NANCY R. WEBB

Ph.D.

ASSOCIATE PROFESSOR, REGULAR TITLE SERIESUNIVERSITY OF KENTUCKY MEDICAL CENTER

Updated: October, 2009I. Home Address

**** ********** ****

Lexington, Kentucky 40502

Home Telephone: 859-***-****

Office Address: University of KentuckyDepartment of Internal Medicine

Division of Endocrinology900 South Limestone

535 Wethington Health Science Building

Lexington, Kentucky 40536-0200

Office Telephone: 859-***-**** x 81385

Laboratory: 859-***-**** x 81386

FAX: 859-***-****

E-mail: abo4w3@r.postjobfree.com

Social Security Number:

Birth Date:

Certifications/Licensure: N/A

Marital Status: Married Bruce A. Webb, Ph.D. Two children.

II. Education

Institution Dates Degree Subject

University of Virginia 1977-1981 B.A. (with Distinction) Biology

University of Colorado 1981-1982 Pharmacology

University of Kentucky 1995-1999 Ph.D. Microbiology and

Immunology

III. Professional Experience

9/82-8/83Department of Biochemistry, University of Kentucky,

Lexington

9/82: Research Analyst

7/83: Promoted to Senior Research Analyst

10/83-1/88Molecular Biology Department, Oncogen, Seattle, WA.

10/83: Research Technologist I

11/84: Promoted to Research Technologist II

11/85: Promoted to Senior Research Associate

1/87: Promoted to Principal Research Associate

3/88-11/90Department of Entomology, Texas A & M University, College Station

Research Associate

1/91-12/94American Cyanamid Agricultural Research Division, Princeton, NJ

Molecular Biologist

Nancy R. Webb, Ph.D.

Curriculum vitae

Page 2

IV. Academic Appointments

1/95-8/99Department of Internal Medicine, Division of Endocrinology and

Molecular Medicine, University of Kentucky, LexingtonBiomedical Scientist

9/99-6/05Department of Internal Medicine, Division of Endocrinology and

Molecular Medicine, University of Kentucky, Lexington

Assistant Professor

7/05-6/09Department of Internal Medicine, Division of Endocrinology and

Molecular Medicine, University of Kentucky, Lexington

Associate Professor

with tenure

7/09- Department of Internal Medicine, Division of Endocrinology and

Molecular Medicine, University of Kentucky, Lexington

Professor with tenure

V. Hospital Appointments N/A

VI. Consultative Service N/A

VII. Teaching Activities

2002-present MI615: Molecular Biology; 3 lecture contact hours

2003-present NS606: Molecular Biological Applications in Nutrition; Course

Director; 20 lecture contact hours

2003 ABT395: Molecular Genetics; 1 lecture contact hour

2004 ABT201: 1 lecture contact hour

2006 ABT201: 1 lecture contact hour

2008 Mechanisms of Human Diseases: 2 lecture contact hours

VII. Advising Activities

Mentor for C.O.B.R.E.

Whitney Browning: advisor for ABT395 research project

2001-2002 Ryan Mulligan: advisor for ABT395 research project

2002-2003Tiffany Taylor: advisor for ABT395 research project

2003-2004Joseph Slusher: advisor for ABT395 research project

2005-2007 Daniel Slusher: advisor for ABT395 research project

(recipient of Agricultural Biotech undergraduate research award)

Nancy R. Webb, Ph.D.

Curriculum vitae

Page 3

2008- Kayla Talbott: advisor for ABT395 research project

(recipient of AMSTEMM Summer Research Grant)

Graduate student committees

2000-2006 Bing Sun (major advisor)

2002-2006 Meredith Bostrom (major advisor)

2003-2008 Lewamy Mamadou

2003-2007 Shoba Shetty

2005-present Xia Li (major advisor)

2006-present Xuan Zhang

2006-present Melissa Zack (major advisor)

