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Cal Poly Pomona

Sepehr Eskandari, Ph.D. - CV

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CURRICULUM VITAE

Sepehr Eskandari, Ph.D.

Professor and Chair

Biological Sciences Department

California State Polytechnic University, Pomona

3801 West Temple Avenue

Pomona, California 91768-4032

Tel.: 909-***-****

Fax: 909-***-****

E-mail: abo2bf@r.postjobfree.com

Web: www.csupomona.edu/~seskandari/

Education

Professional Experience

Membership in Professional Organizations and Honorary Societies

Honors and Awards

Research Focus and Expertise

Teaching Expertise

Research Grants

Teaching Grants

Grants Related to the Advancement of Department, College, and University

Publications

Invited Presentations

Professional Service

Complete CV in pdf format [pdf]

Education

B.S. Chemistry

1993

Chemistry Department

California State Polytechnic University, Pomona

M.S. Biology (Emphasis: Integrative Physiology)

1995

Biological Sciences Department

California State Polytechnic University, Pomona

Mentor: Daniel F. Stiffler, Ph.D.

Ph.D. Physiology

1999

Department of Physiology

School of Medicine

University of California, Los Angeles (UCLA)

Mentor: Ernest M. Wright, D.Sc.

Post-Doctoral Training 1999-2000

Departments of Physiology and Neurobiology

School of Medicine

University of California, Los Angeles (UCLA)

Mentors: Guido A. Zampighi, Ph.D. and Ernest M. Wright, D.Sc.

Professional Experience

2000 - 2005Assistant ProfessorBiological Sciences DepartmentCalifornia State Polytechnic University, Pomona

Pomona, CA 91768-4032

2005 - 2010Associate ProfessorBiological Sciences DepartmentCalifornia State Polytechnic University, Pomona

Pomona, CA 91768-4032

2010 - PresentProfessorBiological Sciences DepartmentCalifornia State Polytechnic University, Pomona

Pomona, CA 91768-4032

2010/2011Professor and Associate ChairBiological Sciences DepartmentCalifornia State Polytechnic University, Pomona

Pomona, CA 91768-4032

07/2011 - 12/2011Professor and Interim ChairBiological Sciences DepartmentCalifornia State Polytechnic University, Pomona

Pomona, CA 91768-4032

2012 - PresentProfessor and ChairBiological Sciences DepartmentCalifornia State Polytechnic University, Pomona

Pomona, CA 91768-4032

Membership in Professional Organizations and Honorary Societies

American Association for the Advancement of Science (1996)

American Physiological Society (1995)

American Society for Biochemistry and Molecular Biology (2003)

Biophysical Society (1995)

Society for Neuroscience (1995)

West Coast Salt and Water Club (1996)

Golden Key National Honor Society (1992)

Honors and Awards

Cal Poly Scholar Athlete of the Year, 1988/89

Vernon Gregory Memorial Scholarship Award, Cal Poly Pomona, 1993/94

Biological Sciences Graduate Student Research Award, Cal Poly Pomona, 1994/95

American Physiological Society Procter & Gamble Professional Opportunity Award, 1998

John Field Award, Department of Physiology, UCLA School of Medicine, 1998

Travel Grant; 1999 International Gap Junction Conference, Gwatt, Switzerland

Ahmanson Foundation Cellular Neurobiology Post-Doctoral Training Grant, Brain Research

Institute, UCLA, 1999/2000

College of Science Distinguished Teaching Award, California State Polytechnic University,

Pomona, 2005

Biotechnology Faculty Research Award, California State University Program for Educationand Research in Biotechnology (

CSUPERB), 2011

Research Focus and Expertise

Research in this laboratory focuses on the brain ?-aminobutyric acid (GABA) transporters.

These molecules are involved in the regulation of inhibitory neuronal signaling in the

brain and, in addition, are the targets of several important experimental and clinical

drugs. Because GABA is the most abundant inhibitory neurotransmitter in the brain, the

GABA transporters are implicated in the treatment of epileptic seizures, and in the

control of the devastating consequences of stroke. Our goal is to elucidate a

comprehensive understanding of GABA transporter structure and function. In addition, we

are interested in the nature of drug interaction with the GABA transporters. Our

functional experiments examine wild-type, chimeric, and mutant transporters and are

designed with the goal of gaining a deeper understanding of the mechanism of transport

cycle. The pharmacological experiments focus on identifying the minimum substrate

structural features needed for recognition and translocation by the transporter. The long-

term goal of the pharmacological studies is to identify/develop compounds that selectively

target various isoforms of the GABA transporters found in different brain regions. Such

research will pave the way for localized pharmacological treatment of epileptic seizures,

stroke, and other pathophysiological conditions in which neurons enter hyper-excited

states. Electrophysiological (two-electrode voltage clamp, patch clamp, ion-selective

electrodes), molecular and cell biological (site-directed mutagenesis, western blots,

etc.), imaging (light and fluorescence microscopy, thin section and freeze-fracture

electron microscopy), as well as isotope methods are used to achieve these goals.

