Assistant Health

Jasmin N. Dynek, Ph.D.

*** **** **. *** #*, San Francisco, CA 94110

Telephone: 707-***-**** Email: ******.*****@*****.***

SUMMARY

An accomplished medical research scientist with over 10 years of

professional training in the fields of cancer, cell and molecular biology,

and:

. strong leadership skills to initiate, organize, drive, and manage

projects

. collaborative abilities to strengthen team-oriented tasks

. advanced communication skills to efficiently, creatively, and

productively convey

scientific information to diverse audiences.

PROFESSIONAL EXPERIENCE

2006-present Postdoctoral Researcher, Genentech

. Contributed discoveries towards understanding

the mechanism of action of a small molecule therapeutic,

currently in FDA clinical trials, in cell death

signaling and chemotherapeutic resistance in cancer

. Collaborated on, and managed, multi-department projects

. Published four high impact peer-reviewed scientific

publications

2005-2006 Postdoctoral Researcher, University of California,

Berkeley

. Applied biochemistry, molecular biology, and

cell biology techniques to investigate the epigenetic

regulation of cell fate in development

2000-2005 Doctoral Researcher, New York University

. Discovered a pivotal role for a human protein in cancer

cell division

. Published 5 scientific manuscripts and presented at

numerous meetings

. Managed day-to-day operations of the lab, including

oversight of several lab personnel.

1999-2000 Research Assistant, Cook College, Rutgers University

. Researched evolutionary conservation and divergence in RNA

viruses

. Coauthored 2 scientific publications

MENTORING EXPERIENCE

. Mentor, Graduate Student Interns, Genentech, 2007-2008

. Mentor, Graduate Rotation Students, New York University, 2001-2005

SCIENTIFIC WRITING EXPERIENCE

. Authored or coauthored eleven peer-reviewed research articles in

high impact journals

. Wrote proposals for fellowships, and received funding from the

American Cancer Society and

the National Institutes of Health

. Wrote peer reviews for various biochemical, cell biological and

cancer research journals

. Reviewed and edited colleagues' manuscripts and research funding

proposals

EDUCATION

Ph.D. Cell and Molecular Biology, New York University, The Sackler

Institute of Biomedical Research, New York, New York, June 2005

B.A. Biology, German Minor, Rutgers College, Rutgers University, New

Brunswick, New Jersey, January 2000

PUBLICATIONS:

Ndubaku C, Varfolomeev E, Wang L, Zobel K, Lau K, Elliott LO, Maurer B,

Fedorova AV, Dynek JN, Koehler M, Hymowitz SG, Tsui V, Deshayes K,

Fairbrother WJ, Flygare JA, Vucic D. (2009) Antagonism of c-IAP and XIAP

proteins is required for efficient induction of cell death by small-

molecule IAP antagonists. ACS Chem Biol. 4(7):557-66.

Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K,

Fairbrother WJ, Vucic D. (2008) c-IAP1 and c-IAP2 are critical mediators of

tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation. J Biol

Chem. 283(36):24295-9.

Dynek JN, Chan SM, Liu J, Zha J, Fairbrother WJ, Vucic D. (2008)

Microphthalmia-associated transcription factor is a critical

transcriptional regulator of melanoma inhibitor of apoptosis in melanomas.

Cancer Res. 68(9):3124-32.

Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P,

Zobel K, Dynek JN, Elliott LO, Wallweber HJ, Flygare JA, Fairbrother WJ,

Deshayes K, Dixit VM, Vucic D. (2007) IAP Antagonists Induce

Autoubiquitination of c-IAPs, NF-kappaB Activation, and TNFalpha-Dependent

Apoptosis. Cell. 131(4):669-81.

Canudas S, Houghtaling BR, Kim JY, Dynek JN, Chang WG, Smith S.( 2007)

Protein requirements for sister telomere association in human cells. EMBO

J. 26(23):4867-78.

Liu YC, Dynek JN, Hillman BI, Milgroom M. (2007) Diversity of viruses in

Cryphonectria parasitica and C. nitschkei in Japan and China, and partial

characterization of a new chrysovirus species. Mycol Res. 111(Pt 4):433-42.

Chang W, Dynek JN, and Smith S. (2005) NuMA is a major acceptor of poly(ADP-

ribosyl)ation by tankyrase 1 in mitosis. Biochemical Journal. 391(Pt

2):177-84

Linder-Basso D, Dynek JN, and Hillman B. (2005) Genome analysis of

Cryphonectria hypovirus 4, the most common hypovirus species in North

America.Virology. 337(1):192-203.

Dynek JN, and Smith S. (2004) Resolution of sister telomere association is

required for progression through mitosis. Science 304: 97-100.

Chang W, Dynek JN, and Smith S. (2003) TRF1 is degraded by ubiquitin-

mediated proteolysis after release from telomeres. Genes Dev. 17(11): 1328-

33.

*Cook BD, *Dynek JN, Chang W, Shostak G, and Smith S. (2002) Role for the

related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.

Mol Cell Biol. 22(1): 332-42.

* indicates co-first author

PROFESSIONAL PRESENTATIONS

. Poster presentation at European Molecular Biology Organization

Conference: Ubiquitin

and Ubiquitin-like Modifiers in Health and Disease, 2009

. Platform speaker at the Cold Spring Harbor Symposium, Symposium on

Telomeres

and Telomerase, 2005

. Poster presentation at the Annual Meeting of the American Society for

Cell Biology, 2003

. Poster presentation at the Cold Spring Harbor Symposium, Symposium on

Telomeres

and Telomerase, 2003

HONORS AND AWARDS

American Cancer Society Postdoctoral Research Fellowship, 2005

. Best Student Paper Award from the Department of Cell and Molecular

Biology, New York University, 2004

. Predoctoral Travel Award from the American Society for Cell Biology, 2003

Predoctoral Training Grant from the National Institutes of Health, 2002

References available upon request.

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