2008-present Akin Akinmusire

2008-present Nicholas Hatch

2008 Huiyun Shen (outside examiner)

2008 Phillip Owens (outside examiner)

2008 Huiyun Shen (outside examiner)

2009-present Nadeem Mohammed

IX. Administrative Activities

2000-present VA Medical Center Institutional Animal Care and Use Committee

2002 Chair, VAMC Institutional Animal Care and Use Committee

2003-2005 Curriculum Committee, Graduate Center for Nutritional Sciences

2003-present Equipment Committee, Graduate Center for Nutritional Sciences

2003 Search Committee, Graduate Center for Nutritional Sciences

Director

2004-present University of Kentucky College of Medicine Non-indemnified Risk

Committee

2004-present Department of Medicine Committee on Gender Equity

2005 Search Committee, Veteran s Administration Research Service

Administrative Officer

2005 Member, University of Kentucky Center on Drug and Alcohol

Research Six Year Review Committee

2005 Member, University of Kentucky HHMI Committee

2006 Search Committee, University of Kentucky Department of Surgery

Chair

Member, University of Kentucky Department of Internal Medicine

2006-present

Appointments, Promotion, and Tenure Committee

Chair-elect, VAMC Institutional Animal Care and Use Committee

2008

Chair, VAMC Institutional Animal Care and Use Committee

2009

Search Committee, University of Kentucky Center for Nutritional

2009

Sciences

XI. Special Assignments

XII. Honors and Awards

1981-1982 NIH NRSA Pre-doctoral Fellowship1999 NIH Postdoctoral Fellowship (declined)

1999 American Heart Association Postdoctoral Fellowship (declined)

2000-2001 University of Kentucky Medical Center Research Fund Award

2001-2004 American Heart Association Scientific Development Grant

2002-2003 Atorvastatin Research Award

2004 Finalist, Irvine H. Page Young Investigator Research Award

Nancy R. Webb, Ph.D.

Curriculum vitae

Page 4

American Heart Association, Council on Arteriosclerosis,

Thrombosis and Vascular Biology

2004-2009 Annual University of Kentucky Wethington Research Award

XII. Professional Activity and Public Service

1989-present American Society for Virology

2001-present American Heart Association

2001-present Arteriosclerosis Council of the American Heart Association

2006 Member, Program Committee, Conference on Arteriosclerosis,

Thrombosis and Vascular Biology

2006-2007 Member, Research Committee, American Heart Association

Ohio Valley Affiliate

2006-2007 Member, Steering Committee, American Heart Association

Ohio Valley Affiliate

2007-2011 Member, Research Committee, American Heart Association

Great Rivers Affiliate

2008-2010 Member, Women s Research Leadership Committee, American

Heart Association Council on Arteriosclerosis, Thrombosis, and

Vascular Biology

2009 Co-Chair, Southeast Lipid Research Conference, Callaway

Gardens, GA October 2009

2010 Chair, Southeast Lipid Research Conference

Grant Member, NIH Study Section, Clinical and Integrative

reviewer: Cardiovascular Science (March 2005-June 2011)

Member, NIH Special Emphasis Panel Hematology IRG, ZRg1-

HEME-C (February 2007 and December 2007)

Member, Peer Review Committee 2B, American Heart

Association, Ohio Valley Affiliate (2003-2006)

Co-chair, Peer Review Committee 2B, American Heart

Association, Great Rivers Affiliate (2007-2009)

Chair, Peer Review Committee 2B, American Heart Association,

Great Rivers Affiliate (2010)

Ad hoc reviewer, Natural Sciences and Engineering Research

Council of Canada

Ad hoc reviewer, Austrian Science Fund

Manuscript Atherosclerosis

reviewer: Arteriosclerosis, Thrombosis and Vascular Biology

Biochimica et Biophysica Acta

Circulation

Circulation Research

Journal Lipid Research

Journal Clinical Investigations

Lipids

Nature Medicine

New England Journal of Medicine

Pharmacological Research

Abstract grader Scientific Sessions, American Heart Association, 2004-2007

Conference on Arteriosclerosis, Thrombosis, and Vascular

Biology, 2005-2008

Nancy R. Webb, Ph.D.

