Process Engineer

GENE E. KIDMAN, Ph.D.

* ******* *******, *****, ** 13753

Phone: 607-***-****

*********@*****.***

Manager/Biotech Specialist/Engineer

A versatile contributor in a business, marketing or technical setting

Project Management/ Large Scale Production/ Research and Development

Wastewater Engineering/ Process, Quality and Regulatory Documentation

Dynamic career of successful project leadership, profitable process start-

up and outstanding technical support. Excellent analytical, organizational,

problem solving, team building, and communication skills. Liaison to

regulators, customers, and the technical community.

Professional Experience:

DMV-International, Delhi, NY 2007-2009

Senior Process Technologist

Food Safety

Provided production support to validate a new Critical Control Point, (CCP)

for a hydrolysate. Received training in HACCP (Hazard Analysis & CCP) and

became a member of our Food Safety Management, (FSM) team.

. Reviewed the HACCP plan

. Updated safe holds and rework loops

. Selected a challenge team

. Recommended change to pest control

. Reviewed plans for CCP validation

. Reviewed the challenge team's challenges

. Implemented corrective actions to FSM

Process Trouble-shooting

As a member of the material review board and a member of small group

activity on Out Of Specification, (OOS).

. Supervised a summer intern's investigations of non conformances

. Proposed specifications changes in-line with process capacity of several

products

. Determined measures for management to track improvement to OOS

. Implemented process change as corrective actions. Reduced OOS by 6%

Support to Quality Control

. Participated in audits by customer

. Investigated of batches for possible causes of specific complaints

. Modeled and analyzed process data to find new ways to meet new customer

requirements

. Correlation of customer performance data to process measurements

New Project Development

Managed multi-discipline new process development projects.

. A new hydrolysate for cell culture market to improve growth and

performance (i.e antibody production)

. A new hydrolysate for infant formula that is lightly hydrolyzed and

tastes good

DMV-International, Delhi, NY continued

Change Control

As a member of the change control board, reviewed all change requests. This

work involved a 2 hour team meeting once a week and follow-up assignments

such as lab experiments, data analysis and updates to PFDs, recipes, etc.

Change requests included:

. Alternative raw materials

. Equipment or hygiene upgrades

. Process improvement recommendations

. Rework plans

Engineering Team

Participated in a team to examine plans for a new plant and conducted small

research projects.

. Identified a better way to access powder appearance

. Improved the removal of endotoxin by ultrafiltration

. Reviewed new HTST design for a new plant

. Assisted in validation of new water sources for a new plant

. Conduced experiments to improve ultra filtration performance

Martek Biosciences Kingstree Corp., Kingstree, SC

2004- 2006

Fermentation Engineer

Member of Process Teams

. Co-led a cross-disciplinary multi-site team to scale-up a process for DHA

(omega 3 oil)

. Provided statistical analyses of production lots to trouble shoot scale-

up

. Advised on expansion of wastewater treatment plan

. Conducted process-training classes.

. Provided expert input in HACCP plan

Process Improvement

. Discovery and reduction to practice of glucose starvation to remove

lauric acid and increase DHA purity (25,000-40,000 gallons Fermentors)

. Statistical determined (and applied) airflow and glucose profiles to

minimize lauric acid and maximize DHA

. Increased productivity by increasing recipe weights

. Introduced reduced cost seed medium

. Made mass balances for recovery of dihydroxyacetone

. Analyzed pilot data to create kinetic model for dihydroxyacetone

University of Wisconsin, Madison, WI

2002- 2004

Research Associate, School of Pharmacy

Research Team

. Contributed to the team's effort to better understand how enzymes work.

(see publications)

. Discovered unusual solute protection against pressure inactivation of

enzymes

. Measured change in binding with pressure of oxidized and reduced

nucleotides

. Demonstrated pressure stability's relation to protein isoelectric point

. Experimented with kinetic isotope effects in proteinases and

deydrogenases

Gene Kidman Ph.D. - Page Two

Consultant, Brookfield WI

1992- 2002

Concurrent with the work experience below, contributed to various projects.

