M ARK TRUDGETT

B S C, M S C (H ONS ), M S C M, M RACI, C C HEM

R SUM A ND C URRICULUM V ITAE

R SUM AND C URRICULUM V ITAE

CONTENTS

Contact Details 2

Profile 2

In Brief 3

Employment Summary 4

Professional Achievements 6

Summary of Formal Education 11

Publications 12

Patents 12

Training Courses 12

Research Abstracts 13

Additional Knowledge and Experience 14

Interests 15

Associations and Community Activities 15

Languages 15

Referees 15

C ONTACT DETAILS

E-Mail: abo92o@r.postjobfree.com

Home Page: http://www.mark.trudgett.com

P ROFILE

Over twenty years experience in analytical chemistry including research, quality control,

education and management, sales, marketing and information technology. Known for a

capacity to quickly master the challenges of new environments, providing efficient, easily

implemented solutions to problems arising in numerous fields of endeavour.

Broad cross-disciplinary knowledge and understanding combined with a consultative

management style that focuses on empowerment present a powerful enhancement to

almost any workplace.

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I N BRIEF

Formal Education:

M. Sc. (Hons.) (Master of Science by Research, University of Western Sydney)

Thesis title: The Ultra-Trace Level Analysis of Xanthates by High Performance Liquid

Chromatography.

M. Sc. M. (Master of Science Management, University of Technology, Sydney)

PhD (In progress: Completion on schedule for March 2013)

Professional Associations:

Member, Chartered Chemist of the Royal Australian Chemical Institute (MRACI CChem,

Membership # 30244)

Member of the American Chemical Society (ACS)

Member of CASSS An International Separation Science Society

Supervisory/Management Experience:

Managed all aspects of successful small businesses. Supervision of junior and mid -level

laboratory staff and postgraduate students. Day-to-day administration of consultant

analytical laboratories. Managed research, stability and quality assurance testing in a TGA

regulated laboratory for complementary medicines. Formal postgraduate training in the

management of science and scientists (M.Sc.M.) and the management and

commercialisation of research projects.

Research and Methods Development:

The equivalent of four full-time years has been devoted to research and method

development and validation using GC-MS, HPLC-DAD, FTIR and UV-VIS. This work

included methods for pharmaceutical, biological and environmental analysis. Many

analytical techniques/methodologies were improved or refined in the course of routine

analyses.

Experience in Analytical Chemistry:

Over twenty years laboratory experience, approximately half of which was dedicated to

pharmaceutical and therapeutic good analysis in GMP/GLP environments regulated by the

Therapeutic Goods Administration (TGA). Expertise was also developed in consultant

analytical laboratories processing veterinary, environmental, pharmaceutical and

agrichemical samples at the levels of parts per hundred to parts per billion.

Summary of Key Expertise:

Proficient in the interpretation of data and the use, operation and maintenance of most

modern analytical laboratory instrumentation, with an emphasis of chromatographic

separations. High level of computer literacy combined with software and electronics

development proficiency. Development of embedded systems and digital signals

processing.

Communication and people skills:

Exemplary written and verbal communication skills. Able to supervise, teach and co -

operate with a wide range of people of different backgrounds and ages.

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E MPLOYMENT SUMMARY

Doctoral Candidate (UWS)

2010 Present

Project Title: Comprehensive Online Multidimensional Fast

Fourier Transform Separations

Managing Director (Full time)

2006 2009

AppleLeaf Pty Ltd

Laboratory Manager (Full time, Casual, 3 mths)

2007

Centre for Complementary Medicine Research

(CompleMED),

Herbal Analysis Laboratory, University of Western Sydney

Senior Analyst (Full time, 3 mths)

2006

Advanced Analytical, Australia

Analytical Scientist (Full time, Casual)

2006

Q + T Recruitment contracted to GlaxoSmithKline

Academic Research Analytical Chemistry

2002 2005

House builder/renovator

1998 2003

Fly Fishing Guide and Instructor (Casual)

2000 2002

Riverlands Fly and Sports Fishing.

3 Dewdney Rd., Emu Plains, NSW 2750

Acting University Subject Co-ordinator, Tutor

1998 2001

and Lecturer (Part time, Casual)

University of Western Sydney, Nepean.

Sole Trader Manager and Photographer.

