Project Years Experience
Resume:
Ravindra R. Yarragunta
Greensboro, NC-27455
Email: *********@*****.***
Phone: 704-***-****(cell)
Summary:
o More than 9 years experience in medicinal chemistry and multi-step
synthesis of bio-active small molecule inhibitors.
o Drug discovery experience in the field of phosphatase and kinase
metabolic disorders.
o Proficient in structure-based inhibitor design and medicinal
chemistry principles (SAR, QSAR, Pharmacology, Pk, and ADME/Tox)
o Solid background & excellent hands in parallel synthesis, lead
optimization, scale-up and combinatorial chemistry.
o US citizen through Naturalization.
Professional Experience
Trans Tech Pharma & Pharmacore
December 2000- 2013
Senior Research Scientist
August 2009-2013
Pharmacore
High Point, NC-27265
. Involved in Custom synthesis and Contract med-chem Research projects
with major companies for different therapeutic targets, like anti-
viral drugs, Diabetic and biologically active ingredients
. Develop the new synthetic procedures and scale-up the reaction
conditions from small scale to plant scale & check the feasibility of
the process following the n-GMP/GMP procedures
Principal Scientist
December 2006-2009
Trans Tech Pharma
High Point, NC-27265
o Discovered a novel and proprietary lead series of small molecule
inhibitors on glucagon-like peptide 1 (GLP-1).
o Synthesized heterocyclic inhibitor libraries for lead discovery
against AMP kinase.
o Designed and synthesized a new series of back up compounds for a
pre-clinical program based on SAR and toxicity studies.
Senior Research Scientist
December 2003-2006
Trans Tech Pharma Inc.,
High Point, NC-27265
o Played a major role in development of clinical candidate in PTP-1B
project: structure-based design: physicochemical properties and in
vivo efficacies and molecular modeling scores, used to optimize
relatively week non-phosphorus, non-peptide general PTP-inhibitor
in to highly potent, orally available, moderately selective and low
molecular weight PTP-1 inhibitor.
o Incorporated new thiazolidinone (TDZ) warhead in on going series
and developed lead compound for protein tyrosine phosphatase
project.
o Involved in IND filing procedures and patent applications.
Research Scientist
December 2000-2003
Trans Tech Pharma Inc.,
High Point, NC-2726
o Designed and synthesized different classes of molecules (seven
classes) in the lead discovery and lead optimization effort for the
PTP-1B project.
o Developed cyclohexyl biphenyl imidazole series based on structure-
activity relationships to improve the potency and ADME characters.
o Synthesized, isolated and identified the active isomer in the lead
series for phosphatase inhibitors.
Post-doctoral Research Scientist, Medicinal Chemistry
October 1999-2000
Albany Molecular Research Inc., Albany, NY-12203
o Performed linear multistep milligram to multigram organic synthesis
o Engaged in custom synthesis and process development of various
heterocyclic compounds.
o Designed synthesis of heterocyclic compounds based upon
interpretation of the biological data obtained by collaborators and
molecular modeling.
Post-doctoral Fellow, Evans laboratory,
March 1998 -1999
The Ohio State University, Columbus, OH-43210
Supervisor: Prof. Leo A. Paquette
o Involved in efforts towards total synthesis of tetraquinane
diterpenoid Crinipellin-B, synthesizing requisite vinylbromides for
di-anionic cascade reaction from triquinane pentalene frame in a
single step.
o Successfully studied the effect of hetro-atom (S, O) on remote
acceleration of Oxy-Cope rearrangements in determining the rates of
rearrangement and in elucidating product stereochemistry.
o Performed synthesis of Chiral Ligands from Camphor and Thujone.
Senior Scientific Asst. - Natural Products Laboratory
April 1994 -1998
Indian Institute of Chemical Technology, Hyderabad, India
o Chiron approach was effectively used in design & synthesis of
unusual amino acids like 3-hydroxy leucine (part structure of
antibiotic Telomycin) and (2S, 3R) 3-hydroxy homotyrosine (part
structure of antifungal agent Echinocandin-D) starting from readily
availabe D-glucose.
o Developed a novel enzymatic resolution of chemically labile racemic
cyclopropane carboxyl esters to enantiopure carboxylic acids (a key
component of Lambda Cyhalothrin/Pyrethroid )
o Developed a new Lewis acid system for activation of inexpensive and
non-hazardous PMHS for selective reduction of carbonyl compounds to
alcohols & selective reduction of highly sensitive benzylidene
acetals of sugars in a regio selective manner.
o Applied TaCl5 as an effective Lewis acid catalyst in chemoselective
trimerisation, aldolization and thioketalization.
Junior Scientific Asst., - Organic Division I
May 1989-1994
Indian Institute of Chemical Technology, Hyderabad India
o Thorough understanding of the challenges involved in scaling-up
chemical process.
o Improved process development for the manufacture of 1-triacontanol
(plant growth regulator) and Dipyridamole (cardiovascular drug).
o Developed an efficient process for Lambda Cyhalothrin (active
pyrethroid) at the bench scale and later to facilitate transfer of
pilot plant and technologies with the collaboration of chemical
engineering section of IICT.