. The molecular biology of the cytochromes of Shewanella putrefaciens at

UWM

. Development of a biopesticide used in San Joaquin valley in California

. Development of a flavor agent (enzyme modified cheese)

. Searched out answers to regulatory matters for biotech companies

BTI-MBD Project LLC, Waukesha, WI 1999-

2002

Principal investigator

Conducted all laboratory testing and analysis in microbiology and

chemistry for a project that produced a test method for the detection

of fecal contamination based on fluorescent spectroscopy.

Siemens Fossil Power Corp, Milwaukee, WI

1997- 2000

Technical Writer

Authored descriptions of systems operations and organized all the

technical data for all the component parts for multimillion-dollar gas

turbine electric power plants.

Jayto Corp. Sussex, WI

1995- 2002

Vice President of Research and Development

Engineered the membrane systems, quoted equipment, consulted on

chemical and regulatory questions, assisted with sales calls and

installations.

North American BioIndustries Corp. New Berlin, WI

1993- 1995

Vice President of Research and Development

Managed research and all technical aspects of the business. Obtained

environmental permits, maintained compliance with regulatory agencies

and built wastewater reactors. Liaison with customers, suppliers, sub

contractors, and university research groups.

Biotronics Technologies, Inc. Waukesha, WI

1992- 1993

Manager Chemistry and Microbiology

Led a group of 4 scientists, all of whom developed analytical methods

for instrumentation: spectroscopy (IR, UV, VIS, FLUR, and Time

Resolved), atomic absorption, and acoustic wave devices. Our

biological subjects included bacteria, fungi, cell culture and blood.

Also performed hands on experiments; wrote research reports and

collaborated on SBIR proposals.

Universal Foods, Milwaukee, WI

1991

Group Leader Biochemistry and Microbiology

Directed the laboratory and 4 scientists developing and carrying out

projects focused on making yeast extracts and other food products from

yeast.

NutraSweet Company, Harbor Beach, MI

1982- 1991

Senior Fermentation Scientist

Supervision

. Supervised two biochemical engineers, two laboratory technicians and the

fermentation pilot plant supervisor

. Provided relief supervision for production

Gene Kidman Ph.D. - Page Three

NutraSweet Company, Harbor Beach, MI continued

Direct Support to Production:

. Completed industrial instrumentation and Foxboro users course then

implemented and validated a distributed control system for process

fermentation

. Wrote manufacturing instruction, standard operating procedures and helped

scale L-phenylalanine fermentation to 40,000 gallons

. Trained personnel and provided technical assistance to production

. Helped develop and implement process change control

. Provided expert help in resolution of various technical problems

(restoration of sterility, elimination of phage, salvaging batches after

various types of equipment failure, debottlenecking, and simplification

of process and process control improvement)

. Reviewed procedures, medium and equipment for start-up of second plant

Support to Production

Prior to first scale-up preformed multi factor analysis of sugar feed

strategies, pH profiles and the effects of temperature, backpressure and

airflow on L-phenylalanine synthesis

. Helped develop recovery process and helped improve recovery process which

over many years increased recovery from near 50% to near 90%. (cell

settling, evaporation, belt filtration, carbon treatment,

recrystallization and drying)

. Determined critical control ranges for temperature, pH, and glucose

concentration from process data. Then combined parameter control to

stepwise to bring titers for 20 gm/L to over 30 gm/L

. Reduced cost by eliminating ammonium phosphate from the fermentation

media

. Improved titers by adding trace minerals and then validated the

usefulness of each

. Discovered that water quality affects titer

. Evaluated phage resistant strains, culture lots and improved titer stains

. Explored the limits of cell density on production

. Determined that lactose would not substitute for sucrose but controlled

feeding of high fructose corn syrup or dextrose syrup would

. Found less expensive substitutes for tyrosine

. Modified pH profile of the fermentation to improved conversion of

intermediate to final product. Improved conversion by addition of

aspartate, glutamate or fumarate. Discovered accumulation of the

unexpected by product, phenyllactic acid

. Discovered how the interaction of specific growth rate with glucose

affects titer

. Discovered physiological relationship between glucose concentration early

in the fermentation and final titer

. Developed a computer program to test adapting physiological responses of

culture to glucose in order to develop an optimum glucose profile

. Discovered a process for the conversion of D-phenylalanine to L-

phenylalanine

Research and Development

. Discovered a method for selective crystallization of L-phenylalanine from

racemic mixtures

. Invented a device to make and sort beads of immobilized cells

. Received several awards by the company and the patents

. Planned, led and completed expansion of fermentation pilot plant (40L-

4000L fermentors) distributed control with supervisory computer)

. Led scale-up of an enzyme immobilization process (60-80 kilos of catalyst

per day) on schedule and on budget.