1994 1998

Lightsmith Photography

9 Leonay Parade, Leonay NSW 2750

Analytical Chemist (Full time, Casual)

1994 1995

Labstaff Pty Ltd - Contracted to

Sterling Pharmaceuticals Pty Ltd and

Merck Sharp & Dohme (Aust.) Pty Ltd

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Master Technician

1988 1994

3M Pharmaceuticals Pty Ltd,

9 Chilvers Road, Thornleigh NSW 2120.

Chief Chemist

1988

National Analytical Laboratories,

Qiya Road, Gunnedah NSW 2380.

Analytical Chemist

1987 1988

Pfizer Pty Ltd,

38 Warf Road, West Ryde NSW 2114.

Laboratory Analyst

1985 1987

Analchem Consultants Pty Ltd,

36-40 Halloran Street, Lilyfield NSW.

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P ROFESSIONAL ACHIEVE MENTS

U NIVERSITY OF WESTER N SYDNEY .

Position Title: Doctoral Candidate

Invented a new technique for rapid chromatographic separations in two or more

dimensions: Comprehensive Online Multidimensional Fast Fourier Transform

Separations (COMForTS).

Development of software to model the behaviour of COMForTS systems and to

digitally process the resulting simulated signals.

Development and testing of electronics, intelligent computer interfaces and

prototypical COMForTS systems.

This work has been published in high-ranking scientific journals and is the subject

of Australian and international patent applications.

A PPLELEAF PTY LTD .

Position Title: Managing Director

Establishment of a company with demonstrably high standards of ethics and

integrity, treating both employees and customers with the dignity and respect

deserved by reasoning human beings.

Responsible for all aspects of small business management achieving high

profitability and a minimum 30% annual sales growth over three years in a

shrinking economy with industry-average negative growth.

Maintained high levels of employee satisfaction with very low staff turnover.

Achieved extremely high levels of customer satisfaction with customer complaints

five times lower than the industry average.

T HE UNIVERSITY OF WE STERN SYDNEY

Position Title: Laboratory Manager, Herbal Analysis Laboratory

TGA nominated Laboratory Licensee for the Testing of Therapeutic Goods.

Overhaul of Laboratory Standard Operating Procedures.

Client liaison providing advice on regulatory requirements for the testing of herbal

medicines and appropriate testing regimes and methods.

Maintenance of GLP and OH&S standards and monitoring.

Supervision and scheduling of workloads for chemists and laboratory assistants.

Provision of research methods support, advice, training and troubleshooting for

postgraduate research students.

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A DVANCED ANALYTICAL A USTRALIA .

Position Title: Senior Analyst

Achieved the status of APVMA Approved Analyst.

Nominated NATA signatory.

Principal Analytical Chemist for HPLC-MS-MS

Training and professional development of laboratory assistants and chemists.

Assessment and review of Standard Operating Procedures, Quality Systems and

Quality Systems management.

Further developed skills in chromatographic instrumentation with mass-

spectroscopy and tandem mass-spectroscopic detection.

G LAXOSMITHKLINE.

Position Title: Analytical Scientist

Refreshed knowledge of GLP/GMP in a TGA regulated environment via intensive

training.

Mastered Waters Millenium32 and Empower software as well as Waters Alliance

HPLC systems.

T HE UNIVERSITY OF WE STERN SYDNEY.

Position Title: Postgraduate Research Student for the Degree of M.Sc. (Hons)

Designed and implemented a sound research protocol for ultra-trace environmental

analyses.

Developed and validated an extremely sensitive HPLC-DAD method for the ultra-

trace analysis of xanthates. Limits of detection for this method were three orders of

magnitude lower than previously available and allowed, for the first time,

simultaneous detection of seven xanthates at levels known to have significant

toxicity.

Produced several scientific software packages for NMR and HPLC data analysis,

transformation and reporting. The result was significant time-savings, publication

quality reports and the elimination of transcription errors.

Conducted searches and reviews of scientific literature and wrote a high-quality

thesis that easily (met) the requirements of a master s degree .

Designed and manufactured a computer controlled multi-head (8) precision low-

flow pump for solid phase extraction (SPE) of trace organics from large (5 L)

samples thereby decreasing operator time from 42 hours per sample to less than

one hour per experiment. This system was more versatile and handled a greater

throughput than commercial systems costing more than twenty times more.

