Manager Medical

ROBERT SCHOONHOVEN, HT, HTL

**** ****** ******

Portage, MI 49024

(H) 269-***-****

(C) 269-***-****

OBJECTIVE: To join a progressive and successful clinical reference laboratory as the

Histology, IHC or Anatomic Pathology Laboratory Director/Manager.

EDUCATION:

1975 University of California at Riverside, Riverside CA, Chemistry

Certifications: HT (ASCP # 008716)/HTL (ASCP # 000275)

EXPERIENCE:

2006 –Present MPI Research, Mattawan, MI, Scientist, Pathology (see cover letter for

details).

1991- 2006 University of North Carolina, Dept. of Environmental Sciences &

Engineering, Chapel Hill, NC, Director CEHS Core for IHC and Image

Analysis

2003-2005 Cee Tox, Kalamazoo, MI, Consultant

1999-2003 Pharmacia-Upjohn, Kalamazoo, MI, Consultant (image analysis & IHC)

1991- 2004 Dow Corning Corp., Midland, MI, Consultant (image analysis & IHC)

1990-1991 Glaxo-Smith Kline, RTP, NC, Consultant (IHC)

1989-90 Bio-Tek Research Consultants Inc., RTP, North Carolina, Biotechnology

Consultant & Director of Marketing.

1986-89 Bio-Rad Microsciences Division, Cambridge, MA, Marketing and Business

Unit Manager, Director of Sales.

1983-86 Reichert Jung, Inc., Buffalo, New York

Product Manager, Marketing Manager Histology and Electron Microscopy.

1976-83 Blodgett Memorial Medical Center, Grand Rapids, MI, Section Chief of

Histopathology, Director School of Histotechnology.

1972-76 N.C.O.I.C., March Air Force Base, Riverside, CA Histology, Cytology, and

Autopsy.

Detailed descriptions available on request

PAGE TWO, ROBERT SCHOOHOVEN

SPECIAL TRAINING:

1988 Microwave Irradiation Procedures for Histology and Electron Microscopy,

Dr. M.E. Boon, Leiden, the Netherlands.

1987 Operating Theory and use of the M.R.C. Confocal Laser Scanning

Microscope, Dr. John White, MRC, Cambridge England.

1986 Operation, Theory and use of Cryo-Techniques In Scanning Electron

Microscopy, University College of London, London England.

1986,84 Cryo-fixation and sectioning for TEM, Professor Helmut

and 1983 Sitte, Seefeild, Austria.

1986,84 Large Specimen Techniques, Sectioning and Ultramiillng,

and 1983 Jung, Heidelberg, Germany.

PUBLICATIONS AND PRESENTATIONS:

1980 Manual for Muscle Biopsy Enzyme-Histochemistry, Blodgett Memorial

Medical Center.

1981 Manual of Plastic Techniques for Light Microscopy, Blodgett

Memorial Medical Center. Co-author: Alexandra Brady.

1989 Microwave Irradiation In Histopathology, N.Y. Society of Histology.

1983-86 Presented lectures, workshops, and short courses on Cryopreparation

Techniques, Plastic Sectioning for Light Microscopy and Histochemistry to

numerous Institutions and societies. These include the National Society for

Histotechnology, the Electron Microscopy Society of America (now MSA) and

the American Society for cell Biology. Lectures and Short courses were

presented at Duke University Marine Laboratory, NCSU School of Veterinary

Medicine, University of Pennsylvania Medical School, University of Chicago

and NIH Baltimore. All workshops and short courses were approved by the

AMA for Continuing Education Units.

PAGE THREE, ROBERT SCHOOHOVEN

Heider TR, Lyman S, Schoonhoven R, Behrns KE. Ski promotes tumor growth through abrogation of

transforming growth factor-beta signaling in pancreatic cancer. Ann Surg. 2007 Jul;246(1):61-8.

PMID: 17592292

Roper JC, Brown DM, Sullivan MA, Schoonhoven R, Swenberg JA, Pfaender FK. Epifluorescence microscopy

and image analysis of high-level polycyclic aromatic hydrocarbon contamination in soils. Environ Toxicol Chem.

2006 Dec;25(12):3093-100.

PMID: 17220076

Barrick CJ, Rojas M, Schoonhoven R, Smyth SS, Threadgill DW. Cardiac response to pressure overload in

129S1/SvImJ and C57BL/6J mice: temporal-and background-dependent development of concentric left

ventricular hypertrophy. Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2119-30. Epub 2006 Dec 15.

