Medical Engineering

Hui Dai, MD, Ph.D

Address: **** ******* ****, *******, ******** 62629

Phone: 206-***-**** E-mail: ******@*****.***

QUALIFICATIONS PROFILE

ACCOMPLISHED MEDICAL PROFESSIONAL AND SCIENTIST, offering over 16 years of experience in medical areas, hepatobiliary/vascular surgery, organ /cell transplantation, immunology, oncology, neuroscience, molecular biology, and drug discovery. Equipped with focused expertise in nanomedicine and infectious diseases, human /mouse stem cells research, neuroinflammation/neurodegenerative diseases, diabetes, drug delivery and control drug delivery, and biomaterials in vivo and in vitro applications and their screening for drug delivery applications.

RECOGNIZED LEADER IN INNOVATION, having authored numerous publications, secured patents, and earned commendations for extensive work in researching new scientific concepts and driving potential clinical applications. Armed with stellar ability in leading and performing all phases of research, developing strategies and coordinating execution. Equipped with remarkable analytical, documentation, technical report writing, presentation, and advocacy skills.

SOUGHT-AFTER CONTRIBUTOR to various leading institutions and medical organizations through skillful development, enhancement, and creative orchestration of technologies and resources. Powered with scientific leadership skills; effective in working within team settings. Known for keen eye on details, with proven capability to multitask in a globally competitive, challenging, and fast-paced environment. Solid track record in maintaining compliance with ethics, health and safety regulations.

AREAS OF EXPERTISE

Pharmaceuticals

Molecular Biology

Small/Large Animal Survival and Non-Survival Surgery

Human Surgery

Microsurgery (Hepatobiliary/Vascular)

Organ Transplantation

Animal Model Development/Validation

In vivo Pharmacology Models

Viral/Nonviral/Stem-Cell Gene Therapy

Cell Transplantation/ Human xenograft Tumor Models Development

Experimental Surgery

Biological Assays

Primary Cell Isolation and Cultures/ Flow Cytometry (FACS)

Tissue Engineering(3D)/Stem Cell Biology

Advanced Materials and Nanotechnology In vitro/In vivo Studies

Tissue Harvesting

Nanomedicine Techniques

RT-PCR,QPCR, DNA Sequencing

Research and Data Analysis

Presentations

EDUCATION

Doctor of Philosophy in Hepatobiliary Surgery/Biomedical Engineering: 2001–2004

The Fourth Military Medical University Xi’an, China/Johns Hopkins University in Singapore Singapore

Master of Science in Hepatobiliary Surgery: 1998–2001

The Fourth Military Medical University Xi’an, China

Doctor of Medicine in Clinical Medicine: 1990–1995

The Fourth Military Medical University Xi’an, China

INTERNSHIP AND RESIDENCY

Chief, Hepatobiliary Surgery Residents and Fellows: 1997–1998

Resident, Hepatobiliary Surgery: 1995–1997

Department of Hepatobiliary Surgery, Xijing Hospital Xi’an, Shaanxi Province, China

Intern, General Medicine (Internal Medicine, General Surgery, Gynecology and Pediatrics): 1994–1995

The Fourth Military Medical University, Xijing Hospital Xi’an, Shaanxi Province, China

CAREER HISTORY

SOUTHERN ILLINOIS UNIVERSITY (School of Medicine), Springfield, Illinois • 2011-

Educational institution with 380 faculty and 260 full-time researchers and administrative staff.

Research Assistant Professor: Design and lead biomedical research projects, working closely with researchers and residents to complete plastic surgery laboratory work. Direct microsurgery research lab, supervising a team of 4, including 1 postdoctoral researcher and 3 technicians. Closely manage data collection and analysis. Author manuscripts for peer-reviewed journals and prepare compelling grant applications.

Key Accomplishments:

• Led exploration of therapeutic potential of adipose-derived stem cells (ADSC) isolated from human burn tissue and self-assembly engineering skin substitutes by adipose-derived stem cells from debrided human burned skin for wound healing and tissue regeneration.

