CURRICULUM VITAE

PART I: General Information

Date Prepared: 9/30/2010

Name: Philip Richard Orrin Payne

Office Address: The Ohio State University

Department of Biomedical Informatics

**** ****** Hall

th

333 W. 10 Avenue

Columbus, OH 43210

Tel.: 614-***-****; Fax.: 614-***-****

Email: abo51q@r.postjobfree.com

Web: http://bmi.osu.edu/~payne

Home Address: 7098 Violet Veil Court

Dublin, OH 43016

Place of Birth: San Diego, CA (Citizen of United States)

Education:

1995-1999: B.A. University of California - San Diego, La Jolla, CA (Political Science)

1999-2000: M.A. Columbia University, New York, NY (Medical Informatics)

2003-2006: M.Phil. Columbia University, New York, NY (Biomedical Informatics)

Ph.D. Columbia University, New York, NY (Biomedical Informatics)*

* With Distinction

Academic Appointments:

2006-2010: Assistant ProfessorDepartment of Biomedical Informatics, The Ohio State University

2008-present: Director, Biomedical Informatics Program

The Ohio State University,

Center for Clinical and Translational Science

2008-2010: Senior Scientific Advisor

The Ohio State University, Center for IT Innovation in Healthcare

2009-present: Director of Data Management Services, Biomedical Informatics Shared

Resource

The Ohio State University, Comprehensive Cancer Center

2010-present: Associate Professor and ChairDepartment of Biomedical Informatics, The Ohio State University

2010-present: Executive DirectorThe Ohio State University, Center for IT Innovation in Healthcare

Payne, P.R.O.

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Professional Appointments:

1995-1999: Lead Programmer and Systems AnalystHamilton Glaucoma Center, University of California - San Diego

2000-2003: Director of Biomedical Informatics

CLL Research Consortium, Moores Comprehensive Cancer Center,

University of California - San Diego

2006-present: Translational Research Informatics Architect

The Ohio State University Medical Center

University Committee Assignments:

2005-2006 Graduate School Advisory Committee

Columbia University, Graduate School of Arts and Sciences

2005-2006 Graduate Admissions Committee

Columbia University, Department of Biomedical Informatics

2006-2008 Clinical and Translational Science Award Planning Committee

The Ohio State University Medical Center

2006-2008 Systems Committee

The Ohio State University, Department of Biomedical Informatics

2006-Present Faculty Search Committee

The Ohio State University, Department of Biomedical Informatics

2007-Present Clinical Trials Management System Task Force (Co-Chair)

The Ohio State University Medical Center

2007-Present Research Information Systems Steering Committee

The Ohio State University Medical Center

2007-Present HIPAA Privacy and Security Committee

The Ohio State University Medical Center

2008-Present Center for Clinical and Translational Science Executive Committee

The Ohio State University

2009-Present Promotion Credit and Criteria for Team Science Task Force

The Ohio State University, College of Medicine

2010-Present Research Computing Steering Committee

The Ohio State University

2010-Present Rules and Bylaws Committee

The Ohio State University, College of Medicine

Payne, P.R.O.

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Professional Organizations:

American Medical Informatics Association (AMIA)

Association for Computing Machinery (ACM)

American Association for the Advancement of Science (AAAS)

Peer Review:

Journals (Editorial Board):

2007-Present Biomedical Informatics Insights

Journals (ad hoc):

2007-Present Journal of the American Medical Informatics Association (JAMIA)

2007-Present Journal of Biomedical Informatics (JBI)

2009-Present BMC Medical Informatics and Decision Making

2009-Present Artificial Intelligence in Medicine

2010-Present Applied Clinical Informatics

Symposia (Scientific Program Committee):

2009 - Present AMIA Summit on Translational Bioinformatics

Awards and Honors:

1995 California Biomedical Research Association Scholarship

1995 University of California Academic Achievement Scholarship

2003 Distinguished Poster, AMIA Annual Symposium

2004 Apple World Wide Developers Conference Student Scholarship

2007 Nominated to Bio-Ohio Thirty in Their 30 s

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PART II:

Research, Teaching, and Clinical Contributions

Research Narrative:

In order to fully realize the promise of translational research and personalized

medicine, it is

necessary to couple high-throughput biomarker and phenotypic information sources, and

reason

upon resulting integrative data sets. In this context, translational research can be

defined as

both the testing of novel therapeutic strategies (in humans) that were developed through

basic

laboratory experimentation and taking observations from the bedside-to-the-bench .

