YUHUA CHEN

***** *. ****** ********* **** #****, Phoenix, AZ, 85021

Email: abndkz@r.postjobfree.com; Cell phone: 201-***-****

EDUCATION

Ph.D. August 2008, New Jersey Institute of Technology, Newark, NJ

Master of Science, March 2002, Southeast University, Nanjing, China

Bachelor of Science, July 1999, Shijiazhuang Railway Institute, Shijiazhuang, China

INDUSTRY EXPERIENCES

10/2008 present, Material Scientist, Marlyn Nutraceuticals Inc. Phoenix, AZ

New product development, Formulation/re formulation of nutraceutical products

Track the market trend of nutritional supplements, propose and evaluate the feasibility of potential

products;

Seek new delivery technology to achieve higher bioavailability and easier oral administration;

Develop innovative process to accomplish the function of new products;

Investigate the possible interaction between ingredients used in the formulation;

Scale up formulation from lab scale to full size through pilot trial;

Design and conduct experiments to correlate powder properties with manufacturing conditions;

Optimize the manufacturing process to assure consistent quality of nutritional product;

Tablet:

Controlled release

Effervescent

Chewable

Sublingual

Fast disintegrating

Capsule: Hard Gelatin and Vegetarian

Improved the productivity by ~30% via re formulation.

Powder Stick pack

Process development, scale up and technical transfer

Modify and optimize particulate material properties by means of coating, granulation and size reduction.

Establish SOPs for process and manufacturing to instruct the production

Prepare the Master Batch Record and Batch to comply with the cGMPs

Resolve the substantial major technical challenges related to powder characterization,

manufacturing process and product quality

Trouble shooting, optimization on the manufacturing process regarding the flowability, compressibility,

tablet hardness, lamination and capping as well as powder encapsulation

Material Searching and Characterization

Searching vendors and selecting the suitable raw materials for specific product

Testing on physical chemical properties of raw materials, active ingredients and blends by using in house

instruments such as Powder Flow tester, Particle size analyzer, FT IR, Kar Fisher and HPLC

Assist QC and customer service in handling customer complaints and providing additional

information

Trainings:

Colorcon Formulation School

Powder Flowability Training Course in EGG

05/2007– 07/2007, Internship, Particle Technology Group, DuPont, Wilmington, DE

Drug Delivery by fluid bed coating/layering

Improvement on packing of fine polymeric powders

02/2007, Technical Assistant, Nara Machinery Co. LTD., Tokyo, Japan

Training on the application of a novel rotating fluidized bed in pharmaceutical, chemical and

cosmetic industries.

RESEARCH EXPERIENCES

Formulation Processing and Process Development

Conventional fluid bed coating/encapsulation of fine particles (<20 m m) to control release

developed a new technique to coat fine particles in a wurster fluidized bed

accomplished uniform particle coating without serious agglomeration

performed in vitro dissolution study and obtained extended release profile of coated particles

applied SEM, EDX, FTIR, PSD, Thermal Analysis and dissolution test to characterize coated particles

Conventional fluid bed granulation of fine powders

developed a novel technique to granulate fine particles in a wurster fluidized bed

achieved desired size/size distribution of granules

achieved great flow/compaction properties of final granules

optimized the processes

prepared SOPs and trained cooperative technicians for technique transfer and commercialization

Rotating fluidized bed coating/granulation of fine particles for release control

successfully granulated fine APIs (~50 m m) into bigger granules with desired size distribution

individually coated fine porous particles (~10m m) by polymer film

In situ particle milling and coating in an air jet mill

developed a novel technique to mill and coat particles simultaneously

coated ground particles evenly with discrete nanoparticles or liquid for surface modification

coated ground particles with polymer film for release control

Powder fuctionalization and formulation preparation

altered thermal and electrical conductivity, color, abrasion resistance, compressibility and hydrophilicity

applied dry particle coating and intensive blending to prepare pharmaceutical formulations, contributing to

subsequent dry processing, e.g. dry granulation and direct tableting.

Flowability improvement of fine powders by surface modification (<20 m m)

achieved free flow of surface modified particles

achieved stable fluidization of particles as small as 5 m m

Material Characterization

Cohesiveness evaluation/estimation of pharmaceutical formulations

predicted the cohesiveness/flowability of fine powders

AFM (Atomic Force Microscopy) for measuring surface roughness

IGC (Inverse Gas Chromatography) for measuring surface free energy

Coulter LS 230 and Aerodynamic particle sizer for measuring particle size

evaluated cohesiveness/flowability of fine powders

angle of repose (AOR), Hausner ratio, shear stress, unconfined tensile strength, settling and

bubbling velocity

PATENTS

Rajesh Dave, Robert Pfeffer, Jun Yang and Yuhua Chen, US Patent 200********, Dry Coating and

Downstream Processing of Cohesive Powders.

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