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Position Title: Lecturer/Tutor and Acting Subject Co-ordinator

Successfully taught chemistry and computing subjects to undergraduate students.

Implemented simplified and computerised marking of laboratory quizzes that

greatly reduced the time required for administration.

Implemented paperless distribution of assignment work (with anti-plagiarism

measures) and collection of reports allowing students greater freedom in their time-

management and reducing the time required for administration.

R IVERLANDS FLY AND S PORTS FISHING

Position Title: Assistant Guide

Accomplished fruitful instruction of adults, at beginning and intermediate levels, in

fly-casting techniques, equipment and acceptable practice in Australian freshwater

fishing.

Achieved high levels of customer satisfaction when guiding clients on inland rivers,

teaching techniques for finding (sighting) fish, fly-casting/presentation and humane

capture and release.

L IGHTSMITH PHOTOGRAP HY.

Position Title: Sole Trader - Manager/Photographer

Number of Employees: (Casual) 1-2

Established and built a successful business offering professional photographic

services to individuals and corporations.

Developed robust marketing, management and accounting skills that produced

strong and profitable business growth.

Designed, constructed and commissioned a fully equipped professional darkroom

in order to meet customer deadlines and the stringent quality requirements of

commercial and industrial photography.

Mastered all types of photographic film, print and transparency processing to

exacting standards.

Executed professional photographic assignments and darkroom work to the

highest standards with extremely short turn-around times, satisfying client needs

and expectations that were not previously met locally. Clients won from competing

businesses included Australian Defence Industries, Lend Lease, Civil and Civic,

Penrith Lakes Development Corporation, Penrith Council, Penrith Chamber of

Commerce, Sterling Pharmaceuticals and Durashine Furniture

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3 M PHARMACEUTICALS P TY LTD:

Position Title: Master Technician

1. Enhanced expertise in the analysis of pharmaceutical raw materials and products

using HPLC, GLC and FTIR and UV-VIS spectroscopy.

2. Methods development/modification (HPLC and FTIR spectroscopy) for quality

assurance including multi-component quantitative assays by FTIR.

3. Designed, development and implemented:

(a) Application software for the control of FTIR spectrophotometer by IBM PC,

including automated quantitative analyses and database management of infra -red

spectra and laboratory data;

(b) Online statistical analysis package for continuous manufacturing process.

Analysis performed by a smart terminal interfaced to a digital balance and

controlled by an IBM PC;

(c) Q.A. product information database (dBaseIV) for statistical trend analysis and

generation of certified reports;

(d) Application software to interface IBM PC with UV-VIS spectrophotometer for

the purpose of direct data acquisition, statistical manipulation, reporting and

archival of results for tablet dissolution testing;

(e) Various data handling routines in Quick BASIC, Visual Basic, Lotus 1 -2-3,

Microsoft Excel and dBASE IV;

(f) Multi-user chromatographic data analysis system, supporting up to nine users

using VGA graphics console terminals and acquisition from up to fifteen

chromatographic instruments simultaneously.

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N ATIONAL ANALYTICAL L ABORATORIES:

Position Title: Chief Chemist

Gained significant supervisory and training experience (Overseeing the work of one

laboratory analyst and up to four laboratory technicians).

Ensured the integrity of all analytical results (in accordance with GLP and NATA

requirements) and that analytical reports were provided to statutory authorities

before daily deadlines.

Completed timely investigations of results that exceeded maximum residue limits.

Provided liaison with the Australian Quarantine Inspection Service and

Department of Primary Industries.

Established, single-handedly, a microbiological laboratory testing for Salmonella sp.

and Escherichia coli in meat meals and process waters.

Enhanced expertise in the analysis of pesticide residues in animal and plant tissues

by GC/FID/ECD/NPD and GC/MS. Ovine, bovine and porcine tissues and were

tested to meet Australian export requirements for residue limits of organo-chlorine

and organo-phosphorous chemicals. Wheat and canola seed were also tested for

trace OC s.

Installed and commissioned a Varian Atomic Absorption Spectrophotometer

including performance validation.

P FIZER PTY LTD:

Gained considerable training and experience in the chemical analysis of veterinary

and pharmaceutical raw materials and products, using HPLC, AAS, UV -VIS and

fluorescence spectroscopy.