Similarly, personalized medicine can be defined as the use of genetic susceptibility or

pharmacogenetic testing to tailor an individual's preventive care or drug therapy . The

benefits

of these approaches to biomedical research and healthcare delivery focus primarily on the

ability

to predict risk profiles of individual patients for both the development and progression

of

disease, and subsequently plan for and deliver adaptive preventative and therapeutic

interventions based upon an understanding of how a patient s unique phenotype and bio-

molecular profile will influence their response to such treatment modalities. Over the

last

several years, there has been a significant focus on the development of novel, high-

throughput

bio-molecular data generation and management methods and platforms. However, similar

attention has not been placed upon the development of high-throughput phenotyping

approaches.

Given the increasing availability of potential sources for phenotype data, such as

electronic

health record systems and clinical trial management systems, the need for the development

and

validation of informatics methods for such phenotyping is critical. It is this gap in

knowledge

that motivates the following research focus areas within my laboratory:

The development and evaluation of systems-level architectures and socio-technical

models related to the efficient conduct of clinical and translational studies involving

high-throughput phenotyping;

The design of integrative translational research information management systems

that incorporate clinical trial and bio-specimen management functionality with service-

oriented electronic data interchange modalities in order to increase the scope, quality

and

fidelity of ensuing data repositories, and the measurement of the impact of such systems

on research productivity; and

The application of conceptual knowledge engineering techniques to support high-

throughput hypothesis generation in multi-dimensional biomedical data sets, and the

identification and evaluation of the characteristics of such hypotheses that correspond

to

their perceived and realized validity and ability to inform novel study designs.

The motivating hypothesis underlying these aims is that increased phenotyping throughput

and

quality in both single and multi-site clinical and translational research programs will

be made

possible through the use of a combination of: 1) distributed computing platforms for

electronic data interchange between heterogeneous data sources; 2) conceptual knowledge

engineering tools and techniques; and 3) rigorous planning and evaluation of information

technology deployment and adoption using socio-technical methods and systems-level

frameworks.

Payne, P.R.O.

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Research Funding:

2006-2011National Cancer Institute (PO1 Award)

Role: Co-Investigator, Biomedical Informatics Program Director

Title:

Chronic Lymphocytic Leukemia Research Consortium2008-2013National Center for Research Resources (CTSA

)

Role:

Co-Investigator, Biomedical Informatics Program Director

Title: OSU Center

for Clinical and Translational Science

2008-2012National Cancer Institute (R01 Award)

Role: Principal Investigator

Title: Re-Engineering the CRC Integrated Information Management System

2008-2012National Library of Medicine (R01 Award)

Role: Co-Investigator

Title: Evaluating EHR-based, Point-of-Care Trial Recruitment

2009-2011National Cancer Institute / Booz Allen Hamilton (Contract)

Role: Principal Investigator

Title: OSU Cancer Center Getting Connected With caBIG Project

2009-2011National Library of Medicine (R01/EUREKA/ARRA Award)

Role: Co-Principal Investigator

Title: OAMiner - knowledge-anchored discovery, verification and validation

of hypotheses from heterogeneous data sources

2009-2011National Center for Research Resources (CTSA Administrative Supplement)

Role: Co-Principal Investigator

Title: The Translational Research Informatics and Data Management

(TRIAD) Grid Project

2009-2014National Cancer Institute (P50 SPORE Award)

Role: Co-Investigator, Biomedical Informatics Core Director

Title: Experimental Therapeutics of Leukemia

2010-2015National Cancer Institute (R01 Award)

Role: Co-Investigator

Title: Assays for Screening Histone Modifications in Cancer

Payne, P.R.O.

