Project Assistant

AMY L. WHITTON

**** ******** ***** ******, ******** 48176 734-***-**** abnsnm@r.postjobfree.com

EDUCATION: Eastern Michigan University, Ypsilanti, Michigan

Graduate Certificate in Clinical Research Administration, December 2007

Eastern Michigan University, Ypsilanti, Michigan

Graduate courses in Business Administration, 1995 to 1997

The University of Michigan, Ann Arbor, Michigan

Secondary Science Teaching Certification, 1991

Purdue University, W est Lafayette, Indiana

BS in Biological Sciences, 1989

HIGHLIGHTS:

18+ years in the pharmaceutical research industry with experience in multiple

therapeutic areas

2.5 years clinical monitoring experience involving investigational drugs in

clinical trials including ophthalmology and renal failure

16+ years pre-clinical research experience involving new drug target

identification and validation

Excellent communicator in both oral and written formats

Progressive career with proven ability to balance multiple projects and achieve

goals efficiently

Strong problem solving and data analysis skills

Current Workload:

3 protocols

3 sites

Phase I Renal Failure study in dialysis patients

THERAPEUTIC

EXPERIENCE:

Renal Failure

ESRD (Phase I)

Ophthalmology

Post cataract Surgery Anti-Inflammation (Phase II)

Adult Macular Degeneration (Phase II/III)

Cardiovascular Disease

Hypertension (Pre-Clinical)

Dyslipidemia (Pre-Clinical)

Endocrinology

Obesity (Pre-Clinical)

Diabetes (Pre-Clinical)

Hormone Replacement Therapy (Pre-Clinical)

Infectious Disease

Broad Spectrum Antibiotic development (Pre-Clinical)

Oncology

Breast Cancer (Pre-Clinical)

Ovarian Cancer (Pre-Clinical)

A. Whitton 1

PROFESSIONAL

EXPERIENCE: INDEPENDENT CLINICAL RESEARCH ASSOCIATE, Saline, Michigan

January 2007 to Present

Provide regional clinical monitoring of Phase I/II/III Clinical Trials on

a contractual basis

Qualify and Initiate Sites

Monitor study progress

Conduct Study Close-Out

Ensure the completion and collection of regulatory documents

Ensure adherence to FDA regulations and ICH guidelines

Instruct site staff in their roles and responsibilities

Perform source document verification

Evaluate and report site performance and protocol compliance

Perform drug accountability and study supply tracking

Pharma Client List: Sorbent Therapeutics

CRO Client List: Zemba Research, LLC

PFIZER GLOBAL RESEARCH AND DEVELOPMENT, DEPARTMENT

OF ANTIBACTERIAL BIOLOGY/ANTIBACTERIAL MOLECULAR

SCIENCES, Ann Arbor, Michigan

August 2000 to July 2007, Held the Following Positions:

Scientist, June 2003 to July 2007

Contributed to the understanding of mechanisms of resistance to

Antibacterial compounds

Independently designed experiments, searched literature, wrote

protocols, completed experimental work and analyzed data for

project

Received recognition award for studies which informed project

team about features of compounds that lead to bacterial

resistance

Mentored and trained interns and students

Senior Associate Scientist, August 2000 to June 2003

Led team across technology lines to set up a database reporting

genetic changes in response to drug treatments

Developed and wrote protocols

Determined all experimental conditions for project

W rote reports summarizing research

Successfully advocated new technology utilization to achieve

results

Analyzed data and partnered with Bioinformatics group to

determine optimal database format

Presented data at global research seminar

PARKE-DAVIS PHARMACEUTICAL RESEARCH, DEPARTMENT OF

MOLECULAR BIOLOGY/CELL BIOLOGY, Ann Arbor, Michigan

August 1991 to August 2000, Held the Following Positions:

Senior Associate Scientist, December 1999 to August 2000

Conceptualized, initiated and led project aimed at identifying new

drugs for use in the treatment of osteoporosis

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W rote and developed new experimental procedures for project

