Project Manager Development

Name David Lonergan

Address **** ***** ****** *****, *** Marcos, CA 92078

Phone # 858-***-****

Email abmpsc@r.postjobfree.com

Summary: Biotech and business professional with 13 years of experience in

the Biotech, CRO, and Venture Capital industries and a successful track

record of advancing projects from discovery to the clinic.

Career Highlights:

. Assisted in the development of four compounds which are currently in

Phase I or Phase II clinical trials (TRPV1, P2X7, Ghrelin, and Motilin

programs).

. Successful Medicinal Chemistry career within Biotech and Contract

Research Organizations.

. Initiated and led a Hit-to-Lead program at Research Corporation

Technologies (RCT)

. Initiated and led the Combinatorial Chemistry Group at Tranzyme

Pharma.

Recent Achievements:

. Identified several early stage drug discovery technologies.

. Assisted in Seed and Series A funding of early stage companies.

. Initiated a program directed at in-licensing/funding early stage

academic discoveries/ technologies for virtual development of small

molecule therapeutics.

. Successfully transitioned into a career in Venture

Capital/Development.

. Opened and led Nanosyn's San Diego discovery chemistry operations.

Key Skills:

. Project management-successfully managed >20 projects during the last 8

years.

. Preparation of Investment Committee Memorandums and presentation to

Management.

. Identification of early stage investment opportunities.

. Drafting, review, and negotiation of term sheets and licensing

agreements/contracts.

. Company/Technology diligence and valuations.

. Critical scientific analysis of early stage

products/technologies/companies and assessment of commercialization

potential (small molecule therapeutics and biologics).

. Business plan preparation and execution.

. Budgeting of development projects.

. Financial analysis and financial model building.

. Biotech and pharmaceutical competitive intelligence, market and metric

analysis.

. Intellectual Property analysis.

. Strategizing/planning while maintaining critical deadlines.

. Establishing product development plans from discovery through IND-CB1,

ACE2, STAT3, AC1, anti-convulsant/epilepsy, undisclosed kinase, and

HDAC programs.

. Managed out-sourced development programs through a network of CRO's

(chemistry, biology, and pharmacology).

. Expert in data analysis-analytical, computational, biological,

pharmacological, ADME-Tox; Complex problem solving.

. Experienced in fragment screening, biological screening, and

computational modeling.

. Supervisory skills-directed a medicinal chemistry team of > 10

chemists.

Positions and Employment

2010-Present Director, Project and Alliance Management, Medicinal

Chemistry, Nanosyn Inc.

2008-2010 Associate/Project Manager, RCT; BioVentures

Investment/Commercialization

2008-Present Principal Advisor, USDA SBIR Commercialization

Program/LARTA

2007- 2008 Site Director, Nanosyn Inc., San Diego, CA

2004-2006 Director, Medicinal Chemistry, Nanosyn Inc., Menlo

Park, CA

2004. Senior Scientist, Medicinal Chemistry, Nanosyn Inc., Menlo

Park, CA

1999-2001 Group Leader, Tranzyme Pharma, Quebec, Canada

Education

1998-1999 Industry Post-Doc; Tranzyme (formerly Neokimia); Supervisor:

Pierre Deslongchamps

1994-1997 Ph.D., Chemistry; University of New Brunswick, Canada

1990-1994 BSc., Biology-Chemistry (Hons); University of New

Brunswick, Canada

Patents, Publications, and Presentations:

High Throughput Solid Phase Parallel Synthesis of Macrocyclic

Peptidomimetics. E. Marsault, H. R. Hoveyda, M. L. Peterson, R. Gagnon,

M. V zina, J.F. Pinault, A. Landry, C. Saint-Louis, L. G. Ouellet,

S. Beauchemin, K. Benakli, S. Beaubien, M. Brassard, Z. Wang, M. Champagne,

F. Galaud, N. Fortin, D. Fortin, V. Plourde, M. Ramaseshan, S. Bhat,

F. Bilodeau, D. Lonergan, R. Lan, S. Li, G. Berthiaume, L. Foucher,

X. Peng, Y. Dory and P. Deslongchamps. Advances in Experimental Medicine

and Biology, Book Series, 2009, 611, 15-16.

IRE-1? Inhibitors. Patterson, John B; Lonergan, David G; Flynn, Gary A;

Zeng, Qingping, Pallai, Peter V. US 200*-******* A1

IRE-1? Inhibitors. Patterson, John Bruce and Lonergan, David Gregory.

WO/2008/154484 A1

Efficient parallel synthesis of macrocyclic peptidomimetics. Eric Marsault,

a,, Hamid R. Hoveyda, a, Ren Gagnona, Mark L. Petersona, Martin V zinaa,

Carl Saint-Louisa, Annick Landrya, Jean-Fran ois Pinaulta, Luc Ouelleta,

Sophie Beauchemina, Sylvie Beaubiena, Axel Mathieua, Kamel Benaklia,

Zhigang Wanga, Martin Brassarda, David Lonergana, Fran ois Bilodeaua,

Mahesh Ramaseshana, Nadia Fortina, Ruoxi Lana, Shigui Lia, Fabrice Galauda,

V ronique Plourdea, Manon Champagnea, Annie Douceta, Patrick Bh rera, Maude

Gauthiera, Gilles Olsena, G rald Villeneuvea, Shridhar Bhata, Laurence

Fouchera, Daniel Fortina, Xiaowen Penga, Sylvain Bernarda, Alexandre

Drouina, Robert D ziela, Gilles Berthiaumea, Yves L. Dory, Graeme L.