PMID: 17172276

Powell CL, Kosyk O, Ross PK, Schoonhoven R, Boysen G, Swenberg JA, Heinloth AN, Boorman GA,

Cunningham ML, Paules RS, Rusyn I. Phenotypic anchoring of acetaminophen-induced oxidative stress with

gene expression profiles in rat liver. Toxicol Sci. 2006 Sep;93(1):213-22. Epub 2006 Jun 2.

PMID: 16751229

Russo MW, Firpi RJ, Nelson DR, Schoonhoven R, Shrestha R, Fried MW. Early hepatic stellate cell activation is

associated with advanced fibrosis after liver transplantation in recipients with hepatitis C. Liver Transpl. 2005

Oct;11(10):1235-41.

PMID: 16184580

Bataller R, Gäbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R, Brenner DA, Rippe RA.

Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Hepatology. 2005

May;41(5):1046-55.

PMID: 15841463

Calderón-Garcidueñas L, Maronpot RR, Torres-Jardon R, Henríquez-Roldán C, Schoonhoven R, Acuña-Ayala H,

Villarreal-Calderón A, Nakamura J, Fernando R, Reed W, Azzarelli B, Swenberg JA. DNA damage in nasal and

brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and

neurodegeneration. Toxicol Pathol. 2003 Sep-Oct;31(5):524-38.

PMID: 14692621

Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH,

Lemasters JJ, Brenner DA. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is

critical in hepatic fibrosis. J Clin Invest. 2003 Nov;112(9):1383-94.

PMID: 14597764

Ríos-Blanco MN, Yamaguchi S, Dhawan-Robl M, Kessler W, Schoonhoven R, Filser JG, Swenberg JA.

Effects of propylene oxide exposure on rat nasal respiratory cell proliferation. Toxicol Sci. 2003 Oct;75(2):279-

88. Epub 2003 Jul 11.

PMID: 12857943

Zhong Z, Froh M, Lehnert M, Schoonhoven R, Yang L, Lind H, Lemasters JJ, Thurman RG. Polyphenols from

Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats. Am J Physiol Gastrointest

Liver Physiol. 2003 Nov;285(5):G1004-13. Epub 2003 Jun 4.

PMID: 12791596

PAGE FOUR, ROBERT SCHOOHOVEN

Bataller R, Gäbele E, Schoonhoven R, Morris T, Lehnert M, Yang L, Brenner DA, Rippe RA. Prolonged infusion

of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver.

Am J Physiol Gastrointest Liver Physiol. 2003 Sep;285(3):G642-51. Epub 2003 May

28.

PMID: 12773299

McDorman KS, Chandra S, Hooth MJ, Hester SD, Schoonhoven R, Wolf DC. Induction of transitional cell

hyperplasia in the urinary bladder and aberrant crypt foci in the colon of rats treated with individual and a mixture

of drinking water disinfection by-products. Toxicol Pathol. 2003 Mar-Apr;31(2):235-42.

PMID: 12696585

Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R, Brenner DA. c-Jun-N-terminal

kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology. 2003 Apr;37(4):824-

32. PMID: 12668975

Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R, Brenner DA, Fried

MW. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine

therapy for chronic hepatitis B. J Hepatol. 2001 Dec;35(6):749-55. Erratum in: J Hepatol 2002 May;36(5):714.

Burkhardt ER [corrected to Burchardt ER].

PMID: 11738102

Yin M, Wheeler MD, Connor HD, Zhong Z, Bunzendahl H, Dikalova A, Samulski RJ, Schoonhoven R, Mason

RP, Swenberg JA, Thurman RG. Cu/Zn-superoxide dismutase gene attenuates ischemia-reperfusion injury in the

rat kidney. J Am Soc Nephrol. 2001 Dec;12(12):2691-700.

PMID: 11729238

Larouche, L., Swenberg, J.A., Schoonhoven, R., and Charbonneau, M. (1993). Possible association between

porphyria induced by hexachlorobenzene (HCB) and liver cell proliferation in the rat. Abstract presented at the

1993 Society of Toxicology annual meeting, New Orleans, LA.

Frankenberg, M.v., Bojes, H.K., Iimuro, Y., Schoonhoven, R., Lemasters, J.J., and Thurman, R.G. (1995).

ICAM-1 is elevated dramatically in fatty liver grafts from alcohol-treated rats. Abstract presented at the 1995

American Association for the Study of Liver Disease annual meeting, Chicago, IL.

La, D.K., Schoonhoven, R., Ito, N., and Swenberg, J.A. (1995). Exposure-related differences in DNA adduct

formation and cellular proliferation by 1,2,3-trichloropropane. Fund. Appl. Toxicol. 15(1):153. Abstract

presented at the 1995 Society of Toxicology annual meeting, Baltimore, MD.

