Medical Hospital
Resume:
Curriculum Vitae
Date Prepared: March *nd, ****
Name: Mariana Concepcion Castells
Office Address: Smith Building, Room
626D, One Jimmy Fund Way, Boston, MA 02115
Home Address: (6
Work Phone: 617-***-****
Work Email: abo9bf@r.postjobfree.com
Work
FAX:
Place of Birth: (6
Education
--b(6)-- B.S
.
1979
1991
Postdoctoral Training
M.D
.
1980
Medicine
1981
-1983
Ph.D.
Medicine
1983
-19851992
-1994Instructor Medicine Harvard Medical School, Boston,
MA
Lycee Francais
1995
-2005Assistant ProfessorMedicine Harvard Medical School
2005
- Associate ProfessorMedicine Harvard Medical School
Immunology Barcelona, Spain
Appointments at Hospitals/Affiliated Institutions
1985
-19881
Universidad Autonoma
Intern
Barcelona, Spain
1988
-1990Universidad Complutense
Madrid, Spain
1990
-1992Resident
Fellowship
Fellowship
Resident
Fellowship Internal Medicine
Allergy and Clinical Immunology
Allergy and Clinical Immunology
Internal Medicine
Hospital Provincial, Madrid, Spain
Department of Rheumatology,
Allergy and Immunology Ciudad Sanitaria La Paz,
Madrid, Spain
Ciudad Sanitaria La Paz,
Madrid, Spain
Medical College of Virginia,
Richmond, VA
Kansas University Medical Center
Kansas City, KS
Brigham and Women s Hospital,
Boston, MA
Faculty Academic Appointments
Associate Staff Allergist
1998
-
2002
-
2003
-
2004
2005
-
2009
- Immunology Training Program
Regional
2002- Director Mastocytosis Registry
Professional Societies
1983- Sociedad Espanola de Alergia e
1984
-
1986
-2000
2001
- Immunologia Clinica
2
Consultant in
Allergy
Rheumatology, Allergy and
Director, Adverse Drug Reactions and European Academy of Allergy
Associate Physician Immunology
MIT Medical Services
Desensitizations Service American Academy of Allergy and
Immunology
Member
American Academy of Allergy and
Preceptor, Patient-Doctor (PD) 2 Preceptor-
Member
Brigham and Women s Hospital
Rheumatology, Immunology
Student Project
and Allergy Boston, MA
Member
Massachusetts Institute of Technology
Cambridge, MA
Mentor, Mentored Clinical Casebook Fellow
New England Deaconess Hospital
Project
Boston, MA
Brigham and Women s Hospital
Major Administrative Leadership Positions
Mentor, Career Development Program
Director, Clinical Allergy
Rheumatology, Immunology and Allergy
Director, Allergy and Immunology
Training Program Brigham and Women s Hospital
Brigham and Women s Hospital
Brigham and Women s Hospital/Harvard Medical
School
Brigham and Women s Hospital/Harvard Medical
School
Brigham and Women s Hospital
Brigham and Women s Hospital Allergy Clinic
Rheumatology, Immunology and Allergy
Brigham and Women s Hospital
Immunology
1989-
1989-
2002-
2004-
2005- 2004
2011
1979 Licenciatura con sobresaliente:
Special Graduation Award of
3
Excellency
Editorial Board (Spanish)
Universidad Autonoma
Editor Medico Interamericano:
Barcelona, Spain
Asthma and Allergies
2005-
Anaphylaxis and Hypersensitivity Reactions
Honors and Prizes
2005-
2007-
2007-
2009
2010-
American Medical Association
American College of Physicians
Society of Teaching Scholars Brigham and
Women s Hospital/Harvard Medical School
Drug Hypersensitivity Research Alliance
The Mastocytosis Society Member, Adverse Reactions to Drugs and
