Ravindra R. Yarragunta

****-**, **** ****** ****

Greensboro, NC-27455

Email: aboj6f@r.postjobfree.com

Phone: 704-***-****(cell)

Summary:

o More than 9 years experience in medicinal chemistry and multi-step

synthesis of bio-active small molecule inhibitors.

o Drug discovery experience in the field of phosphatase and kinase

metabolic disorders.

o Proficient in structure-based inhibitor design and medicinal

chemistry principles (SAR, QSAR, Pharmacology, Pk, and ADME/Tox)

o Solid background & excellent hands in parallel synthesis, lead

optimization, scale-up and combinatorial chemistry.

o US citizen through Naturalization.

Professional Experience

Trans Tech Pharma & Pharmacore

December 2000- 2013

Senior Research Scientist

August 2009-2013

Pharmacore

High Point, NC-27265

. Involved in Custom synthesis and Contract med-chem Research projects

with major companies for different therapeutic targets, like anti-

viral drugs, Diabetic and biologically active ingredients

. Develop the new synthetic procedures and scale-up the reaction

conditions from small scale to plant scale & check the feasibility of

the process following the n-GMP/GMP procedures

Principal Scientist

December 2006-2009

Trans Tech Pharma

High Point, NC-27265

o Discovered a novel and proprietary lead series of small molecule

inhibitors on glucagon-like peptide 1 (GLP-1).

o Synthesized heterocyclic inhibitor libraries for lead discovery

against AMP kinase.

o Designed and synthesized a new series of back up compounds for a

pre-clinical program based on SAR and toxicity studies.

Senior Research Scientist

December 2003-2006

Trans Tech Pharma Inc.,

High Point, NC-27265

o Played a major role in development of clinical candidate in PTP-1B

project: structure-based design: physicochemical properties and in

vivo efficacies and molecular modeling scores, used to optimize

relatively week non-phosphorus, non-peptide general PTP-inhibitor

in to highly potent, orally available, moderately selective and low

molecular weight PTP-1 inhibitor.

o Incorporated new thiazolidinone (TDZ) warhead in on going series

and developed lead compound for protein tyrosine phosphatase

project.

o Involved in IND filing procedures and patent applications.

Research Scientist

December 2000-2003

Trans Tech Pharma Inc.,

High Point, NC-2726

o Designed and synthesized different classes of molecules (seven

classes) in the lead discovery and lead optimization effort for the

PTP-1B project.

o Developed cyclohexyl biphenyl imidazole series based on structure-

activity relationships to improve the potency and ADME characters.

o Synthesized, isolated and identified the active isomer in the lead

series for phosphatase inhibitors.

Post-doctoral Research Scientist, Medicinal Chemistry

October 1999-2000

Albany Molecular Research Inc., Albany, NY-12203

o Performed linear multistep milligram to multigram organic synthesis

o Engaged in custom synthesis and process development of various

heterocyclic compounds.

o Designed synthesis of heterocyclic compounds based upon

interpretation of the biological data obtained by collaborators and

molecular modeling.

Post-doctoral Fellow, Evans laboratory,

March 1998 -1999

The Ohio State University, Columbus, OH-43210

Supervisor: Prof. Leo A. Paquette

o Involved in efforts towards total synthesis of tetraquinane

diterpenoid Crinipellin-B, synthesizing requisite vinylbromides for

di-anionic cascade reaction from triquinane pentalene frame in a

single step.

o Successfully studied the effect of hetro-atom (S, O) on remote

acceleration of Oxy-Cope rearrangements in determining the rates of

rearrangement and in elucidating product stereochemistry.

o Performed synthesis of Chiral Ligands from Camphor and Thujone.

Senior Scientific Asst. - Natural Products Laboratory

April 1994 -1998

Indian Institute of Chemical Technology, Hyderabad, India

o Chiron approach was effectively used in design & synthesis of

unusual amino acids like 3-hydroxy leucine (part structure of

antibiotic Telomycin) and (2S, 3R) 3-hydroxy homotyrosine (part

structure of antifungal agent Echinocandin-D) starting from readily

availabe D-glucose.

o Developed a novel enzymatic resolution of chemically labile racemic

cyclopropane carboxyl esters to enantiopure carboxylic acids (a key

component of Lambda Cyhalothrin/Pyrethroid )

o Developed a new Lewis acid system for activation of inexpensive and

non-hazardous PMHS for selective reduction of carbonyl compounds to

alcohols & selective reduction of highly sensitive benzylidene

acetals of sugars in a regio selective manner.

o Applied TaCl5 as an effective Lewis acid catalyst in chemoselective

trimerisation, aldolization and thioketalization.

Junior Scientific Asst., - Organic Division I

May 1989-1994

Indian Institute of Chemical Technology, Hyderabad India

o Thorough understanding of the challenges involved in scaling-up

chemical process.

o Improved process development for the manufacture of 1-triacontanol

(plant growth regulator) and Dipyridamole (cardiovascular drug).

o Developed an efficient process for Lambda Cyhalothrin (active

pyrethroid) at the bench scale and later to facilitate transfer of

pilot plant and technologies with the collaboration of chemical

engineering section of IICT.