• Spearheaded study to explore melanoma circulating tumor cells metastases and self-seeding prevention via combined ADSc cell therapy and dendrimer-based drug delivery system in human xenograft tumor using nude mice models.

• Ensured process integrity and on-time delivery of important research studies, using exceptional technical leadership skills to coach and mentor staff.

• Made key contributions to 4 peer-reviewed publications, participated in 4 global conferences and successfully applied for 2 major research grants.

• Collaborated with a PGY-5 plastic surgery resident on a research project that was nominated for the top prize at the 11th Annual SIU Surgery Resident Research Day event, exploring the skin regenerative potential of adipose-derived stem cells in vitro and in vivo.

Senior Research Associate Department of Pediatrics/Perinatology Research Branch

CHILDREN’S HOSPITAL OF MICHIGAN (WAYNE STATE UNIVERSITY) Detroit, MI, USA 2007–2011

Performed multiple functions, including management of two animal disease models; animal model development; animal survival and non-survival surgery; as well as post-surgical care, anesthesia, vein and artery catheterization, biodistribution study in vivo([(11)C]PK11195 labled compound), PET scan, and laparotomies in one of the nation’s top 30 pediatric treatment and research facilities. Provided expert oversight in the design and evaluation of a targeted novel nano dendritic drug conjugates for treatment of maternal and fetal inflammation. Supervised a variety of biological assays (ELISA, western blot, RT-PCR and QPCR,RT2-PCR array, antibody array, microarray, proliferation/apoptosis assays, immunofluorescence staining, and immunohistochemistry staining, confocal laser scanning microscopy (LSCM), and fluorescence microscopy) as well as coordinated harvesting of tissue and tissue processing and sectioning(frozen and paraffin embedded). Worked in close partnership with multidisciplinary scientists on chemical engineering, tissue engineering, and medicine.

Gained the Postdoctoral Scholars Research Award (2008) for leading the study on “Intrinsic Targeting of Neuroinflammation by Polyamidoamine dendrimers in a Rabbit Model of Cerebral Palsy” that explored endotoxin-induced brain injury in neonatal rabbit model of cerebral palsy and novel dendrimer-mediated drug delivery nanodevice in in vivo application research work was published on Science Translational Medicine (2012) and Future Medicine (Nanomedicine), and was highlighted by Nature, Science, and Toronto News.

Supervised the creation of a guinea pig model for maternal-fetal infection (inoculation of E. coli in cervix).

Served as advisor to a year II critical care fellow regarding work on microglial activation and neuronal cell death in rabbit perinatal brain injury model that gained recognition for best fellowship research project by the Society of Critical Care Medicine (2009) and Wolf-Zuelzer Award for best fellow research (2009).

Earned patent for dendrimer-based nanodevices for maternal-fetal applications.

Made significant contributions to 7 peer-reviewed publications and participated in 10 international conferences.

Research Associate Division of Neonatology

MOUNT SINAI MEDICAL CENTER Miami, FL 2006–2007

Supervised all animal surgical operations, blood gas measurement, ECG,tissue collections, and biochemical assays (including ELISA, western blot, real-time RT-PCR and QPCR, tissue sectioning, H&E staining, and immunohistochemistry staining) in an internationally acclaimed tertiary-care teaching facility for excellence in clinical care.

Led the setup of traumatic hemorrhagic pig model and rat hemorrhagic shock model to study resuscitation with Na+/H+ exchanger inhibitor.

Shared insights based on comprehensive data assessments and evaluation for two peer-reviewed publications and took part in three international conferences.

Senior Postdoctoral Fellow Department of Pediatrics

UNIVERSITY OF WASHINGTON SEATTLE, WA, USA 2005–2006

Handled multiple responsibilities for the top-ranked primary-care medical school in the country, including administering cell isolation and transplantation, confocal images, and biological assays. Efficiently led the generation of transduced bone marrow cell with lentivirus in vitro and in vivo; vector design, construction and co-transfection of recombinant virus vector; and provision of BB rat pancreas (islet cell) isolation, cell mitotic index assay, cell colony-forming assay, cell growth curve assay, flow cytometry (FACS), lentivirus production, and replication competent lentivirus (RCL) assays.