Biologicals Committee
Leader, Practice Parameters,
AAAAI/ACAAI Desensitization Task Force
Chair, Mastocytosis Task Force
Vice Chair, Adverse Reactions to Drug and
Biologicals Committee
Secretary, Food Allergy, Anaphylaxis,
Dermatology and Drug Allergy Committee
Vice Chair FAADA
Chair ITE Committee
Member
Member
Member
Member and Leader
Medical Advisory Board
Editorial Activities
1991 Ph.D. Doctoral Thesis:
1992
1996
1997
2002
2002
2004
2004
2008
2009
2009
2010
2010
2010 Summa Cum Laude
4
Immunology Research Institute
of New England (IRINE)
Award
GlaxoWelcome Allergy
Fellowship Basic Research
Partners Outstanding
Performance and Commitment
to Excellence Award
Harvard Society of Teaching
Scholars (Elected Member)
Appreciation Award
Innovation in Medicine
Program Award
Quality Improvement Award
Innovation in Medicine
Program Award
Quality Improvement Award
Champion Innovator in Health
Award
Gail G. Shapiro Memorial
Lectureship
AAAAI Women s Involvement
in the AAAAI Special
Recognition Award
Partners in Excellence Award
GlaxoWelcome
Mastocytosis Society
Brigham and Women s
Hospital
Dana-Farber Cancer
Institute
Universidad Complutense
Brigham and Women s
Hospital
Dana-Farber Cancer
Institute
Boston Business Journal
American Academy of
Allergy, Asthma and
Immunology
American Academy of
Allergy, Asthma and
Immunology
Desensitization Program Madrid, Spain
Immunology Research
Institute of New England
IRINE
Report of Funded and Unfunded Projects
2000-2003
Mast Cell Inhibitory Receptor gp49B1 Interactions with Blood vessel Integrin aBgp49B1
v 3
interactions with aB
v 3
KO8 Award NIH
P.I.
2003-2004
American Heart Association
Mast Cell Inhibitory Receptor gp49B1 Interactions with Blood vessel Integrin aBgp49B1
v 3
interactions with aB
v 3
American Heart Association
2004-2006
Mastocytosis Registry Project
P.I.
Mastocytosis Society
2004-2006
Rapid Desensitization Program for Adverse Drug Reactions
P.I.
Innovations Program 2004 Award Brigham and Women s Hospital
2007-2008
Randomized, Double-Blind, Parallel-Group, b(4
P.I.
Genentech/Novartis Sponsor
2008-2012
Bench Research
Project: In-vitro mouse mast cell model of antigen desensitization.
PI
Ovations for a Cure Desensitization Program
2009-2011
Clinical Study
Oxaliplation Skin Test value in patients with colon cancer
Co- PI
--b(6 Dana-Farber Cancer Institute
Sanofi-Synthelabo Sponsor
2009-2011
Rapid Desensitization Program for Adverse Drug Reactions
P.I.
Innovations Program 2008 Award Brigham and Women s Hospital
2009-2014
Rapid Desensitization Program for Adverse Drug Reactions
Ovations for a Cure Desensitization Program
5
2010-2012 Clinical Research
2010-2012
2011-2013
2010-2013 Project: TSO (Tricuris suis) for peanut anaphylaxis
Report of Local Teaching and Training
Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs)
1996-2009 Director, Introductory Allergy Course for Fellows at the Brigham and Women's
Hospital
Participants: Fellows (average 20-25/year), Residents (average 3-5/years) and Medical
Students (2-3).
Preparation time for the course: up to 50 hours/year.
Course Faculty: 25-30/year from BWH, MGH, Tufts, Children s, Beth Israel Deaconess
Medical Center.
Contact time: 26 hours.
