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Assistant Engineering

Location:
Lansdale, Pennsylvania, 19446, United States
Posted:
May 24, 2010

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***** *********

**** ****** ****, ***#**, Lansdale, PA 19446

Email: **************@*****.***

Phone: 215-***-****[pic]

OBJECTIVE:

Seeking a fulltime position in pharmaceutical industry, where I can apply

my strong technical skills and practical experience for research,

development and commercialization of novel products.

Education:

. Drexel University, Philadelphia, PA

March' 2009

Master of Science in Biomedical Engineering (Thesis Option). GPA -

3.63/4.0

. Sathyabama University, Chennai, India

April' 2006

Bachelor of Technology in Bioinformatics. GPA - 3.9/4.0

Skill Set:

Assay Techniques Sandwich Immunoassay, Antibody Conjugation to

fluorescent dyes and Quantum Dots

Liquid Handling/HTS Biomek FX

Systems

LIMS PointDragon (GraphLogic Inc.)

Spectroscopy UV/VIS Spectroscopy (Tecan, Nanodrop), Raman

Spectroscopy (Renishaw)

Microscopy Techniques Fluorescence Microscopy (Leica)

Software MS Office, Visual Basic Application for Excel Macros,

Adobe Photoshop, Image J, ORIGIN Pro

Other Techniques Dynamic Light Scattering (Malvern Zeta Sizer),

Tangential Flow Filtration (TFF), Gel Electrophoresis,

Micro flow imaging (BrightWELL), Size Exclusion

Chromatography, Western Blot

EXPERIENCE:

Chemist I, Merck & Co., Inc., West Point, PA

April 2009 - Present

(Temporary Position)

. Formulation of lipid nano-particle (LNP) for robust siRNA delivery.

. Customize (hardware & software), operate and maintain a novel high

throughput formulation screening system (Biomek FX).

. Optimization of formulation variables and process variables for Ultra

filtration and dialysis.

. Supporting development of targeted drug delivery of LNPs, sterile

filtration and in house characterization (DLS, Turbidity).

School of Biomedical Engineering, Drexel University, Philadelphia, PA

Jan 2007 - March 2009

(Role: Graduate Research Assistant)

. Conceived, designed and developed protocol for Coulter Foundation

funded project which optimizes sandwich assay and uses next generation

fluorescent nano particles (Quantum Dots) as reporting molecules.

. Designed and validated a highly sensitive and sophisticated optical

immunosensor for the detection of Myeloperoxidase (MPO) inside a micro-

capillary.

. Developed and optimized a sandwich assay protocol utilizing just 1-5 L

of reagents for detecting MPO.

. Designed an optical set up for detection of fluorescence from the

capillary.

. Successfully detected MPO in animal stool samples.

School of Biomedical Engineering, Drexel University, Philadelphia, PA

November 2008 - March 2009

(Role: Graduate Research Assistant)

. Investigated the stability of fluorescence signal from Quantum Dots

(QDs).

. Investigated the effect of various buffer and pH on QDs signal

stability.

School of Biomedical Engineering, Drexel University, Philadelphia, PA

April 2008 - June 2008

(Role: Graduate Student)

. Conceptualized and conceived a novel design and a product development

plan for an In-vitro diagnostic device (IVD) for Detection of

Inflammation Markers according to FDA regulation protocol.

o Developed requirement and design specifications of the IVD kit.

o Analyzed the hazard and risks associated in development phase.

School of Biomedical Engineering, Drexel University, Philadelphia, PA

Jan 2008 - Sept 2008

(Role: Graduate Research Assistant)

. Surface Enhanced Raman Spectroscopy (SERS) was used for

differentiating native Myeloperoxidase (MPO), a MPO polyclonal

antibody (Ab) from the bound immunocomplex MPO/Ab.

. Carried out Antibody-Antigen (MPO) reaction on the surface of polymer

and gathered SERS spectra.

. Used gold nano-particle to enhance SERS signals.

. Analyzed the Raman Spectra for identifying any significant differences

between the samples.

