C University

Shubhasish Mukherjee

HudsonAlpha Institute for Biotechnology

*** ****** ***

Huntsville, AL 35806

Work Phone: 256-***-****

Home address: *** ***** **** #****

Madsion, AL 35758

Ph: 256-***-****

E-mail: abnay0@r.postjobfree.com

OBJECTIVE:

A research and development position as a synthetic organic chemist

SUMMARY:

. Extensive experience in multi-step organic synthesis, parallel solution

phase chemistry and solid phase synthesis

. Strong background in polymer chemistry and bioconjugation

. Worked as a part of multidisciplinary team, strong organizational skills,

multitasking ability

. Published 19 research papers in peer reviewed journals, a book chapter,

presented in conferences

RESEARCH EXPERIENCE:

Scientist, HudsonAlpha Institute for Biotechnology (2006-present),

. Established and maintained combinatorial chemistry platform, purchased

and installed necessary equipments

. Planned and implemented industrial research projects, synthesized

small molecule libraries based on dihydropyrans and Shikimic acid

derivatives utilizing medicinal chemistry principles

Visiting Scientist, Broad Institute of Harvard and MIT (2005), Chemical

Biology Program, Advisor: Dr Jared Shaw

. Solid and parallel solution phase synthesis and medicinal chemistry

optimization of novel sulfonamide library with antibacterial

properties

. Constructed probes to validate the biological target

Postdoctoral Fellow, University of Kansas (2001-2005), Advisor: Professor

Paul R. Hanson

. Developed a novel Phase trafficking, chromatography free synthesis of

amines, alkyl hydrazines, sulfamides using norbornenyl group as a

chemical tag

. Solution-phase parallel synthesis of 1,4-Diazepin-5-ones library

. Synthesized P-heterocycles via three-component coupling/metathesis

approach

. Created guanidine based cationic polymers for gene delivery

Visiting Researcher, University of Liverpool, UK (1998), Advisor: Professor

Stanley M. Roberts

. Accomplished synthesis of enantiomerically pure epoxy ketones

using polyamino acids and their reduction using baker's yeast

Graduate Student, University of Delhi, Advisor: Professor Virinder S.

Parmar (1994-2000), successfully completed the following research projects

. Lipase catalyzed deacetylation of isoxazolidines, polyacetoxy aromatic

acids and polyphenolics

. Synthesis and medicinal chemistry of novel 1,3-diarylpropenones and

their evaluation as antioxidants, anti-invasive activity against

cancer cell lines

. Facile synthesis of pyrazoles, spiro-(indole-isoxazolidines)

SKILLS ACQUIRED:

. Spectroscopic Techniques and instrument handling: Well-versed with

spectroscopic techniques like 1H & 13C NMR, 2-D NMR, UV, IR and MS.

Experience with analytical instruments like LC-MS, GC and HPLC.

. Synthetic skills: Experience in design and synthesis of bioactive

organic compounds from milligram to multi-gram scale, biocatalysis,

solid phase synthesis, transition metal catalyzed reactions, parallel

synthesis, handling air and moisture sensitive compounds, isolation,

purification of organic compounds and all chromatographic purification

techniques.

. Experience with Microwave Reactors, Horizon and Isco High Performance

Flash Chromatography system.

. Computer: Well versed with scientific literature searches, chemical

structure drawing and word processing.

. Familiar with western blot, SDS PAGE and cell culture

EDUCATION:

Ph.D. in Organic Chemistry, University of Delhi (India)

1994-2000

Master of Science, Major: Organic Chemistry, Indian Institute of Technology

(Delhi, India) 1992-1994

Bachelor of Science (Honors), Major: Chemistry, University of Delhi (India)

1989-1992

ACHIEVEMENTS AND AWARDS:

. Qualified all India research fellowship through National Eligibility

Test (NET) in 1994

. Qualified for research fellowship through Graduate aptitude test in

Engineering (GATE) in 1994

. Merit scholarship at Indian Institute of Technology (Delhi)

AFFILIATIONS:

Sigma-Xi (The scientific research society)

2005-present

American Chemical Society Member

2000-present

MENTORING EXPERIENCE: Mentored undergraduate students

Danielle R. Snyder, HudsonAlpha Institute for Biotechnology (summer 2007)

Justin Hanke, University of Kansas, Kansas (summer 2004)

PUBLICATIONS:

. Fenster, E.; Rayabarapu, D. K.; Zhang, M.; Mukherjee, S.; Hill, D.;

Neuenswander, B.; Schoenen, F.; Hanson, P. R.; Aub , J. "Three-

Component Synthesis of 1,4-Diazepin-5-ones and the Construction of (-

Turn-like Peptidomimetic Libraries" J. Combi. Chem. 2008, 10, 230-234.