Curriculum vitae

Page 5

Session chair Southeast Lipid Research Conference, 2004

Scientific Sessions, American Heart Association, 2004

Scientific Sessions, American Heart Association, 2006

Conference on Arteriosclerosis, Thrombosis and Vascular

Biology, 2006

Scientific Sessions, American Heart Association, 2007

Southeast Lipid Research Conference, 2008

Mentor University of Kentucky Girls in Research Program for middle

school age girls 2004-present

Judge Kentucky State Science Fair 2007

Regional Science Fair 2008

XIII. Speaking Engagements

Local

1995 Department of Internal Medicine Research Seminar Series

Viral Vectors: Tools for the Researcher and Clinician

2000 Graduate Center for Nutritional Sciences Seminar Series

The HDL receptor SR-BI

2001 University of Kentucky Cardiovascular Seminar Series

The metabolic fate of high density lipoproteins after processing by

the scavenger receptor B-I.

2002 Department of Pathology Seminar Series

Charting the fate of HDL particles in vivo: Studies in mice over-

expressing the scavenger receptor B-I

2004 Graduate Center for Nutritional Sciences Seminar Series

A mechanistic link between LDL and atherosclerosis

National

1996 Gordon Research Conference on Serum Amyloid A (Ventura, CA)

Adenoviral vectors in the study of SAA function

1999 American Heart Association (Atlanta, Georgia)

SR-BI over-expression results in depletion of apoB-containing

lipoproteins that accumulate in apoE-deficient, but not LDL

receptor-deficient or apoB transgenic, mice

2002 Southeast Lipid Research Conference (Callaway Gardens, GA)

The fate of HDL particles after selective lipid uptake

2003 Atorvastatin ResearchAwards Summit (Salt Lake City, Utah)

Secretory phospholipases and atherosclerosis: Local and systemic

effects

2003 Southeast Lipid Research Conference (Callaway Gardens, GA)

Group V sPLA: Potential Role in Atherosclerosis

2

th

2004 5 Annual Conference on Arteriosclerosis, Thrombosis and

Vascular Biology (San Francisco, CA) Hydrolysis of low-density

lipoprotein by secretory phospholipase A results in spontaneous

2

particle aggregation and promotes macrophage foam cell

formation

2004 Gordon Research Conference on Lipoprotein Metabolism (Meriden,

NH) Role of secretory phospholipases in lipoprotein metabolism

and atherosclerosis

2005 University of California, Davis

Secretory phospholipase A enzymes: A link between LDL and

2

atherosclerosis?

Nancy R. Webb, Ph.D.

Curriculum vitae

Page 6

2005 Columbia University

Group V sPLA: A mechanistic link between LDL and

2

atherosclerosis?

th

2006 7 Annual Conference of Arteriosclerosis, Thrombosis and

Vascular Biology (Denver, CO) Secretory Phospholipase A2 in

Atherosclerosis

2006 FASEB Research Conference on Phospholipases (Saxtons River,

VT) Secretory phospholipase A enzymes: A mechanistic link

2

between LDL and atherosclerosis?

Boehringer Ingelheim Pharmaceuticals, Inc. (Ridgefield, CT)

2007

Secretory Phospholipase A in Atherosclerosis

2

Pfizer (Chesterfield, MO) Secretory Phospholipase A and

2007

2

Atherosclerosis

University of Cincinnati Obesity Research Center Secretory

2007

phospholipase A s and atherosclerosis

2

Scientific Sessions (Orlando, FL) Group X sPLA deficiency

2007

2

increases adiposity and adipose tissue inflammation in mice

Gordon Research Conference on Lipoprotein Metabolism

2008

(Waterville Valley, NH) Group X sPLA negatively regulates

2

lipolysis in adipose tissue

FASEB Research Conference on Phospholipid Metabolism (New

2008

Haven, CT) Group V sPLA in atherosclerosis: An update

2

Southeast Lipid Research Conference (Callaway Gardens, GA)

2008

Role of Group X sPLA in adipose tissue

2

International

1999 European Atherosclerosis Society (Athens, Greece)

Scavenger Receptor BI (SR-BI) and clearance of apoB-containing

lipoproteins in apoE-deficient mice

XIV. Research and/or Creative Productivity

PUBLICATIONS

and de Beer, F.C. (2001) The fate of HDL particles in vivo after SR-BI selective

lipid uptake. Conference on Arteriosclerosis, Thrombosis, and Vascular Biology

(Arlington, VA).

