TIM NOLAN

**** ******** **** ***. *, Blacksburg, VA 24060 . 540-***-**** .

abmqtb@r.postjobfree.com

PROFILE

Registered Patent Agent with more than six years of progressive

biotechnology intellectual property experience encompassing patent

searches, patentability and freedom-to-operate analyses, intellectual

property management, technology licensing, and patent preparation and

prosecution. Broad scientific background with more than 10 years of

research experience and more than eight years of technical writing

experience in the life sciences. Strong analytical, interpersonal

communication, on-line information acquisition, technical and persuasive

writing, and project management skills.

Diverse technology experience includes gene therapy systems, stem cells,

research tools, biologics, recombinant DNA technology, RNAi/antisense,

diagnostics, biomarkers, immunotherapy, drug screening assays,

bioinformatics algorithms and software, pharmaceutical compositions and

methods, and medical devices.

PROFESSIONAL EXPERIENCE

INTREXON CORPORATION, DEPT. OF INTELLECTUAL PROPERTY, Blacksburg, VA

Patent Agent (March 2007-October 2008)

Identified patentable subject matter from invention disclosures, developed

detailed patent specifications in collaboration with inventors, and filed

patent applications. Converted provisionals to PCT applications.

Prosecuted US and international applications in conjunction with outside

patent counsel and foreign associates. Managed and maintained a docket of

biotechnology and organic chemistry cases. Performed patentability and

freedom-to-operate searches and analyses using biological sequence and word

searching tools.

Key accomplishments:

. Drafted 18 provisional patent applications from invention disclosures.

. Successfully prosecuted two patent applications to issuance.

WVHTC FOUNDATION, INTELLECTUAL PROPERTY MANAGEMENT GROUP, Wheeling, WV

Intellectual Property Analyst (June 2005-March 2007)

Reviewed invention disclosures, performed patent searches, and provided IP

due diligence reports that addressed patentability, competing patents, and

potential freedom-to-operate issues. Managed client IP portfolios by

providing patent filing strategy and maintenance recommendations.

Monitored and advised on patent prosecution developments. Developed and

prepared non-disclosure agreements, cooperative research agreements, and

license agreements. Served as sole in-house resource on IP matters.

Key accomplishments:

. Conducted more than 30 patentability assessments.

. Facilitated four license agreement deals and four cooperative research

agreement discussions.

NATIONAL TECHNOLOGY TRANSFER CENTER/WVHTC FOUNDATION, Wheeling, WV

Life Science Technology Agent/Scientist (February 2004-December 2004)

(Position transferred to West Virginia High Technology Consortium (WVHTC)

Foundation)

Evaluated early stage biomedical inventions for technical significance in

view of the state of the art. Researched the patent record and scientific

literature to determine novelty. Interviewed inventors to determine

commercial applications of inventions and assess stage of development.

Summarized findings and formulated recommendations with respect to

patenting strategies in written reports.

Select projects:

. Evaluated therapeutics for treatment of bone fracture and

osteoporosis.

. Assessed drug screening assay for potential anabolic agents.

PHASE-1 MOLECULAR TOXICOLOGY, DEPT. OF BIOINFORMATICS, Santa Fe, NM

Research Associate (1999-2003)

Collaborated on data mining teams for identifying genomic biomarkers from

gene expression databases; prepared patent applications and presentations

on discoveries. Tracked and managed patent deadlines and prepared

filings. Captured, analyzed, and summarized scientific and patent

intelligence through information mining projects

CORNELL UNIVERSITY, DEPARTMENT OF ANIMAL SCIENCE, Ithaca, NY

Graduate Research Assistant (1996-1999)

Developed avian models of cadmium ovarian toxicity to investigate

mitigating nutritional factors. Performed radioimmune, biochemical, and

hematological assays on blood samples. Presented lectures and

demonstrations for undergraduate reproductive biology laboratory sections.

STATE UNIVERSITY OF NEW YORK AT BUFFALO, DEPT. OF PHARMACEUTICS, Buffalo,

NY

Research Technician (1993-1996)

Executed industry-sponsored cardiovascular pharmacology research projects

for investigation of potential therapeutic compounds. Collaborated in the

preparation of manuscripts, abstracts, and posters on the results of

preclinical pharmaceutical development experiments.

UNIVERSITY OF ROCHESTER, BIOPHYSICS DEPT., Rochester, NY

Laboratory Technician (1992-1993)

Created a library of recombinant DNA constructions using molecular biology

techniques. Analyzed protein expression of DNA repair enzymes using SDS-

PAGE and Western blotting.