Explored studies on lentivirus-mediated gene transfer of IAN5 gene to treat type 1 diabetic rats, along with rat bone marrow cell transplantation and BB rat bone marrow cell isolation and cultivation.

Postdoctoral Fellow Tissue and Therapeutic Engineering Laboratory (Singapore)/Department of Biomedical Engineering (Baltimore, MD, USA)

JOHNS HOPKINS UNIVERSITY BALTIMORE, MD, USA 2002–2005

Oversaw the implementation of liver-targeting gene therapy and non-viral vector gene transfer in vitro and in vivo. Handled the effective isolation, purification and cultivation of rat liver cells transfected with non-viral vector with plasmid complex. Ensured timely completion and accurate results gathering through stem cell culture generation, in vitro studies, in vivo implantations, and tissue sample harvesting as well as through biological assays, including plasmid DNA isolation, protein, DNA/RNA isolation from cell and tissue, ELISA, western blot, real-time PCR and RT-PCR, confocal laser scanning microscopy (LSCM), and fluorescence microscopy.

Facilitated the successful setup of retrograde intrabiliary infusion of plasmid DNA and DNA nanoparticles rat model after conducting all surgical operations and biological assays.

Completed the testing of different nanoparticles transgene expression in hepatocyte, kupffer cells, and sinusoidal endothelial cells, as well as in vivo retrograde intrabiliary infusion of plasmid DNA and DNA nanoparticles rat model.

Provided technical guidance and insights to students on laboratory work:

- Contributed two publications while assisting a year III MS student on a study in inducing hepatic differentiation of human mesenchymal stem cells study.

- Authored four publications while mentoring a year II MS student and a year I PhD student in laboratory work on liver-targeted gene delivery by Chitosan-g-PEG/DNA nanoparticles and PEG-b-PPA/DNA micelles.

Secured grant from American Society of Gene Therapy’s 8th Annual Meeting (2005) for “Role of Kupffer Cells in Hepatic Transgene Expression Mediated by Intrabiliary Infusion of Nonviral Vectors.”

Contributed articles to 11 peer-reviewed publications and participated in six international conferences.

Attending Surgeon and Instructor Hepatobiliary Surgery

THE FOURTH MILITARY MEDICAL UNIVERSITY Xi’an, China 1998–2002

Administered general surgery operation and liver transplantation as well as managed clinical and basic research on organ transplantation and cancer in a major medical facility focused on medical service, teaching, and research.

Played a key role in the first successful case of living-related liver transplantation in China in 1997.

Ranked 2nd as the Outstanding Young Surgical Paper of Chinese National General Surgery in 2001.

Secured patent for drainage tubec of diplo-cannula surgery remedial and prophylacti.

Made significant contributions to 16 publications.

PROFESSIONAL AFFILIATIONS

Member, Chinese Medicine Society Associate Member, American Society of Gene Therapy (ASGT)

Associate Member, American Heart Association (AHA) Associate Member, Society for Neuroscience (SFN)

Full Member, Sigma Xi (Scientific Research Society)

REVIEWER FOR JOURNALS

Nanomedicine: Nanotechnology, Biology and Medicine Biomaterials Future Medicine (Nanomedicine)

Int. J. Nanomedicine Tissue Engineering Human Gene Therapy Nanotechnology, Science and Applications

Hepatic Medicine: Evidence and Research

TECHNICAL SKILLS

Windows OS MS Office Suite SciFinder Crossfire Endnote SPSS

Reference Manager ImageJ Adobe Acrobat Adobe Photoshop Primer Express ANOVA

SELECTED PEER REVIEW PUBLICATIONS

Shi, X. J., Guan, W. X., Dou, K. F., Gao, Z. Q., Li, K. Z., and Dai, H. (1998). Living-related liver transplantation in liver transplantation and repair irrigation. World Journal of Gastroenterology, 6(48): 116–118.

Dou, K.F., Guan, W.X, Li, K. Z., Gao Z. Q., Fu.Y.C., Dai, H., Wang. DS. (1998). Blood of the living-related liver transplantation case report. Chinese Journal of Surgery, 36(4).203-205.