. Mukherjee, S.; Robinson, C. A.; Howe, A. G.; Mazor, T.; Wood, P. A.;

Urgaonkar, S.; Hebert, A. M.; RayChaudhuri, D.; Shaw, J. T. " N-Benzyl-

3-sulfonamidopyrrolidines as novel inhibitors of cell division in E.

coli" Bioorg. Med. Chem. Lett. 2007, 17, 6651-6655.

. Harned, A. M.; Zhang, M.; Vedantham, P.; Mukherjee, S.; Herpel, R. H.;

Flynn, D. L.; Hanson, P. R. "ROM Polymerization in Facilitated

Synthesis," Aldrichimica Acta 2005, 38, 3-16.

. Raunak; Kumar, V.; Mukherjee, S.; Poonam; Prasad, A. K.; Olsen, C. E.;

Sch ffer, S. J. C.; Sharma, S. K.; Watterson, A. C.; Errington, W.;

Parmar, V. S. "Microwave mediated efficient synthesis of novel spiro-

(indole-isoxazolidines) and their biological activity evaluation"

Tetrahedron 2005, 61, 5687-5697.

. Mukherjee, S.; Raunak; Dhawan, A.; Poonam; Prasad, A. K.; Olsen, C.

E.; Cholli, A. L.; Errington, W.; Raj, H. G.; Watterson, A. C.;

Parmar, V. S. "Synthetic and biological activity evaluation studies on

novel isoxazolidines" Indian Journal of Chemistry, Section B: Organic

Chemistry Including Medicinal Chemistry 2004, 43B(12), 2670-2682.

. Mukherjee, S.; Poon, K. W. C.; Flynn, D. L.; Hanson, P. R. "Capture-

ROMP-Release: Application to synthesis of amines and alkyl hydrazines"

Tetrahedron Lett. 2003, 44, 7187-7190.

. Harned, A. M.; Mukherjee, S.; Flynn, D. L.; Hanson, P. R. "Ring-

opening Metathesis Phase Trafficking (ROMpt) Synthesis: the first

Multi-step Synthesis on Soluble ROM supports" Org. Lett. 2003, 5, 15-

18.

. Parmar, V. S.; Sharma, N. K.; Husain M.; Watterson, A. C.; Kumar, J.;

Samuelson, L. A.; Cholli, A. L.; Prasad, A. K.; Kumar, A.; Malhotra,

S.; Kumar, N.; Jha, A.; Singh, A.;l Singh, I.; Himanshu; Vats, A.;

Shakil, N. A.; Trikha, S.; Mukherjee, S.; Sharma, S. K.; Singh, S. K.;

Kumar, A.; Jha, H. N.; Olsen, C. E.; Stove, C. P.; Bracke, M. E.;

Mareel, M. M. Synthesis, characterization and in vitro anti-invasive

activity screening of polyphenolic and heterocyclic compounds. Bioorg.

Med. Chem. 2003, 11, 913-929.

. Mukherjee, S.; Kumar, V.; Prasad, A. K.; Raj, H. G.; Bracke, M. E.;

Olsen, C. E.; Jain, S. C.; Parmar, V. S. "Synthetic and biological

activity evaluation studies on novel 1,3-diarylpropenones" Bioorg.

Med. Chem. 2001, 9, 337-345.

. Mukherjee, S.; Prasad, A. K.; Howarth, O. W.; Parmar, V. S. "Novel

Lipase-catalyzed enantioselective deacetylation of -5-acetoxy-3-

(4-fluorophenyl)-2- phenylisoxazolidine" Bioorg. Med. Chem. Lett.

2001, 11, 2117-2121.

. Parmar, V. S.; Kumar, A.; Prasad, A. K.; Singh, S. K.; Kumar, N.;

Mukherjee, S.; Raj, H. G.; Goel, S.; Errington, E.; Puar, M. S.

"Synthesis of E- and Z-pyrazolylacrylonitriles and their evaluation as

novel antioxidants" Bioorg. Med. Chem. 1999, 7, 1425-1436.

. Mukherjee, S.; Parmar, V. S.; Errington, W. "5-Acetoxy-2,3-

diphenylisoxazolidine and 5-acetoxy-3-(4-nitrophenyl)-2-

phenylisoxazolidine" Acta Cryst. 1999, C55, 1829-1831.

. Allen, J. V.; Bergeron, S.; Griffiths, M. J.; Mukherjee, S.; Roberts,

S. M.; Williamson, N. M.; Wu, L. E. "Julia-Colonna asymmetric

epoxidation reactions under non-aqueous conditions: rapid, highly

regio- and stereo-selective transformations using a cheap, recyclable

catalyst" J. Chem. Soc. PerkinTrans. 1 1998, 3171-3179.

. Mukherjee, S.; Parmar, V. S.; Errington, W. "3-Acetoxy-6-hydroxy-2,4-

dimethoxyacetophenone" Acta Cryst. 1998, C54, 123-125.