Bojes, H.K., Germolec, D.R., Bruccoleri, A., Schoonhoven, R., Luster, M.I., and Thurman, R.G. (1995).

Antibodies to tumor necrosis factor-α inhibit cell replication caused by the peroxisome proliferator Wy-14,643.

Abstract presented at the 1995 American Association for the Study of Liver Disease annual meeting, Chicago, IL.

Bojes, H.K., Germolec, D.R., Simeonova, P., Schoonhoven, R., Luster, M.I., and Thurman, R.G. (1996).

Peroxisome proliferators (PP) activate the production of mitogens by Kupffer cells in vivo: Studies with

antibodies to TNFα. Fund. Appl. Toxicol. 30(1, Pt2):257. Abstract presented at the 1996 Society of Toxicology

annual meeting, Anaheim, CA.

Dressler, W.E., Sharma, R., Azri-Meehan, S., Schoonhoven, R., and Swenberg, J.A. (1996).

PAGE FIVE, ROBERT SCHOOHOVEN

Immunohistochemical evaluation of alpha2u-globulin in kidneys of male rats fed HC Orange No.1 in the diet for

13 weeks. Fund. Appl. Toxicol. 30(1, Pt2):306. Abstract presented at the 1996 Society of Toxicology annual

meeting, Anaheim, CA.

La, D.K., Schoonhoven, R., Ito, N., and Swenberg, J.A. (1996). The effects of exposure route on DNA adduct

formation and cellular proliferation by 1,2,3-trichloropropane. Tox. Appl. Pharmacol. 140:108-114.

Hegi, M.E., Soderkvist, P., Foley, J.F., Schoonhoven, R., Swenberg, J.A., Maronpot, R.R., Anderson, M.W., and

Wiseman, R.W. (1996). Characterization of p53 mutations in methylene chloride-induced lung tumors from

B6C3F1 mice. Carcinogenesis 14:803-10.

Bojes, H.K., Germolec, D.R., Simeonova, P., Bruccoleri, A., Schoonhoven, R., Luster, M.I., and Thurman, R.G.

(1997). Antibodies to tumor necrosis factor-α prevent increases in cell replication in liver due to the potent

peroxisome proliferator, Wy-14,643. Carcinogenesis 18(4):669-674.

Morishita, K., Schoonhoven, R., and Swenberg, J.A. (1997). Mechanistic studies on isophorone and preputial

gland carcinomas. Fund. Appl. Toxicol. 36(1, Pt 2):94. Abstract presented at the 1997 Society of Toxicology

annual meeting, Cincinnati, OH.

Rose, M.L., Germolec, D.R., Schoonhoven, R., and Thurman, R.G. (1997). Kupffer cells are causally

responsible for the mitogenic effect of peroxisome proliferators. Carcinogenesis 18(8):1453-1456.

Rose, M.L., Germolec, D.R., Arteel, G.E., Schoonhoven, R., and Thurman, R.G. (1997). Dietary glycine

prevents increases in hepatocyte proliferation caused by the peroxisome proliferator WY-14,643. Chem. Res.

Toxicol. 10(10):1198-1204.

Raleigh, J.A., Rinker, L.H., Calkins Adams, D.P., Chou, S.-C., Schoonhoven, R., Kennedy, A.S., and Varia, M.A.

(1997). Immunohistochemical analyses of human tumor microenvironment. Abstract presented at the 1997

Radiation Oncology Gordon Research Conference.

McKim, J.M., Kolesar, G.B., Schoonhoven, R., Breen, J.G., Burns, L.A., Wilga, P.C., Dochterman, L.W., Regan,

J., Gallavan, R., Stanton, E., Goodman, J.I., and Swenberg, J.A. (1997). Octamethylcyclotetrasiloxane (D4)

produces transient hepatic hyperplasia in a manner similar to phenobarbital (PB). Fund. Appl. Toxicol. 36(1, Pt

2):124. Abstract presented at the 1997 Society of Toxicology annual meeting, Cincinnati, OH.

Schemmer, P., Schoonhoven, R., Bunzendahl, H., and Thurman, R.G. (1997). Brief in-situ manipulation during

organ harvest decreases survival of fatty livers from ethanol-treated rats after transplantation: Role of Kupffer

cells. Abstract presented at the 1995 American Association for the Study of Liver Disease annual meeting,

Chicago, IL.

Schemmer, P., Schoonhoven, R., Swenberg, J.A., Bunzendahl, H., Raleigh, J.A., Lemasters, J.J., and Thurman,

R.G. (1997). Gentle organ manipulation during harvest as a key determinant of survival of fatty livers after

transplantation in the rat. Transpl. Int. 12:351-359.