Bostrom, M.A., de Beer, F.C., Daugherty, A., Webb, N.R. (2002) Macrophage

expression of Group IIA sPLA in LDL receptor-deficient mice increases

2

atherosclerotic lesion formation in the absence of systemic effects on lipoprotein

metabolism. Conference on Arteriosclerosis, Thrombosis, and Vascular Biology (Salt

Lake City, UT).

Wooton-Kee, C.R., Nasser, M., deVilliers,W.J.S., de Beer, F.C., Webb, N.R. (2002)

Macrophage-expressed Group V secretory phospholipase A modifies LDL and HDL

2

particles and is present in human and mouse atherosclerotic lesions. Conference on

Arteriosclerosis, Thrombosis, and Vascular Biology (Salt Lake City, UT).

Wooton-Kee, C.R., Webb, N.R. (2003) Hydrolysis of LDL by Group V sPLA

2

results in spontaneous particle aggregation. Conference on Arteriosclerosis,

Thrombosis, and Vascular Biology (Washington D.C.).

De Beer, M.C., Webb, N.R., Asztalos, B.F., van der Westhuyzen, D.R., de Beer, F.C.

(2003) Remodelling of SR-BI-generated HDL remnants. Conference on

Arteriosclerosis, Thrombosis, and Vascular Biology (Washington D.C.).

Sun, B., van der Westhuyzen, D.R., and Webb, N.R. (2004) Class B scavenger

receptors: Defining receptor and ligand trafficking. Southeast Lipid Research

Conference (Callaway Gardens, GA).

Eckhardt, E., Cai, L., Szanto, A., Webb, N.R., van der Westhuyzen, D.R. (2004)

HDL particle uptake by scavenger receptor B-II requires the carboxy-terminal di-

leucine motif. Conference on Arteriosclerosis, Thrombosis, and Vascular Biology

(San Francisco, CA).

Bostrom, M.A., Forrest, K., Boyanovsky, B. Daugherty, A., and Webb, N.R. (2005)

Retroviral vector-mediated overexpression of Group V secretory phospholipase A in

2

hematopoietic cells promotes atherosclerosis in low density lipoprotein receptor

deficient mice. Conference on Arteriosclerosis, Thrombosis and Vascular Biology

(Washington D.C.).

Sun, B., van der Westhuyzen, D.R., and Webb, N.R. (2005) Class B scavenger

receptor-mediated high density lipoprotein trafficking. Conference on

Arteriosclerosis, Thrombosis and Vascular Biology (Washington D.C.).

Boyanovsky, B., van der Westhuyzen, D.R., and Webb, N.R. (2005) Group V

secretory phospholipase A-modified low density lipoprotein promotes foam cell

2

formation by a SR-A and CD36-independent process that involves cellular

proteoglycans. Conference on Arteriosclerosis, Thrombosis and Vascular Biology

(Washington D.C.).

Nancy R. Webb, Ph.D.

Curriculum vitae

Page 12

Sun, B., van der Westhuyzen, D.R., and Webb, N.R. (2005) A quantitative analysis

of high density lipoprotein retroendocytosis by scavenger receptor class B type I.

Southeast Lipid Research Conference (Callaway Gardens, GA).

Bostrom, M.A., Forrest, K. Boyanovsky, B., Daugherty, B., and Webb, N.R. (2005)

Retrovirus-mediated Group V secretory phospholipase A expression in bone

2

marrow-derived cells promotes atherosclerosis in LDLR mice. Scientific Sessions,

American Heart Association (Dallas, TX).

Boyanovsky, B, Shridas, P., and Webb, N.R. (2006) Syndecan-3 and -4 participate in

macrophage uptake of low-density lipoproteins hydrolyzed by Group V secretory

phospholipase A. Conference on Arteriosclerosis, Thrombosis and Vascular Biology

2

(Denver CO).