Preparation of Dr Castells lectures for the Course (2-3/year) 20-30 hours
PI
1996 Introductory Course for Allergy and Immunology Fellows
1. Anaphylaxis and Hymenoptera Sensitivity - Presenter
2. Systemic Mastocytosis - Presenter
1998 Introductory Course for Allergy and Immunology Fellows
1. Anaphylaxis and Hymenoptera Sensitivity - Presenter
2. Systemic Mastocytosis - Presenter
2000 Introductory Course for Allergy and Immunology Fellows
1. Mastocytosis - Presenter
2. Adverse Drug Reactions - Presenter
2002 Introductory Course for Allergy and Immunology Fellows
1. Mastocytosis - Presenter
2. Adverse Drug Reactions Presenter
3. Anaphylaxis-Presenter
2003 Introductory Course for Allergy and Immunology Fellows
1. Mastocytosis - Presenter
Food Allergy Network Sponsor
2. Adverse Drug Reactions - Presenter
2004 Introductory Course for Allergy and Immunology Fellows
6
Xolair in b(4
PI
Genentech Sponsor
b(4
b(6
---b(4
(4
---
-b(4)-
(4
1. Mastocytosis - Presenter
2. Adverse Drug Reactions Presenter
2005 Introductory Course for Allergy and Immunology Fellows
1. Mastocytosis - Presenter
2. Desensitizations for Adverse Drug Reactions Presenter
2006 Introductory Course for Allergy and Immunology Fellows
1. Anaphylaxis Presenter
2. Mastocytosis Presenter
3. Desensitizations - Presenter
2007 Introductory Course for Allergy and Immunology Fellows
1. Images in Medicine: Mastocytosis Presenter
2. Anaphylaxis Presenter
3. Desensitizations - Presenter
2008 Introductory Course for Allergy and Immunology Fellows
1. Images in Medicine: Mastocytosis Presenter
2. Anaphylaxis Presenter
3. Desensitizations for Drug HSR Presenter
2009 Introductory Course for Allergy and Immunology Fellows
1. Images in Medicine: Mastocytosis - Presenter
2. Anaphylaxis - Presenter
3. Desensitizations for Drug HSR Presenter
2010 Introductory Course for Allergy and Immunology Fellows
1. Images in Medicine: Mastocytosis - Presenter
2. Anaphylaxis - Presenter
3. Desensitizations for Drug HSR - Presenter
Invited Teaching Presentations
1999 Seminar - Brigham Medical Group: Drug Adverse Reactions. Participants: Students,
Fellows, Residents 20. Preparation: 5 hours. Contact Time: 1 hour.
1999 Course for Allergy Board Preparation American Academy of Allergy,
Asthma & Immunology (Boston Hyatt):
1. Adverse Drug Reactions. Participants: Students, Fellows, Residents 100.
Preparation: 5 hours. Contact Time: 1 hour.
2. Mastocytosis and Mast Cell Diseases. Participants: Students, Fellows, Residents
100. Preparation: 5 hours. Contact Time: 1 hour.
2000 Residents Grand Rounds - Brigham and Women s Hospital: Anaphylaxis
Participants: Students, Fellows, Residents 30. Preparation: 5 hours. Contact Time: 1
hour.
2000 Lecture Presentation - Dana-Farber Cancer Institute: Mastocytosis Participants:
Students,
Fellows, Residents 50. Preparation: 5 hours. Contact Time: 1 hour.
2000 Lecture Presentation- Endocrine Service Brigham and Women s Hospital:
Insulin Allergy. Participants: Students, Fellows, Residents 40. Preparation: 5 hours.
Contact Time: 1 hour.
2000 American Lung Association: Asthma for Health Care Workers. Participants: Students,
Fellows, Residents 40. Preparation: 2 hours. Contact Time: 1 hour.
7
2000 Grand Rounds for Anesthesia Brigham and Women s Hospital: Latex Allergy.
Participants: Students, Fellows, Residents 30. Preparation: 10 hours. Contact Time: 1
hour.
2001 Boston City Wide Rounds: Systemic Mastocytosis. Participants: Students, Fellows,
Residents 40. Preparation: 5 hours. Contact Time: 1 hour.
2002 Adolescent Medicine Meeting: Allergy and Asthma Update. Participants: Students,
Fellows, Residents 100. Preparation: 5 hours. Contact Time: 1 hour.
2003 Medical Grand Rounds
BWH:
Drug Desensitizations. Participants: Students, Fellows,
Residents 50. Preparation: 10 hours. Contact Time: 1 hour.
2003 Children s Hospital Allergy Grand Rounds: Drug Desensitizations. Participants:
Students, Fellows, Residents 20. Preparation: 2 hours. Contact Time: 1 hour.