Teaching Expertise

Transport across Cell Membranes

Electrophysiological Methods

Freeze-Fracture Electron Microscopy

Molecular and Cellular Physiology

Animal Physiology

Human Physiology

Radiation Biology

Biophysics

Introductory Biology

Research Grants

Molecular physiology of ?-aminobutyric acid transporters. Principal Investigator.

($444,791 in direct and indirect costs). National Institutes of Health (S06 GM-53933).

20012004.

The effect of anti-epileptic drugs on the brain ?-aminobutyric acid transporters.

($5,000). Research, Scholarship, and Creative Activities Grant. California State

Polytechnic University, Pomona. 2001.

The effect of anti-epileptic drugs on the brain ?-aminobutyric acid transporters ($750).

Faculty Professional Development Mini-Grant. California State Polytechnic University,

Pomona. 2001.

Equipment supplement to S06 GM-53933. Co-Principal Investigator. ($485,610). National

Institutes of Health. 2002.

Molecular physiology of ?-aminobutyric acid transporters. Principal Investigator.

($640,727 in direct and indirect costs). National Institutes of Health (S06 GM-53933).

20042008.

Molecular physiology of ?-aminobutyric acid transporters. Principal Investigator.

($1,278,000 in direct and indirect costs). National Institutes of Health; National

Institute of General Medical Sciences (SC1GM086344). 2009 2012.

Equipment supplement to SC1GM086344. Principal Investigator. ($39,282). National

Institutes of Health (3SC1GM086344-01S1 from the National Institute of General Medical

Sciences). 2009 2010.

Components of inhibitory signal transmission in bovine sperm. Principal Investigator.

($50,000). California State University Agricultural Research Institute. 2011-2012.

Teaching Grants

Data Acquisition and Analysis in the Modern Physiology Teaching Laboratory. ($20,000).

Funding obtained from California State University Program for Education and Research in

Biotechnology (CSUPERB). 2000 2001.

Electrophysiological Screening of Drugs in Xenopus laevis Oocytes. ($20,000). Funding

obtained from California State University Program for Education and Research in

Biotechnology (CSUPERB). 2001 2002.

Grants Related to the Advancement of Department, College, and University

Kellogg Distinguished Public Lecture Series. Project Co-director. ($210,000). Kellogg

Legacy Project Endowment. 2011/12, 2012/13, and 2013/14 academic years.

Publications

) A mutagenesis database prototype for

Neurotransmitter:Sodium Symporters. Society for Neuroscience, Washington, D.C.

Invited Presentations

Institute of Physiology, University of Zurich, Switzerland. September, 1999.

Department of Biology, California State University, San Bernardino. November, 1999.

Biological Sciences Department, California State Polytechnic University, Pomona.

February, 2000.

Minority Biomedical Research Support Seminar Series, California State Polytechnic

University, Pomona. October, 2001, November 2003.

Biological Sciences Seminar Series. Department of Biological Sciences, California State

University, Los Angeles. November, 2005.On Teaching Physiology at Cal Poly Pomona. 6th Annual College of Science Award Seminar

for Teaching Excellence. California State Polytechnic University, Pomona. December, 2005.

Program in Biology, California State University, Channel Islands. March, 2006.

Basic Medical Sciences Seminar Series, College of Osteopathic Medicine of the Pacific,

Western University of Health Sciences. January, 2008.

Department of Biology, California State University, San Bernardino. October, 2008.

Science Lecture Series, Saddleback College, Mission Viejo, California. February, 2010.

Department of Biological Science, California State University, Fullerton. December, 2010.

2011 Biotechnology Faculty Research Award Lecture. California State University

Biotechnology Symposium, Garden Grove, California. January, 2011.

Annual meeting of the American Association for Laboratory Animal Science (AALAS), San

Diego, California. October, 2011.

Professional Service

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