Medical Management

Curriculum Vitae

Yu Sin Lau

BMedSci (Hons), BM BS, MRCS (Edinburgh), DM

Specialty Registrar in Plastic Surgery

Yu Sin LAU, BMedSci (Hons), BM BS, MRCS (Edinburgh), DM

** ******* *****, ****le Quay Close, Nottingham, NG7 1HR, United Kingdom

Tel: +44-794-*******, +44-115-*******

E-mail: ********@*******.***

Personal details

Date of birth 15th August 1974

Nationality Singaporean

Qualifications

1996 Bachelor of Medical Sciences (Hons)

University of Nottingham, UK

1998 Bachelor of Medicine, Bachelor of Surgery

University of Nottingham, UK

2002 Membership of the Royal College of Surgeons of

Edinburgh

Royal College of Surgeons of Edinburgh, UK

2008 Doctor of Medicine (postdoctoral research degree)

University of Nottingham, UK

Academic Distinctions, Awards and Diplomas

2008 Advanced Trauma Life Support, Singapore

2007 Immediate Life Support, Livingston UK

2005 Finalist - Young Investigator's Award at the 12th

Hong Kong International Cancer Congress/ 2nd Annual

Meeting

of the Centre for Cancer Research

2005 European Paediatric Life Support, Oxford UK

2005 Best paper presented at the 2005 British Orthopaedic

Oncology Society Conference,

2003 Royal College of Surgeons of Edinburgh

Pump Priming Research Grant

2003 Jenny Mays-Smith Skin Cancer Scholarship

Present Appointment

Jan 2010 - present Specialty Registrar in Plastic Surgery,

Nottingham City Hospital (equivalent to Advanced

Surgical Residency)

Previous Appointments

Nov 2007 - Dec 2009 Specialty Registrar in Plastic Surgery, Leicester

Royal Infirmary (equivalent to Advanced Surgical

Residency)

Aug 2007 - Oct 2007 Specialty Registrar in Plastic Surgery, Aberdeen

Royal Infirmary, Aberdeen (equivalent to Advanced

Surgical Residency)

Oct 2006 - July 2007 Specialist Registrar in Plastic Surgery, St

John's Hospital, Livingston (equivalent to Advanced

Surgical Residency)

July 2006 - Sept 2006 Specialist Registrar in Plastic Surgery, Radcliffe

Infirmary, Oxford (equivalent to Advanced Surgical

Residency)

April 2003 - July 2006 Research Fellow in Plastic Surgery, Radcliffe

Infirmary, Oxford

Nov 2002 - Aug 2003 Senior House Officer in Plastic Surgery,

Radcliffe Infirmary, Oxford (equivalent to PGY4

Residency)

April 2002 - Nov 2002 Senior House Officer in Burns and Plastic Surgery,

St Andrew's Centre for Burns and Plastic Surgery,

Chelmsford (equivalent to PGY3 Residency)

Feb 2002 - April 2002 Anatomy Prosectorship

Department of Human Anatomy, University of Oxford

Aug 2001 - Feb 2002 Senior House Officer in Trauma Surgery &

Orthopaedics

John Radcliffe Hospital & Nuffield Orthopaedic

Centre, Oxford (equivalent to PGY3 Residency)

Feb 2001 - Aug 2001 Senior House Officer in Paediatric Surgery and

Burns Royal Hospital for Sick Children, Glasgow

(equivalent to PGY2 Residency)

Aug 2000 - Feb 2001 Senior House Officer in Accident & Emergency

Medicine, Glasgow Royal Infirmary, Glasgow

(equivalent to PGY2 Residency)

Feb 2000 - Aug 2000 Senior House Officer in Hand Surgery, Trauma

Surgery & Orthopaedics, Victoria Infirmary, Glasgow

(equivalent to PGY1 Residency)

Aug 1999 - Feb 2000 Senior House Officer in General & Vascular

Surgery, Victoria Infirmary, Glasgow (equivalent to

PGY1 Residency)

Aug 1998 - Aug 1999 Pre-registration House Officer in General

Surgery, General Medicine & General Practice,

Derbyshire Royal Infirmary, Derby (equivalent to

internship)

