Pamala B. Adams

**** ******* ***** *****/***: 858-***-****

San Diego, CA 92122 abmhzn@r.postjobfree.com

Career Summary

** **** ****** ***** ** Pharmacology R&D

Calcium Channels Receptors Enzymes

Senior pharmacology researcher with extensive pharmaceutical and biotech

experience. Area of expertise is in assay development and implementation of

ex vivo and in vitro models in support of drug discovery efforts.

In Vitro and Ex Vivo Pharmacology R&D

. Immunoassays

(ELISA: growth factors, RIAs: CGRP Release)

. Spectrophotometric Assays

(Ca2+ Imaging: Glutamate Release)

. Radioisotopic Assays

. Neurotransmitter Assays

. Smooth Muscle Assay

. Tissue Culture

. Small Animal Surgical Techniques

Managerial and Organizational Skills

. Manager at SIBIA and Merck

. Assistant RSO at Merck.

. Radiation Safety Representative at SIBIA and Merck

. Developed Animal Usage Protocols for multiple departments at SIBIA and

Merck.

. Effectively presented experimental results at departmental meetings,

project team meetings, and scientific conferences.

. Responsible for laboratory maintenance of compound inventory,

radioactive

inventory, new machine implementation and ongoing maintenance of

machines for multiple departments at SIBIA and Merck.

Professional Research Experience

1999-2004 Merck Research Laboratories

Research Biologist (Neuropharmacology)

Responsible for developing and implementing assays in order to

Characterize drug candidates for Department of Pharmacology.

Implemented radioligand binding assays utilizing tissue, human serum, and

cell

lines in support of neuropathic pain, Alzheimers and cognition programs in

order

to evaluate compounds as agonists.

Developed and implemented numerous neurotransmitter release assays of the

brain,

spinal cord, and smooth muscle in support of neuropathic pain, ischemia,

and

cognitive programs.

Implemented Immuno assays and Fluro-3 assay which became an ongoing

screen for various projects.

1994-99 SIBIA Neurosciences

Senior Associate Scientist (Neuropharmacology)

Responsible for developing and implementing in vitro assays in

characterizing drug candidates for Department of Neuropharmacology.

Implemented growth factor (ELISA) assays.

Implemented neurotransmitter release assays.

1987-94 Abbott Laboratories

Associate Scientist (Neuroscience Discovery)

Responsible for implementing in vitro and in vivo assays in

characterizing drug candidates for Department of Neuropharmacology and

Cardiovascular Department.

Small animal Surgical Techniques for screening in search of Cardiovascular

drug

discovery efforts.

Education

1985- Idaho State University

M.S. Program (Microbiology)

Course work completed and partial completion of M.S.

thesis research

1982- College of Great Falls

B.S. Degree: Biology (Major)/Chemistry (Minor)

Publications

Dopamine D I receptor stimulation of cyclic AMP accumulation in COS- I

cells. Steffey ME,

Snyder GL, Barrett RW, Fink A, Ackerman M, Adams P, Bhatt R, Gomez E,

MacKenzie RG.

European Journal of Pharmacology 207(4):311-317, August 14, 1991

Abt418: A novel cholinergic channel ligand with cognition enhancing and

anxiolytic activity: 1. In

vitro characterization. S. Arneric, J. Sullivan, C. Briggs, D. Donnelly-

Roberts, D. Anderson, J.

Raszkiewicz, M. Hughes, E. Cadman, P. Adams, D. Garvey, J. Wasicak, and M.

Williams. J.

Pharmacol. Exp. Therapeutics January 1994. -Epibatidine elicits a diversity of in vitro and in vivo effects

mediated by nicotinic acetylcholine

receptors. J.P. Sullivan, M.W. Decker, J.D. Brioni, D. Donnelly-Roberts,

D.J. Anderson, A. W.

Bannon, C-H. Kang, P. Adams, M. Piattoni-Kaplan, M.J. Buckley,

M.G.Krisfinan, M. Williams,

and S.P. Arneric. Feb. 1994: J. Mol. Pharm.