Accelrys K.K., Bangalore, India

Feb 2006 - April 2006

(Role: Technical Intern)

. Investigated the applicability of LigandFit Scoring Functions in

Screening Chemical compounds.

. Executed this study using variants of Cytochrome P450 receptors.

. Docked various ligands to the target receptor using Cerius2 LigandFit.

Malladi Drugs and Pharmaceuticals Ltd., Chennai, India

Dec 2003 - Jan 2004

(Role: Research Intern)

. Performed SDS-PAGE for protein separation.

. Prepared polyacrylamide gels using company protocol for

electrophoresis.

PRESENTATIONS:

"Automated Assembly of Lipid Nanoparticles", Greg Barker, Rob Celano,

Steve Krotzer, Al Rauch, Mike Wismer, ***** *********, Jason Murphy, Jim

Cunningham, Dave Mathre, Merck PR&D Symposium, September 2009, Merck &

Co., Inc., West Point, PA.

" Quantum Dot Linked ImmunoSorbent Assay (QLISA) - A Practical Approach

Towards Immuno Sensing in MicroLiter Volume.", ***** *********, Sundar

Babu, Leonid Zubkov, Sreekanth Murthy, Elisabeth Papazoglou. Biomedical

Talent and Technology Showcase November 2008, Drexel University,

Philadelphia, PA.

"A Capillary Based Platform for Detection of Inflammation Markers", *****

*********, Sundar Babu, Leonid Zubkov, Sreekanth Murthy, Elisabeth

Papazoglou. Research Day, April 2008, Drexel University, Philadelphia,

PA.

"Comparative Modeling Approaches To Investigate The Role Of Aromatic

Residues In Membrane Proteins" S. Sri Krishna, Srijak Bhatnagar, *****

Sing *********, and K. Vinay Kashyap. International Conference on

Systemics, Cybernetics and Informatics (ICSCI), Hyderabad, Andhra

Pradesh, India, January 2006.

"A Machine Learning Approach for Prediction of Promoter Sequences in Homo

Sapiens" ***** Sing ********* and

K. Vinay Kashyap .International Conference on Biomedical Engineering

(ICBME), Singapore, December, 2005.

"Evolution of SARS - A Sequence Alignment Approach" ***** Sing *********

and Srijak Bhatnagar. SRIJAN'04, National Level Symposium Organized by

Vellore Institute of Technology Tamil Nadu, India. August 2004.

PUBLICATIONS:

. "Identification of binding interactions between myeloperoxidase and

its antibody using SERS", E. S. Papazoglou, S. Babu, S. *********, D.

R. Hansberry and C. Patel, Nano-Micro Letters, Volume 2, Issue 2,

Pages 74-82, May 2010.

. "Research in Nanomedicine Technologies", Biomedical Research: From

Ideation to Publication, ***** *********, Kalyan Chakravarthy,

Sreekant Murthy. Publisher: Wolters Kluwer Health India Chapter 09,

ISBN: ***-**-****-200-9, Dec '09.

"A PMMA Microcapillary Quantum dot Linked Immunosorbent Assay

(QLISA)", Sundar Babu, ***** *********, Leonid Zubkov, Sreekanth

Murthy, Elisabeth Papazoglou Biosensors and Bioelectronics Volume 24,

Issue 12, 15 August 2009, Pages 3467-3474.

Honors AND Achievements:

. Filed a provisional patent on "Developing a Device Using Quantum Dots

for Detection of Biomarkers".

. Gold Prize Integra Foundation Entrepreneurial Technology for research

work with "Potential for Rapid Translation to Health Care and

Entrepreneurial Enterprise" November 2008, Drexel University,

Philadelphia, PA.

. Technical Vice President of Drexel IEEE Graduate Forum (June 2007 -

June 2008).

. Chaired IEEE Technical Poster Symposium at Drexel in March 2008 and

won Star Organization Award.

. Dean's Fellow (September 2006 - March 2009), Drexel University,

Philadelphia, PA.

. Received Merit Award for securing overall 3rd rank in B.Tech

Bioinformatics.

. Awarded second prize in the oral presentation category of SRIJAN'04,

Vellore Institute of Technology, TN, India.

REFERENCES:

Available upon request



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