Documented findings in research reports and presented results

at inter-departmental seminars

Supervised 4 scientists in the completion of this project

Associate Scientist, April 1997 to December 1999

Developed methods for the identification of novel drugs for use in

diabetes, heart disease and cancer

W rote, planned and carried out experimental procedures and

protocols

Analyzed and interpreted data

Presented data at Keystone Symposium

Senior Assistant Scientist, November 1994 to April 1997

Developed protocols and methodologies to ident ify new compounds

for use in the treatment of diabetes

Examined the effects of anti-diabetic compounds on gene expression

Trained and directed the research of students and interns

Acted on behalf of multiple departments as safety warden to ensure

safety compliance

Arranged and conducted quarterly inspections and reported findings

W rote protocols and data summaries

Presented research at departmental meetings

Assistant Scientist, August 1991 to November 1994

Served as laboratory manager for group of 15 people

Conducted research to determine the mechanism of action of anti-

diabetic compounds

THE UNIVERSITY OF MICHIGAN, HOWARD HUGHES MEDICAL

INSTITUTE/DEPARTMENT OF PEDIATRICS, Ann Arbor, Michigan

July 1989 to September 1990

Health Science Research Assistant

Served as laboratory manager for group of 20 people

Supervised and trained work study students

Monitored and ordered supplies, serviced equipment and met with

sales representatives

Responsible for ensuring that environmental and safety regulati ons

were followed for chemical, biological and radioactive materials;

scheduled safety inspections and corrected any problems

Conducted genetic and molecular biology research focusing on birth

defects

Independently completed all experimental laboratory procedures

Analyzed and wrote summary reports of experimental research

Presented research results at seminars

Trained students in molecular biology protocols

PURDUE UNIVERSITY, DEPARTMENT OF BIOLOGICAL SCIENCES,

W est Lafayette, Indiana

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June 1987 to May 1989

Research Assistant

Carried out a research project involving the study of a bacterial gene

Presented research findings at inter-departmental seminars of faculty

and students

Documented findings in research report

UPJOHN, DEPARTMENT OF MOLECULAR BIOLOGY, Kalamazoo,

Michigan

May - August 1988

Research Assistant

Performed mapping of a gene in bacteria

W rote reports summarizing experimental data and project analysis

Presented data at departmental seminar

COMPUTER

SKILLS:

Electronic Data Capture (EDC): ClinPlus

Microsoft:

Word (reports for all monitor visits, research reports,

publications)

Power Point (presentations for site initiation meetings, data

sharing among project team members)

Excel (spreadsheets for data collection and analysis, project

tracking, graphing, statistical calculations)

Access (management of database information)

TRAINING:

Completed Management Training Courses in the following: Decision

Making, Time Management, Effective Communication Skills and

Basic Negotiations

Completed Computer Training Courses in the following: ClinPlus,

Microsoft Excel, Word, Access and PowerPoint

CERTIFICATIONS:

Certified Clinical Research Associate

PUBLICATIONS &

PRESENTATIONS:

Stover, CK, Zhu, Whitton, A, T, Wang, Z, Wang, L, VanderRoest, S,

Thomas, VH, Sulavik, M, Skerlos, L, Shelly, J, Prasad, V, Ohren, J,

Ogden, A, Narasimhan, L, Mueller, WT, Mehrens, S, Liu, J,

Limberakis, C, Kuhn, M, Karnovsky, A, Huband, MD, Harwood, HJ,

Hanna, D, Dunkle, B, Buist, S, Bowman, M, Banotai, C, Mochalkin, I,

Dunham, S, Miller, JR (2009) A New Class of Selective

Antibacterials Derived from a Protein Kinase Inhibitor

Pharmacophore PNAS 106, 1737-1742

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Whitton, A, Karnovsky, A, Dunham, S, Miller, R (2006) Cross-

resistance of E. coli XXXX inhibitors to eleven different spontaneous

resistant mutants derived against two XXXX inhibitors. Presented at

Pfizer Biology Symposium

Whitton, AL, W ang, M, Rojas-Caro, S, Tafuri, SR (2000) PPAR beta

and LXR ligands regulate metabolic genes involved in cholesterol

efflux in macrophages. Presented at Parke-Davis Molecular Biology

Symposium

Camp, HS, Whitton, AL, Tafuri, SR (1999) PPAR gamma activators

down-regulate the expression of PPAR gamma in 3t3-L1 adipocytes

FEBS Letters 186, 186-190

Whitton, AL and SR Tafuri (1999) Binding specificity of PPAR

gamma and PPAR delta Abstract presented at Keystone symposia

conference on the PPARs: Transcriptional Links to Obesity, Diabetes

and Cardiovascular Disease

Whitton, AL, Storer, C, Tafuri, S (1998) Screening for Estrogen

Receptor Ligands using a Fluorescence Resonance Energy Transfer

(FRET) Assay. Presented at Parke-Davis Molecular Biology

Symposium

Camp, HS, Whitton, AL, and SR Tafuri (1996) Regulation of PPAR

gamma2 gene expression by Troglitizone and 2-Bromopalmitate in

3T3-L1 preadipocytes and adipocytes Abstract presented at

Keystone symposia-Steroid/Thyroid/Retinoic acid gene family 202:49

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