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Teaching Activities:

1. Columbia University Medical Center

Courses:

2004 Course Title: Interactive Healthcare Communication

School: School of Nursing

Role: Lecture Teaching Assistant, Laboratory Instructor

2005 Course Title: Theory and Methods in Biomedical Informatics

School: Graduate School of Arts and Sciences

Role: Lecture Teaching Assistant, Laboratory Instructor

Trainees Supervised:

2006-2007 Amy Chused, Post-doctoral Trainee (Biomedical Informatics)

2006-2007 James Deitzer, Masters Candidate (Biomedical Informatics)

2. The Ohio State University Medical Center

Courses:

2006-Present Course Title: Advanced Topics in Biomedical Data Management

School: College of Medicine

Role: Guest Lecturer

2007-Present Course Title: Bioinformatics Applied to Humans

School: College of Medicine

Role: Guest Lecturer

2007-Present Course Title: Advanced Topics in Biomedical Informatics

School: College of Medicine

Role: Guest Lecturer

2007-Present Course Title: Foundational Knowledge Nursing and Health Systems

School: College of Nursing

Role: Guest Lecturer

2007-Present Course Title: Healthcare Information Systems

School: School of Allied Medical Professions

Role: Guest Lecturer

2008-Present Course Title: Seminar in Biomedical Informatics

School: College of Medicine

Role: Course Director

2010-Present Course Title: Introduction to Clinical Informatics

School: College of Medicine

Role: Course Director

Payne, P.R.O.

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Teaching Activities (Continued):

Trainees Supervised:

2006-2007Shirley Luong, Doctoral Candidate

(IBGP)

2008-2009Kristin Circle, Masters of Science Candidate

(IBGP/Pathology)

2008-2009Tyler Wagner,

Undergraduate Nursing Student

2008-2009Taylor Pressler, Masters of Science Candidate

(Statistics)

2008-PresentKishore Jayanti,

Medical Student

2009-PresentJoe Schultz, Doctoral Candidate

(Biophysics)

2010-PresentMarcelo Lopetegui, Visiting Scholar (Chile)

3. Other Teaching Activities

2009-Present Course: Introduction to Clinical Research Informatics

Venue: AMIA 10x10 Program (Distance Learning)

Role: Lecturer

2009-Present Course: Clinical Research Informatics Theory, Methods, and Best Practices

Venue: AMIA Spring Congress (Tutorial)

Role: Tutorial Director, Instructor

2009-Present Course: Clinical Research Informatics Theory, Methods, and Best Practices

Venue: AMIA Annual Symposium (Tutorial)

Role: Tutorial Director, Instructor

Payne, P.R.O.

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Community Service:

2003-2004Consultant, Institute of Medicine, Clinical Research Roundtable

2003-2006Consultant, CLL Research Consortium

2006-2008 Leadership Committee, AMIA Clinical Research Informatics Working Group

2007-Present Co-Chair, AMIA Clinical Research Informatics Steering Task Force

2008-2009Consultant, Emory University, Center for Comprehensive Informatics

2008-2009Consultant, University of North Carolina

Chapel Hill, CTSA Program

2008-PresentSecretary,

AMIA Clinical Research Informatics Working Group

2008-Present Advisory Board, University of California Irvine, ICTS

2008-Present Advisory Board, Virginia Commonwealth University, CTSA Planning

Committee

2008-Present Advisory Board, Research Centers in Minority Institutes Consortium (RCMI)

2009-PresentSPC Member, AMIA Translational Bioinformatics Summit

2009 SPC Track Chair, AMIA Spring Congress

2009-Present Operations Committee, CTSA Informatics Key Function Committee (IKFC)

2009-2010 SPC Track Chair, Summit on Clinical Research Informatics

2009-Present Steering Committee, Workshop on Interactive Systems in Healthcare (WISH)

2010-Present SPC Chair, AMIA Clinical Research Informatics Summit

2010-PresentNLM, Informatics for in silico Discovery Advisory Committee 2010-Present

Advisory Board, Case Western Reserve University / Cleveland Clinic CTSA

Presentations at International Conferences:

2003 AMIA Annual Symposium

Washington, D.C.