Guan, W. X., Dou, K. F., Gao, Z. Q., Li, K. Z., Dai, H., and Koichi T. (1998). Clinical living donor liver transplantation surgery dressing. Chinese Journal of Hepatobiliary Surgery, 6(34): 106–109.

Dai, H., Dou, K. F., Gao, Z. Q., Li, K. Z., Fu.Y.C., Chen, Y. (2000). Investigation and analysis of diagnosis of carcinoma of head of pancreas (a report of 156 cases). Chinese Journal of Practical Surgery, 20(8): 253–255.

Dai, H., Qiu, K., Li, K. Z., Dou, K. F., Gao, Z. Q, Chen Z.N. (2000). The biological characteristics of β-glucuronidase cDNA transfected bile duct cell line QBC939-βG. Chinese Journal of Cellular and Molecular Immunology, 16(4): 378–380.

Yi, J., Dai, H., and Zhang, J. L. (2000). Multilocular pancreatic retention cyst in 1 case. Journal of the Fourth Mil. Med. Univ., 21(5) 78–79.

Dai, H., Chen, Y., Li, K. Z., Dou, K. F., Gao, Z. Q. (2001). Expression of era gene in bile-duct carcinoma and gallbladder carcinoma and its implications. Journal of Chinese Surgery, 22(4): 246–247.

Dai, H., Chen, Y., Li, K. Z., Dou, K. F. (2001). Expression of zebra gene in bile-duct carcinoma and gallbladder carcinoma and its implications. Chinese Journal of Experimental Surgery, 17(6) (suppl.): 521–523.

Dai, H., Li, H.M., Chen, Y., Li, K. Z., Dou, K. F. (2001). Investigation and analysis of early diagnosis of carcinoma of head of pancreas (a report of 22 cases). Chinese Journal of Hepatobiliary Surgery, 11(1): 46–48.

Dai, H., Chen, Y., Dou, K. F., Gao, Z. Q., Li, K. Z. (2001). The effects of β-G prodrug on β-Glucuronidiase-cDNA transfected bile duct carcinoma cell line QBC939. Chinese Journal of Experimental Surgery, 18(2): 175-176.

Dai, H., Chen, Y., Li, K. Z., Dou, K. F., Gao, Z. Q. (2001). Expression of β-G gene in bile-duct carcinoma and gallbladder carcinoma and its implications. Chinese Journal of Experimental Surgery, 20(10): 930–932.

Dai, H., Dou, K. F., Gao, Z. Q., Li, K. Z., Chen, Y. (2001). Expression of β-G gene in primary hepatocellular carcinoma and pericarcinomatous cirrhosis tissue and its implication. Medical Journal of Chinese People’s Liberation Army, 26(6): 445–447.

Sun, K., Li, H. M., Jiang, Y.S., Wang, D.S., Dai, H., and Yang, Y.L. (2000). Drainage of abdominal puncture and lavage treatment of acute pancreatitis. Practical Medicine, 21(5) 178–179.

Dai, H., Qiu, K., Li, K. Z., Dou, K. F., Gao, Z. Q., Chen, Y., Chen, Z.N. (2002). The bystand-effects and effect of β-G prodrug on β-Glucuronidase-cDNA transfected bile duct carcinoma cell line QBC939. World J. Gastroenterol, 7(3): 336–339.

Chen, Y., Cui, D. X., and Dai, H. (2003). Cloning of sFGFR1 and its high efficient expression in rats. Journal of the Fourth Mil. Med. Univ., 24(8): 703–705.

Li, H. M., Dai, H., Dou, K. F., Gao, Z., Q., and Li, K. Z. (2003). Diagnosis and treatment for carcinoma of the head of pancreas. Chinese Journal of General Surgery, February, 12(2): 97–100.

Chen, Y., Cui, D. X., Yang, Y. L., and Dai, H. (2003). Adenovirus mediate FGF receptor gene transfer inhibits accelerated graft arteriosclerosis in rat aortic transplants. Zhonghua Yi Xue Za Zhi, September 25, 2003, 83(18): 1607–10.

