Engineering Engineer

ZHANWU CUI

**** *. ***** **., ***. *** Phone: ***. 399. 5319

Tempe, AZ 85281 Email: abnmoo@r.postjobfree.com

Objective

To obtain a R&D position applying interdisciplinary skills in polymer materials for

controlled drug delivery

Summary

• Materials scientist with specialization in polymer materials for controlled drug

delivery system

• Detail-oriented with hands-on experience on a variety of analytical instruments

• Team-oriented with good interpersonal and communication skills

Education

Ph.D., Bioengineering, Aug, 2009

Department of Bioengineering, Arizona State University, Tempe, AZ

Area of Concentration: Polymer Materials for Controlled Drug Delivery

Advisor: Professor Brent L. Vernon

Master of Engineering, Civil Engineering, Dec. 2003

Department of Civil Engineering, University of Florida, Gainesville, FL

Bachelor of Engineering, Polymer Materials and Engineering, July, 1996

Tianjin Institute of Urban Construction, Tianjin, China

Skills

Instrumentation:

• HPLC • GPC • NMR • FTIR • Rheometery • DSC

• UV-Vis Spectrophotometry • Fluorescence Spectrophotometry

Procedures:

• Cytotoxicity Test of Biomaterials • In Vivo Biocompatibility Test

• In vitro/In vivo Drug Release • Anti-tumor Efficacy Study

• Cell Culture of Mammalian Cells

Animal Technique:

• Mice Necropsy • In Vivo Tumor Cell Passage

• Tissue and organ Identification, Harvest and Dissections

Computer Skills: MS Word, Excel, PowerPoint, ISIS Draw

ZHANWU CUI 2/3

Professional Experience

Research Associate, Arizona State University, Aug. 2003-now

Polymerization and characterization of injectable and biodegradable polymer

hydrogels for sustained drug delivery

• Designed, implemented and conducted free radical polymerization

• Determined molecular weight, polydispersity and chemical composition

• Characterized materials’ gelation properties

• Identified and characterized materials’ degradation mechanism and properties

• Modeled materials degradation kinetics based on experimental data

Assessment on in vitro cytotoxicity and in vivo biocompatibility of polymer

hydrogels for controlled drug delivery

• Designed, conducted and analyzed in vitro cytotoxicity tests of polymer gels on

mammalian cells

• Designed and conducted in vivo biocompatibility test of polymer gels on rat

after subcutaneous injection of polymer solution

• Analyzed the immune response to polymer gels by histology analysis

Investigation on in vitro/in vivo drug release from biodegradable polymer

hydrogels and anti-tumor efficacy study

• Designed, conducted and analyzed in vitro drug release from biodegradable

polymer gels of both hydrophilic and hydrophobic drugs

• Conducted Maximum Tolerated Dose (MTD) test of Paclitaxel by subcutaneous

injection of sustained drug delivery system

• Conducted anti-tumor efficacy study of subcutaneous injection of sustained

drug delivery system of Paclitaxel against murine bladder tumor (MBT-2) on

mice

• Implemented cancer drug delivery protocol submitted to IACUC at Arizona

State University

Participating Research Projects

• Simultaneously physically and chemically gelling polymer system using

poly(NIPAAm)-based copolymers

• Poly(acrylic acid)-based gels for buccal delivery of erythromycin lactobinate for

gastroparesis

• X-ray opaque material based on NIPAAm-based copolymers

Related Coursework

Polymeric materials for drug delivery Advanced Biomaterials

Tissue Engineering Physiology for Engineers

Cellular and Molecular Biology Medical and Diagnostic Instrument

Advanced Transport Phenomena Statistics

Design of Experiment (DOE)

ZHANWU CUI 3/3

Other Experience

Research Assistant, University of Florida, Aug. 2001-Aug. 2003

• Investigated on mechanical properties of SBS-modified asphalt concrete using

Bending Beam Rheometer (BBR) and Dynamic Shear Rheometer (DSR)

Engineer, Beijing Residence Construction Corporation (BRCC), Beijing,

China, July 1996-July, 2001

• Designed high performance cement concrete with polymer additives and

conducted tests on its flowability, strength and weather resistance

• Developed and investigated energy-saving technology for building system

using a composite material of polystyrene and glass fiber-reinforced mortar

Publications

Cui Z, Lee BH, Lunt B, Mead C, Vernon BL, NIPAAm-based sustained release

formulation of Paclitaxel: In vitro and In vivo study, In Preparation

Cui Z, Lee BH, Vernon BL, A new hydrolysis-dependent thermosensitive polymer

for an injectable degradable drug delivery system, Biomacromolecules, 8(4), 1280-

1286, (2007).

Cui Z, Lee BH, Pauken C, Vernon BL, Reducing degradation time in N-

isopropylacrylamide-based copolymer with hydrolysis-dependent LCST, Journal of

Biomaterials Sciences, Polymer Edition (Accepted)

Eric Henderson, Bae Hoon Lee, Zhanwu Cui, Ryan McLemore, Tedd Brandon,

Brent L. Vernon, In vivo evaluation of injectable thermo-sensitive polymer with time-

dependent LCST, Journal of Biomedical Materials Research, part A (In Press)

Selected Conference Presentations and Posters

Degradation and Sustained Release from injectable, Bioresorbable,

Thermosensitive Copolymer, Poly(NIPAAm-co-dimethyl-gamma-butyrolactone

acrylate-co-acrylic acid), Controlled Release Society (CRS) Annual Meeting, July,

2008, New York City, NY

Thermosensitive Copolymer, poly(N-isopropylacrylamide-co-dimethyl-gamma-

butyrolactone acrylate-co-acrylic acid), as Injectable, in-situ Gelling Material for

Controlled Drug Release with Hydrolysis-dependent LCST, Materials Research

Society (MRS) Fall Meeting, Nov. 2007, Boston, MA.

N-isopropylacrylamide-based Copolymer with Hydrolysis-dependent Lower Critical

Solution Temperature as Injectable, Bioresorbable Gelling Materials for Controlled

Drug Delivery, Society for Biomaterials (SFB) 2006 Annual Meeting, Apr. 2006,

Pittsburg, PA

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