Education
Ph.D. Organic Chemistry, August 1993- March 1998
Indian Institute of Chemical Technology, Hyderabad, India
Thesis Topic: Synthesis of Enantiopure Intermediates and Development of New
Reduction Procedures
Adviser: Dr. J. S. Yadav
Post-Graduate Diploma in Personal Management and Industrial Relations
(PMIR), September 1992
Kakatiya University, Warangal, Andhra Pradesh, India
M.Sc. Organic Chemistry, August 1986 - November 1988
S.V. University, Tirupathi, Andhra Pradesh, India
Bachelors in Science (Chemistry, Physics, & Geology) September 1983 - May
1986
S. V. University, Anantapur, Andhra Pradesh, India
Publications
Leo A. Paquette ; Y. Ravindra Reddy ; Gregory Vayner ; K. N. Houk "High
Rate Accelerations in Oxy-Cope Rearrangements Induced by Sulfar
Substitutions: A Kinetic Study Involving Electronically and Geometrically
Differentiated 1-Alkenyl-2-(Z-1-Propenyl)-7,7-dimethyl-exo-norbornan-2-ols"
J. Am. Chem. Soc. 2000, 122, 10788.
Leo A. Paquette ; Y. Ravindra Reddy ; Fredrik Haeffner ; K. N. Houk "
Consequences of Hetroatomic
C-6 Substitution on Rates of the Oxyanionic Cope Rearrangement. The
Remarkable Accelerating Effect of Sulfide Groups " J. Am. Chem. Soc. 2000,
122, 740
Fredrik Haeffner ; K. N. Houk ; Y. Ravindra Reddy ; Leo A. Paquette "
Mechanistic Variations and Rate Effects of Alkoxy and Thioalkoxy
Substituents on Anionic Oxy-Cope Rearrangements " J. Am. Chem. Soc. 1999,
121, 11880.
S. Chandrasekhar ; Y. Ravindra Reddy ; Ch. Raji Reddy " Regioselective
Reductive Ring Opening of Cyclic 1,2- and 1,3-Benzylidene Acetals "
Chemistry Letters 1998, 12, 1273.
J. S. Yadav ; A. B. Rao ; Y. Ravindra Reddy ; K. V. Reddy " Enzymatic
Resolution of Cis-3-(2,2-dichloro-3,3,3-trifluoropropyl)-2,2-dimethyl
Cyclopropanecarboxylate " Tetrahedron Asymmetry 1997, 8, 2291.
S. Chandrasekhar ; M. Takhi ; Y. Ravindra Reddy ; S. Mohapatra ; C. Ramarao
; K. V. Reddy " TaCl5 Silicagel and TaCl5 as new Lewis acid systems for
selective tetrahydropyranylation of alcohols and thioacetalisation,
trimerisation and alsolisation of aldehydes " Tetrahedron 1997, 53, 14997.
S. Chandrasekhar ; Y. Ravindra Reddy ; C. Ramarao " Chemoselective
Reduction of Carbonyl Compounds with PMHS-ZnCl2 " Synth. Commun. 1997, 27,
2251.
S. Chandrasekhar ; K. Rajashaker ; Y. Ravindra Reddy " Selective Oxidative
Cleavage of Di-oxolane derivatives of Sugars using FeCl3-NaIO4 "
Carbohydrate Letters 1997, 2, 217.
J. S. Yadav ; S. Chandrasekhar ; Y. Ravindra Reddy ; A. V. Rama Rao "
Synthesis of (2S, 3R)-3-Hydroxy Leucine : A Constitutent of Lysobactin "
Tetrahedron 1995, 51, 2749.
Patents
US20070191385: "Substituted Imidazole Derivatives, Compositions, and
methods of use as PTPase Inhibitors". A.M.M. Mjalli, D.R. Polisetti, G.
Subramanian, J.C. Quada, Ravindra R. Yarragunta, R.C. Andrews, R. Xie.
US20050187277: " Substituted Azole Derivatives, Compositions, and Methods
of Use". A.M.M. Mjalli, D.R. Polisetti, G. Subramanian, J.C. Quada, M.N.
Arimilli, Ravindra R. Yarragunta, R.C. Andrews, R. Xie.
US20040192743: "Substituted Azole Derivatives as Therapeutic Agents".
A.M.M. Mjalli, R.C. Andrews, Ravindra R. Yarragunta, R. Xie, G.
Subramanian, J.C. Quada, M.N. Arimilli, D.R. Polisetti.
US20040186151: " Substituted Azole Derivatives as Therapeutic Agents ".
A.M.M. Mjalli, R.C. Andrews, Ravindra R. Yarragunta, R. Xie, T. Ren, G.
Subramanian, J.C. Quada.
Indian Patent No. 1021/DEL/96: "A Novel Bio-Catalytic Resolution of Cis-3-(2,2-dichloro-3,3,3-trifluoropropyl)-2,2-dimethyl Cyclopropane
Carboxylate". J. S. Yadav; A.B. Rao ; Y. Ravindra Reddy ; K. V. Reddy.
Presentations
Poster presentation titled " Synthesis of (2S, 3R) 3-Hydroxy homotyrosine
from DAG " at 11th Carbohydrate Conference held at IICB, Calcutta, India,
November 21-22, 1996.
Poster presentation titled " Synthesis of Unusual Amino acid Components of
Echinocandin-D " at 10th International Conference on Organic Synthesis-
IUPAC, held at Indian Institute of Science, Bangalore, India, December 11-
16, 1994.
Professional Affiliations
American Chemical Society, Member.
References: Available upon request.
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