Victor I. Deaciuc

**** ***** **., ***. ****

San Diego, CA 92122

858-***-****

Email: abm4eg@r.postjobfree.com

Objective: To secure a technically challenging position as an Analytical

Chemist/Scientist in a modern, fast paced, and teamwork oriented

pharmaceutical company. As a strongly motivated and detailed

oriented employee, I will be able to apply my relevant

analytical experience towards the accurate and timely completion

of projects assigned to me.

Experience: March 2007-September 2008, Itherx Inc. (formerly Immusol

Inc.), San Diego

Research Associate IV

. Repaired, maintained, acquired and setup HPLC systems in

the analytical chemistry laboratory

. Trained laboratory staff in the proper use and care of

said systems and software, including analytical method

development, data processing, and interpretation

. Gave analytical chemistry support in the development of new

chemical entities (NCE'S) for the the in house drug

development programs (ophthalmology, oncology, virology)

. Developed and validated analytical methods suitable for the

assay of analytes in complex matrices (i.e. blood, plasma,

sera, various cell extracts, etc.)

. Performed numerous physico-chemical drug screening tests

(i.e. solubility, in vitro metabolic stability in

microsomes and hepatocytes, protein (HSA) binding, CACO

assessment, etc)

. Performed CYP450 inhibition studies in order to elucidate

metabolic liabilities of candidate drug substances

. Set up and executed accelerated stability studies on lead

API 's and their respective formulations (solids,

suspensions, solutions, emulsions, etc.)

. Participated in the selection and evaluation of excipients

in said formulations

. Supported the organic synthesis group by confirming purity,

identity, etc. of new entities

. Presented data to the board on a weekly and sometimes more

frequent basis

March 2001-November 2006, Cardinal Health, San Diego

(2001-2003 Magellan Laboratories, 2003-2006 Cardinal Health,

Company ownership change)

Scientist, Dosage and Formulation Design

. Participated in multiple facets of various existing

preformulation and formulation studies.

. Performed extensive analytical development work in a cGMP

compliant environment in support of ongoing formulation

protocols.

. Transferred, developed, and validated analytical

methodology employed in assessing the stability of multiple

API's and sterile liquid, lyophilized, and emulsion

injectable dosage forms.

. Responsibilities included: experimental design, protocol

authorship, development and documentation of relevant

analytical test methods, preparation and placement of

formulations on stability programs, coordination and

execution of the analysis of pulled aliquots, and

generation, analysis, trending of the stability data.

. Presented data in meetings with clients and staff,

delivered updates, results, and overall project status.

. Served as a useful HPLC method development resource for our

facility and participated in troubleshooting HPLC systems

and separations on various ongoing projects.

. Instructed new and junior staff by introducing them to the

proper operation and care of instrumentation systems and

associated software interfaces previously unfamiliar to

them (Waters HPLC hardware coupled with Empower data

processing/reporting package).

September 1999-December 2000, Contract Employee, YOH Scientific,

San Diego

Analytical Chemist, Alliance Pharmaceutical, San Diego

. Developed and validated HPLC assays for various excipients

in Oxygent, a perfluorocarbon-egg yolk phospholipid based

emulsion that served as an artificial blood substitute.

Analytical Chemist, Integra Lifesciences, San Diego

. Executed FMOC synthesis and purification of RGD peptides, a

class of compounds that mediates adhesion between cells and

the extracellular matrix, maintained peptide library.

. Conducted manual and synthesizer assisted syntheses of

various RGD peptide homologues to enrich the existent

peptide library.

. Developed and employed semi-preparative and analytical

scale reversed phase chromatography methods aimed at

purifying and identifying the peptides that were

synthesized in house.

Chemist, Gen-Probe, San Diego

. Responsible for instrument assisted synthesis of milligram

to gram scale of oligonucleotides in support of Gen-Probe's

Transcription-Mediated Amplification (TMA) diagnostic kits.

. Purified and released synthesized oligonucleotides by means

of semi-preparative scale ion exchange chromatography and

gel electrophoresis.

August 1998-April 1999, Witco Corporation, Oleosurfactant Unit,

Harahan, Louisiana

QC Chemist, Chemical Plant QC Department

. Provided release testing for raw materials and finished

products in a high throughput 24 hour/day, 7 day/week, ISO

9001 certified facility.

. Employed a variety of analytical methodology to

characterize the ethoxylated amines, phenols, and alcohols

that were the bulk of the product line.

. Conducted RP-HPLC with RI detection, headspace GC-FID,

various titrations, refractive index, specific gravity,

Karl Fischer, hydroxyl number, etc.

May 1991-April 1997, Louisiana State University Medical Center,

New Orleans, Louisiana

Research Associate, LSUMC Center for Excellence in Neuroscience

. Participated in the dissection of donated human brain

specimens from schizophrenic patients and developed

analytical methodology for the assay of biogenic amines in

human brain tissue.

Research Associate, LSUMC Core Laboratories

. Performed oligonucleotide/PCR primer synthesis, FMOC

peptide synthesis, peptide and protein sequencing, amino

acid composition analysis.

. Executed chromatographic purification of in-house

manufactured peptides and peptide QC work by electrospray

mass spectrometry.

Education: Bachelors in Chemistry, 1986-1991, University of New Orleans,

New Orleans, Louisiana

Courses taken include Qualitative and Quantitative Analysis,

Organic Chemistry, Physical Chemistry, Differential, Integral,

and Multiple Variable Calculus.

Skills:

. Performed numerous HPLC method transfers, developments, and

validations.

. Familiarity with a number of chromatographic separation

modes including: RP-HPLC, SEC/GPC, and IEX-HPLC with

various detection modes (UV/VIS, PDA, RI, Scattering, etc).

. Thorough familiarity with the operation of Waters 2690/2695

separations module, Waters 486, 2487, and 2996 detectors as

well as Waters' Empower data processing and reporting

software.

. Troubleshooting and configuration skills in a networked

Empower environment, knowledge of Agilent 1100 and 1090

HPLC systems and the Chemstation software.

. Proficient at a number of instrumental techniques: UV-VIS

spectrophotometry, spectrofluorometry, SDS-PAGE and IEF,

titrations, particle size measurements by light scattering,

dissolution and disintegration, dialysis, osmolality

measurements, etc.

. Proficient with Microsoft's Office suite of applications

and have elementary programming skills in Basic.

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