Developed a sound knowledge of GLP/GMP and TGA requirements.

Analytical methods development and validation.

A NALCHEM CONSULTANTS P TY LTD.

Established primary skills in the chemical analysis of foods, pharmaceutical and

agricultural/agrichemical materials using traditional wet chemical techniques, AAS,

HPLC, GLC, UV-VIS and IR spectroscopy.

Became highly familiar with NATA requirements and participated in inter-

laboratory testing programs.

Responsible for some methods development for AAS and maintenance of

instrumentation.

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S UMMARY OF F ORMAL E DUCATION

2010 Present Doctor of Philosophy Ph.D. (On-going)

University of Western Sydney.

Undertaking research in high peak-capacity, high peak-production

multidimensional liquid chromatography.

Thesis title: Comprehensive Online Multidimensional Fast

Fourier Transform Separations .

On schedule for completion in March 2013

2007 Master of Science Management - M.Sc.M.

University of Technology, Sydney.

2006 Master of Science (Honours) - M.Sc.(Hons.)

Master s degree by research in environmental analytical chemistry

with the thesis title: The Ultra-Trace Level Analysis of Xanthates

by High Performance Liquid Chromatography.

University of Western Sydney.

1997 Bachelor of Science (B.Sc.)

Chemistry Major. University of Western Sydney, Nepean

1982 Higher School Certificate.

St Dominic's College, Penrith.

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P UBLICATIONS

Trudgett, M. J. E., Guiochon, G., Shalliker, R.A. (2011). "Theoretical description of a

new analytical technique: Comprehensive online multidimensional fast Fourier

transform separations." Journal of Chromatography A 1218(22): 3545-3554. (ERA

Rank: A*)

PA TENTS

PCT/AU2012/000142 entitled Method for Analysing a Sample

Priority from AU 201*******, 23 December 2011

Applicant: The University of Western Sydney

Inventors: Mark Trudgett and Ross Andrew Shalliker

T RAINING COURSES

GLP/GMP - Regulatory requirements, documentation and procedures

(GlaxoSmithKline, 2006)

Waters Millenium32/Empower and Waters Alliance HPLC systems

(GlaxoSmithKline/UWS, 2006)

Nuclear Magnetic Resonance (NMR) Spectrometer Operation Varian Mercury

400BB (400MHz). (UWS)

dBASE IV Programming (Intermediate). (Management Technology Education.)

HPLC Methods Development and Trouble Shooting (Waters Associates)

BASIC Programming (3M)

Data Communications (3M)

Data Processing (3M)

Digital Computer Design (3M)

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R ESEARCH ABSTRACTS

Comprehensive Online Multidimensional

Fast Fourier Transform Separations

Australian Centre for Research on Separation Science (ACROSS), School of Natural

Sciences,

University of Western Sydney (Parramatta), Sydney, NSW, Australia

Supervisory Panel:

A/ Professor R. Andrew Shalliker (University of Western Sydney, ACROSS)

Professor Georges A Guiochon (Department of Chemistry,

University of Tennessee, Knoxville, TN, USA)

Practical comprehensive multidimensional chromatography is today dominated by systems

that are fundamentally limited to highly asymmetrical online separations sacrificing

separation space, or to lengthy, time consuming offline separations. With few exceptions,

separations have thus been essentially limited to two dimensions. It is proposed that these

limitations may be overcome by employing multi-dimensional detection. Application of

Fourier analysis of pulsed signals, across the time domain affords detection of analyte

response in both the time and frequency domains.

Analyte pulses of the same physical wavelength appear to the detector to have differing

frequencies proportional to their relative velocity. The technique may be used for high

speed comprehensive analyses in multiple dimensions with negligible increases in the total

analysis time.

This technique is unique in its capacity to numerically resolve physically unresolved peaks

and has been shown, in theory, to be applicable to short, high-efficiency separations,

producing extraordinarily high peak capacities per unit of analysis time. A semi-empirical

computer model of this system was developed and the validity of the theory and the

feasibility of practical implementation positively established.

It is envisaged that these comprehensive online multidimensional Fourier transform

separations will leverage emerging high-efficiency micro- and nano-scale separations

technologies.