2004 Worcester Allergy Rounds: Drug Desensitizations. Participants: Students, Fellows,
Residents 15. Preparation: 2 hours. Contact Time: 1 hour.
2004 Brigham and Women s Medical Residents Rounds: Drug Adverse reactions and
Desensitizations: Faculty, Participants: Students, Fellows, Residents 50. Preparation:
10 hours. Contact Time: 1 hour.
2005 Children s Hospital Allergy Grand Rounds : Drug Desensitizations. Participants:
Faculty,
Students, Fellows, Residents 20. Preparation: 2 hours. Contact Time: 1 hour.
2005 Harvard Medical School, The Longwood Seminars, Allergies: from pollen to Peanuts.
Participants: General public, Students, Fellows, Residents 100. Preparation: 10 hours.
Contact Time: 1 hour.
2006 Massachusetts General Hospital Allergy Grand Rounds: Mastocytosis. Participants:
Students, Fellows, Residents and Faculty 15. Preparation: 2 hours. Contact Time: 1
hour.
2006 Brigham & Women's Hospital Asthma Grand Rounds. . Participants: Students, Fellows,
Residents and Faculty 50. Preparation: 10 hours. Contact Time: 1 hour.
2006 Woods Hole. Brigham & Women's Hospital Allergy and Asthma Conference. .
Participants: Students, Fellows, Residents and Faculty 35 Preparation: 10 hours. Contact
Time: 1 hour.
2007 Brigham & Women's Hospital Asthma Grand Rounds. . Participants: Students, Fellows,
Residents and Faculty 50. Preparation: 5 hours. Contact Time: 1 hour.
2007 Brigham & Women's Hospital Anaphylaxis Grand Rounds. . Participants: Students,
Fellows, Residents and Faculty 50. Preparation: 2 hours. Contact Time: 1 hour.
2008 Brigham & Women's Hospital and Mass General Hospital Combined Conference
Desensitization. Participants: Students, Fellows, Residents and Faculty 20.
Preparation:
5 hours. Contact Time: 1 hour.
2008 Partners Health Care Multiple Sclerosis Center. Desensitization to Multiple
Sclerosis
Medications. Participants: Students, Fellows, Residents and Faculty 30. Preparation: 10
hours. Contact Time: 1 hour.
2008 Brigham & Women's Hospital Asthma Grand Rounds. . Participants: Students, Fellows,
Residents and Faculty 50. Preparation: 5 hours. Contact Time: 1 hour.
2008 Brigham & Women's Hospital Anaphylaxis Grand Rounds. . Participants: Students,
Fellows, Residents and Faculty 50. Preparation: 2 hours. Contact Time: 1 hour.
2008 Brigham & Women's Hospital Desensitization in Service. Participants: Students,
Fellows,
Residents, Nurses, and Faculty 20. Preparation: 5 hours. Contact Time: 1 hour.
2008 Brigham & Women's Hospital Rheumatology Grand Rounds. . Participants: Students,
Fellows, Residents and Faculty 20. Preparation: 2 hours. Contact Time: 1 hour.
8
2008 Brigham & Women's Hospital MICU Case Review Desensitizations. Participants:
Students, Fellows, Residents, Nurses, and Faculty 20. Preparation: 5 hours. Contact
Time: 1 hour.
2008 Dana Farber Cancer Institute. Desensitizations for Chemotherapy. Grand Rounds.
Participants: Students, Fellows, Residents, and Faculty 50. Preparation: 5 hours.
Contact Time: 1 hour.
2008 Brigham & Women's Hospital Residency Rounds. Anaphylaxis .Participants: Residents
30.
Preparation: 2 hours. Contact Time: 1 hour.
2009 Brigham & Women's Hospital MICU Case Review Desensitizations. Participants:
Students, Fellows, Residents, Nurses, and Faculty 20. Preparation: 5 hours. Contact
Time: 1 hour.
2009 Brigham & Women's Hospital MICU Anaphylaxis. Participants: Students, Fellows,
Residents, and Faculty 20. Preparation: 5 hours. Contact Time: 1 hour.
2009 Children s Hospital Allergy Grand Rounds: Aspirin Desensitizations and NSAID .
Participants: Fellows, and Faculty 20. Preparation: 2 hours. Contact Time: 1 hour.