EDUCATION

Virginia Polytechnic Institute and State University, Blacksburg, VA

Part-time graduate coursework in molecular biology, immunology, virology,

and cell biology (2008-2009).

CORNELL UNIVERSITY, Ithaca, NY

Master of Science in Environmental Toxicology, 2000, GPA 3.81

UNIVERSITY OF ROCHESTER, Rochester, NY

Bachelor of Science in Ecology and Evolutionary Biology, 1992, GPA 3.39

Honors: Cum laude graduate, Dean's List, Undergraduate Research Fellowship

Undergraduate coursework includes genetics, cell biology, cell biology

laboratory, biochemistry, developmental biology, neuroscience, organic

chemistry, pharmacokinetics, and physiology.

PROFESSIONAL LICENSES

United States Patent and Trademark Office (January 2003), Registration No.

53394

PROFESSIONAL DEVELOPMENT

Fundamental and Intermediate Intellectual Asset Management, 2006, Licensing

Executives Society

The Essentials of Licensing, September 2005, Licensing Executives Society

Patent Bar Review, 2002, Patent Resources Group

COMPUTER AND INFORMATICS SKILLS

USPTO Electronic Filing System; Public and Private PAIR; PatentIn Sequence

Listing Authoring Software; Delphion, Micropatent, STN, USPTO, Espacenet,

and Patent Lens Patent Search Databases; GenomeQuest and NCBI-BLAST

Sequence-Based Searches and Analyses; Pattsy Docketing Software; Microsoft

Word, Excel, Access, Outlook, Internet Explorer; PC & Macintosh Platforms

REPRESENTATIVE APPLICATIONS (PROSECUTION)

Site-specific recombinases and methods of their use. US 2006/0172377 A1 and

US 2008/0020465 A1.

Bioavailable diacylhydrazine ligands for modulating the expression of

exogenous genes via an ecdysone receptor complex. US 7,563,928.

Mutant receptors and their use in a nuclear receptor-based inducible gene

expression system. US 2005/0266457 A1.

Novel ecdysone receptor/invertebrate X receptor-based inducible gene

expression system. AU 2002247184B2.

Multiple inducible gene regulation system. AU 2001294916B2 and US

2002/0110861 A1.

REPRESENTATIVE APPLICATIONS (PREPARATION)

Therapeutic inhibitors of PAI function and methods of their use. US

61/020,137 and US 61/080,640 (published as WO 2009/089059 A2).

Synthetic 5'UTRs, expression vectors, and methods for increasing transgene

expression. WO 2009/042971 A2.

PP1 ligands. WO 2008/137681 A2.

MEK ligands and polynucleotides encoding MEK ligands. WO 2008/119058 A2.

Kidney toxicity predictive genes*. WO 03/100030 A2.

Liver inflammation predictive genes*. US 2004/0067507 A1 and WO 2003/095624

A2.

Liver necrosis predictive genes*. US 2004/0076974 A1 and WO 2003/085083 A2.

* co-inventor

ABSTRACTS AND PUBLICATIONS

Kier LD et al. Applications of microarrays with toxicologically relevant

genes (tox genes) for the evaluation of chemical toxicants in Sprague

Dawley rats in vivo and human hepatocytes in vitro. Mutat. Res. 549(1-

2):101-13, 2004.

Nolan TD, and Li A. Reciprocal regulation of cytochrome p450 3a1 and p-

glycoprotein by carbon tetrachloride and chloroform. Society of Toxicology

42nd Annual Meeting 2003 Abstracts.

Nolan TD, Hicken S, Suizu R, Farris G, and Farr S. Utility of historical

dynamic range data in microarray gene expression analysis. Society of

Toxicology 41st Annual Meeting 2002 Abstracts.

Nolan TD and Brown D. The influence of elevated dietary zinc, selenium, and

their combination on the suppressive effect of dietary and intraperitoneal

cadmium on egg production in laying hens. J. Tox. Env. Health, Part A

60:549-565, 2000.

Bauer JA, Nolan T, and Fung HL. Vascular and hemodynamic differences

between organic nitrates and nitrites. J. Pharmacol. Exp. Ther. 280:326-

331, 1997.

Booth BP, Nolan TD, and Fung HL. Nitroglycerin-inhibited whole blood

aggregation is partially mediated by calcitonin gene-related peptide: a

neurogenic mechanism. Brit. J. Pharmacology 122(3):577-583, 1997.

Bauer JA, Nolan T, and Fung HL. Differential effects of nitric oxide donors

in an in vivo rat model of penile erection. Faseb Journal V9, N4 (Mar 10),

PA 921, 1995.

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