Courses attended

2009 Facial Plastic Surgery course, St Mary's Hospital, London UK

2008 Use of Flaps in Reconstructive Plastic Surgery course, Canniesburn

Plastic Surgery Unit, Glasgow UK

2008 Irmer course for the use of the Mini C Arm, Leicester Royal Infirmary,

Leicester UK

2008 Mini Fragment Fracture Fixation course, Pulvertaft Hand Centre, Derby

UK

2006 Project Management Skills, Medical Sciences Division, University of

Oxford, Oxford UK

2006 Building a Business, Said Business School, University of Oxford

2005 Emergency Management of Severe Burns course, Queen Victoria Hospital,

East Grinstead UK

2004 Microsurgical workshop

Northwick Park Institute for Medical Research, Harrow UK

2002 St Andrew's Hand Fracture Fixation Workshop

Broomfield Hospital, Chelmsford

Research & Audit

2008 - present

I am currently leading three audit projects.

2003 - 2006

I was awarded a DM degree for research at the Institute of Musculoskeletal

Sciences, University of Oxford which analysed the cellular and humoral

mechanisms whereby melanoma, sarcoma and Staphylococcus aureus promote

human-osteoclast differentiation, osteoclast resorbing activity and

survival.

2002

I performed an audit to investigate plastic surgeons' perception of the

minimum standards of reporting of skin neoplasia at the time of publication

of the Royal College of Pathologists' guidelines. The results were

published in Br J Plast Surg in 2004 and showed that awareness of

substandard reporting was relatively poor across all grades and this was

correlated with a poor patient management. It highlighted that awareness of

the guidelines and increased understanding of basic pathology should

correct these weaknesses.

2000

I performed an audit comparing the effectiveness of two ablative procedures

for treating in-growing toenails at Victoria Infirmary, Glasgow. The

results were published in Scot Med J in 2005 and demonstrated that surgical

outcome and recurrence rates for phenol ablation and germinal matrix

excision performed by junior surgeons were similar to published figures. It

highlighted that phenol ablation is just as effective as germinal matrix

excision. This has altered clinical practice within the unit, where phenol

ablation is now the preferred treatment.

1995-1996

I pioneered and developed a computer-assisted learning package in exercise

physiology as basis of B. Med. Sci. (Hons) degree at the Department of

Physiology, University of Nottingham. This package was the first prototype

used by the University of Nottingham Medical School for teaching the

undergraduate curriculum.

Teaching Experience

Undergraduate

As an anatomy tutor at the Department of Human Anatomy, University

of Oxford, I prepared prosections used for teaching anatomy to medical

students, facilitated anatomy and histology sessions and supervised

research projects.

Postgraduate and Nursing/ allied medical professionals

I participate in the weekly educational program for junior surgical

residents teaching plastic surgery principles. I also supervise and teach

junior surgical residents surgical skills in the operating room on a daily

basis. I was involved with improving nursing knowledge on wound healing and

facial trauma through postgraduate workshops.

Publications (Peer-reviewed)

Gibbons CL, Sun SG, Vlychou M, Kliskey K, Lau YS, Sabokbar A, Athanasou NA

Osteoclast-like cells in soft tissue leiomyosarcomas

Virchows Arch 2010;456(3):317-23

Lau YS, Offer GJ

Treating soft tissue contour defects by a combination of surgical subcision

with a BeaverTM tympanoplasty blade and autologous fat graft

Aesthetic Plast Surg 2009 (Epub ahead of print)

Lau YS, Varma S

Pre-operative planning of free flap - will we burn the bridge we are about

to cross?

J Plast Reconstr Aesthet Surg 2010;63(4):e424

Lau YS, Danks L, Sun SG, Fox S, Sabokbar A, Harris A, Athanasou NA

RANKL-dependent and RANKL-independent mechanisms of macrophage-osteoclast

differentiation in breast cancer

Breast Cancer Res Treat 2007;105(1):7-16

Lau YS, Adamopoulos IE, Giele H, Gibbons CLMH, Athanasou NA

Cellular and humoral mechanisms of osteoclast formation in Ewing's sarcoma

Br J Cancer 2007;96(11):1716-22

Adamopoulos IE, Xia Z, Lau YS, Athanasou NA

Hepatocyte growth factor can substitute for M-CSF to support

osteoclastogenesis.