Chen, Y., Cui, D. X., Yang, Y. L., and Dai, H. (2003). Fas-mediated apoptotic pathway in chronic graft rejection due to the role of vascular lesions. Chinese Journal of Experimental Surgery, 20(10):930–932.

Dai, H., Zhang, P. C., Lim W. S., Chen, Y., Leong, K. W., and Mao, H-Q (2003). Liver-targeted gene transfer mediated by Chitosan-DNA nanoparticles through bile duct, portal vein, and tail vein injections. Molecular Therapy (Vol. 7, No. 5), Part 2, S322–23.

Jia, N., Dai, H., Mao, H-Q., Chen, S. M., and Guo, S. Z. (2004). New non-viral nanosphere-VEGF complexes transfected mouse fibroblast cells in vitro study. Chinese Journal of Aesthetic Medicine, 13(2): 146–150.

Dai, H., Jiang, X., Jiang, S., Lim, W. S., Chen Y., Leong, K. W., and H-Q. Mao (2004) Selective depletion of Kupffer cells leads to enhanced transgene expression in rat liver following intraductal infusion of naked DNA and DNA nanoparticles. Molecular Therapy (Vol. 9), S136–37.

Dai, H., Zhang, P. C., Lim, W.S., Chen, Y., Leong, K.W., Mao, H-Q. (2005). Role of Kupffer cells in hepatic transgene expression mediated by intrabiliary infusion of non-viral vectors. Molecular Therapy (Vol. 11, Supplement 1), S77.

Jiang, X., Dai, H., Leong, K. W. and Mao, H-Q. (2006). PEG-β-PPA/DNA micelles for liver-targeted gene delivery. Molecular Therapy (Vol. 13), S66.

Wong, K. H., Zhang, X., Dai, H., Leong, K. W. (2006). PEI-g-chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo. Bioconjug Chem., 17(1): 152–8.

Jiang, X., Dai, H., Leong, K. W, Goh, S. H., Mao, H-Q., and Yang, Y. Y. (2006). Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusions. J. Gene Med, 8(4): 477–87.

One, S. Y., Dai, H., and Leong, K. W (2006). Hepatic differentiation potential of commercially available human mesenchymal stem cells. Tissue Engineering, 12(12): 3477–85.

One, S. Y., Dai, H., and Leong K. W. (2006). Inducing hepatic differentiation of human mesenchymal stem cells in pellet culture. Biomaterials, 27(22): 4087–97.

Dai, H., Jiang, X., Chen, Y., Leong, K. W., and Mao, H-Q (2006). Chitosan-DNA nanoparticles delivered by intrabiliary infusion enhance liver-targeted gene delivery. Int. J. Nanomedicine, 1(4): 507–522.

Jiang, X., Dai, H., Ke, C.Y., Mo, X., Torbenson, M.S., Li, Z., and Mao, H-Q. (2007). PEG-b-PPA/DNA micelles improve transgene expression in rat liver through intrabiliary infusion. J Control Release, 122(3): 297–304.

Wu, D., Dai, H., Arias, J., Latta, L., and Abraham, W.M (2009). Low-volume resuscitation from traumatic hemorrhagic shock with Na+/H+ exchanger inhibitor. Crit. Care Med., 37(6): 1994-1999.

Wu, D., Qi, J., Dai, H., Doods, H., and Abraham, W. M (2010). Resuscitation with Na+/H+ exchanger inhibitor in traumatic haemorrhagic shock: Cardiopulmonary performance, oxygen transport, and tissue inflammation. Clin. Exp. Pharmacol. Physiol, 37(3): 337–42.

Wang, B., Navath, R. S., Menjoge, A.R., Bellair, R., Balakrishnan, B., Dai, H Kannan, R. M. (2010). Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers. Inter. J. Pharm, 395(1–2): 298–308.

Kannan, S., Saadani-Makki, F., Bindu, B., Dai, H., Chakraborty, P.K., Roberto, R.,Chugani DC. (2011). Decreased cortical serotonin in neonatal rabbits exposed to endotoxin in utero. Journal of Cerebral Blood Flow & Metabolism, 31(2):738-49.

