Quality Assurance Technical Support

*** ******** ** #*** . *** Jose, CA *****

Phone 408-***-**** . E-mail *********@*****.***

kassandra I. Oates

objective

A highly self motivated and disciplined chemist seeking a

challenging position in a pharmaceutical/biotechnology company with

excellent career growth potential.

Summary of qualifications

Knowledge in a range of analytical techniques used to conduct

research and determine structure and purity of organic compounds.

Experienced in analytical method development and data analysis.

Solid experienced in conducting maintenance, troubleshooting and

calibration of laboratory instruments.

Operational knowledge of analytical instrumentation including HPLC,

LC/MS, UV-VIS equipment, and data stations required.

Knowledgeable in technical writing and operations such as Return

Goods Authorization (RGA), Standard Operating Procedures (SOPs),

batch records and manuals.

Working knowledge of operating systems such as MS-Office, ChemDraw,

and SciFinder.

Familiar with compliance requirements within cGMP, safety and

regulatory environments.

Laboratory skills and techniques

Purification Techniques: Reverse Phase HPLC, ISCO normal phase

flash column chromatography, preparative TLC, liquid-liquid

extraction, and precipitation techniques.

Instrumentation: NMR, HPLC, HPLC/MS, HPLC/ELSD, UV/Vis, Pickering

Post-Column Derivitization, Gilson Liquid Handler, Genevac, Vacuum

Oven, Biodot Liquid Handling Robot, GenePix Microarray Scanner,

ISCO Companion, Lyophilizer, pH meter.

Professional experience

Research Associate (Temporary)

Theravance Pharmaceuticals South San Francisco, CA

12/2009 - 03/2010

Responsible for method development and compound purification of

target compounds (10-13g each) using Varian Preparative HPLC.

Responsible for assisting Lead Analytical Chemists in the

AutoPurification Lab with purification and method development to

increase purity and yield.

Solid understanding of the instruments, workflow, and the

informatics platform used within the laboratory.

Hands on experience operating the Waters MS-based AutoPurification

System and the Bohdan Automation Weigh System in performing

purifications of discovery arrays.

Generate SOP for the workflow and instruments used in the

AutoPurification lab.

Process Chemist

CELLective Dx Mountain View,

CA 03/2008 - 01/2009

Responsible for the production of Biochips and Cell Capture assay

components for capturing cancer cells from whole blood.

Responsible for the design and execution of experiments for

optimizing and scaling up BioChip production protocols, process,

and testing methods.

Responsible for the documentation, experimental verification and

validation of process changes.

Monitor and replenish reagents and manufactured component

inventories to support operations.

Technology transfer from R&D to Operations including writing and

tracking Standard Operating Procedures (SOPs).

Shelf life testing on reagents and BioChips in order to schedule

regular builds and set expiration dates on inventory.

Reagent formulation development and optimization.

Technical Support Chemist

Pickering Laboratories Mountain View, CA

07/2007-02/2008

Technical support for environmental, clinical, pharmaceutical, and

food and feedstuff applications.

Assist in application validation of HPLC/Pickering methods.

Responsible for generating user manuals and materials for

installation and technical training.

Returned Goods Authorization (RGA): monitor process and ensure

quality service.

Collaborate in new product development efforts and assist in QC and

R&D when needed.

Research Associate II

Elan Pharmaceuticals South San Francisco, CA

06/2003 - 06/2007

Responsible for design, synthesis, purification (reverse & normal

phase), and characterization of novel small molecules on a variety

of scaffolds.

Responsible for preparation of chemistry updates, trimester

reports, and contributing chemistry experimentals to be included in

patents and to be used for scale up purposes.

Maintain the community pump and the ISCO Companion.

Submit final targets for assays and to the compound collection.

Submit relevant intermediates to the compound collection.

Organizing the submission of compounds for biological assays.

Education

Continued Professional Education

Short Courses Attended:

Quality Assurance for Analytical Laboratories, AOAC 2007

Synthetic Organic Chemistry: Modern Methods and Strategies, ACS

2006

Organic Chemistry of Drug Design and Drug Action, ACS 2006

Mastering the Art of Writing Reasonable Organic Reaction

Mechanisms, ACS 2006

B. S. Biochemistry and Molecular Biology

University of California Santa Cruz

Santa Cruz, CA

Senior Thesis: "Progress Towards the Synthesis of a Copper Binding

Model of the Active Sight of Cytochrome c Oxidase.

Fellowships and awards

Elan Award of Excellence

Minority Access to Research Careers Fellowship, UCSC

UCSC Karl S. Pister Leadership Opportunity Award

Outstanding Academic Achiever Award in Math and Sciences

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