Key Words: Comprehensive, online, two-dimensional, multidimensional, chromatography,

frequency domain, Fast Fourier Transform, high-efficiency, separations

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The Ultra-Trace Level Analysis of Xanthates

by High Performance Liquid Chromatography

Principal Supervisor:

Dr Gary Dennis (University of Western Sydney, Sydney, NSW, Australia)

An ion-interaction, reversed-phase high performance liquid chromatographic method was

developed for the simultaneous analysis of seven xanthates of simple alcohols. The effects

on chromatographic behaviour of mobile phase composition changes (level of organic

modifier, buffer type and pH) and different ion-pairing (IP) reagents as well as IP

concentrations were examined. An assessment was also made of detection limits and the

accuracy and precision of quantitation by peak area and peak height at the two strongest

xanthate (UV) absorbance wavelengths of 227 nm and 300 nm. Linearity of response for all

xanthates was confirmed within the concentration range encompassing three orders of

magnitude: 10 g L-1 to 50 mg L-1. The most efficient separations were achieved when

using tetrabutylammonium bromide as the ion-pairing reagent. Near-baseline separation of

the seven xanthates was achieved with isocratic elution and a run time of less than nine

minutes. Absolute limits of detection were between 0.08 ng and 0.42 ng.

The high degree of accuracy and precision of this method has been demonstrated in field

trials involving the analysis of tailings samples and wastewater from several mines in north -

western New South Wales, Australia. This method has proven to be a simple, rapid and

inexpensive means of determining ultra-trace xanthate levels for the purposes of

environmental assessments and process monitoring.

A DDITIONAL K NOWLEDGE AND E XPERIENCE

M ARK TRUDGETT HAS UN USUALLY STRONG SKILL S

A ND KNOWLEDGE IN THE F OLLOWING AREAS :

Windows Operating Systems and Windows Networking, IBM PC software/ hardware

installation and repair.

Microsoft Office Applications including Word, Excel, PowerPoint and Access.

Scientific and applications programming in Visual Studio .NET

Web domain administration, web design and development and deployment

Astronomical observation and measurement including CCD imaging and image

processing, photometry and stellar and nebular spectroscopy.

Education of children and adults in the basics and principles of sciences including

astronomy, chemistry, physics and biology.

Bush care principles and techniques for the regeneration of native bush lands.

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I NTERESTS

Astronomy (Astrophotography, spectroscopy and astrophysics)

Fly-fishing and fly-tying.

Photography (landscapes, portraiture and fine art).

Music (playing flute, piano and classical guitar).

Literature (philosophy and English, French and Russian classics).

French and Cantonese language.

Sailing currently in a Mirror Class Dinghy.

Gardening including landscape, design and Bonsai with indigenous plants.

Camping and four-wheel drive touring.

Cabinet making and woodturning.

Education of gifted children.

A SSOCIATIONS A ND COMMUNITY A CTIVITIES

Member of the Astronomical Society of NSW (2008 Present)

Member of Royal Australian Chemical Institute (MRACI)(2002 Present)

Member of CASS An International Separation Science Society. (2012 Present)

Member of ACS American Chemical Society. (2012 Present)

Space Is Big! (An educational astronomy night for the very young)

Volunteer bush-care worker with the Mt. Riverview Bush-Care Group (2004-Present)

Member of Subaru & Recreational 4WD Club. (2001 2005)

Member of Australian MENSA. (1994 2001)

Member of Penrith Chamber of Commerce. (1995-1997)

Member of Australian Photographic Society. (1993 1996)

Member of Southern Cross Gliding Club. (1991-1993)

Student Member of Royal Australian Chemical Institute. (1985 1987)

Member of North Rocks Carlingford Chess Club. (1987 1988)

Member of Nepean District Amateur Cycling Club. (Penrith Panthers Cycling

Club)(1984 1987)

Flautist for Nepean Valley Symphonia. (Now known as the Penrith Symphony

Orchestra)(1982 1985)

L ANGUAGES

English Native at a very high standard. Vocabulary: 50,000+ words

French For casual / conversational communication. Vocabulary: ~5,000 words

Cantonese Sufficient for survival purposes and small talk . Vocabulary: ~200 words

R EFEREES

Academic and Professional Referees will be made available upon request.

Certified copies of Testamurs and Academic Transcripts will be provided upon request.

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