Dai, H., Jiang, X., Leong, K. W. and Mao, H-Q. (2011). Transient depletion of Kupffer cells leads to enhanced transgene expression in rat liver following retrograde intrabiliary infusion of plasmid DNA and DNA nanoparticles. Human Gene Therapy; 22(7):873-8.

Dai, H., Navath, R. S., Bindu, B., Rajaguru, R. Romero, R., Kannan, M. and Kannan, S. (2010). Intrinsic targeting of neuroinflammation by polyamidoamine dendrimers in a rabbit model of cerebral palsy. Future Medicine (Nanomedicine), 5(9):1317-1329.

Navath, R. S., Menjoge, A. R., Dai, H., Romero, R., Kannan, S., Kannan, R. M (2011). In-situ forming injectable intravaginal hydrogels for the treatment of ascending genital infections during pregnancy: Formulation, in vitro and in vivo evaluation. Mol. Pharm. Aug 1; 8(4):1209-23.

Menjoge, A. R., Navath, R. S., Dai, H., Romero, R., Kannan, S., Kannan, R. M. (2012). Prospects for use polymeric nanocarriers for selective therapy during pregnancy: Transport patterns across normal and endotoxin treated rabbit fetal membranes. Submitted to Mol. Pharm. Under review.

Dai, H., Sandiford, P., Bindu, B., Romero, R., Kannan, S. (2012). Microglia modulate the neuroinflammatory response in a neonatal rabbit model of cerebral palsy. Submitted to Free Radical Biol. Med. Under review.

Kannan, S., Dai, H., Navath, R. S., Bindu, B., Romero, R., Kannan, R. M. (2012). Novel dendrimer-mediated drug delivery nanodevice (PAMAM-G4OH-NAC) improves motor deficits and attenuates endotoxin-induced brain injury in a neonatal rabbit model of cerebral palsy. Science Translational Medicine, Vol. 4, Issue 130, p. 130ra46.

Derby, B., Dai, H., Reichensperger, J., Harrison, C, Cox, L, Bueno, R., and Neumeister, MW (In Progress). Adipose-derived stem cell to skin stem cell transdifferentiation: a mechanism to improve understanding of fat grafts’ skin regenerative potential. Submitted to Plastic and Reconstructive Surgery.

Lough, D, Dai, H., Yang, M., Reichensperger, J., Cox, L., Harrison, C. and Neumeister, M. (In Progress) Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Human Alpha Defensin 5 Results in Decreased Bacterial Presence, Enhanced Wound Healing and Hair Growth from Tissues Devoid of Adnexal Structures. Submitted to Plastic and Reconstructive Surgery. Under review.

Liu, G., Dai, H., Neumeister, M., Reichensperger, J., and Yang, R D (In Progress). Therapeutic potential of human adipose stem cells in a cancer stem cell-like gastric cancer cell model. Submitted to International Journal of Cancer Research.

Dai, H., Derby, B., Reichensperger, J., Harrison, C., Cox, L, Neumeister, MW (2012). The role and therapeutic potential of the ADSC isolated from human burn tissue. (In preparation).

PUBLISHED ABSTRACTS

Dai, H., Tan, G., Lim, W. S., Chen, Y., Leong, K. W., and Mao, H-Q. (2003). Enhanced gene transfer using nanoparticles through intraductal administration route [Abstract]. International Conference on Materials for Advanced Technologies, Singapore.

Dai, H., Zhang, P. C., Lim, W. S., Chen, Y., Leong, K. W., and Mao, H-Q. (2003). Liver-targeted gene transfer mediated by Chitosan-DNA nanoparticles through bile duct, portal vein, and tail vein injections [Abstract]. Molecular Therapy (Vol. 7), Part 2, S322–23.

Dai, H., Tan, G., Lim, W. S., Chen, Y., Leong, K. W., and Mao, H-Q. (2003). Nanoparticles mediated liver-directed gene transfer [Abstract]. 7th NUS-NUH Annual Scientific Meeting, in conjunction with the Genome Institute of Singapore, Institute of Molecular & Cell Biology, & Johns Hopkins Singapore, Abstract 189.