Schemmer, P., Schoonhoven, R., Bunzendahl, H., and Thurman, R.G. (1997). Gentle in-situ manipulation during

organ harvest decreases survival after rat liver transplantation: Role of Kupffer cells. Transplantation 65:1015-

1020.

Yin, M., Schoonhoven, R., Swenberg, J.A, and Thurman, R.G. (1998). Dietary glycine attenuates chronic

rejection of rat aortic allografts. Abstract presented at the Transplantation Society XVII World Congress,

Montreal, Québec, Canada.

PAGE SIX, ROBERT SCHOOHOVEN

Franklin, D.S., Godfrey, V.L., Lee, H., Kovalev, G.I., Schoonhoven, R., Chen-Kiang, S., Su, L., and Xiong, Y.

(1998) CDK inhibitors p18INK4c and p27Kip1 mediate two separate pathways to collaboratively suppress pituitary

tumorigenesis. Genes and Development 12:2899-2911.

Iimuro, Y., Nishiura, T., Hellerbrand, C., Behrns, K.E., Schoonhoven, R., Grisham, J.W., and Brenner, D.A.

(1998). NFκB prevents apoptosis and liver dysfunction during liver regeneration. J. Clin. Invest. 101:802-811.

Lehmann, T.G., Wheeler, M.D., Schoonhoven, R., Bunzendahl, H., Samulski, R.J., Thurman, R.G. (1998).

Delivery of Cu/Zn-superoxide dismutase genes with a viral vector minimizes liver injury and improves survival

after liver transplantation in the rat. Transplantation 69:1051-7.

Rose, M.L., Schoonhoven, R., Swenberg, J.A., Rivera, C.A., and Thurman, R.G. (1998). Peroxisome

proliferators (PPs) activate Kupffer cells directly. Abstract presented at the 1998 Society of Toxicology annual

meeting, Seattle, WA.

Rose, M.L., Rivera, C.A., Bradfords, B.U., Graves, L.M., Cattley, R.C., Schoonhoven, R., Swenberg, J.A., and

Thurman, R.G. (1999). Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators.

Carcinogenesis 20:27-33.

Rusyn, I., Bradham, C.A., Cohn, L., Schoonhoven, R., Swenberg, J.A., Brenner, D.A., and

Thurman, R.G. (1999). Corn oil rapidly activates NF-κB in hepatic Kupffer cells by oxidant-

dependent mechanisms. Carcinogenesis 20:2095-2100.

Schoonhoven, R. (1999). Staining for bromodeoxyuridine (BrdU) immunohistochemistry. Microscopy Today

99:34.

Yin, M., Rusyn, I., Schoonhoven, R., Harding, T.W., Graves, L.M., Rusyn, E.V., Li, X., Cox, A.D., Bunzendahl,

H., Swenberg, J.A., and Thurman, R.G. (1999). Inhibition of chronic rejection of aortic allografts by dietary

glycine. Transplantation 69:773-780.

Rusyn, I., Yamashina, S., Segal, B.H., Schoonhoven, R., Holland, S.M., Cattley, R.C., Swenberg, J.A., and

Thurman, R.G. (1999). Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in

triggering cell proliferation in the liver due to peroxisome proliferators. Cancer Res. 60:4798-4803.

Lang, A., Schoonhoven, R., Tuvia, S., Brenner, D.A., and Rippe, R.A. (2000). Nuclear factor κB in proliferation,

activation, and apoptosis in rat hepatic stellate cells. J. Hepatol. 33:49-58.

Lang, A., Schrum, L.W., Schoonhoven, R., Tuvia, S., Solis-Herruzo, J.A., Tsukamoto, H., Brenner, D.A., and

Rippe, R.A. (2000). Expression of small heat shock protein αB-crystallin is induced after hepatic stellate cell

activation. Am. J. Physiol. Gastrointest. Liver Physiol. 279:1333-1342.

Schoonhoven, R., Bodes, I., and Swenberg, J.A. (2001). Di(isononyl)phthalate binds reversibly to α2u-globulin

and induces cell proliferation in male rat kidneys. Abstract presented at the 2001 Society of Toxicology annual

meeting, San Francisco, CA.

Yin, M., Currin, R.T., Peng, X.-X., Mekeel, H.E., Schoonhoven, R., and Lemasters, J.J. (2001). Carolina Rinse

Solution minimizes kidney injury and improves graft function and survival after prolonged cold ischemia.

Transplantation, submitted.

Yin, M., Currin, R.T., Peng, X.-X., Mekeel, H.E., Schoonhoven, R., and Lemasters, J.J. (2001). Different

patterns of renal cell killing after warm and cold ischemia. Renal Failure, submitted.

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