Frasera and Pierre Deslongchamps, Bioorganic and Medicinal Chemistry

Letters; 2008, 16, 4731-4735

Novel compounds as P2X7 modulators and uses thereof. Kincaid, John; Cao,

Yeyu; Kaub, Carl; Lonergan, David; Kelly, Michael. WO/2007/0202822

Bicycloheteroaryl amine compounds as ion channel ligands and uses thereof.

Kelly, Michael; Janagani, Satyanarayana; Wu, Guoxhian; Kincaid, John;

Lonergan, David; Fang, Yunfeng; Wei, Zhi-Liang. WO/2006/118598

Identification of novel, orally-active inhibitors of the TRPV1 (VR1)

receptor. Wei, Zhi-Liang; Fang, Yunfeng; Kaub, Carl; Janagani,

Satyanarayana; Sahasrabudhe, Kiran; Wu, Guoxhian; Kincaid, John; Duncton,

Matthew; Lonergan, David; Orike, Nina; Ramomoorthy, Krithika; Dourado,

Michelle; Acevedo, Alejandra; Vincent, Fabien; Hackos, David; Zhang,

Qingling; Liu, Luna; Shumilla, Jennifer; Maruyama, Karly; Haque, Nadia;

Brotz, Tilmann; Emerling, Daniel; Martin, Kathleen; Takada, Junji; Nakao,

Kazunari; Baba, Katsuhiro; Nakagawa, Tetsuhiko; Yamamura, Kenzo; Kelly,

Michael. Abstracts of Papers, 232nd ACS National Meeting, San Francisco,

CA, United States, Sept. 10-14, 2006 (2006), MEDI-496.

The application of MAOS to medicinal chemistry and drug discovery. David

Lonergan. Biotage Symposium on Microwave Assisted Organic Chemistry,

February 21, 2006, San Francisco.

Bicycloheteroaryl amine compounds as ion channel ligands and uses thereof.

Kelly, Michael; Janagani, Satyanarayana; Wu, Guoxhian; Kincaid, John;

Lonergan, David; Fang, Yunfeng; Wei, Zhi-Liang. WO/2005/066171

Preparation of pyridopyrimidines and analogs thereof as ion channel

ligands. Kelly, Michael G.; Janagani, Satyanarayana; Wu, Guoxian; Kincaid,

John; Lonergan, David; Fang, Yunfeng; Wei, Zhi-Liang. U.S. Pat. Appl.

Publ. (2005)

Preparation of bicycloheteroarylamines like 2,6-naphthyridinamines and

pyrido[3,4-d]pyrimidinamine as ion channel ligands and uses thereof.

Kelly, Michael G.; Janagani, Satyanarayana; Wu, Guoxian; Kincaid, John;

Lonergan, David; Fang, Yunfeng; Wei, Zhi-Liang. WO 2005/066171/ A1

Microwave Assisted Organic Synthesis on Solid Support: A Comparison of

Microwave Effects Between SynPhase Lanterns and Standard Resin. David

Lonergan, Aydar Sabirov and Nikolai Sepetov. Northern

California Symposium on Microwave Assisted Organic Chemistry, May 2004,

South San Francisco.

A Comparative Probe For Stacking Interactions in Simple A:T Base Pair

Mimics. David G. Lonergan, Jonathon Halse, and Ghislain Deslongchamps.

Tetrahedron Letters 1998, 39, 6865

Tricyclic Scaffolds for the Rapid Assembly of Abiotic Receptors. David G.

Lonergan and Ghislain Deslongchamps. Tetrahedron 1998, 54, 14041

A Remarkable Adenine Binding Cleft Based on a Hydroxyimide Scaffold. David

G. Lonergan, Salvador Tomas, and Ghislain Deslongchamps. Tetrahedron

Letters 1998, 39, 7861

A Comparative Probe For Stacking Interactions in Simple A:T Base Pair

Mimics. David G. Lonergan, Jonathon Halse, and Ghislain Deslongchamps. 81st

CSC Conference and Exhibition, Whistler, B.C. June 1, 1998. Poster

An Improved Hydroxyimide Module for Molecular Recognition. D.G. Lonergan

and G. Deslongchamps. 80th CSC Conference and Exhibition, Guelph, Ont. June

1, 1997. Oral Presentation. Award for Best Graduate Student Presentation.

A Convergent Hydroxyimide Module for Molecular Recognition. David G.

Lonergan, Juan Riego, and Ghislain Deslongchamps. Tetrahedron Letters 1996,

34, 6109

Tricyclic Units for the Modular Assembly of Abiotic Receptors. D. Mink, S.

Devarenne, D.G. Lonergan, G. Deslongchamps. 78th CSC Conference and

Exhibition, Windsor, Ont. May 30, 1995

References Available Upon Request

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