Wang, XL, Zhang, P.C., Dai, H., Leong, K.W. and Mao, H-Q (2003). Effect of pendant chain length of polyphosphoramidate gene Carriers on their transfection efficiency [Abstract]. The 2003 Annual Meeting and Exposition, Society for Biomaterials, Reno, NV.

Dai, H., Jiang, X., Jiang, X. S., Lim, W. S., Chen, Y., Leong, K. W., and Mao H-Q. (2004) Selective depletion of Kupffer cells leads to enhanced transgene expression in rat liver following intraductal infusion of naked DNA and DNA nanoparticles [Abstract]. Molecular Therapy (Vol. 9), S136–37.

Dai, H., Zhang, P. C., Lim, W.S., Chen, Y., Leong, K.W., and Mao, H-Q (2005). Role of Kupffer cells in hepatic transgene expression mediated by intrabiliary infusion of non-viral vectors [Abstract]. Molecular Therapy (Vol. 11, Supplement 1), S77.

One, S. Y., Dai, H., and Leong, K. W. (2005). Hepatic differentiation potential of commercially available human mesenchymal stem cells [Abstract]. Workshop on Tissue Engineering - The Next Generation, May 02-04, Boston, MA, p.3477-3485.

Jiang, X., Dai, H., Leong, K. W. and Mao, H-Q. (2006). PEG-β-PPA/DNA micelles for liver-targeted gene delivery. [Abstract]. Molecular Therapy (Vol. 13), S66.

Wu, D., Dai, H., Arias, J., Latta, L, and Abraham W. M (2007). Low-volume resuscitation from traumatic hemorrhagic shock with Na+/H+ exchanger inhibitor [Abstract]. Circulation (Vol. 116, Supplement 16), Abstract 1807.

Wu, D., Dai, H., Qi, J., Doods, H., and Abraham, W. M. (2008). Fluid resuscitation with Na+/H+ exchanger inhibitor improves cardiovascular and metabolic function in a pig model of uncontrolled hemorrhagic shock [Abstract]. Circulation (Vol. 118, Supplement 18), Abstract 2049.

Wu, D., Dai, H., Arias, J., Latta, L., Abraham, W. M. (2009). Resuscitation from traumatic hemorrhagic shock with Na+/H+ exchanger inhibitor [Abstract]. IFMBE (International Federation for Medical and Biological Engineering) Proceedings (Vol.24), 307.

Dai, H., Navath, R. S., Fadoua, S. M., Rajaguru, B., Romero, R., Kannan, R. M., and Kannan, S. (2008) Novel dendrimer-based nanodevices for delivery of therapeutics to activated microglia and astrocytes in a neonatal rabbit model of cerebral palsy [Abstract]. Society for Neuroscience, the 38th Annual Meeting, USA, abstract 597.11/VV12.

Saadani-Makki, F., Kannan, S., Makki, M., Lu, X., Dai, H., Janisse, J., Romero, R., and Chugani D. (2008). White matter changes in perinatal rabbit brain induced by intrauterine inflammation: Detection by diffusion tensor imaging [Abstract]. Society for Neuroscience, the 38th Annual Meeting, USA, abstract 53.10/Z19.

Kannan, S., Saadani-Makki, F., Lu, X., Chakraborthy, P., Dai, H., Muzik, O Chugani, D. (2008) [11C] AMT uptake by small animal PET in a neonatal rabbit model of intrauterine inflammation induced brain injury [Abstract]. Society for Neuroscience, the 38th Annual Meeting, USA, abstract 53.9/Z18.

Kannan, R. M., Dai, H., Kannan, S., Romero, R. (2008). Biodistribution of dendrimer-based nanodevices for brain delivery of therapeutics [Abstract]. American Institute of Chemical Engineers (AICHE), Annual Meeting, November, USA, abstract 164b.

Kannan, S., Dai, H. Navath, R., Balakrishnan, B., Romero, R., Kannan, R. M. (2009). PAMAM dendrimers for the brain delivery of therapeutics for the treatment of cerebral palsy [Abstract].The International Dendrimer Society Meeting, Sweden, abstract 1011.