2004 MEDINFO

San Francisco, California

2006 CHI 2006: Conference on Human Factors in Computing Systems

Montreal, Quebec, Canada

2007 AMIA Annual Symposium

Washington, D.C.

Invited Seminars and Presentations:

2000 Update of Medical Informatics

San Diego State University, Department of Public Health

2001 Clinical Research Information Management

M.D. Anderson Cancer Center, Leukemia Department

2002 Information Management in the CLL Research Consortium

National Cancer Institute, Cancer Therapy Evaluation Program

Information Management in the CLL Research Consortium

Columbia University, Department of Biomedical Informatics

Clinical Research Information Management

San Diego Telecom Council

2004 Tissue and Data Repositories and HIPAA

Columbia University Bioethics Program

Dangers in the Cyber Cafe

Columbia University Bioethics Program

A Practical Guide to HIPAA Compliance in Tissue Banking

Columbia University Bioethics Program

2005 Biomedical Informatics at the Intersection of Clinical and Laboratory Services

University of California at San Diego Medical Center

Privacy & Confidentiality in Research

Columbia University Bioethics Program

2007 Human Subjects Protection in Social and Behavioral Research

Columbia University IRB Training Symposium

Payne, P.R.O.

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Invited Seminars and Presentations (Continued):

Leveraging Enterprise Data Warehousing to Support Translational Research

University of Cincinnati

The Value of Integrative Informatics Platforms

Moores UCSD Cancer Center

Enterprise Data Warehousing to Support Clinical and Translational Research

NSF Workshop: Expanding Secondary Use of Health Data

Semantic Interoperability in Translational Research

The Ohio State University, IT Innovations in Healthcare Symposium

2008 Challenges and Opportunities in Translational Research Informatics

Arizona State University, Department of Biomedical Informatics Seminar

Catalyzing Translational Research: Integrative Biomedical Informatics Platforms

University of Cincinnati

Catalyzing Translational Research Using Integrative Biomedical Informatics

UC Irvine, Institute for Clinical and Translational Science Seminar

Catalyzing Translational Research Using Integrative Biomedical Informatics

Virginia Commonwealth University

Research Collaborations in Health Care

The Ohio State University, Advances in Health Care through Data Analytic

Symposium

2009 Integrating Enterprise Research Systems and Epic

Epic Research Advisory Council (Madison, WI)

Catalyzing Translational Research Using Integrative Biomedical Informatics

University of North Carolina at Chapel Hill

The High Throughput Data Problem: Hypothesis Generation and Phenotype

Modeling in Translational Research

Ohio Collaborative Conference on Bioinformatics 2009 (Cleveland, OH)

caBIG and CTSA: Advancing Translational Research Using Integrative

Biomedical Informatics Platforms

caBIG Annual Meeting (Washington, D.C.)

Payne, P.R.O.

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Invited Seminars and Presentations (Continued):

The High Throughput Data Problem: Hypothesis Generation and Phenotype

Modeling in Translational Research

University of Chicago

The High Throughput Data Problem: Hypothesis Generation and Phenotype

Modeling in Translational Research

Indiana University / Purdue University

2010 TRIAD: The Translational Research Informatics and Data Management Grid

Cleveland Clinical and Translational Science Collaborative (Cleveland,OH)

The TRITON Project: An Integrative Platform for Clinical and Translational

Research

CLL Research Consortium Annual Meeting (Washington, DC)

The High Throughput Data Problem: Hypothesis Generation and Phenotype

Modeling in Translational Research

University of Texas Medical Center (Houston, TX)

Biomedical Informatics: Enabling a Learning Healthcare System

American Academy of Optometry Summer Research Institute (Columbus, OH)

The OAMiner Project: An Integrative Informatics Platform for Hypothesis

Generation and in silico Science

National Library of Medicine Informatics for in silico Discovery Workshop

(Bethesda, MD)

Payne, P.R.O.

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