2009 Brigham & Women's Hospital Pulmonary Rounds, Anaphylaxis . Participants: Fellows,
10.
Preparation: 2 hours. Contact Time: 1 hour.
2010 Brigham & Women's Hospital Pulmonary Rounds, Anaphylaxis Conference
2010 Brigham & Women's Hospital Grand Rounds on Anaphylaxis. Participants: Residents
2010 Center for Women and Newborns, Use of Epinephrine at Safety Conference for Pharmacy
and Nursing
Formally Supervised Trainees and Faculty
1990-1992 --b(6 North Shore Emergency Medicine Practice
1994-1996 (6 Associate Professor in Medicine, Harvard Medical
School
and Brigham and Women s Hospital
1996-1998 (6 Faculty, Division of Rheumatology, Johns Hopkins
University
1996
-1999
--b(6 now in private practice
1998
-2000
--b(6 now in private practice
1999
-2000 --b(6 now in private practice
1999
-2002
--b(6 now in private allergy practice
2000
-2003 --b(6 Instructor in Medicine, Harvard Medical School, Associate
Physician,
Brigham and Women s Hospital
(Allergy)
2000
-2003 --b(6 Instructor in Medicine, Harvard Medical School,
Associate
Physician, Brigham and Women s Hospital
(Allergy)
2000
-2003
--b(6
Asst. Professor of Pediatrics, Cincinnati Children s Hospital
Medical Center, Cincinnati, OH
2001
-2004
--b(6 now in private practice
2001
-2004 --b(6 now in private practice
2002
-2005
--b(6 private practice
2002
-2005 (6 now in private practice
2002
-2005 --b(6 now in private practice
2003
-2006 --b(6 now in private practice
2003
-2006 --b(6 Instructor in Medicine, Harvard Medical School, Associate
Physician, Brigham and Women s Hospital
9
2004
-2007 --b(6 Instructor in Medicine, Harvard Medical School/Brigham and
Women s Hospital
2004
-2007
--b(6 Private Practice
2005
-2008
--b(6 Private Practice
2005
-2008 --b(6 Instructor in Medicine, Harvard Medical School/Brigham and
Women s Hospital
2006
-2009
--b(6 Private Practice
2006
-2009
--b(6 Private Practice
2006
-2009 (6 Instructor in Medicine, Harvard Medical
School/Brigham
and Women s Hospital
2007
-2010 (6 Clinical/Research Fellow, Harvard Medical School,
Brigham and Women s Hospital
2007
-2010 (6 Clinical/Research Fellow, Harvard Medical
School, Brigham and Women s Hospital
2007
-2010 (6 Clinical/Research Fellow, Harvard Medical
School,
Brigham and Women s Hospital
2008
-2011 (6 Clinical/Research Fellow, Harvard Medical School,
Brigham and Women s Hospital
2008
-2011 --b(6 Clinical/Research Fellow, Harvard Medical School, Brigham and
Women s Hospital
2008
-2011 (6 Clinical/Research Fellow, Harvard Medical
School,
Brigham and Women s Hospital
2009
-2012 (6 Clinical/Research Fellow, Harvard Medical School,
Brigham
and Women s Hospital
2009
-2012 (6 Clinical/Research Fellow, Harvard Medical
School,
Brigham and Women s Hospital
2010
-2013 (6 Clinical/Research Fellow, Harvard Medical School,
Brigham
and Women s Hospital
2010
-2013 (6 Clinical/Research Fellow, Harvard Medical
School,
Brigham and Women s Hospital
2010
-2013 (6 Clinical/Research Fellow, Harvard Medical School,
Brigham
and Women s Hospital
Formal Teaching of Peers (e.g., CME and other continuing education courses)
American Academy of Allergy, Asthma and Immunology Board Review of Adult and Pediatric
Immunology: Invited Speaker
2001 Mastocytosis Boston. Preparation: 5 hours. Contact Time: 1 hour
2001 Adverse Drug Reactions Boston. Preparation: 5 hours. Contact Time: 1 hour
Intensive Review of Internal Medicine - Harvard Medical School
2003 Allergy/Immunology Pearls for the IM Board (IRIM). Preparation: 12 hours. Contact
Time: 1
hour.