Kannan, S., Saadani-Makki, F., Dai, H., Chakraborthy, P., Muzik, O., Romero, R., and Chugani D. (2009). Brain tryptophan metabolism using small animal PET in a neonatal rabbit model of cerebral palsy [Abstract]. Journal of Cerebral Blood Flow & Metabolism 29, S93–S98, abstract 1056.

Kurtoglu, Y. E., Navath, R. S., Wang, B., Dai, H., Romero, R., Kannan, S., and Kannan, R. M. (2009). PAMAM dendrimers conjugates for intracellular delivery of N-Acetyl-Cysteine [Abstract]. AICHE, Annual Meeting, November, USA, abstract 348e.

Kannan, R. M., Navath, R. S., Dai, H., Wang, B., Kannan, S., and Romero, R. (2009). PAMAM dendrimers for brain delivery of therapeutics for the treatment of cerebral palsy. Chemistry, In vivo Efficacy and Imaging [Abstract]. AICHE, Annual Meeting, November, USA, abstract 442b.

Kannan, R. M., Navath, R. S., Dai, H., Bindu, B., Romero, R., Kannan, S (2010). Dendrimer-based nanodevices for the treatment of neuroinflammation in cerebral palsy [Abstract]. Nanomedicine and Drug Delivery, AICHE Annual Meeting, USA, abstract 656f.

Kannan, S., Bindu, B., Dai, H., Lesniak, W., Jyoti, A, Muzik, O., …Chugani, D.C. (2011). Maternal intrauterine inflammation induces kynurenine pathway activation and leads to decreased cortical serotonin in the newborn rabbit brain: Implications for maternal infection and autism [Abstract]. International Meeting for Autism Research (IMFAR Annual Meeting), USA, Abstract #8628.

Liu, G., Dai, H., Neumeister, M, Reichensperger, J, Yang, R D (2012). Therapeutic potential of human adipose stem cells in a cancer stem cell-like gastric cancer cell model [Abstract]. Gastroenterology, Vol. 142, Issue 5, Supplement 1, Page S-31; abstract 128.

Derby, B., Dai, H., Reichensperger, J., Harrison, C., Cox, L., Bueno, R. MD, and Neumeister, MW (2012) Adipose-derived stem cell to skin stem cell transdifferentiation: a mechanism to improve understanding of fat grafts’ skin regenerative potential [Abstract]. The Midwestern Association of Plastic Surgeons (51th Annual Educational Meeting), Page 27.

Lough, D, Dai, H., Yang, M., Reichensperger, J., Cox, L., Harrison, C. and Neumeister, MW. (2012). Stimulation of the follicular bulge LGR5+ and LGR6+ stem cells with the gut-derived human alpha defensin 5 results in decreased bacterial presence, enhanced wound healing and hair growth from tissues devoid of adnexal structures [Abstract]. The Plastic Surgery Research Council (57th Annual Meeting), abstract 22.

Dai, H., Lough, D., Derby, B., Reichensperger, J., Harrison, C., Cox, L.,…Neumeister, MW (2012). The role and therapeutic potential of the ADSC isolated from human burn tissue [Abstract]. International Federation of Adipose Therapeutics and Science (IFATS, 10th Annual Meeting).Québec Canada, abstract# 283.

PRESENTATIONS

Dai, H., Tan, G., Lim, W. S., Chen, Y., Leong, K. W., and Mao H-Q (2003). Enhanced gene transfer using nanoparticles through intraductal administration route. Oral Presentation. International Conference on Materials for Advanced Technologies Poster Presentation, Singapore.

Dai, H., Zhang, P. C., Lim, W. S., Chen, Y., Leong, K. W., and Mao, H-Q (2003). Liver-targeted gene transfer mediated by Chitosan-DNA nanoparticles through bile duct, portal vein, and tail vein injections. Oral Presentation. American Society of Gene Therapy, 6th Annual Meeting, Washington, DC, USA.

Dai, H., Tan, G., Lim, W. S., Chen, Y., Leong, K. W., and Mao, H-Q (2003). Nanoparticles mediated liver-directed

Contact this candidate