Cosford, NDP, Bleicher, L, Herbaut, A., McCallum, JS, Vernier, J-M, Dawson,

H, Whitten, JP,

Adams, P, Chavez-Noriega, LE, Correa, L, Crona, JH, Mahaffy, LS, Menzaghi,

F, Rao, TS, 9. Reid,

R., Sacaan, A., Santori, E., Stauderman, KA, Whelan, K, Lloyd, K and

McDonald,IA. (S)- -5-

Ethynyl-3-(l-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): A novel

antiparkinsonian agent

with selectivity for neuronal nicotinic acetylcholine receptors. Journal of

Medicinal Chemistry, 39:

3235-3237, 1996.

Cosford, N. P., Bleicher, L. D., Herbaut, A., McCallum, S., Vernier, J.-M.,

Dawson, H., Whitten, J.

P., Adams, P. B, Chavez-Noriega, Correa, L. D., Crona, J, H., Mahaffy, L.

S., L., Menzaghi, F., Rao,

T. S., Reid, R. T., Sacaan, A. I., Santori, E. S., Stauderman, K., Whelan,

K. Lloyd, G. K., and

McDonald, 1. (S)- -5-Ethynyl-3-(l-methyl-2-pyrrolidinyl)pyridine maleate

(SIB-1508Y): A novel

anti-parkinsonian agent with selectivity for neuronal nicotinic

acetylcholine receptors. J. Med.

Chem. 39, 3235-3237, 1996.

Saccan, A. L, Reid, R., Santori, E., Adams, P. B., Correa, L. D., Bleicher,

L., Cosford, N. C.,

Mahaffy, S., Stauderman, K., McDonald, I., Rao, T. S. and Lloyd, G. K.

Pharmacological

characterization of SIB-1 765F, a novel neuronal nicotinic acetylcholine

receptor agonist. J.

Pharmacol. Exp. Ther. 280, 393-400, 1997.

Stauderman, KA, Mahaffy, LS, Akong, M., Velicelebi, G., Chavez-Noriega, LE,

Crona, JH, Johnson,

EC, Elliott, K.J., Gillespie, A, Reid, RT, Adams, P, Harpold, M and Corey-

Naeve, J Characterization

of human recombinant neuronal nicotinic acetylcholine receptor subunit

combinations a2p4, a3b4

and a4b4 stably expressed in HEK293 cells. Journal of Pharmacology and

Experimental

Therapeutics, 284: 777-789, 1998.

Chavez-Noriega, LE., Stauderman, KA, Mahaffy, LS, Crona, JH, Johnson, EC,

Elliott, K, Gillespie,

A, Reid, RT, Adams, P, Velicelebi, G., Harpold, M and Corey-Naeve

Characterization of the

recombinant human neuronal nicotinic acetylcholine receptors a3b2 and a4b2

stably expressed in

HEK293 cells. Neuropharmacology, 2000,39: 2543-2560.

Rao, T.S., Correa, L.D., Adams, P., Santori, E.M., Sacaan, A.I.

Pharmacological characterization of

dopamine, norepinephrine, and serotonin release in the rat prefrontal

cortex by neuronal nicotinic

acetylcholine receptor agonists, Brain Res. 990: 203 (2003).

Rao, T.S., Adams, P., Correa, L.D., Santori, E.M., Sacaan, A.I., Reid,

R.T., Suto, C.M., Vernier, J.M.

In vitro pharmacological characterization of -4-[2[(1-methyl-2-

pyrorolidinyl)ethyl]thiophenol

hydrochloride (SIB-1553A), a novel cholinergic ligand. Brain Res. 981:85

(2003).

