC, TGA, Circular dichorism, Isothermal Titration

Calorimetry (ITC), HPLC/GPC, Mass Spectroscopy.

COMPUTER SKILLS

Microsoft Office (Word, Excel, PowerPoint), origin (data analysis), Scifinder, Beilstein for literature search,

Chem Draw, ACD Lab for NMR data processing, Desktop molecular modeler.

LANGUAGE: English, Bengali (Full proficient), Hindi

PROFESSIONAL MEMBERSHIP

• American Chemical Society

• American Association for the Advancement of Science (publisher of the journal Science)

LEADERSHIP

• Trained and supervised graduate students for chemical synthesis in NDSU.

• Instructed an undergraduate researcher in National Taiwan University, Taipei.

• Supervised, guided and trained co-workers as a group leader of four at Cheminova (I) limited.

HONORS

• Special discussion of JACS 2004, 126 (35), 108**-***** publication in Modern Drug Discovery

published by the American Chemical Society as new and noteworthy on November 2004 issue. Bb-

• For Journal of Physical Chemistry C 2007, 11, 8437-8442 publication

a. BBC posted one article on 14th June 2007

(http://news.bbc.co.uk/2/hi/health/6749707.stm)

b. Press release by the American Chemical Society on June-06, 2007.

c. One article in June 15th, 2007 on www.spectroscopynow.com

• In the editorial board of online organic chemistry journal Arkivoc.

Contact this candidate