Sun, B., van der Westhuyzen, D.R., and Webb, N.R. (2006) Distinct mechanisms for

oxLDL uptake and trafficking by class B scavenger receptors SR-BI and CD36.

Conference on Arteriosclerosis, Thrombosis and Vascular Biology (Denver CO).

Shridas, P. and Webb, N.R. (2007) Group X secretory phospholipase A2 plays a role

in the regulation of adrenal corticosteroid synthesis. Conference on Arteriosclerosis,

Thrombosis and Vascular Biology (Chicago, IL).

Shridas, P., Bailey, W., Oslund, R.C., Gelb, M.H., and Webb, N.R. (2007) Group X

secretory phospholipase A negatively regulates adrenal glucocorticoid synthesis.

2

Scientific Sessions, American Heart Association (Orlando, FL).

Boyanovsky, B., Zack, M., and Webb, N.R. (2008) The capacity of Group V sPLA

2

-/- -/-

to increase atherogenecity of apoE and LDLR mouse LDL in vitro predicts its

atherogenic role in vivo. Conference on Arteriosclerosis, Thrombosis and Vascular

Biology (Atlanta, GA).

-/- -/-

Boyanovsky, B., Zack, M., and Webb, N.R. (2008) Studies in apoE and LDLR

mice reveal multiple roles for GV sPLA in atherosclerosis. Southeast Lipid

2

Research Conference (Callaway Gardens, GA).

Li, X. and Webb, N.R. (2008) Role of Group X secretory phospholipase A in

2

adipocytes. Southeast Lipid Research Conference (Callaway Gardens, GA).

Shridas, P. and Webb, N.R. (2008) Group X secretory phospholipase A modulates

2

macrophage inflammatory responses. Southeast Lipid Research Conference

(Callaway Gardens, GA).

Shridas, P., Bailey, W. and Webb, N.R. (2009) Group X secretory phospholipase A

2

enhances macrophage inflammatory responses by modulating expression levels of

ABCA1 and ABCG1. Conference on Arteriosclerosis, Thrombosis and Vascular

Biology (Washington, D.C.).

Zack, M., Shridas, P., Bailey, M., Forrest, K., Howatt, D.A., Daugherty, A. and

Webb, N.R. (2009) Group X secretory phospholipase A deficiency protects apoE-

2

deficient mice from angiotensin II-induced abdominal aortic aneurysms. Conference

on Arteriosclerosis, Thrombosis and Vascular Biology (Washington, D.C.).

Nancy R. Webb, Ph.D.

Curriculum vitae

Page 13

De Beer, M.C. Webb, N.R., Wroblewski, J.M., Rateri, D.L., Ji, A., van der

Westhuyzen, D.R., and de Beer, F.C. (2009) Impact of serum amyloid A on high-

density lipoprotein composition, levels, and function. Conference on Arteriosclerosis,

Thrombosis and Vascular Biology (Washington, D.C.). Conference on

Arteriosclerosis, Thrombosis and Vascular Biology (Washington, D.C.).

Shridas, P., Bailey, W., Gizard, R., Bruemmer, D., and Webb, N.R. (2009) Group X

secretory phospholipase A negatively regulates activation of liver X receptors.

2

Scientific Sessions, American Heart Association (Orlando, FL).

GRANT AND CONTRACT ACTIVITY

Active Research Support

NIH

P.I.: N.R. Webb

Group X sPLA: Regulator of Lipolysis and Glucose Homeostasis (R01

2

DK082419)

08/01/09 - 07/31/14; $1,659,111 (Direct costs $1,132,500)

NIH

P.I. A. Daugherty

Project 3 Leader: N.R. Webb

Mechanisms of Abdominal Aortic Aneurysms (P01 HL080100-01A1)

04/08/06 03/31/11; $8,438,000 (Direct costs $5,760,000)

NIH

P.I.: D.R. van der Westhuyzen

Project 3 Leader: N.R. Webb

HDL function and metabolism during inflammation (P01 HL086670)

04/01/07 3/31/2012; (Direct costs, $4,081,724)

