San Francisco Ms Office
Resume:
Hyo Jeang Lee
****Valley Trails Drive
Pleasanton, CA 94588
650-***-**** (C)
925-***-**** (H)
abm3ai@r.postjobfree.com
OBJECTIVE
A Reagent Chemist position where I can best contribute through my
knowledge and skills.
HIGHLIGHTS
. Medicinal and combinatorial chemistry
Developed and synthesized 16 clinic trial compounds, 7 potential
drug candidate compound libraries, and 26 hit expansion and early
lead optimization libraries.
. Biocatalysis (enzyme) chemistry
Developed and optimized enzyme reaction for drug development and
bio-fuel.
. Inorganic chemistry
Multi-step synthesis of organometalic compounds, study of
electrochemistry for metalic compounds and extensive kinetic study
of electron transfer between inorganic compounds.
Education
M.S. Inorganic Chemistry, November 1998, University of San Francisco, San
Francisco, CA
Thesis Title: Stopped-flow Kinetic Studies of Ruthenium Complex Electron
Transfer Rates; Effect of Protonation of Distal Ligand Base Site and
Pyridyl ring Substituent Placement
B.A. Chemistry, March 1995, Soong-Sil University, Seoul, Korea
RESEARCH EXPERIENCE
Codexis, Inc. Redwood City, CA
Research Associate II, June 2006-Sept. 2009
. Multi-step synthesis of organic substrates, intermediates and
products used in the enzyme (biocatalytic) reactions.
. Test and validation of High Through Put screening methods for
enzyme reactions using fluorescent .
. Analyzed and characterized the enzymes and bio-masses.
. Designed and implanted bench scale process to desired product for
scale up reaction in process.
. Designed and executed experiments aimed at optimizing performance
of developmental enzymes.
Discovery Partners International, South San Francisco, CA
Research Associate II, Sept. 2002-June 2006 .
Research Associate I, Oct. 1999-Sept. 2002.
. Developed, optimized and synthesized drug candidate compound.
. Synthesized hit expansion and early lead-optimization libraries
within four to six weeks turnaround time; two weeks for testing
feasibility and optimizing reaction, one or two weeks for producing
library and one or two weeks for purifying library.
. Developed and optimized of solid- and liquid-phase and parallel
synthesis applied to drug discovery.
. Wrote detailed synthesis protocols as per The ACS Style Guide.
. Managed projects from beginning to successful conclusion working
with analytical, informatics, production, purification and QA
groups.
. Multi-step synthesis of organic compounds from large scale (mol) to
small scale (mmol).
University of San Francisco, San Francisco, CA
Graduate study, 1995-1998.
. Investigation of proton coupled electron transfer and deuterated
electron transfer of ruthenium amine complexes using stopped-flow
kinetic spectroscopy.
. Synthesis and characterization of ruthenium amine complexes.
. Spectrophotometric study of intervalence transfer (light induced
metal to metal charge transfer) between hydrogen bonded metals.
. Electroanalytical studies of ruthenium complexes in non-aqueous
solvents.
Skills
Technical and Instrumental Skills
. Trained in product isolation and purification using
recrystallization, preparative HPLC, column chromatography,
distillation.
. Trained in the interpretation and use of spectroscopic methods to
characterize compounds: FT- NMR (1H,13C), FT-IR, HPLC, GC-MS and LC-
MS spectrometer, Stopped-Flow Kinetic Spectroscopy, UV-VIS-NIR, UV-
VIS spectrometer, Bioanalyzer, PCR
. Software: ChemDraw, Scifinder, ISIS/Draw, ISIS/Base, MDL, Sigma
Plot, Hyper-Chem, MS Office.
Certifications and Awards
. Adult/Child/Infant First Aid and Responder Environmental
Emergencies
. First Responder Awareness and Operation for Hazardous Materials
(California Government code: 8574.19-23)
. Received two Employee recognition awards (2000, 2005) at DPI for
outstanding performance.
References
1) Prof. Jeff C. Curtis
Department of Chemistry
University of San Francisco
2130 Fulton Street
San Francisco, CA 94117
abm3ai@r.postjobfree.com
2) Dr. Onorato Campopiano
Staff Scientist
Codexis, Inc.
200 Penobscot Drive
Redwood City, CA 94068
abm3ai@r.postjobfree.com
3) Michael Cook
Director of Engineering
Codexis, Inc.
200 Penobscot Drive
Redwood City, CA 94063
abm3ai@r.postjobfree.com
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