Biochem Biophys Res Commun 2006;350(2):478-83

Lau YS

An insight into burns in a developing country; a Sri Lankan experience

Public Health 2006;120(10):958-65

Lau YS, Sabokbar A, Giele H, Cerundolo V, Hofstetter W, Athanasou NA

Malignant melanoma and bone resorption

Br J Cancer 2006; 94(10):1496-503

Lau YS, Wang W, Sabokbar A, Simpson AHRW, Nair S, Henderson B, Berendt A,

Athanasou NA

Staphylococcus aureus capsular material promotes osteoclast formation

Injury 2006;37(2S):S41-S48

Sun SG, Lau YS, Itonaga I, Sabokbar A, Athanasou NA

Bone stromal cells in pagetic bone and Paget's sarcoma express RANKL and

support human osteoclast formation

J Pathol 2006; 209(1):114-20

Lau YS, Sabokbar A, Gibbons CLMH, Giele H, Athanasou NA

Phenotypic and Molecular studies of Giant Cell Tumours of Bone and Soft

Tissue

Hum Pathol 2005;36(9):945-54

Lau YS, Yeung JMC

Surgical treatment of in-growing toenails performed by Senior House

Officers: Are they good enough?

Scot Med J 2005;50(1):22-23

Lau YS, Banwell PE, Pay AD

Basal cell carcinoma arising in scars: late presentation 16 years post-

operatively following midline sternotomy

Plastic and Reconstructive Surgery 2004;113(4):1297-1299

Lau YS, Suvarna SK, Kangesu L, Mosahebi A

Audit of Plastic Surgeon's understanding of pathology reports of skin

neoplasia

Br J Plast Surg 2004;57:134-138

Publications (Non-peer-reviewed)

Lau YS

Reconstructing lives

Surgeons News 2005;4(2):103-104

Lau YS, Yeung JMC

Tips on writing an operative note

BMJ (Supp) 2005;330:116

Yeung JMC, Cheong E, Lau YS

Getting to grips with general surgery

BMJ (Supp) 2004;328(7446):163-164

Lau YS, Yeung JMC, Lingam MK

Vascular Disease of the Upper Limb

Modern Hypertension Management 2003;5:9-12

Book chapter

Handbook of Plastic and Reconstructive Surgery (Oxford Specialist Handbooks

in Surgery series). Giele H, Cassell O, eds. Oxford, Oxford University

Press, 2008

Paper presented to Learned Societies (oral presentation*)

1. *Lipofilling of the breast for reconstruction after cancer excision -

a 10 -year series

The International Meeting of Oncoplastic & Reconstructive Breast Surgery,

2009

2. *Cellular and humoral mechanisms of osteoclast formation in Ewing's

sarcoma

British Orthopaedic Oncology Society Conference, 2006

3. *Cellular and humoral mechanisms of osteoclast formation and

resorption in melanoma metastases (Finalist of Young Investigator's

Award)

12th Hong Kong International Cancer Congress/ 2nd Annual Meeting of the

Centre for Cancer Research, 2005

4. *Cellular and humoral mechanisms of osteoclast formation and

resorption in melanoma metastases (Best paper)

British Orthopaedic Oncology Society Conference, 2005

J Bone Joint Surg Br Proceedings 2006; 88-B: 290

5. *Direct induction by melanoma, prostate cancer and Ewing's sarcoma

tumour cells of osteoclast formation by a RANKL-independent mechanism

Pathological Society of Great Britain and Ireland Winter Conference, 2004

6. *Melanoma cells support osteoclast-mediated bone resorption in

metastases

British Association of Plastic Surgeons Winter Conference, 2004

7. Phenotypic and molecular studies of Giant Cell Tumours of bone and soft

tissue

European Orthopaedic Research Society 2004 Meeting, Amsterdam

8. RANKL-dependent and independent mechanisms of osteoclast differentiation

by macrophage in primary and secondary tumours

European Orthopaedic Research Society 2004 Meeting, Amsterdam

9. Staphylococcus aureus produces a soluble factor that promotes osteoclast

formation

British Orthopaedic Research Society 2004 Meeting, Manchester

10. *The potential of reducing scar formation following acute injury

utilizing Plastic Surgery techniques

9th Oxford-European Wound Healing Summer School, 2004

11. Sarcoma-associated macrophages differentiate into osteoclastic bone-

resorbing cells

Bone and Tooth Society Summer 2004 Meeting, Oxford

12. *Do Plastic Surgeons understand Pathology reports?

British Association of Plastic Surgeons Winter Conference, 2002

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