. Helped develop continuous process for aspartic acid production

Gene Kidman Ph.D. - Page four

EDUCATION

Ph.D. Microbiology, Brigham Young University, GPA: 3.7

1983

Specialty: Microbial Physiology & Genetics Minor: Chemical

Engineering

M.S. Microbiology, Brigham Young University, GPA: 3.4

1979

Study area: Industrial Microbiology Minor Biochemistry

B.A. Microbiology, Weber State University, Cum Laude

1976

Minor: Chemistry

Memberships, HONORS AND ACTIVITIES

* 27 year member of the American Chemical Society.

* Hurricane relief worker.

* Elected to Sigma Xi.

* Member of the American Society for Microbiology.

* Member of the Society for Industrial Microbiology.

* Listed in Who's Who Among Students in American Universities and

Colleges, 1975-76 edition.

PATENTS AND PUBLICATIONS

Kidman, G., and Northrop, D.B. Unusual Solute Protection against Pressure

Inactivation of Yeast Alcohol Dehydrogenase. Prot. Pept. Lett. Vol. 12,

No. 8, pp. 801-803, 2005

Park, H., Kidman, G. and Northrop, D.B. Effects of Trehalose on Pressure-

Induced Inactivation of Yeast Alcohol Dehydrogenase. Prot. Pept. Lett. Vol.

12, No. 6, pp. 597-599, 2005

Kidman, G., and Northrop, D.B. Effect of Pressure On Nucleotide Binding to

Yeast Alcohol Dehydrogenase. Prot. Pept. Lett. Vol. 12, No. 5, pp. 495-497,

2005

Park, H., Kidman, G. and Northrop, D.B. Effects of Pressure on Deuterium

Isotope Effects of Yeast Alcohol Dehydrogenase Using Alternative

Substrates. Arch. Biochem. & Biophys Vol. 433, pp. 335-340, 2005

Kidman, G., Park, H. and Northrop, D.B. Pressure Stability of Proteins at

Their Isoelectric Points. Prot. Pept. Lett. Vol. 11, No. 6, pp. 1-4, 2004

Kidman et al. Racemic Conversion of Using a Transaminase. U.S. Patent

5,316,943 May 31, 1994

Kidman, G. E. Exploiting the Property of Cooperative Binding to Improve

Analytical Sensitivity for Rubidium. American Chemical Society Meeting,

Denver, April 1993

Fotheringham, I.G., Kidman, G. E., McArthur, B.S., Robinson, L. and

Scollar, M.P. Aminotransferase-catalysed Conversion of D-Amino Acids to L-

Amino Acids. Biotechnol. Prog. Vol. 7, pp. 380-381. 1991

Patents and publications continued

Kidman et al. Recovery of L-amino Acid Isomers from Their Racemic

Mixtures. U.S. Patent 4,847,409 Jul. 11, 1989

Kidman, G. E. Ergosterol Accumulation in Saccharomyces cerevisiae -

Factors influencing the Rate of Accumulation. Ph.D. Dissertation Brigham

Young University. 1983

Larsen, D. H. and Kidman, G. E. Influence of Culture Conditions on the

Ratio of Ergosterol to 24(28) Dehydroergosterol in Saccharomyces

cerevisiae. Abstracts of the Annual Meeting of the American Society for

Microbiology. 1983

Kidman, G. E. Ergosterol Accumulation in Saccharomyces cerevisiae -

Influence of Nutritional Factors and Cultural Age. M.S. Thesis, Brigham

Young University, 1979

Kidman, G. E. and Larsen D. H. Influence of Nutritional Factors on

Accumulation of Ergosterol and 24(28)Dehydroergosterol in Saccharomyces

cerevisiae. Abstracts of the Annual Meeting of the American Society for

Microbiology. 1979

Gene Kidman Ph.D. - Page five

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