. Parmar, V. S.; Kumar, A.; Bisht, K. S.; Mukherjee, S.; Prasad, A. K.;

Sharma, S. K.; Wengel, J.; Olsen, C. E. "Novel chemoselective de-

esterification of esters of polyacetoxy aromatic acids by lipases"

Tetrahedron 1997, 53, 2163-2176.

. Parmar, V. S.; Jain, S. C.; Jha, A.; Kumar, N.; Kumar, A.; Vats, A.;

Jha, H. N.; Mukherjee, S.; Singh, S. K.; Jennings, K. R.; Summerfield,

S. G.; Errington, W.; Olsen, C. E. "Synthetic and mass spectral

fragmentation studies on trisubstituted 2H-pyran-2-ones and

comparative EIMS behaviour of biologically active 3,5-disubstituted

pyrazoles and isoxazoles" Indian Journal of Chem. 1997, 36B, 872-879.

. Parmar, V. S.; Gupta, S.; Bisht, K. S.; Mukherjee, S.; Boll, P. M.;

Errington, W. "Synthesis and X-ray structure of 2-(3-methyl-2-butenyl)-

3,4,5-trimethoxyphenol: a potent anti-invasive agent against solid

tumours" Acta Chemica Scandinavica 1996, 50, 558-560.

. Kumar, N.; Mukherjee, S.; Parmar, V. S.; Errington, W. "[3-(4-

methylphenyl)-5-isoxazolyl]acetonitrile" Acta Cryst. 1996, C52, 2294-

2296.

. Mukherjee, S.; Bisht, K. S.; Parmar, V. S.; Errington, W. "3,5-Dcholro-

2,6-dimethoxycyclohexa-2,5-diene-1,4-dione" Acta Cryst. 1996, C52,

1211-1213.

MANUSCRIPT UNDER PREPERATION

. Mukherjee, S. Hanson, P. R. Three-component coupling/ring-closing

metathesis approach to the synthesis of phosphonopyrroles derived from

amino acids.

BOOK CHAPTER:

. Whitehead, A.; Sieck, S.; Mukherjee, S.; In Science of Synthesis,

Houben-Weyl:Methods of Molecular Transformations, Weinreb, S.M. Ed.;

Georg Thieme Verlag: New York, 2005; Vol 21 pg 907-939.

PRESENTATIONS:

. Mukherjee, S.; Warner, J.; Hanson, P. R. Three-component coupling/ring-

closing metathesis approach to the synthesis of functionalized

phosphonopyrroles. Presented at 39th Midwest Regional Meeting of the

American Chemical Society, Manhattan, KS, Oct 20- Oct 22, 2004; Paper

78.

. Mukherjee, S.; Harned, A. M.; Hanson, P. R.; Flynn, D. L. "Capture-

ROMP-release: Applications in synthesis," Poster Presentation, ORGN-

152, National Meeting of the American Chemical Society, NY, September

7-11, 2003.

. Mukherjee, S.; Harned, A. M.; Poon, K. W.; Flynn, D. L.; Hanson, P. R.

"Applications of Capture-ROMP-Release strategies in synthesis," Poster

Presentation, ORGN-233, Proceedings of the 37th Midwest Regional

Meeting of the American Chemical Society, Lawrence, KS, October 23-25,

2002.

. Harned, A. M.; Mukherjee, S.; Hanson, P. R.; Flynn; D. L. Capture-ROMP-

Release: sulfonamide oligomers as soluble suports. Presented at 224th

National Meeting of the American Chemical Society, Boston, Ma, Aug 17-

Aug 22, 2002; ORGN 436.

. Harned, A. M.; Mukherjee, S.; Flynn, D. L.; Hanson, P. R.; Ring-

opening metathesis phase trafficking synthesis: application to RCM and

other reactions. Presented at 37th Midwest Regional Meeting of the

American Chemical Society, Lawrence, KS, Oct 24 -Oct 26, 2002; Paper

234.

. Hanson, P. R.; Harned, A. M.; Mukherjee, S.; Petz, M. D.; Poon, K. W.

C.; Probst, D. A.; Sheriff, B. A. Metathesis approaches to polymeric

delivery vehicles. Presented at 36th Midwest Regional Meeting of the

American Chemical Society, Lincoln, NE, Oct 10-Oct 13, 2001; Paper 70.

REFERENCES:

. Professor Paul R. Hanson, 4027 Malott Hall, Department of Chemistry,

University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045, Ph:

785-***-****. Email: abnay0@r.postjobfree.com

. Professor Jared T. Shaw, Department of Chemistry, University of

California, One Shields Avenue, Davis, CA 95616, Ph: 530-***-****.

Email: abnay0@r.postjobfree.com

. Professor Kripal S. Bisht, Department of Chemistry, SCA 400,

University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620,

Ph: 813-***-****. Email: abnay0@r.postjobfree.com

VISA STATUS:

Permanent Resident

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