Rao, T.S., Sacaan,A.I., Menzaghi, F.M., Reid, R.T., AdamsP.B. Correa,

L.D.,Whelan,

K.T.,Vernier,J.M. Pharmacological characterization of SIB-1663, a

conformationally rigid analog of

nicotine, Brain Res. 1003(1-20:42-53 (2004)

Tadimeti S. Rao, Pamala B. Adams, Lucia D. Correa, Emily M. Santori,

Aida I. Sacaan, Richard T. Reid, Nicholas D.P. Cosford, Pharmacological

characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine

HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor

agonist

Brain Research, ISSN: 0006-8993, Vol: 1234, Issue:, Date: 2008-10-09,

Pages: 16-24

Select Abstracts

Synthesis and pharmacological evaluation of 1-aminoethyl-3,4-dihydro-

5hygroxyl-lH-2-

benzopyrans as dopamine D1 selective ligands. Michaelides MR, Schoenleber

R, Thomas

S, Yanamoto DM, Adams P, Gomez E, Steffey M, Bonjour L, Curzon P, Britton

DR, Mackenzie R,

Kebabian JW. 202nd ACS National Meeting,New York, August 25-30,1991

Abstract MEDI-127

Modulatory role of nicotine on NMDA-induced increases in cGMP levels in rat

cerebellar slices.

Adams P, Sheng H, Kohlhass K, Arneric SP, Sullivan JP. Abstracts of the

22nd Annual Meeting of

the Society for Neuroscience, Anaheim, October 25-30, 1992 p. 902. Abstract

337. 10

Rao, T. S., Saccan, A. I., Reid, R., Correa, L., Adams, P., Bleicher, L.,

Cosford, N. McDonald, 1. and

Lloyd, G. K. In vitro characterization of SIB-1765F, a novel nicotinic

agonist. Society For

Neuroscience. 21, # 247.4, 1995.

Chavez-Noriega, L.E., Zahl, N., Mahaffy, S., Crona, J.H., Reid, R., Adams,

P., Elliott, K.J.,

Berckhan, K., Stauderman, K.A. and Corey-Naeve, J. Characterization of

human neuronal nicotinic

acetylcholine receptors (nAChRs) a4b2 and Ob2 stably expressed in HEK-293

cells. Society for

Neuroscience Meeting Abstracts Vol. 22, p. 1527, 1996.

Menzaghi, F., Sacaan, A. I., Reid, R. T., Santori, E., Correa, L. D.,

Adams, P. B., Whelan, K.,

Risbrough,V.,Rao,T. S., Schneider, J., G. K. Lloyd. Characterization of SIB-

1508Y, the active

enantiomer of a novel nicotinic acetylcholine receptor (NAChR) agonist, SIB-

1765F. Society for

Neuroscience. 22, # 602.11, 1996.

P.B. Adams, R.T. Reid, J.Corey-Naeve,G.K. Lloyd and T.S. Rao

Characterization of Ligand

Binding to Cell Lines Stably Expressing Human Recombinant Neuronal

Nicotinic Acetycholine

Receptor (NAChR) Subunits In Pairwise Combinations. Society For

Neuroscience Meeting

Abstracts 1997 Abstract MEDI-1 57.7

Reid, R. T., Sacaan, A. I., Adams, P. B., Correa, L. D., Santori, E. M.,

McDonald, 1. A., Lloyd, G.

K. and Rao, T. S. Pharmacological characterization of SIB-1553A, a novel

subtype selective

neuronal nicotinic acetylcholine receptor agonist. Soc. Neuroscience. 23,

#477.17, 1997.

Varney, M.A., Sacaan, A.I., Adams, P., Correa, L., Glotfelty, A., Chavez-

Noriega, L., Washburn, M.,

Johnson, E.C., McIntosh, J.M., Rao, T.S., Lloyd, G.K. Pharmacological

characterization of

neuronal nicotinic acetylcholine receptor (nAChR)-mediated neurotransmitter

release from rat brain

slices. Experimental Biology, ASPET Symposium 1999.

Adams, P.B., Urban, M.O., Ren, K., Aiyar, J., Stearns, B., Campbell, B.,

Cohen, C.J., and Varney,

M.A. Gabapentin inhibition of K+-evoked [3H]-norepinephrine release from

rat annocygeus

muscle.

Society For Neuroscience New Orleans 2004.

Contact this candidate