Meagan M. Corrigan

*** **** ******* ******, *** Floor

West Chester, Pa 19382

(P): 570-***-****

(E): abmj75@r.postjobfree.com

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Work Experience

Protez Pharmaceuticals (subsidiary of Novartis Pharmaceuticals,

Infectious Diseases), Malvern, Pa

Research Associate (co-op research associate from 04/2008 to 04/2009,

then full-time research associate from

04/2009 to 04/2010)

. Performed microbiological and biochemical assays in support of

a beta-lactamase inhibitor program

. Profiled resistance mechanisms in gram-negative bacteria

impacting activity of beta-lactam antibiotics

. Experience in protein purification of beta-lactamases, steady-

state characterization of inhibitor binding affinities (Ki) and

IC50 determinations of inhibitor activity against purified

enzymes

. Experience with medium and high throughput screening (both

target-based and whole-cell screens) using a Biomek FX liquid

handling system

. Responsible for mammalian cell culture and compound

cytotoxicity profiling

. Performed and optimized Western blot analysis for detection of

p53 in HeLa cells in support of compound mode of action (MOA)

studies

TetraLogic Pharmaceuticals, Malvern, Pa

Research Assistant (co-op position), April 2007 to September 2007

. Performed cell-based assays and western blotting to determine

effectiveness of chemotherapeutic

molecules

. Treated and prepared cells for FACS determinations

. Carried out fluorescence polarization assays to examine

binding affinity

. Conducted a high throughput screen to identify HAUSP active

molecules

. Maintained several mammalian cell lines

Technical skills and experience

IC50 determinations

MIC (fixed ratios, fixed antibiotics)

Checkerboard synergy testing

High throughput screening

Time-kill determination

Compound solubility testing

Familiarity with DNA isolation and quantization methods

Familiarity with protein purification and quantization

Hemolysis testing

Enzymatic assays

Resistance profiling (serial passages and mutational frequency)

Outer membrane protein profiling

Serum protein binding assays for small molecules

Mammalian cell culture

Compound cytotoxicity (MTT and MTS)

Gel electrophoresis

Western blotting

Familiarity with FACS

Microbial identification (RapidID, NF Strips, gram staining)

Streaking plates

Generating plate counts

Education and Honors

Drexel University, Philadelphia, PA

Degree acquired: Bachelor's of Arts and Sciences in Unified

Sciences, 2009

Cumulative GPA: 3.43

Drexel University, Philadelphia, PA

Penonni Honors College, September 2004-June 2009

Publications (Poster abstracts)

In vitro resistance development to tobramycin by Pseudomonas aeruginosa is

minimized by addition of PTZ601. D.M. Daigle, J. Hamrick, M. Corrigan, D.

Peaver, C. Burns, L. Xerri. European Congress of Clinical Microbiology and

Infectious Diseases (ECCMID), Helsinki, Findland, May 16-19, 2009.

References

Denis M. Daigle, Ph.D, Senior Scientist, Protez Pharmaceuticals,

Malvern PA. (reporting manager) abmj75@r.postjobfree.com, 484-***-****

(cell).

Daniel C. Pevear, Ph.D. Head of Biology, Protez Pharmaceuticals,

Malvern PA, abmj75@r.postjobfree.com, 617-***-**** (cell).

Christopher Benetatos, Senior Scientist, TetraLogic Pharmaceuticals,

Malvern, PA,

abmj75@r.postjobfree.com. 610-***-**** (work).

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