2004 Allergy/Immunology Pearls for the IM Board (IRIM). Preparation: 5 hours. Contact
Time: 1
hour.
2005 Allergy/Immunology Pearls for the IM Board (IRIM). Preparation: 5 hours. Contact
Time: 1
hour
10
2006 Allergy/Immunology Pearls for the IM Board (IRIM). Preparation: 5 hours. Contact
Time: 1
hour
2007 Allergy/Immunology Pearls for the IM Board (IRIM). Preparation: 5 hours. Contact
Time: 1
hour
2008 Allergy/Immunology Pearls for the IM Board (IRIM). Preparation: 5 hours. Contact
Time: 1
hour
2009 Allergy/Immunology Pearls for the IM Board (IRIM). Preparation: 5 hours. Contact
Time: 1
hour
2010 Allergy/Immunology Pearls for the IM Board (IRIM). Preparation: 5 hours. Contact
Time: 1
hour
Risk Management Course (IRINE, Immunology Research Institute of NE):
1999 Drug Adverse Reactions - Providence, RI. Preparation: 10 hours. Contact Time: 1
hour.
1999 Drug Adverse Reactions - Hartford, CT. Preparation: 5 hours. Contact Time: 1 hour.
1999 Food Reactions and Allergies. Preparation: 10 hours. Contact Time: 1 hour.
2001/2002 Adverse Drug Reactions: Management and Desensitization. Preparation: 5 hours.
Contact
Time: 1 hour.
Local Invited Presentations
Those presentations below sponsored by outside entities are so noted and the sponsor is
identified.
2003 Cardiovascular Disease Update/ Grand Rounds
Department of Medicine, BWH
2003 Treatments for Asthma in Children: Update/ Lunchtime Speaker Series
Harvard Vanguard Medical Associates (Novartis)
2006 Asthma Grand Rounds
2007 Asthma Grand Rounds
2008 Asthma Grand Rounds
Report of Regional, National, and International Invited Teaching and
Presentations
Invited Presentations and Courses
Regional:
2007 Northern Essex Community College, Haverhill, MA
Invited Speaker: Asthma and Allergies in Latinos: An underserved population in the USA
2007 Ovations for the Cure, Learning for Living Symposium, Boston, MA
Invited Speaker: Chemotherapy Drug Allergies: New Approaches to Drug Desensitization
2010 Invited Speaker: Allergy Division, Mastocytosis, Massachusetts General Hospital,
Boston,
MA
2010 Invited Speaker: Drug Hypersensitivity Practice Parameters, New England Society of
Allergy, Marlborough, MA
National:
1999 American Academy of Allergy, Asthma and Clinical Immunology, Orlando, FL
11
Seminar Invited Speaker: Mast cells and Basophil Biology
2002 Mount Sinai Medical Center, New York, NY
Invited Speaker: Clinical Immunology Grand Rounds: Diagnosis and Treatment of
Systemic Mastocytosis
2003 American Academy of Allergy, Asthma and Clinical Immunology, Denver, CO
NIAID Focus Group Participant
2003 Eastern Allergy Conference, Palm Beach, FL
Invited Speaker: Mastocytosis
2004 Immune Mediated Drug Hyposensitivity Reactions Workshop, Washington, DC
Desensitivity Leader
2007 American Academy of Allergy, Asthma and Clinical Immunology, San Diego, CA
Seminar Speaker: Desensitization Protocols for Antibiotics and Other Medications
Workshop Speaker: Drug Allergy: Ask the Experts
Seminar Speaker: New Facets in Drug Desensitization
2007 Swineford Conference, University of Virginia, Charlottesville, VA
Invited Speaker: Acute Desensitization for Anaphylactic and Anaphylactoid Adverse Drug
Reactions
2007 National Institutes of Health/NIAID Grand Rounds, Bethesda, MD
Invited Speaker: Rapid Desensitization for Chemotherapy Drugs, Antibiotics, and