NIH

P.I.: Lisa A. Cassis

Mentor: N.R. Webb

Center of Research in Obesity and Cardiovascular Disease (1P20 RR021954-01A1)

07/01/08 6/30/13; (Direct costs $7,224,657)

NIH

P.I.: Lisa Tannock

Co-Investigator: N.R. Webb

Role of serum amyloid A in atherosclerosis (R01 HL096589)

09/01/09 08/31/11 (Direct costs $524,000)

Completed Research Support

NIH

P.I.: N.R. Webb

Co-investigators: F.C. de Beer, D.R. van der Westhuyzen, A. Daugherty

Group V sPLA in Atherosclerosis (R01 HL071098)

2

04/01/03 - 09/31/08; $1,810,000 (Direct costs $1,250,000)

Nancy R. Webb, Ph.D.

Curriculum vitae

Page 14

NIH

P.I.: D.R. van der Westhuyzen

Co-Investigator: N.R. Webb

SR-BI and SR-BII recycling and selective lipid uptake

8/15/057/31/09; (Direct costs $1,125,000)

NIH

P.I.: S.R. Post

Co-investigators: N.R. Webb. W. Akers, C. Loftin, G.R. Post

Regulation of Ras signaling by Rlf in myocytes (R01 HL75241)

12/1/03 11/30/08; $1,416,623 (Direct costs, $1,025,000)

NIH

P.I.: F.C. de Beer

Co-investigators: N.R. Webb, D.R. van der Westhuyzen

SR-BI mediated selective cholesterol ester uptake (R01 AG17237)

03/01/01 02/28/06; $1,102,500 (Direct costs $875,000)

NIH

P.I.: F.C. de Beer

Co-investigators: N.R. Webb

SAA and sPLA: Role in atherogenesis (R01 HL69463)

2

09/30/01 07/31/05; $1,206,440 (Direct costs $1,000,000)

NIH

P.I.: D.R. van der Westhuyzen

Co-investigators: N.R. Webb, A. Daugherty, F.C. de Beer

Class B scavenger receptors and foam cell formation (R01 HL65730)

09/15/00-08/31/04; $882,000 (Direct costs $700,000)

American Heart Association, Ohio Valley Affiliate

P.I.: Boris Boyanovsky

Sponsor: N.R. Webb

Bioactive molecules generated by secretory phospholipase A Group V and Group

2

X hydrolysis of LDL (AHA 0525425B)

07/01/05 06/30/07; $82,000 (Direct costs $82,000)

American Heart Association, Ohio Valley Affiliate

P.I.: Bing Sun

Sponsor: N.R. Webb

Class B scavenger receptors: Defining receptor and ligand trafficking (AHA

0415238B)

07/01/04 06/30/06; $36,000 (Direct costs $36,000)

American Heart Association, Ohio Valley Affiliate

P.I.: Meredith Bostrom

Sponsor: N.R. Webb

Macrophage-derived GX sPLA and atherosclerosis (AHA 0315079B)

2

07/01/03 06/30/04; $36,000 (Direct costs $36,000)

American Heart Association, National Center

P.I.: N.R. Webb

Scavenger receptor BI: Distinct functional domains (AHA 0130020N)

01/01/01 12/31/04; $260,000 (Direct costs $236,364)

Nancy R. Webb, Ph.D.

Curriculum vitae

Page 15

Atorvastatin Research Awards Program

P.I.: N.R. Webb

Inflammatory modification of HDL promotes delivery of oxidized lipids to

macrophages

07/01/02 06/30/03; $50,000 (Direct costs $50,000)

University of Kentucky Medical Center Research Award

P.I.: N.R. Webb

Scavenger receptor B-I and remnant lipoprotein metabolism

07/01/00 6/30/01; $15,000 (Direct costs $15,000)

OTHER CREATIVE ACTIVITY

Issued patents

Cloning and expression of transforming growth factor B2 issued June 22, 1993.

Compositions and methods for detecting and treating atherosclerosis ( U.S.

patent number #7,521,198) issued April 21, 2009.

Contact this candidate