Education

Ph.D. Organic Chemistry, August 1993- March 1998

Indian Institute of Chemical Technology, Hyderabad, India

Thesis Topic: Synthesis of Enantiopure Intermediates and Development of New

Reduction Procedures

Adviser: Dr. J. S. Yadav

Post-Graduate Diploma in Personal Management and Industrial Relations

(PMIR), September 1992

Kakatiya University, Warangal, Andhra Pradesh, India

M.Sc. Organic Chemistry, August 1986 - November 1988

S.V. University, Tirupathi, Andhra Pradesh, India

Bachelors in Science (Chemistry, Physics, & Geology) September 1983 - May

1986

S. V. University, Anantapur, Andhra Pradesh, India

Publications

Leo A. Paquette ; Y. Ravindra Reddy ; Gregory Vayner ; K. N. Houk "High

Rate Accelerations in Oxy-Cope Rearrangements Induced by Sulfar

Substitutions: A Kinetic Study Involving Electronically and Geometrically

Differentiated 1-Alkenyl-2-(Z-1-Propenyl)-7,7-dimethyl-exo-norbornan-2-ols"

J. Am. Chem. Soc. 2000, 122, 10788.

Leo A. Paquette ; Y. Ravindra Reddy ; Fredrik Haeffner ; K. N. Houk "

Consequences of Hetroatomic

C-6 Substitution on Rates of the Oxyanionic Cope Rearrangement. The

Remarkable Accelerating Effect of Sulfide Groups " J. Am. Chem. Soc. 2000,

122, 740

Fredrik Haeffner ; K. N. Houk ; Y. Ravindra Reddy ; Leo A. Paquette "

Mechanistic Variations and Rate Effects of Alkoxy and Thioalkoxy

Substituents on Anionic Oxy-Cope Rearrangements " J. Am. Chem. Soc. 1999,

121, 11880.

S. Chandrasekhar ; Y. Ravindra Reddy ; Ch. Raji Reddy " Regioselective

Reductive Ring Opening of Cyclic 1,2- and 1,3-Benzylidene Acetals "

Chemistry Letters 1998, 12, 1273.

J. S. Yadav ; A. B. Rao ; Y. Ravindra Reddy ; K. V. Reddy " Enzymatic

Resolution of Cis-3-(2,2-dichloro-3,3,3-trifluoropropyl)-2,2-dimethyl

Cyclopropanecarboxylate " Tetrahedron Asymmetry 1997, 8, 2291.

S. Chandrasekhar ; M. Takhi ; Y. Ravindra Reddy ; S. Mohapatra ; C. Ramarao

; K. V. Reddy " TaCl5 Silicagel and TaCl5 as new Lewis acid systems for

selective tetrahydropyranylation of alcohols and thioacetalisation,

trimerisation and alsolisation of aldehydes " Tetrahedron 1997, 53, 14997.

S. Chandrasekhar ; Y. Ravindra Reddy ; C. Ramarao " Chemoselective

Reduction of Carbonyl Compounds with PMHS-ZnCl2 " Synth. Commun. 1997, 27,

2251.

S. Chandrasekhar ; K. Rajashaker ; Y. Ravindra Reddy " Selective Oxidative

Cleavage of Di-oxolane derivatives of Sugars using FeCl3-NaIO4 "

Carbohydrate Letters 1997, 2, 217.

J. S. Yadav ; S. Chandrasekhar ; Y. Ravindra Reddy ; A. V. Rama Rao "

Synthesis of (2S, 3R)-3-Hydroxy Leucine : A Constitutent of Lysobactin "

Tetrahedron 1995, 51, 2749.

Patents

US20070191385: "Substituted Imidazole Derivatives, Compositions, and

methods of use as PTPase Inhibitors". A.M.M. Mjalli, D.R. Polisetti, G.

Subramanian, J.C. Quada, Ravindra R. Yarragunta, R.C. Andrews, R. Xie.

US20050187277: " Substituted Azole Derivatives, Compositions, and Methods

of Use". A.M.M. Mjalli, D.R. Polisetti, G. Subramanian, J.C. Quada, M.N.

Arimilli, Ravindra R. Yarragunta, R.C. Andrews, R. Xie.

US20040192743: "Substituted Azole Derivatives as Therapeutic Agents".

A.M.M. Mjalli, R.C. Andrews, Ravindra R. Yarragunta, R. Xie, G.

Subramanian, J.C. Quada, M.N. Arimilli, D.R. Polisetti.

US20040186151: " Substituted Azole Derivatives as Therapeutic Agents ".

A.M.M. Mjalli, R.C. Andrews, Ravindra R. Yarragunta, R. Xie, T. Ren, G.

Subramanian, J.C. Quada.

Indian Patent No. 1021/DEL/96: "A Novel Bio-Catalytic Resolution of Cis-3-(2,2-dichloro-3,3,3-trifluoropropyl)-2,2-dimethyl Cyclopropane

Carboxylate". J. S. Yadav; A.B. Rao ; Y. Ravindra Reddy ; K. V. Reddy.

Presentations

Poster presentation titled " Synthesis of (2S, 3R) 3-Hydroxy homotyrosine

from DAG " at 11th Carbohydrate Conference held at IICB, Calcutta, India,

November 21-22, 1996.

Poster presentation titled " Synthesis of Unusual Amino acid Components of

Echinocandin-D " at 10th International Conference on Organic Synthesis-

IUPAC, held at Indian Institute of Science, Bangalore, India, December 11-

16, 1994.

Professional Affiliations

American Chemical Society, Member.

References: Available upon request.

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