Biologicals
2007 The Mastocytosis Society, Houston, TX
Invited Speaker: Patients Presenting with Anaphylaxis to Hymenoptera
2008 American Academy of Allergy, Asthma and Clinical Immunology, Philadelphia, PA
Symposium Moderator: Mast Cells and Basophils: An Update on Their Role in
IgE-Mediated Diseases and Beyond
Seminar Discussion Leader: Desensitization Protocols for Antibiotics and Other
Medications
Oral Abstract Session Moderator: Markers of Anaphylaxis and Adverse Drug
Reactions
Workshop Speaker: Rapid Drug Desensitization for Anaphylactic and
Anaphylactoid Reactions: Mechanisms and Practice
2008 American College of Physicians, Washington, DC
Meet the Professor Session: Consult the Allergist
2008 Internal Medicine Grand Rounds, Winthrop University Hospital, Mineola, NY
Invited Speaker: Hypersensitivity Reactions to Antibiotics, Chemotherapy Drugs, and
Monoclonals: Treatment with Rapid Desensitization
2008 AAAAI Meeting Chicago, Illinois
2009 AAAAI Meeting Washington, DC
2009 Gynecology and Oncology Society Meeting (GOG). Baltimore, MD
2010 Kaiser Permanente Allergy Symposium, Newport Beach, CA
Invited Speaker: Desensitizations
2010 The Mastocytosis Society, Tucson, Arizona
Presentation: Systemic Mastocytosis
International:
2003 FOCIS (Federation of Clinical Immunology Societies) in Paris, France
Poster Presentation: In-vitro IgE Mast Cell Desensitization to Antigen
2003 Simposio Internacional sobre avances en alergia y mastocytosis, Madrid, Spain
12
Invited Speaker: Inhibitory Mechanisms of Mast Cell Activation
2007 European Competence Network on Mastocytosis (ECNM), Paris, France
Invited Speaker: New Type of Indolent Mastocytosis Without Skin Lesions and Severe
Anaphylaxis to Hymentoptera Stings
2007 World Allergy Congress, Bangkok, Thailand
Invited Speaker: Desensitization for NSAID Sensitivity
2007 Mahidol University Immunology Seminar, Bangkok, Thailand
Invited Speaker: Rapid Desensitization: A Novel Approach to treat Anaphylactic and
Anaphylactoid Reactions to Medication
2008 Southwest Allergy Forum, Puerto Vallarta, Mexico
Invited Speaker: What s New in Drug Allergy and Desensitizations
2008 International Hypersensitivity Meeting (DHM3), Paris, France
Invited Speaker: Effectiveness of tolerance induction to anti-cancer drugs
Workshop Coordinator: Induction tolerance for drug hypersensitivity
2008 Symposium of the Collegium Internationale Allergologicum (CIA), Curacao
Abstract Poster Presentation: Rapid IgE-antigen desensitization of mouse bone marrow
derived mast cells inhibits degranulation, STAT6 phosphorylation and calcium release in
an antigen-specific manner
Co-Chair Oral Abstract Session: Mast cells and basophils, eosinophils and dendritic cells
2008 European Academy of Allergology and Clinical Immunology (EAACI), Barcelona, Spain
Invited Speaker: A New Approach to Complex Allergies: How Rapid Desensitization
Turns Off Signal Transduction
2008 Dermatology meeting in Athens, Greece
2008 Visiting Professor in Granada, Spain. December 2008
2009 Lankenau Institute for Medical Research. Grand Rounds
2009 Toronto Allergy Meeting
2009 European Mastocytosis Meeting. Toledo, Spain.
2009 British Allergy and Asthma Society. Nottingham, UK
th st
2010 25 Anniversary of 1 Allergy Division in Spain, Toledo Spain, Opening Lecture:
Desensitizations
2010 American College of Physicians, Toronto, Canada
Invited Speaker: Allergies
2010 International Drug Hypersensitivity Meeting, Rome, Italy.
Presentation: Desensitizations on Adverse Drug Reactions and Hypersensitivity
2010 European Academy of Allergy and Clinical Immunology, London, England
Invited Speaker: Drug Desensitizations
2010 Dermatology and Allergy Society, Munich, Germany
Invited Speaker: Anaphylaxis and Hypersensitivity
2010 Mast Cell Activation Meeting, Vienna, Austria
Invite Speaker: Definition and Diagnosis of MCAS
2010 European Society for Clinical Cell Analysis, Valencia, Spain
Invited Speaker: Mast Cell Receptors
2010 Spanish Gastrointestinal Society, Valladolid, Spain
Invited Speaker: Hypereosinophilic Syndromes
2010 Spanish Society of Allergy and Clinical Immunology, Madrid, Spain
Opening Lecture: Mast Cell Activation
2010 Indian Portuguese Society, Goa, India
Invited Speaker: Hypersensitivity Reactions to Drugs and Desensitizations
13
Report of Clinical Activities and Innovations
Current Licensure and Certification
1979 Medical License, Barcelona, Spain
1980
1987
1991
1993
1996
2003
2005
2008 Medical License, Madrid, Spain
1990 Attending Allergy and Immunology Four sessions per week
Brigham and Women s
Hospital
Virginia Medical License
Clinical Innovations
Desensitization Program
at the Dana-Farber Created an inpatient and outpatient facility where patients can
receive the
Cancer Institute and medication they are highly allergic to. They receive this treatment
by
Brigham and Women's undergoing our Desensitization protocol.
Hospital.
Massachusetts Medical License
Report of Education of Patients and Service to the Community
1999 Summer Minority Summer Program, Harvard Medical School Glenn Hall.
Preparation of experimental design and daily supervision of experimental work with direct
contact of over 1 hour daily. 10 hours/week for 6 weeks
European Allergy and Immunology Committee, Fellowship Program
1999, summer b(6 50 hours/month for 3 months.
Diplomate, American Board of Internal Medicine
2000, summer b(6 50 hours/month for 4 months
2002, summer b(6 50 hours/month for 4 months
2004, fall b(6 50 hours/month for 4 months
1999- Teaching Rounds at Joslin Diabetes Center on Insulin Allergy and Desensitization
(yearly)
Preparation for teaching: 4-6 hours
2002- Desensitization rounds Dana-Farber Cancer Institute (monthly)
Preparation time: 1-2 hours. Contact Time: 1-2 hours.
Diplomate, American Board of Allergy and Clinical Immunology
2003- Mastocytosis Conference
Recertification American Board of Internal Medicine
Visiting Professorship and Mini-Symposium Organization:
Recertification American Board of Allergy and Clinical Immunology
Recertification American Board of Allergy and Clinical Immunology
14
Practice Activities
Brigham and Women s Hospital, Massachusetts General Hospital, Children s Hospital,
and Beth Israel Deaconess Medical Center participation
Invited Speaker: Dr. Luis Escribano from Spain.
Preparation: 10 hours. Contact Time: 4 hours.
Report of Scholarship
Original Articles:
1. Castells MC, Pascual C, Esteban MM, Ojeda JA. Allergy to white potato. J Allergy Clin
Immunol. 1986; 78:1110-4.
2. Castells MC, Irani AM, Schwartz LB. Evaluation of human peripheral blood leukocytes
for mast
cell tryptase. J Immunol. 1987; 138:2184-9.
3. Schwartz LB, Irani AM, Roller K, Castells MC, Schechter NM. Quantitation of histamine,
tryptase, and chymase in dispersed human T and TC mast cells. J Immunol. 1987; 138:2611-
5.
4. Castells MC, Schwartz LB. Tryptase levels in nasal-lavage fluid as an indicator of the
immediate
allergic response. J Allergy Clin Immunol. 1988; 82:348-52.
5. Perez-Ramirez B, Castells M. In vitro biosynthesis of rat sperm outer dense fiber
components.
Life Sci. 1991; 49:1549-54.
6. Kaye RE, Fruman DA, Bierer BE, Albers MW, Zydowsky LD, Ho SI, Jin YJ, Castells MC,
Schreiber SL, Walsh CT, Burakoff SJ, Austen KF, Katz HR. Effects of cyclosporin A and
FK506
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